WilliamTMahleMD

Pediatric Cardiology • Atlanta, GA

Fetal Cardiology

Associate Professor, Pediatrics, Emory University School of Medicine

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Office
2835 Brandywine Rd
Suite 400
Atlanta, GA 30341
Phone+1 404-256-2593

Fax+1 404-252-7431
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Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Cardiology, 1996 - 2000
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1993 - 1996
University of Maryland School of MedicineClass of 1993

Certifications & Licensure

GA State Medical License 2001 - 2025
SC State Medical License 2013 - 2013
PA State Medical License 1994 - 2002
American Board of Pediatrics Pediatric Cardiology

Awards, Honors, & Recognition

Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACC) American College of Cardiology

Clinical Trials

Terminal Graft Failure Start of enrollment: 2003 Oct 01
Terminated
Spironolactone in Patients With Single Ventricle Heart Start of enrollment: 2004 Nov 01
Completed
Not Applicable
Impact of Race and Re-Transplantation Start of enrollment: 2005 Mar 01
Terminated
Pulse Oximetry Readings and Hourly Variation in Oximetry Readings With CHD Start of enrollment: 2005 Nov 01
Terminated
Mild Valvar Pulmonary Stenosis Start of enrollment: 1984 Jan 01
Terminated
Aortic Arch Reconstruction
Terminated
Palliative Care of Children With End-Stage Heart Failure Start of enrollment: 1995 Jan 01
Terminated
Hepatitis C in Adults Who Underwent Congenital Heart Surgery Before Screening Start of enrollment: 1980 Jan 01
Terminated
Neurodevelopmental Outcomes in Hypoplastic Left Heart Syndrome Start of enrollment: 2006 Nov 01
Completed
Iron Prophylaxis for Anemia in Infants With Cyanotic Congenital Heart Disease Start of enrollment: 2007 Apr 01
Withdrawn
Not Applicable
Magnetic Resonance Imaging (MRI) to Evaluate Brain Injury in Congenital Heart Disease Start of enrollment: 2009 Aug 01
Completed
Genetic Determinants of Congenital Heart Disease Outcomes Start of enrollment: 2011 Mar 01
Completed
Impact of Allo- and Autoantibodies on Chronic Cardiac Allograft Function Start of enrollment: 2014 Jul 15
Completed
Pumps for Kids, Infants, and Neonates Start of enrollment: 2018 Oct 22
Active, not recruiting
Early Phase 1
Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. Start of enrollment: 2021 Jun 25
Recruiting
Phase 2
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Publications & Presentations

PubMed

Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.
Shriprasad R Deshpande, Steven D Zangwill, Marc E Richmond, Steven J Kindel, Jacob N Schroder, Nunzio Gaglianello, David P Bichell, Mark A Wigger, Kenneth R Knecht, Ph...> ;Pediatric Transplantation. 2024 May 1
School age and adolescent heart failure following the Norwood procedure.
William T Mahle, Rohali Keesari, Felicia Trachtenberg, Jane W Newburger, Heang Lim, Jonathan Edelson, Aamir Jeewa, Ashwin Lal, Steven J Kindel, Kristin M Burns, Sean L...> ;The Journal of Heart and Lung Transplantation. 2024 Mar 1
Statistical modeling of extracellular vesicle cargo to predict clinical trial outcomes for hypoplastic left heart syndrome.
Jessica R Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O Platt, Joshua M Hare, Sunjay Kaushal, Judith L Bettencourt, Dejian Lai, Timothy C Slesnick, William T Mahle, Micha...> ;Iscience. 2023 Oct 20
2 citations
Impact of donor-specific anti-HLA antibody on cardiac hemodynamics and graft function 3 years after pediatric heart transplantation: First results from the CTOTC-09 mu...
Steven A Webber, Hyunsook Chin, James D Wilkinson, Brian D Armstrong, Charles E Canter, Anne I Dipchand, Debra A Dodd, Brian Feingold, Jacqueline M Lamour, William T M...> ;American Journal of Transplantation. 2023 Dec 1
Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Ne...
Vanessa Schmithorst, Rafael Ceschin, Vincent Lee, Julia Wallace, Aurelia Sahel, Thomas L Chenevert, Hemant Parmar, Jeffrey I Berman, Arastoo Vossough, Deqiang Qiu, Nad...> ;Diagnostics. 2023 Apr 30
Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Ne...
Vanessa Schmithorst, Rafael Ceschin, Vince Lee, Julia Wallace, Aurelia Sahel, Thomas Chenevert, Hemant Parmar, Jeffrey I Berman, Arastoo Vossough, Deqiang Qiu, Nadja K...> ;Medrxiv. 2023 Apr 17
8 citations
The pediatric heart network's study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohor...
Caren S Goldberg, J William Gaynor, William T Mahle, Chitra Ravishankar, Peter Frommelt, Dawn Ilardi, David Bellinger, Stephen Paridon, Michael Taylor, Kevin D Hill, L...> ;American Heart Journal. 2022 Dec 1
Living the Optimal Life After Fontan Procedure.
William T Mahle> ;The Canadian Journal of Cardiology. 2023 Feb 1
3 citations
Perioperative Metabolites Are Associated With Adverse Neonatal Congenital Heart Disease Surgical Outcomes.
Jessica Heibel, Eric M Graham, William T Mahle, Aurelie Roux, David Graham, Cedric Manlhiot, Allen D Everett> ;Journal of the American Heart Association. 2022 Aug 16
3 citations
Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation.
Shriprasad R Deshpande, Steven D Zangwill, Steven J Kindel, Jacob N Schroder, David P Bichell, Mark A Wigger, Marc E Richmond, Kenneth R Knecht, Elfriede Pahl, Nunzio ...> ;Pediatric Transplantation. 2022 Jun 1
Left Ventricular Noncompaction in Children: Is It a Tale of Two Diseases?
William T Mahle> ;The Canadian Journal of Cardiology. 2022 Jun 1
Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults.
Marc E Richmond, Shriprasad R Deshpande, Steven D Zangwill, David P Bichell, Steven J Kindel, William T Mahle, Jacob N Schroder, Mark A Wigger, Kenneth R Knecht, Elfri...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Feb 1
5 citations
Autologous Cardiac Stem Cell Injection in Patients with Hypoplastic Left Heart Syndrome (CHILD Study).
Sunjay Kaushal, Joshua M Hare, Aakash M Shah, Nicholas P Pietris, Judith L Bettencourt, Linda B Piller, Aisha Khan, Abigail Snyder, Riley M Boyd, Mohamed Abdullah, Rac...> ;Pediatric Cardiology. 2022 Oct 1
3 citations
Long-Term Risk of Heart Failure-Related Death and Heart Transplant After Congenital Heart Surgery in Childhood (from the Pediatric Cardiac Care Consortium).
Lydia K Wright, Rachel Zmora, Yijian Huang, Matthew E Oster, Courtney McCracken, William T Mahle, Lazaros Kochilas, Andreas Kalogeropoulos> ;The American Journal of Cardiology. 2022 Mar 15
1 citations
Getting more hearts into more kids: Can we do it?
William T Mahle, Steven A Webber> ;American Journal of Transplantation. 2022 Mar 1
2 citations
Developmental Care Practice and Documentation Variability in the Cardiac ICU.
Thomas A Miller, Justin J Elhoff, Nneka M Alexander, Samantha C Butler, Karen C Uzark, Kristi L Glotzbach, William T Mahle, Amy J Lisanti> ;Pediatric Critical Care Medicine. 2022 Mar 1
1 citations
Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.
Steven Zangwill, Shriprasad R. Deshpande, Pippa Simpson, Huan Ling Liang, Liyun Zhang, Mahua Dasgupta, Marc E. Richmond, Steven J. Kindel, David P. Bichell, William T....> ;Clinical Transplantation. 2021 Oct 14
3 citations
Relationship of ventricular assist device support duration with pediatric heart transplant outcomes
Arene Butto, Chad Mao, Lydia Wright, Martha Wetzel, Michael Kelleman, Michael P. Carboni, Anne I. Dipchand, Kenneth R. Knecht, Zdenka Reinhardt, Joshua Sparks, Chet R....> ;The Journal of Heart and Lung Transplantation. 2021 Sep 29
1 citations
Variation in Pharmacologic Management of Patients with Kawasaki Disease with Coronary Artery Aneurysms.
Elif Seda Selamet Tierney, Kyle Runeckles, Adriana H. Tremoulet, Nagib Dahdah, Michael A. Portman, Andrew S. Mackie, Ashraf S Harahsheh, Sean M. Lang, Nadine Choueiter...> ;The Journal of Pediatrics. 2021 Aug 30
Reflections on Pulse Oximetry Screening for CCHD.
William T. Mahle> ;Pediatrics. 2021 Sep 1
Protecting the Brain of Hypoplastic Left Heart Syndrome Infants: A Question of Bloodflow Distribution?
William T. Mahle> ;The Canadian Journal of Cardiology. 2021 Jul 21
3 citations
Implementation of a practice plan for the outpatient cardiac evaluation of children after acute SARS-CoV-2 infection and a report of outcomes.
Andrew L. Dailey-Schwartz, Jameson A. Dyal, William T. Mahle, Matthew E. Oster> ;American Heart Journal. 2021 Jul 22
9 citations
Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease
Polakit Teekakirikul, Wenjuan Zhu, George C. Gabriel, Cullen B. Young, Kylia Williams, Lisa J. Martin, Jennifer C. Hill, Tara D. Richards, Marie Billaud, Julie A. Phil...> ;HGG Advances. 2021 Jul 8
11 citations
Unique Challenges of Randomised Controlled Trials in Pediatric Cardiology
Kevin C. Harris, Andrew S. Mackie, Frederic Dallaire, Michael Khoury, Joel Singer, William T. Mahle, Terry P. Klassen, Brian W. McCrindle> ;The Canadian Journal of Cardiology. 2021 Sep 1
Commentary: Not many tools in the toolbox.
William T. Mahle> ;JTCVS Techniques. 2021 Jun 4
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Journal Articles

Neutropenia in Pediatric Heart Transplant Recipients
Shriprasad R Deshpande, William T Mahle, Pediatric Transplantation

Lectures

Section on Cardiology and Cardiac Surgery Program: Day 1
National Conference & Exhibition 2019 - American Academy of Pediatrics - New Orleans, LA - 10/25/2019

Press Mentions

CDC Panel: Rare Heart Inflammation Cases Don’t Warrant Overturning Vaccine AdviceJune 23rd, 2021
Pediatric Cardiologist Has Passion for Saving BabiesJune 12th, 2020
The Marcus Foundation Renews Support for 15 Physician ResearchersOctober 19th, 2018
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