WilliamMarstonLinehanMD

Surgical Oncology

Chief of Urologic Surgery and the Urologic Oncology Branch, Center for Cancer Research, at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland

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Office
9000 Rockville Pike Bldg 10
Bethesda, MD 20892
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Education & Training

Duke University HospitalResidency, Urology, 1978 - 1982
Duke University HospitalFellowship, Thoracic Surgery, 1976 - 1978
Duke University HospitalResidency, Surgery, 1974 - 1976
University of Oklahoma Health Sciences CenterInternship, Internal Medicine, 1973 - 1974
University of Oklahoma College of MedicineClass of 1973

Certifications & Licensure

MD State Medical License 1985 - 2024
American Board of Urology Urology

Awards, Honors, & Recognition

Whos Who in Medicine and Healthcare Marquis Whos Who

Clinical Trials

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders Start of enrollment: 1990 Dec 05
Recruiting
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease Start of enrollment: 1998 Mar 12
Recruiting
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer Start of enrollment: 2002 May 13
Recruiting
Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Start of enrollment: 2003 Feb 24
Recruiting
Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome Start of enrollment: 2003 Dec 01
Completed
Phase II Study of Vandetanib in Individuals With Kidney Cancer Start of enrollment: 2008 Feb 07
Completed
Phase 2
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Publications & Presentations

PubMed

214 citations
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Eric Jonasch, Frede Donskov, Othon Iliopoulos, W. Kimryn Rathmell, Vivek Narayan, Benjamin L. Maughan, Stéphane Oudard, Tobias Else, Jodi K. Maranchie, Sarah J. Welsh,...> ;The New England Journal of Medicine. 2021 Nov 25
10 citations
Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.
Gennady Bratslavsky, Neil Mendhiratta, Michael Daneshvar, James Brugarolas, Mark W. Ball, Adam R. Metwalli, Katherine L. Nathanson, Phillip M. Pierorazio, Ronald S. Bo...> ;Cancer. 2021 Nov 1
1 citations
Intravitreous treatment of severe ocular von Hippel-Lindau disease using a combination of the VEGF inhibitor, ranibizumab and PDGF inhibitor, E10030: Results from a ph...
Christopher K. Hwang, Emily Y. Chew, Catherine A Cukras, Tiarnan D L Keenan, Wai T. Wong, W. Marston Linehan, Prashant Chittiboina, Karel Pacak, Henry E. Wiley> ;Clinical & Experimental Ophthalmology. 2021 Sep 21
15 citations
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
Mark R. Woodford, Alexander J. Baker-Williams, Rebecca A. Sager, Sarah J. Backe, Adam R. Blanden, Fiza Hashmi, Priyanka Kancherla, Alessandro Gori, David R. Loiselle, ...> ;Nature Structural & Molecular Biology. 2021 Aug 1
49 citations
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets.
Nunziata Maio, Bernard A. P. Lafont, Debangsu Sil, Yan Li, J. Martin Bollinger, Carsten Krebs, Theodore C. Pierson, W. Marston Linehan, Tracey A. Rouault> ;Science. 2021 Jul 9
20 citations
A deep-learning based artificial intelligence (AI) approach for differentiation of clear cell renal cell carcinoma from oncocytoma on multi-phasic MRI.
Moozhan Nikpanah, Ziyue Xu, Dakai Jin, Faraz Farhadi, Babak Saboury, Mark W. Ball, Rabindra Gautam, Maria J. Merino, Bradford J. Wood, Baris Turkbey, Elizabeth C. Jone...> ;Clinical Imaging. 2021 Jun 18
5 citations
Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine.
Kazutoshi Yamamoto, Ana Christina L. Opina, Deepak Sail, Burchelle Blackman, Keita Saito, Jeffrey R. Brender, Ronja Maja Malinowski, Tomohiro Seki, Nobu Oshima, Daniel...> ;Scientific Reports. 2021 Jun 9
5 citations
Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma
Mark P. Purdue, Jongeun Rhee, Lee E. Moore, Xiaohua Gao, Xuezheng Sun, Erin L. Kirk, Vladimir Bencko, Vladimir Janout, Dana Mates, David Zaridze, Stacey Petruzella, A....> ;International Journal of Cancer. 2021 May 31
21 citations
Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases
Manik C. Ghosh, De-Liang Zhang, Wade H. Ollivierre, Audrey Noguchi, Danielle A. Springer, W. Marston Linehan, Tracey A. Rouault> ;Blood. 2021 May 6
3 citations
Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group.
Diego Abreu, Gustavo F. Carvalhal, Guillermo Gueglio, Ignacio Tobia, P. García, Álvaro Zúñiga, Luis Meza, Rubén G. Bengió, C. Scorticati, Ricardo Castillejos, Francisc...> ;JCO Global Oncology. 2021 May 1
7 citations
Reoperative Partial Nephrectomy-Does Previous Surgical Footprint Impact Outcomes?
Sandeep Gurram, Nicholas A. Friedberg, Chirag Gordhan, Winston Li, Michael Ahdoot, Jillian Egan, Nitin Yerram, Gennady Bratslavsky, Adam R. Metwalli, W. Marston Lineha...> ;The Journal of Urology. 2021 Apr 27
23 citations
Using Prostate Imaging-Reporting and Data System (PI-RADS) Scores to Select an Optimal Prostate Biopsy Method: A Secondary Analysis of the Trio Study.
Michael Ahdoot, Amir H. Lebastchi, Lori Long, Andrew R Wilbur, Patrick T. Gomella, Sherif Mehralivand, Michael Daneshvar, Nitin Yerram, Luke P. O'Connor, Alex Z. Wang,...> ;European Urology Oncology. 2021 Apr 10
6 citations
X-Capsular Incision for Tumor Enucleation (X-CITE)-Technique: A Method to Maximize Renal Parenchymal Preservation for Completely Endophytic Renal Tumors.
Amir H. Lebastchi, Brittnee Haynes, Sandeep Gurram, Gennady Bratslavsky, Adam R. Metwalli, W. Marston Linehan, Mark W. Ball> ;Urology. 2021 Apr 5
1 citations
18 Fluorodeoxyglucose-positron emission tomography/computed tomography for differentiation of renal tumors in hereditary kidney cancer syndromes
Moozhan Nikpanah, Anna K. Paschall, Mark A. Ahlman, Ali Cahid Civelek, Faraz Farhadi, S. Mojdeh Mirmomen, Xiaobai Li, Babak Saboury, Mark W. Ball, Maria J. Merino, Ram...> ;Abdominal Radiology. 2021 Mar 10
6 citations
Comprehensive characterization of Alu-mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families.
Cathy D. Vocke, Christopher J. Ricketts, Laura S. Schmidt, Mark W. Ball, Lindsay A. Middelton, Berton Zbar, W. Marston Linehan> ;Human Mutation. 2021 Mar 6
15 citations
Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research.
Toni K. Choueiri, Michael B. Atkins, Ziad Bakouny, Maria I. Carlo, Charles G. Drake, Eric Jonasch, Payal Kapur, Bryan Lewis, W. Marston Linehan, Michael J. Mitchell, S...> ;Journal of the National Cancer Institute. 2021 Mar 1
Macronodular adrenal hyperplasia masquerading as an upper pole renal mass
Jeunice Owens-Walton, Sandeep Gurram, Maria J. Merino, W. Marston Linehan, Mark W. Ball> ;Urology Case Reports. 2021 Feb 12
7 citations
Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management.
Patrick T. Gomella, W. Marston Linehan, Mark W. Ball> ;Genes. 2021 Feb 11
70 citations
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.
Ziad Bakouny, David A. Braun, Sachet A. Shukla, Wenting Pan, Xin Gao, Yue Hou, Abdallah Flaifel, Stephen Tang, Alice Bosma-Moody, Meng Xiao He, Natalie I. Vokes, Jacks...> ;Nature Communications. 2021 Feb 5
8 citations
Long term outcomes for patients with von Hippel-Lindau and Pheochromocytoma: defining the role of active surveillance
Thomas Sanford, Patrick T. Gomella, Rashid Siddiqui, Daniel Su, Julie Y. An, Gennady Bratslavsky, Mark W. Ball, W. Marston Linehan, Adam R. Metwalli> ;Urologic Oncology. 2021 Feb 1
19 citations
Glycolytic metabolism of pathogenic T cells enables early detection of GVHD by 13C-MRI.
Julian C. Assmann, Don E. Farthing, Keita Saito, Natella Maglakelidze, Brittany Oliver, Kathrynne A. Warrick, Carole Sourbier, Christopher J. Ricketts, Thomas J. Meyer...> ;Blood. 2021 Jan 7
51 citations
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
Daniel R. Crooks, Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, G. Mariah Cawthon, Ferri Sohelian,...> ;Science Signaling. 2021 Jan 5
10 citations
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma
James Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J Talbot, Megan E Bischoff, Yongzhen Zhang,...> ;The Journal of Clinical Investigation. 2021 Jan 4
2 citations
MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma.
Alessio Giubellino, Christopher J. Ricketts, Vanessa Moreno, W. Marston Linehan, Maria J. Merino> ;Journal of Cancer. 2021 Jan 1
3 citations
Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.
Maria Merino, Christopher J. Ricketts, Vanessa Moreno, Ye Yang, Teresa W.-M. Fan, Andrew N. Lane, Cathy D. Vocke, Daniel R. Crooks, W. M. Linehan> ;The American Journal of Surgical Pathology. 2021 Jan 1
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Press Mentions

Celebrating Outstanding Young Urologists: The Gold Cystoscope AwardApril 14th, 2024

Grant Support

Molecular Genetics Of Kidney CancerNational Cancer Institute2007
Molecular Genetics Of Kidney CancerDivision Of Clinical Sciences - Nci1997–2006
Molecular Genetics Of Prostate CancerDivision Of Clinical Sciences - Nci1997–2002
Tumor Suppressor Genes In Genitourinary MalignancyDivision Of Clinical Sciences - Nci1996