WilliamMullerMDPhD

PubMed

• Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease.
  Maureen E Haynes, David P Sullivan, William A Muller> ;The American Journal of Pathology. 2024 May 1
• 2 citations
  Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.
  Tao Fu, David P Sullivan, Annette M Gonzalez, Maureen E Haynes, Prarthana J Dalal, Nakisha S Rutledge, Abigail L Tierney, Julia A Yescas, Evan W Weber, William A Muller> ;Immunity. 2023 Oct 10
• 1 citations
  Methods for Imaging Inflammation and Transendothelial Migration in Vivo and ex Vivo.
  Vivienne Fang, Maureen E Haynes, Vanessa Hayashi, Erika Arias, Jeremy A Lavine, David P Sullivan, William A Muller> ;Current Protocols. 2023 Apr 1
• 17 citations
  Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma.
  Lizhi Pang, Madeline Dunterman, Wenjing Xuan, Annette Gonzalez, Yiyun Lin, Wen-Hao Hsu, Fatima Khan, Robert S Hagan, William A Muller, Amy B Heimberger, Peiwen Chen> ;Cell Reports. 2023 Feb 28
• 4 citations
  Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke.
  Neil A Nadkarni, Erika Arias, Raymond Fang, Maureen E Haynes, Hao F Zhang, William A Muller, Ayush Batra, David P Sullivan> ;The American Journal of Pathology. 2022 Nov 1
• 2 citations
  Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration.
  Nakisha S Rutledge, Faith T Ogungbe, Richard L Watson, David P Sullivan, William A Muller> ;Journal of Immunology. 2022 Sep 1
• 12 citations
  Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients.
  Ayush Batra, Jeffrey R Clark, Anthony K Kang, Sareen Ali, Tulsi R Patel, Nathan A Shlobin, Steven C Hoffman, Patrick H Lim, Zachary S Orban, Lavanya Visvabharathy, Edi...> ;Geroscience. 2022 Jun 1
• 3 citations
  Inhibition of PECAM-1 Significantly Delays Leukocyte Extravasation into the Subcortex Post-Stroke.
  Erika Arias, Neil Nadkarni, Raymond Fang, Maureen Haynes, Ayush Batra, William Muller, David Sullivan> ;FASEB Journal. 2022 May 1
• 5 citations
  Experimental colitis enhances temporal variations in CX3CR1 cell colonization of the gut and brain following irradiation.
  Ayush Batra, Triet M. Bui, Jacob F. Rehring, Lenore K. Yalom, William A. Muller, David P. Sullivan, Ronen Sumagin> ;The American Journal of Pathology. 2021 Nov 9
• 40 citations
  Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation.
  Natalia Reglero-Real, Lorena Pérez-Gutiérrez, Azumi Yoshimura, Loïc Rolas, Jose Garrido-Mesa, Anna Barkaway, Catherine Pickworth, Rebeca S. Saleeb, Maria Gonzalez-Nune...> ;Immunity. 2021 Sep 14
• 81 citations
  ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
  Rokana Taftaf, Xia Liu, Salendra Singh, Yuzhi Jia, Nurmaa Dashzeveg, Andrew D. Hoffmann, Lamiaa El-Shennawy, Erika K. Ramos, Valery Adorno-Cruz, Emma J. Schuster, Davi...> ;Nature Communications. 2021 Aug 11
• 39 citations
  A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Large Multi-institutional Autopsy Survey Study.
  Jody E. Hooper, Robert F. Padera, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva, Amaro Nunes Duarte-Neto, Meghan E. Kapp, J Matthew Lacy, Thais Mauad, Paulo Hilário...> ;Archives of Pathology & Laboratory Medicine. 2021 May 1
• Viral Loads of SARS-CoV-2 in Young Children-Reply.
  Taylor Heald-Sargent, William J. Muller, Larry K. Kociolek> ;JAMA Pediatrics. 2021 May 1
• 12 citations
  Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration.
  Prarthana Dalal, David P. Sullivan, Evan W. Weber, David B. Sacks, Matthias Gunzer, Isabella M. Grumbach, Joan Heller Brown, William A. Muller> ;The Journal of Experimental Medicine. 2021 Jan 4
• Beyond genes and transcription factors: A potential mechanism for the pathogenesis of cerebral cavernous malformations.
  William A. Muller> ;The Journal of Experimental Medicine. 2020 Oct 5
• 3 citations
  Spinocerebellar Ataxia Type 3: A Case Report and Literature Review
  Matthew R McCord, Eileen H. Bigio, Kwok Ling Kam, Victoria Fischer, Farres Obeidin, Charles L. White, Daniel J. Brat, William A. Muller, Qinwen Mao> ;Journal of Neuropathology and Experimental Neurology. 2020 Jun 1
• 10 citations
  Return of Individual Research Results: A Guide for Biomedical Researchers Utilizing Human Biospecimens.
  Mark E. Sobel, Jennifer C. Dreyfus, Kelsey Dillehay McKillip, Christi L. Kolarcik, William A. Muller, Melanie J. Scott, Gene P. Siegal, Kristine M. Wadosky, Timothy J....> ;The American Journal of Pathology. 2020 May 1
• 96 citations
  Endothelial Cell Calcium Signaling during Barrier Function and Inflammation.
  Prarthana Dalal, William A. Muller, David P. Sullivan> ;The American Journal of Pathology. 2020 Mar 1
• 53 citations
  Human CD4 + T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
  Hideaki Nishihara, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin,...> ;Fluids and Barriers of the CNS. 2020 Feb 3
• 14 citations
  Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis.
  David P. Sullivan, Prarthana Dalal, Fanny Jaulin, David B. Sacks, Geri Kreitzer, William A. Muller> ;The Journal of Experimental Medicine. 2019 Nov 4
• 14 citations
  Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
  Lisa Beckmann, Xian Zhang, Neil A. Nadkarni, Zhen Cai, Ayush Batra, David P. Sullivan, William A. Muller, Cheng Sun, Roman V. Kuranov, Hao Zhang> ;Biomedical Optics Express. 2019 Oct 1
• 19 citations
  Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.
  Jennifer E. Klomp, Mark Shaaya, Jacob Matsche, Rima Rebiai, Jesse Aaron, Kerrie B. Collins, Vincent Huyot, Annette M. Gonzalez, William A. Muller, Teng Leong Chew, Asr...> ;Cell Chemical Biology. 2019 Aug 15
• 107 citations
  PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.
  Isabella Wimmer, Silvia Tietz, Hideaki Nishihara, Urban Deutsch, Federica Sallusto, Fabien Gosselet, Ruth Lyck, William A. Muller, Hans Lassmann, Britta Engelhardt> ;Frontiers in Immunology. 2019 Apr 5
• 17 citations
  In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines
  David P. Sullivan, Triet M. Bui, William A. Muller, Veronika Butin-Israeli, Ronen Sumagin> ;Mucosal Immunology. 2018 Aug 13
• 10 citations
  Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium.
  Yang Mei, Gong Feng, Nina Rahimi, Baobing Zhao, Jingxin Zhang, Lan Cao, Jing Yang, Juehua Gao, Yi Hua Chen, Ronen Sumagin, William A. Muller, Ling Zhang, Peng Ji> ;Blood Advances. 2017 Aug 30
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Journal Articles

• 4-D intravital microscopy reveals strain-dependent differences for the roles of PECAM and CD99 in leukocyte diapedesis  
  Sullivan, D., R.L. Watson, and W.A. Muller, Am J Physiol Heart Circ Physiol, 1/1/2016
• Cutting Edge: CD99 is a novel therapeutic target for control of T-cell mediated CNS autoimmune disease  
  Winger, RC, CT Harp, M-Y Chiang, DP Sullivan, RL Watson, EW Weber, JR Podojil, SD Miller, and WA Muller, J. Immunol., 1/1/2016
• A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 (KLC1C) in Leukocyte Transendothelial Migration  
  Cyrus, BF and WA Muller, Am. J. Pathol., 1/1/2016
• Targeted recycling of the LBRC precedes adherens junction dissociation during transendothelial migration  
  Gonzalez, AM, BF Cyrus, WA Muller, Am. J. Pathol., 1/1/2016
• Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99 Efficient large scale purification from periplasmic inclusion bodies in E coli e...  
  Moricoli, D., WA Muller, DC Carbonella, MC Balducci, S Dominici, R Watson, V Fiori, E Weber, M Cianfriglia, K Scotlandi, and M Magnani, Journal of Immunological Methods, 1/1/2014
• Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice  
  Lishnevsky, M., L.C. Young, S.J. Woods, S.D. Groshong, R.J. Basaraba, J.M. Gilchrist, D.M. Higgins, M. Gonzalez-Juarrero, T.A. Bass, W.A. Muller, and A.R. Schenkel, Experimental and Molecular Pathology, 1/1/2014
• Identification of a severe bleeding disorder in humans caused by a mutation in CalDAG-GEFI  
  Muller WA, The Journal of Experimental Medicine, 1/1/2014
• Poliovirus receptor (CD155) regulates a step in transendothelial migration between PECAM and CD99  
  Sullivan, DP, MA Seidman, WA Muller, Am. J. Pathol., 1/1/2013
• HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes  
  Wu J, Z Liu, C Shao, Y Gong, E Hernando, P Lee, M Narita, W Muller, J Liu, JJ Wei, Cancer Res, 1/1/2011
• Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity  
  Privratsky, JR, CM Paddock, O Florey, DK Newman, WA Muller, PJ Newman, J Cell Sci, 1/1/2011
• Mechanisms of Leukocyte Transendothelial Migration  
  Muller WA, Ann. Rev. Pathol. Mech. Dis., 1/1/2011
• A novel and critical role for tyrosine 663 in PECAM trafficking and transendothelial migration  
  Dasgupta B, E Dufour, Z Mamdouh, WA Muller, J. Immunol., 1/1/2009
• Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages  
  Westhorpe CLV, J Zhou, NL Webster, B Kalionis, SR Lewin, A Jaworowski, WA Muller, SM Crowe, J. Leukoc. Biol., 1/1/2009
• Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment  
  Mamdouh Z, A Mikhailov, WA Muller, J. Exp. Med., 1/1/2009
• Mechanisms of Transendothelial Migration of Leukocytes  
  Muller WA, Circ. Res., 1/1/2009
• Tonsilar NK cells restrict B cell transformation by the Epstein Barr virus via IFNgamma  
  Strowig T, F Brilot, F Arrey, G Bougras, D Thomas, WA Muller, C. Munz, PLOS Pathog, 1/1/2008
• Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the Lateral Border Recycling Compartment  
  Mamdouh Z, GE Kreitzer, WA Muller, J. Exp. Med., 1/1/2008
• CD99 is essential for leukocyte diapedesis in vivo  
  Dufour EM, A DeRoche, Y Bae, WA Muller, Cell Commun. Adhes., 1/1/2008
• Endothelial Src kinase regulates membrane recycling from the Lateral Border Recycling Compartment (LBRC) during leukocyte transendothelial migration (TEM)  
  Dasgupta B and WA Muller, Eur. J. Immunol., 1/1/2008
• CD99 is a key mediator of the transendothelial migration of neutrophils  
  Lou, O., P. Alcaide, F.W. Luscinskas, and W.A. Muller, J. Immunol., 1/1/2007
• Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms  
  Reinke, E.K., J. Lee, A. Zozulya, J. Karman, W.A. Muller, M. Sandor, and Z. Fabry, J Neuroimmunol, 1/1/2007
• Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation  
  Han H., J Roberts, O Lou, WA Muller, N Nathan, C Nathan, J Leukoc Biol, 1/1/2006
• NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion  
  Morandi, B, G Bougras G., WA Muller, G Ferlazzo, C Munz, Eur J Immunol, 1/1/2006
• Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils  
  Han H, A Stessin, J Roberts, K Hess, N Gautam, M Kamenetsky, O Lou, E Hyde, N Nathan, WA Muller, J Buck, LR Levin, C Nathan, J. Exp. Med., 1/1/2005
• Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection  
  Maslin, C.L., K. Kedzierska, N.L. Webster, W.A. Muller, and S.M. Crowe, Curr HIV Res, 1/1/2005
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Books/Book Chapters

• Williams' Hematology 
  Chapter: "Vascular Function in Hemostasis." 
  Hajjar, KA, AJ Marcus, WA MullerEditors: K Kaushansky, MA Lichtman, E Beutler, TJ Kipps, U Seligsohn, JT Prchal.McGraw-Hill, McGraw-HillEdition 9th,2015
• Current Topics in Membranes 
  Chapter: "How Endothelial Cells Regulate Transendothelial Migration of Leukocytes: Molecules and Mechanisms." 
  Muller WAEditors: Ley, K.Academic Press, Burlington2009
• Methods in Enzymology, Vol. 443 Angiogenesis: In Vitro Systems 
  Chapter: "Assays of Transendothelial Migration in vitro." 
  Page 155 - 176Muller WA and FW LuscinskasEditors: Cheresh, D.2008
• Adhesion Molecules: Function and Inhibition 
  Chapter: "PECAM: Regulating the start of diapedesis." 
  Page 201 - 235Muller WAEditors: K. Ley.Birhhauser Publishing, Basel, Switzerland2007
• Williams' Hematology 
  Chapter: "Vascular Function in Hemostasis" 
  Page 1715 - 1739Hajjar, KA, NL Esmon, AJ Marcus, WA MullerEditors: E Beutler, MA Lichtman, TJ Kipps, U Seligsohn, K Kaushansky, JT Prchal.McGraw-Hill, New YorkEdition 7th,2006
• Cell Migration in Development and Disease 
  Chapter: Transendothelial Migration of Leukocytes. 
  Page 237 - 249Muller WA and AR SchenkelEditors: Wedlich D.Wiley-VCH Verlag, Weinheim, Germany2005
• Wiley Encyclopedia of Molecular Medicine 
  Chapter: CD31 (PECAM-1) 
  Page 588 - 591Muller WAEditors: Creighton, TE.John Wiley & Sons, Inc., New York2002
• Williams' Hematology 
  Chapter: Vascular function in hemostasis. 
  Page 1451 - 1469Hajjar KA, NL Esmon, AJ Marcus, WA MullerEditors: Beutler, et al.McGraw-Hill, New York, NYEdition 6th,2000
• Inflammation: Basic Principles and Clincal Correlates 
  Chapter: Leukocyte-endothelial cell adhesion molecules in transendothelial migration. 
  Page 585 - 592Muller WAEditors: Gallin, J, R Snyderman, D Fearon, B Haynes, C Nathan.Lippincott Williams & Wilkins, Philadelphia1999
• Methods in Molecular Biology, vol. 121: Natural Killer Cell Protocols: Cellular and Molecular Methods 
  Chapter: Assay for the transendothelial migration of human natural killer cells. 
  Page 115 - 123ME Berman and WA MullerEditors: K.S. Campbell and M. Colonna.The Humana Press, Inc., Totowa, NJ1999
• Vascular Adhesion Molecules and Inflammation 
  Chapter: The Role of PECAM-1 in Leukocyte Emigration. 
  Page 125 - 140Muller WAEditors: Pearson, J..Birkhauser Verlag Publishing Ltd., Basel, Switzerland1999
• Handbook of Experimental Immunology, v. 2B, Section 3 The Myeloid System 
  Chapter: Assays of transendothelial migration in vitro. 
  Page 1641 - 1646Muller WAEditors: Weir, DM, L.A. Herzenberg, C. Blackwell, L.A. Herzenberg.Blackwell Scientific Publications, Inc., Cambridge, MAEdition 5th,1997
• Leukocyte Typing VI. White Cell Differentiation Antigens 
  Chapter: CD31 Workshop Panel Report. 
  Page 362 - 364Muller WAGarland Publishing, Inc., New York1997
• Leukocyte Typing VI. White Cell Differentiation Antigens 
  Chapter: Transendothelial migration and interstitial migration of monocytes are mediated by separate domains of monocyte CD31. 
  Page 370 - 372Muller WA, T Greene, F LiaoGarland Publishing, Inc., New York1997
• Leukocyte Recruitment In Inflammatory Disease. Section I. Molecular and Cellular Components 
  Chapter: Transendothelial Migration of Leukocytes. 
  Page 3 - 18Muller WAEditors: G. Peltz.R.G. Landes Company, Austin, TX1996
• Methods in Molecular Biology, v. 27. Biomembrane Protocols: II. Architecture and Function 
  Chapter: Determination of cell-surface polarity by solid-phase lactoperoxidase iodination. 
  Page 19 - 30Muller WAEditors: Graham, J. and Higgins, J..The Humana Press, Totowa, NJ1994
• Methods in Molecular Biology, v. 27. Biomembrane Protocols: II. Architecture and Function 
  Chapter: Biochemical methods to determine cell surface topography. 
  Page 31 - 42Muller WAEditors: Graham, J. and Higgins, J..The Humana Press, Totowa, NJ1994
• Mononuclear Phagocytes. The Proceedings of the Fifth Leiden Meeting on Mononuclear Phagocytes 
  Chapter: PECAM-1: An adhesion molecule at the junctions of endothelial cells. 
  Page 138 - 148Muller WAEditors: van Furth, R., Cohn, Z.A., and Gordon, S..Blackwell Publishers, London1992
• Methods in Enzymology, Vol. 98 Biomembranes Part L. Membrane Biogenesis: Processing and Recycling 
  Chapter: Intracellular iodination of lysosome membrane for studies of membrane composition and recycling. 
  Page 404 - 415Muller WA, RM Steinman, ZA CohnEditors: Fleischer S, Fleischer B.Academic Press, New York1983
• Mononuclear Phagocytes: Functional Aspects 
  Chapter: Membrane flow during endocytosis. 
  Page 595 - 612Muller WA, RM Steinman, ZA CohnEditors: van Furth R, Cohn ZA.Martinus Nijhoff, The Hague1980
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Lectures

• "Leukocyte/endothelial cell signaling during transmigration." 
  Houston, TX - 1/20/2016
• "Endothelial cell regulation of transendothelial migration." 
  Girona, Spain - 1/17/2016
• "Endothelial cell PECAM and CD99 signaling pathways that regulate transendothelial migration." 
  Weill Cornell Medical Center, New York, NY - 1/13/2016
• "How Endothelial Cells Regulate Egress of Leukocytes During Inflammation." 
  Brown University School of Medicine, Providence, RI - 1/11/2016
• "Coordination of endothelial cell membrane movements that promote leukocyte transmigration." 
  Oregon Health & Science University, Portland, OR - 1/7/2016
• "Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration." 
  Boston, MA - 1/28/2015
• "Novel endothelial cell signals that regulate transendothelial migration of leukocytes in vitro and in vivo." 
  Feinberg School of Medicine, Chicago, IL - 1/24/2015
• "How endothelial cell PECAM and CD99 regulate transendothelial migration." 
  University of Wisconsin - 1/20/2015
• "Novel endothelial cell signaling mechanisms that regulate leukocyte transendothelial migration." 
  Keuth, Germany - 1/13/2015
• "New insights into the regulation of transendothelial migration by endothelial cells." 
  Department of Pathology, Brigham and Women's Hospital, Boston, MA - 1/19/2014
• "Novel Endothelial Signaling Pathways that Regulate Transendothelial Migration of Leukocytes." 
  Chicago, IL - 1/15/2014
• "The Lateral Border Recycling Compartment and the Regulation of Transendothelial Migration." 
  Chicago, IL - 1/14/2014
• "Novel mechanisms regulating transendothelial migration." 
  1/8/2014
• "How Endothelial CD99 Signals though Soluble Adenylyl Cyclase to Regulate Transendothelial Migration." 
  Tufts Medical Center, Boston, MA - 1/2/2014
• "Sequential molecular interactions in endothelial cells that regulate transmigration of leukocytes." 
  1/27/2013
• "Sequential Molecular Interactions that Regulate Leukocyte Transendothelial Migration: Studies in vitro and in vivo." 
  1/22/2013
• "How Endothelial Cells Regulate Transmigration of Leukocytes in the Inflammatory Response." 
  Boston, MA - 1/21/2013
• "Regulation of Leukocyte Transmigration by the Endothelial Cell LBRC." 
  1/20/2013
• "How Endothelial Cells Regulate Diapedesis of Leukocytes in Inflammation." 
  Ludwig-Maximilians-Universitat Munchen, School of Medicine, Munich Germany - 1/19/2013
• How endothelial cells regulate leukocyte transmigration. 
  University of Minnesota - 1/16/2012
• Membrane recycling: Still essential after all these years. 
  The Rockefeller University, New York, NY - 1/14/2012
• How the endothelial cell Lateral Border Recycling Compartment Regulates Leukocyte Transmigration 
  Wiesbaden, Germany - 1/2/2012
• How vascular endothelial cells regulate leukocyte influx in inflammation. 
  1/27/2011
• The Endothelial Cell Lateral Border Recycling Compartment Regulates Transendothelial Migration of Leukocytes(and tumor cells?) 
  Arizona State University - 1/20/2011
• Targeted trafficking of membrane from the LBRC controls leukocyte transendothelial migration. 
  1/15/2011
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Other

• Sorting the signals from the signals in the noisy environment of inflammation. 
  Muller WA, Science Signaling
  1/1/2011
• Transmigratory cups: Half-full or half-empty? 
  Muller WA, Nature Immunology, Vol. 9, Online Focus "Outstanding Questions" supplement to focus issue on Leukocy
  http://www.nature.com/ni/focus/trafficking/questions.html
  1/1/2008
• The Membrane Polypeptides of the Vacuolar System: Composition and Recycling 
  Muller WA, Ph.D. Thesis, The Rockefeller University
  1/1/1981
• Isolation and Preliminary Characterization of the DNA of Porphyridium aerugineum. 
  Muller WA, Honors Thesis, Harvard College
  1/1/1975
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