WilliamPuMD

PubMed

• Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease.
  Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xu...> ;Nature Genetics. 2024 Mar 1
• Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor.
  Maksymilian Prondzynski, Raul H Bortolin, Paul Berkson, Michael A Trembley, Kevin Shani, Mason E Sweat, Joshua Mayourian, Albert M Cordoves, Nnaemeka J Anyanwu, Yashas...> ;Biorxiv. 2024 Feb 28
• Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution.
  Chen, J., Zhang, X., Trembley, M., Saifee, S., Xiao, F., Chen, J., Zhou, P., Seidman, C., Seidman, J., Pu, W., DeLaughter, D.> ;Circulation Research. 2024 Mar 1
• Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice.
  Shuo Wu, Ping Yang, Zilong Geng, Yige Li, Zhizhao Guo, Yingmei Lou, Shasha Zhang, Junhao Xiong, Huan Hu, Xiaoling Guo, William T Pu, Yan Zhang, Dan Zhu, Bing Zhang> ;Cell Research. 2024 Apr 1
• 1 citations
  Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration.
  Feng Gao, Tian Liang, Yao Wei Lu, Linbin Pu, Xuyang Fu, Xiaoxuan Dong, Tingting Hong, Feng Zhang, Ning Liu, Yuxia Zhou, Hongkun Wang, Ping Liang, Yuxuan Guo, Hong Yu, ...> ;Circulation. 2023 Dec 5
• Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
  Mason E Sweat, Yangpo Cao, Xiaoran Zhang, Ozanna Burnicka-Turek, Carlos Perez-Cervantes, Kulandai Arulsamy, Fujian Lu, Erin M Keating, Brynn N Akerberg, Qing Ma, Hirok...> ;Nature Cardiovascular Research. 2023 Oct 1
• A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation.
  Yuxuan Guo, Yangpo Cao, Blake D Jardin, Neil Mazumdar, Congting Guo, Luzi Yang, Junsen Lin, Zhan Chen, Qing Ma, Mingming Zhao, Erdan Dong, William T Pu> ;Science China. Life Sciences. 2023 Dec 1
• 1 citations
  Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy.
  Sean L Kim, Michael A Trembley, Keel Yong Lee, Suji Choi, Luke A MacQueen, John F Zimmerman, Lousanne H C de Wit, Kevin Shani, Douglas E Henze, Daniel J Drennan, Shail...> ;Stem Cell Reports. 2023 Sep 12
• 7 citations
  Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles.
  Suji Choi, Keel Yong Lee, Sean L Kim, Luke A MacQueen, Huibin Chang, John F Zimmerman, Qianru Jin, Michael M Peters, Herdeline Ann M Ardoña, Xujie Liu, Ann-Caroline He...> ;Nature Materials. 2023 Aug 1
• Editing the trajectory of hypertrophic cardiomyopathy.
  Mason E Sweat, William T Pu> ;The Journal of Cardiovascular Aging. 2023 Jul 1
• 2 citations
  Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation.
  Pingzhu Zhou, Nathan J VanDusen, Yanchun Zhang, Yangpo Cao, Isha Sethi, Rong Hu, Shuo Zhang, Guangyu Wang, Lincai Ye, Neil Mazumdar, Jian Chen, Xiaoran Zhang, Yuxuan G...> ;Developmental Cell. 2023 May 22
• 5 citations
  Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome.
  Suya Wang, Erika Yazawa, Erin M Keating, Neil Mazumdar, Alexander Hauschild, Qing Ma, Haiyan Wu, Yang Xu, Xu Shi, Douglas Strathdee, Robert E Gerszten, Michael Schlame...> ;Human Molecular Genetics. 2023 Jun 5
• Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop.
  Cheryl L McDonald, Pankaj Qasba, Daniel G Anderson, Gang Bao, Richard A Colvin, Donald B Kohn, Punam Malik, Michael J Mitchell, William T Pu, David J Rawlings, David A...> ;Human Gene Therapy. 2023 Feb 1
• 9 citations
  In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity.
  Yangpo Cao, Xiaoran Zhang, Brynn N Akerberg, Haiyun Yuan, Tomoya Sakamoto, Feng Xiao, Nathan J VanDusen, Pingzhu Zhou, Mason E Sweat, Yi Wang, Maksymilian Prondzynski,...> ;Circulation. 2023 Mar 14
• 4 citations
  RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.
  Alexander A Akerberg, Michael Trembley, Vincent Butty, Asya Schwertner, Long Zhao, Manu Beerens, Xujie Liu, Mohammed Mahamdeh, Shiaulou Yuan, Laurie Boyer, Calum MacRa...> ;Circulation Research. 2022 Dec 2
• 4 citations
  GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
  Pingzhu Zhou, Yan Zhang, Isha Sethi, Lincai Ye, Michael A Trembley, Yangpo Cao, Brynn N Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D Jardin, Neil Mazumdar, Qing...> ;Circulation Research. 2022 Nov 11
• 7 citations
  Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome.
  Mengmeng Huang, Alexander A Akerberg, Xiaoran Zhang, Haejin Yoon, Shakchhi Joshi, Celia Hallinan, Christopher Nguyen, William T Pu, Marcia C Haigis, C Geoffrey Burns, ...> ;Nature Communications. 2022 Oct 5
• 2 citations
  Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.
  Caroline Sheldon, Aaron Farley, Qing Ma, William T Pu, Zhiqiang Lin> ;Cells. 2022 Sep 10
• 9 citations
  Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes.
  Antonia T L Zech, Maksymilian Prondzynski, Sonia R Singh, Niels Pietsch, Ellen Orthey, Erda Alizoti, Josefine Busch, Alexandra Madsen, Charlotta S Behrens, Moritz Meye...> ;Cells. 2022 Sep 2
• 1 citations
  Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation.
  Yuxuan Guo, Yangpo Cao, Blake D Jardin, Xiaoran Zhang, Pingzhu Zhou, Silvia Guatimosim, Junsen Lin, Zhan Chen, Yueyang Zhang, Neil Mazumdar, Fujian Lu, Qing Ma, Yao-We...> ;Cardiovascular Research. 2023 Mar 17
• 3 citations
  Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis.
  Robyn J Hylind, Alexandre C Pereira, Daniel Quiat, Stephanie F Chandler, Thomas M Roston, William T Pu, Vassilios J Bezzerides, Jonathan G Seidman, Christine E Seidman...> ;Circulation. Genomic and Precision Medicine. 2022 Jun 1
• 7 citations
  A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis.
  Jihee Sohn, Jelena Milosevic, Thomas Brouse, Najihah Aziz, Jenna Elkhoury, Suya Wang, Alexander Hauschild, Nick van Gastel, Murat Cetinbas, Sara F Tufa, Douglas R Keen...> ;Blood Advances. 2022 Apr 26
• 10 citations
  CMYA5 establishes cardiac dyad architecture and positioning.
  Fujian Lu, Qing Ma, Wenjun Xie, Carter L Liou, Donghui Zhang, Mason E Sweat, Blake D Jardin, Francisco J Naya, Yuxuan Guo, Heping Cheng, William T Pu> ;Nature Communications. 2022 Apr 21
• 11 citations
  CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.
  Zachary L Robbe, Wei Shi, Lauren K Wasson, Angel P Scialdone, Caralynn M Wilczewski, Xinlei Sheng, Austin J Hepperla, Brynn N Akerberg, William T Pu, Ileana M Cristea,...> ;Genes & Development. 2022 Apr 1
• 4 citations
  Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes.
  Yanjiang Zheng, Nathan J VanDusen, Catalina E Butler, Qing Ma, Justin S King, William T Pu> ;Circulation. 2022 Mar 8
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Journal Articles

• An IGF1R-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury  
  Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Spater D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, and Chien KR, Circulation, 1/1/2016
• Single-Cell Resolution of Temporal Gene Expression during Heart Development  
  DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS., Hinson JT, Homsy J, Gray J, Pu WT, Bruneau BG, Seidman JG, Seidman CE, Dev Cell, 1/1/2016
• Recounting Cardiac Cellular Composition  
  Zhou P, and Pu WT, Circ Res, 1/1/2016
• Contribution of Fetal but Not Adult Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis  
  von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B, and Pu WT, Am J Respir Cell Mol Biol, 1/29/2015
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  Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, and Chen J, Proc Natl Acad Sci U S A, 1/4/2015
• Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart  
  Stevens SM, Gise Av, VanDusen N, Zhou B, and Pu WT, Dev Biol, 1/1/2015
• Cellular Origin and Developmental Program of Coronary Angiogenesis  
  Tian X, Pu WT, and Zhou B, Circ Res, 1/1/2015
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  Lin Z, and Pu WT, Circ Res, 1/1/2015
• GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27  
  Aronson BE, Rabello Aronson S, Berkhout RP, Chavoushi SF, He A, Pu WT, Verzi MP, and Krasinski SD, Biochim Biophys Acta, 1/27/2014
• Epicardium-to-fat transition in injured heart  
  Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, and Zhou B, Cell Res, 1/26/2014
• Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion  
  Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, and Zhou B, J Biol Chem, 1/15/2014
• Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine Myocardial Infarction Model  
  Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, and Pu WT, Circ Res, 1/15/2014
• Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation  
  Lin Z, and Pu WT, Stem Cell Res, 1/6/2014
• GATA Factors Promote ER Integrity and beta-Cell Survival and Contribute to Type 1 Diabetes Risk  
  Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF, Pu WT, Kushner JA, Mol Endocrinol, 1/1/2014
• De novo formation of a distinct coronary vascular population in neonatal heart  
  Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, and Zhou B, Science, 1/1/2014
• Ultrasound-guided Transthoracic Intramyocardial Injection in Mice  
  Prendiville TW, Ma Q, Lin Z, Zhou P, He A, and Pu WT, J Vis Exp, 1/1/2014
• Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival  
  Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, and Pu WT, Circ Res, 1/1/2014
• Strategies for Cardiac Regeneration and Repair  
  Lin Z, and Pu WT, Science Translational Medicine, 1/1/2014
• Hippo activation in arrhythmogenic cardiomyopathy  
  Hu Y, and Pu WT, Circ Res, 1/1/2014
• Notching up vascular regeneration  
  Zhang B, and Pu WT, Cell Res, 1/1/2014
• A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity  
  Zhang B, Day DS, Ho JW, Song L, Cao J, Christodoulou D, Seidman JG, Crawford GE, Park PJ, Pu WT, Genome Res, 1/1/2013
• A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds  
  Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J, Pu WT, Bunger C, Sci Rep, 1/1/2013
• Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification  
  Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT, Proc Natl Acad Sci U S A, 1/1/2013
• Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction  
  Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Spater D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT,..., Nat Biotechnol, 1/1/2013
• Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart  
  Tian X, Hu T, He L, Zhang H, Huang X, Poelmann RE, Liu W, Yang Z, Yan Y, Pu WT, Zhou B, PLoS One, 1/1/2013
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Books/Book Chapters

• Muscle: Fundamental Biology and Mechanisms of Disease 
  Chapter: Mammalian Heart Regeneration 
  Zhou B, and Lin Z, Pu WTEditors: Olson, E.N. and Hill, J.H..Elsevier2012
• Molecular Basis of Heart Failure. In Heart Failure: A Companion to Braunwald's Heart Disease 
  Page 10 - 40Izumo S, and Pu WTEditors: Mann, D. L..Saunders, Philadelphia, PA2004

Abstracts/Posters

• Applications of Stem Cell Biology to Heart Disease
  Pu WT, Cardiovascular Grand Rounds University of Arizona Sarver Heart Center, Tuscon, AZ, 1/1/2016
• Transcriptional regulation of heart growth
  Pu WT, Keynote Address, Integrative Vascular Biology Training Program/McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, 1/1/2016
• Modeling heart disease using human stem cell-derived cardiomyocytes
  Pu WT, Department of Anesthesia, NYU Medical Center, New York, NY, 1/1/2016
• Topics in heart development and disease
  Pu WT, Developmental Biology Seminar Series, Children’s Hospital of Philadelphia, Philadelphia, PA, 1/1/2016
• An IGF1R-dependent Pathway Drives Adipogenic Differentiation of Epicardial Progenitor Cells Following MI
  Pu WT, American Heart Association Basic Cardiovascular Sciences Meeting, Phoenix, AZ, 1/1/2016
• ROS cause abnormal calcium handling in Barth syndrome stem cell-derived cardiomyocytes
  Pu WT, Barth Syndrome Foundation Meeting, Tampa, FL, 1/1/2016
• Epigenetic and Transcriptional Regulation in the Cardiovascular System
  Pu WT, American Heart Association Scientific Sessions, New Orleans, LA, 1/1/2016
• YAP regulation of heart growth and regeneration
  Pu WT, American Heart Association Scientific Sessions, New Orleans, LA, 1/1/2016
• Applications of Stem Cell Biology to Heart Disease
  Pu WT, Multiple Locations, 2015, 2016, 1/1/2016
• Transcriptional Regulation of Cardiovascular Development and Disease
  Pu WT, Shanghai Jiaotung University; Peking University Institute of Molecular Medicine, Shanghai, China, 2016; Peking, China, 2016, 1/1/2016
• Transcriptional regulation of cardiac growth and development
  Pu WT, Multiple Locations, 2014, 2015, 1/1/2015
• Applications of Stem Cell Biology to Heart Disease
  Pu WT, Mount Sinai School of Medicine, New York, NY, 1/1/2015
• Using genome editing to study mitochondrial myopathies in iPSC-CMs
  Pu WT, Penn Cardiovascular Institute Symposium on Advances in Genome Editing University of Pennsylvania, Philadelphia, PA, 1/1/2015
• Applications of Stem Cell Biology to Heart Disease
  Pu WT, Nationwide Children’s Hospital, Columbus, OH, 1/1/2015
• Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival
  Pu WT, American Heart Association Scientific Sessions, “Best of Circulation Research”, Orlando, FL, 1/1/2015
• Ribosomal-RNA profiling in lineage specific transcriptome analysis, Next-Generation Transcriptome Analysis of Cardiovascular Diseases
  Pu WT, American Heart Association Scientific Sessions, Orlando, FL, 1/1/2015
• Transcriptional regulation of heart growth and function
  Pu WT, Institute of Molecular Medicine, Texas Heart Institute, Houston, TX, 1/1/2015
• Transcriptional and epigenetic regulation of cardiomyocyte maturation
  Pu WT, Progenitor Cell Biology Consortium Cardiovascular Workshop, Stanford, Palo Alto, CA, 1/1/2014
• Modeling Barth syndrome with iPSC-derived cardiomyocytes
  Pu WT, Stanford Cardiovascular Institute Regenerative Medicine Symposium, Stanford, Palo Alto, CA, 1/1/2014
• Applications of Stem Cell Biology to Heart Disease
  Pu WT, Weill Cornell Medical School, New York City, NY, 1/1/2014
• Modeling Barth syndrome with iPSC-derived cardiomyocytes
  Pu WT, Barth Syndrome Foundation Biannual Meeting, Scientific Session, Tampa Bay, FL, 1/1/2014
• A human cardiomyocyte model of Barth syndrome cardiomyopathy
  Pu WT, Barth Syndrome Foundation Biannual Meeting, Family Sessions, “Scientific Breakthroughs”, Tampa Bay, FL, 1/1/2014
• Applications of Stem Cell Biology to Heart Disease
  Pu WT, University of Toronto, Toronto, Canada, 1/1/2014
• IGF1 stimulates epicardial adipose tissue formation after myocardial infarction
  Pu WT, Progenitor Cell Biology Consortium Annual Meeting, Stanford, CA, 1/1/2014
• An iPSC-CM model of the mitochondrial cardiomyopathy of Barth Syndrome
  Pu WT, American Heart Association Basic Cardiovascular Sciences Meeeting; American Heart Association Scientific Sessions, Las Vegas, CA, 2014; Chicago, IL, 2014, 1/1/2014
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Lectures

• Strategies for cardiac regeneration 
  1/1/2016
• AAV cardiac gene therapy 
  1/1/2016
• Modeling heart disease using human induced pluripotent stem cells 
  1/1/2016
• Transcriptional Regulation of heart growth and function 
  1/1/2016
• VEGF promotes RNAPII pausing release through an ETS1-Brd4 complex to stimulate angiogenesis 
  1/1/2016
• Non-canonical mechanisms of Eed-mediated transcriptional repression in the postnatal heart 
  1/1/2015
• Modeling cardiac disease using induced pluripotent stem cells 
  1/1/2015
• IGF1-driven formation of epicardial adipose tissue after myocardial infarction 
  1/1/2014
• Epigenetic regulation of angiogenesis 
  1/1/2014
• Modeling Barth syndrome with patient-specific iPSC-derived cardiomyocytes 
  1/1/2013
• Transcriptional regulation of heart development and disease 
  1/1/2013
• Transcriptional and epigenetic regulation of angiogenesis 
  1/1/2013
• Driving cardiac repair with modified RNA 
  1/1/2013
• Cardiovascular imaging in mice 
  1/1/2011
• Epicardium in heart development and disease 
  1/1/2011
• Epigenetic regulation of heart development 
  1/1/2011
• Transcriptional regulation in the developing and diseased heart 
  1/1/2011
• Identification of cardiac transcriptional regulatory elements by ChIP-seq 
  1/1/2011
• Epicardial function in adult heart injury 
  1/1/2010
• Regulation of heart development and function by a GATA4-FOG2 transcriptional complex 
  1/1/2010
• Regulation of cardiac development and postnatal function by Gata4 
  1/1/2006
• Regulation of cardiac morphogenesis by the transcription factor GATA4 
  1/1/2006
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Other

• Functional analysis of DNA-binding domain of GCN4, a bZIP transcription factor 
  Pu, WT
  1/1/1993