WilliamWSchlaepferMD

Pathology • Philadelphia, PA

Cytopathology, Neuropathology, Anatomic Pathology, Clinical Pathology

Professor, Pathology & Laboratory Medicine, Perelman School of Medicine

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Office
3400 Spruce St
Philadelphia, PA 19104
Phone+1 215-662-6503
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Education & Training

Yale-New Haven Medical CenterResidency, Pathology-Anatomic and Clinical, 1958 - 1962
Yale School of MedicineClass of 1958

Certifications & Licensure

PA State Medical License 1979 - 2016
American Board of Pathology Anatomic Pathology
American Board of Pathology Neuropathology

Publications & Presentations

PubMed

1 citations
Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes
James S. McKinney, Jonathan Raser, Miguel A. Guzman, William W. Schlaepfer, Brett L. Cucchiara, Steven R. Messé, Lauren H Sansing, Scott E. Kasner> ;Journal of Stroke and Cerebrovascular Diseases. 2012 Jul 1
179 citations
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Yangmi Lim, Ssang-Taek Lim, Alok Tomar, Margaret L. Gardel, Joie A. Bernard-Trifilo, Xiao Lei Chen, Sean Uryu, Rafaela Cañete-Soler, Jinbin Zhai, Hong Lin, William W. ...> ;The Journal of Cell Biology. 2008 Jan 14
89 citations
Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot–Marie–Tooth d...
Jinbin Zhai, Hong Lin, Jean-Pierre Julien, William W. Schlaepfer> ;Human Molecular Genetics. 2007 Dec 15
3 citations
The complex relation between genotype and phenotype in motor neuron disease
Rafaela Cañete-Soler, William W. Schlaepfer> ;Annals of Neurology. 2007 Jul 1
21 citations
Role of neurofilament aggregation in motor neuron disease.
Hong Lin, William W. Schlaepfer> ;Annals of Neurology. 2006 Oct 1
34 citations
RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration
Hong Lin, Jinbin Zhai, William W. Schlaepfer> ;Human Molecular Genetics. 2005 Dec 1
41 citations
The role of RNA and RNA processing in neurodegeneration.
Jean-Marc Gallo, Peng Jin, Charles A. Thornton, Hong Lin, Janice Robertson, Ian D'Souza, William W. Schlaepfer> ;The Journal of Neuroscience. 2005 Nov 9
19 citations
HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS
Jinbin Zhai, Hong Lin, Rafaela Cañete-Soler, William W. Schlaepfer> ;Human Molecular Genetics. 2005 Sep 15
24 citations
3′ Untranslated Region in a Light Neurofilament (NF-L) mRNA Triggers Aggregation of NF-L and Mutant Superoxide Dismutase 1 Proteins in Neuronal Cells
Hong Lin, Jinbin Zhai, Rafaela Cañete-Soler, William W. Schlaepfer> ;The Journal of Neuroscience. 2004 Mar 17
9 citations
Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein.
Junhua Wu, Jinbin Zhai, Hong Lin, Zhenying Nie, Wei Wen Ge, Laura García-Bermejo, Ruth J. Muschel, William W. Schlaepfer, Rafaela Cañete-Soler> ;Brain Research. Molecular Brain Research. 2003 Sep 10
10 citations
Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons.
Hong Lin, Jinbin Zhai, Zhenying Nie, Junhua Wu, Judy L. Meinkoth, William W. Schlaepfer, Rafaela Cañete-Soler> ;Journal of Neuropathology and Experimental Neurology. 2003 Sep 1
154 citations
Direct Interaction of Focal Adhesion Kinase with p190RhoGEF
Jinbin Zhai, Hong Lin, Zhenying Nie, Junhua Wu, Rafaela Cañete-Soler, William W. Schlaepfer, David D. Schlaepfer> ;The Journal of Biological Chemistry. 2003 Jul 4
16 citations
Binding of p190RhoGEF to a Destabilizing Element on the Light Neurofilament mRNA Is Competed by BC1 RNA
Weiwen Ge, Junhua Wu, Jinbin Zhai, Zhenying Nie, Hong Lin, William W. Schlaepfer, Rafaela Cañete-Soler> ;The Journal of Biological Chemistry. 2002 Nov 8
30 citations
Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice.
Zhenying Nie, Junhua Wu, Jinbin Zhai, Hong Lin, Weiwen Ge, William W. Schlaepfer, Rafaela Cañete-Soler> ;The Journal of Neuroscience. 2002 Sep 1
70 citations
Identification of a novel interaction of 14-3-3 with p190RhoGEF.
Jinbin Zhai, Hong Lin, Mohammad Shamim, William W. Schlaepfer, Rafaela Cañete-Soler> ;The Journal of Biological Chemistry. 2001 Nov 2
46 citations
p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript.
Rafaela Cañete-Soler, Junhua Wu, Jinbin Zhai, Mohammad Shamim, William W. Schlaepfer> ;The Journal of Biological Chemistry. 2001 Aug 24
14 citations
Similar poly(C)-sensitive RNA-binding complexes regulate the stability of the heavy and light neurofilament mRNAs
Rafaela Cañete-Soler, William W. Schlaepfer> ;Brain Research. 2000 Jun 9
39 citations
Mutation in Neurofilament Transgene Implicates RNA Processing in the Pathogenesis of Neurodegenerative Disease
Rafaela Cañete-Soler, Debra G. Silberg, Michael D. Gershon, William W. Schlaepfer> ;The Journal of Neuroscience. 1999 Feb 15
5 citations
Characterization of the mouse neurofilament light (NF-L) gene promoter by in vitro transcription
Michael L. Schwartz, Yue Hua, Rafaela Cañete-Soler, William W. Schlaepfer> ;Brain Research. Molecular Brain Research. 1998 Jun 1
19 citations
Characterization of Ribonucleoprotein Complexes and Their Binding Sites on the Neurofilament Light Subunit mRNA
Rafaela Cañete-Soler, Michael L. Schwartz, Yue Hua, William W. Schlaepfer> ;The Journal of Biological Chemistry. 1998 May 15
36 citations
Stability determinants are localized to the 3'-untranslated region and 3'-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter.
Rafaela Cañete-Soler, Michael L. Schwartz, Yue Hua, William W. Schlaepfer> ;The Journal of Biological Chemistry. 1998 May 15
36 citations
Transient expression of the neurofilament proteins NF-L and NF-M by Schwann cells is regulated by axonal contact.
C Fabrizi, B M Kelly, C S Gillespie, William W. Schlaepfer, Steven S. Scherer, Peter J. Brophy> ;Journal of Neuroscience Research. 1997 Oct 15
4 citations
In vitro activation of the mouse mid-sized neurofilament gene by an NF-1-like transcription factor
Michael L. Schwartz, Yue Hua, William W. Schlaepfer> ;Brain Research. Molecular Brain Research. 1997 Sep 1
47 citations
COORDINATE INDUCTION OF THE THREE NEUROFILAMENT GENES BY THE BRN-3A TRANSCRIPTION FACTOR
Martin Smith, Peter J. Morris, Sally J. Dawson, Michael L. Schwartz, William W. Schlaepfer, David Seymour Latchman> ;The Journal of Biological Chemistry. 1997 Aug 22
29 citations
Deletion of 3′-Untranslated Region Alters the Level of mRNA Expression of a Neurofilament Light Subunit Transgene
Michael L. Schwartz, Jennifer Bruce, Paul S. Shneidman, William W. Schlaepfer> ;The Journal of Biological Chemistry. 1995 Nov 3
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Grant Support

Rna-Mediated Motor Neuron DegenerationNational Institute Of Neurological Disorders And Stroke2004–2007
Neurofilament Expression And Motor Neuron DegenerationNational Institute Of Neurological Disorders And Stroke2001–2004
Mechanisms Of Motoneuron Degeneration In TransgenicNational Institute Of Neurological Disorders And Stroke2001–2002
Mechanisms Of Motoneuron Degeneration In Transgenic MiceNational Institute Of Neurological Disorders And Stroke1999–2000
Neurofilament Expression And Motor Neuron DiseaseNational Institute Of Neurological Disorders And Stroke1997–2000
Regulation Of Neurofilament Gene ExpressionNational Institute Of Neurological Disorders And Stroke1992–1995
Neurofilaments: Degradation Turnover &Role In DiseaseNational Institute Of Neurological Disorders And Stroke1985–1991
Neuronal Cytoskeleton In Aging And DiseaseNational Institute On Aging1987–1989

Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Pennsylvania HospitalPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania