WilliamWLockwoodMD

PubMed

• 26 citations
  Coxsackievirus Type B3 Is a Potent Oncolytic Virus against KRAS-Mutant Lung Adenocarcinoma.
  Haoyu Deng, Huitao Liu, Tanya de Silva, Yuanchao Xue, Yasir Mohamud, Chen Seng Ng, Junyan Qu, Jingchun Zhang, William Jia, William W. Lockwood, Honglin Luo> ;Molecular Therapy Oncolytics. 2019 Jul 23
• 36 citations
  Acquired MET Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in EGFR-Mutated Lung Cancer.
  Ken Suzawa, Michael Offin, Adam J. Schoenfeld, Andrew J. Plodkowski, Igor Odintsov, Daniel Lu, William W. Lockwood, Maria E. Arcila, Charles M. Rudin, Alexander Drilon...> ;JCO Precision Oncology. 2019 May 10
• 114 citations
  SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer
  Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Fiset, Ralf J. Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther He...> ;Nature Communications. 2019 Feb 4
• 24 citations
  IL-33 increases ST2 + Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
  Elizabeth C. Halvorsen, S E Franks, Brennan J. Wadsworth, Bryant T. Harbourne, Rachel A. Cederberg, Catherine A. Steer, Itziar Martinez-Gonzalez, Jack Calder, William ...> ;Oncoimmunology. 2019 Jan 1
• 55 citations
  Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.
  Arun M. Unni, Bryant T. Harbourne, Min Hee Oh, Sophia A Wild, John Ferrarone, William W. Lockwood, Harold E. Varmus> ;Elife. 2018 Nov 26
• 10 citations
  In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.
  Ada W. Y. Leung, Chansey J. Veinotte, Nicole Melong, Min Hee Oh, Kent T.J. Chen, Katey S. S. Enfield, Ian Backstrom, Corinna Warburton, Donald T. T. Yapp, Jason N. Ber...> ;Clinical Cancer Research. 2017 Nov 1
• 16 citations
  MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis
  Sanjay Yadav, Nishant Singh, Parag P. Shah, David A. Rowbotham, Danial A. Malik, Ankita Srivastav, Jai Shankar, Wan L. Lam, William W. Lockwood, Levi J. Beverly> ;Neoplasia. 2017 Apr 1
• 13 citations
  How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?
  Harold E. Varmus, Arun M. Unni, William W. Lockwood> ;Cold Spring Harbor Symposia on Quantitative Biology. 2016 Jan 1
• 63 citations
  Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway.
  Traci Kruer, Susan M. Dougherty, Lindsey Reynolds, Elizabeth Long, Tanya de Silva, William W. Lockwood, Brian F. Clem> ;Plos One. 2016 Nov 10
• 128 citations
  Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis.
  Erin A. Marshall, Kevin W. Ng, Sonia H. Y. Kung, Emma M. Conway, Victor D. Martinez, Elizabeth C. Halvorsen, David A. Rowbotham, Emily A. Vucic, Adam W. Plumb, Daiana ...> ;Molecular Cancer. 2016 Oct 27
• 109 citations
  Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma
  Arun M. Unni, William W. Lockwood, Kreshnik Zejnullahu, Shih-Queen Lee-Lin, Harold E. Varmus> ;Elife. 2015 Jun 5
• 50 citations
  Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells
  Parag P. Shah, William W. Lockwood, Kumar Saurabh, Zimple Kurlawala, Sean P. Shannon, Sabine Waigel, Wolfgang Zacharias, Levi J. Beverly> ;Oncogene. 2015 Mar 26
• 32 citations
  The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets
  Kumar Saurabh, Michael T. Scherzer, Parag P. Shah, Alice S. Mims, William W. Lockwood, Andrew S. Kraft, Levi J. Beverly> ;Oncotarget. 2014 Aug 9
• 37 citations
  EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk
  Ian M. Wilson, Emily A. Vucic, Katey S. S. Enfield, Kelsie L. Thu, Yuan Zhang, Raj Chari, William W. Lockwood, Niki Radulovich, Daniel T. Starczynowski, Judit P. Banát...> ;Oncogene. 2014 Sep 4
• 52 citations
  SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling
  Kelsie L. Thu, Nikolina Radulovich, Daiana D. Becker-Santos, Larissa A. Pikor, Pusic A, William W. Lockwood, Wan L. Lam, Ming-Sound Tsao> ;Oncogene. 2014 Jan 16
• 33 citations
  YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway
  Larissa A. Pikor, William W. Lockwood, Kelsie L. Thu, Emily A. Vucic, Raj Chari, Adi F. Gazdar, Stephen Lam, Wan L. Lam> ;Cancer Research. 2013 Dec 15
• 18 citations
  The Novel Ubiquitin Ligase Complex, SCFFbxw4, Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers
  William W. Lockwood, Sahiba K. Chandel, Greg L. Stewart, Hediye Erdjument-Bromage, Levi J. Beverly> ;Plos One. 2013 May 2
• 34 citations
  The Hedgehog processing pathway is required for NSCLC growth and survival
  Jezabel Rodriguez-Blanco, Neal S. Schilling, Robert Tokhunts, Camilla Giambelli, Jun Long, D. Liang Fei, Samer Singh, Kendall E. Black, Zhiqiang Wang, Fabrizio Galimbe...> ;Oncogene. 2013 May 2
• 276 citations
  Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
  William W. Lockwood, Kreshnik Zejnullahu, James E. Bradner, Harold E. Varmus> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov 20
• 42 citations
  Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
  William W. Lockwood, Ian M. Wilson, Bradley P. Coe, Raj Chari, Larissa A. Pikor, Kelsie L. Thu, Luisa M. Solis, Maria I. Nunez, Carmen Behrens, John Yee, John C. Engli...> ;Plos One. 2012 May 21
• 66 citations
  Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma
  Lin Lin, Adam J. Bass, William W. Lockwood, Zhuwen Wang, Amy L. Silvers, Dafydd G. Thomas, Andrew C. Chang, Jules Lin, Mark B. Orringer, Weiquan Li, Thomas W. Glover, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Mar 13
• 56 citations
  Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability
  Kelsie L. Thu, Emily A. Vucic, Raj Chari, Wei Zhang, William W. Lockwood, John C. English, Rong Fu, Pei Wang, Ziding Feng, Calum MacAulay, Adi F. Gazdar, Stephen Lam, ...> ;Plos One. 2012 Mar 7
• 131 citations
  TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
  Daniel T. Starczynowski, William W. Lockwood, Sophie Deléhouzée, Raj Chari, Joanna Wegrzyn, Megan Fuller, Ming-Sound Tsao, Stephen Lam, Adi F. Gazdar, Wan L. Lam, Aly ...> ;The Journal of Clinical Investigation. 2011 Oct 3
• 128 citations
  Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models
  Ayumu Taguchi, Katerina Politi, Sharon J. Pitteri, William W. Lockwood, Vitor M. Faça, Karen S. Kelly-Spratt, Chee Hong Wong, Qing Zhang, Alice Chin, Kwon-Sik Park, Ga...> ;Cancer Cell. 2011 Sep 13
• 45 citations
  Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer
  Kelsie L. Thu, Larissa A. Pikor, Raj Chari, Ian M. Wilson, Calum MacAulay, John C. English, Ming-Sound Tsao, Adi F. Gazdar, Stephen Lam, Wan L. Lam, William W. Lockwood> ;Journal of Thoracic Oncology. 2011 Sep 1
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