WilliamVTamborlaneJr.MD

Pediatric Endocrinology • New Haven, CT

Pediatric Diabetes Endocrinology

Professor of Pediatrics, Yale University

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Office
330 Cedar Street
LMP 3103
New Haven, CT 06519
Phone+1 203-764-9199

Fax+1 203-764-9149
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Education & Training

MedStar Health/Georgetown University HospitalInternship, Internal Medicine, 1972 - 1973
Georgetown University School of MedicineClass of 1972

Certifications & Licensure

CT State Medical License 1975 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Endocrinology

Awards, Honors, & Recognition

Top Doctors: New York Metro Area Castle Connolly, 2003-2014
America's Top Doctors Castle Connolly, 2002-2014
New York Magazine: Top Doctors Castle Connolly, 2002-2009, 2011-2013
Elected Member The American Society for Clinical Investigation, 1989
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Continuous Glucose Monitors for Children With Diabetes Mellitus Start of enrollment: 2002 May 01
Completed
Phase 4
Assessing Continuous Glucose Monitors in Healthy Children Start of enrollment: 2002 Aug 01
Completed
Phase 4
Pilot Study of the GlucoWatch G2 Biographer for the Management of Type 1 Diabetes in Children Start of enrollment: 2003 Feb 01
Completed
Phase 4
Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer Start of enrollment: 2003 Jul 01
Completed
Phase 4
Study to Determine the Relationship Between Exercise and Hypoglycemia in Children With Type 1 Diabetes Start of enrollment: 2004 Jun 01
Completed
The Effect of Insulin During Exercise on the Development of Low Blood Sugar in Individuals With Type I Diabetes Start of enrollment: 2005 May 01
Completed
Pilot Study of the Navigator Continuous Glucose Monitor Start of enrollment: 2005 Aug 01
Completed
Phase 2, Phase 3
Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes Start of enrollment: 2006 Dec 01
Completed
Phase 3
Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy Start of enrollment: 2007 Jan 01
Completed
Not Applicable
Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia Start of enrollment: 2006 Mar 01
Completed
Continuous Glucose Sensor Profiles in Non-Diabetic Subjects Start of enrollment: 2008 Jul 01
Completed
Phase 4
Changing Lifestyles for Better Health Start of enrollment: 2009 Mar 01
Completed
Not Applicable
A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes Start of enrollment: 2013 May 01
Completed
Phase 3
A Pilot Study Examining a Reinforcement Approach to Improve Diabetes Management Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults Start of enrollment: 2013 Nov 01
Completed
Phase 3
Assessment of Intranasal Glucagon in Children and Adolescents With Type 1 Diabetes Start of enrollment: 2013 Nov 01
Completed
Phase 2, Phase 3
Pharmacokinetic Study of CYCLOSET ® 0.8 mg Tablets in Children and Adolescent Type 2 Diabetes Mellitus Subjects Start of enrollment: 2014 Jan 01
Completed
Phase 1
A Reinforcement Approach to Improve Diabetes Management Start of enrollment: 2014 Jul 01
Completed
Not Applicable
Physical Activity and Glycemic Control in Adolescents Start of enrollment: 2016 Feb 01
Completed
Not Applicable
Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin Start of enrollment: 2017 Oct 01
Completed
Early Phase 1
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Publications & Presentations

PubMed

1 citations
Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Ghosh, A., Neda Rasouli, Naji Younes, Jeanine Albu, Robert M Cohen, Ralph A DeFronzo, Elsa Diaz, Laure Sayyed Kassem, José A Luchsinger, Janet B McGill, William I Sivi...> ;Diabetes Care. 2024 Apr 1
Dapagliflozin or Saxagliptin in Pediatric Type 2 Diabetes.
Shehadeh, N., Barrett, T., Galassetti, P., Karlsson, C., Monyak, J., Iqbal, N., Tamborlane, W.> ;NEJM Evidence. 2023 Dec 1
1 citations
Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review.
William Tamborlane, Naim Shehadeh> ;Advances in Therapy. 2023 Nov 1
3 citations
Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Deborah J Wexler, Naji Younes, Ionut Bebu, Silvio E Inzucchi, Janet B McGill, Sunder Mudaliar, David Schade, Michael W Steffes, William V Tamborlane, Meng H Tan, Faram...> ;JAMA Internal Medicine. 2023 Jul 1
1 citations
Impact of school-supervised ultra-long-acting basal insulin injections on ketosis in youth with T1D and elevated haemoglobin A1c: A pilot study.
Laura M Nally, Jennifer L Sherr, Eileen Tichy, Kate Weyman, Andrea Urban, Veronika Shabanova, Sarah McCollum, Amy Steffen, William V Tamborlane, Michelle Van Name> ;Diabetic Medicine. 2023 Oct 1
2 citations
Retinopathy During the First 5 Years of Type 1 Diabetes and Subsequent Risk of Advanced Retinopathy.
John I Malone, Xiaoyu Gao, Gayle M Lorenzi, Philip Raskin, Neil H White, Dean P Hainsworth, Arup Das, William Tamborlane, Amisha Wallia, Lloyd P Aiello, Ionut Bebu> ;Diabetes Care. 2023 Apr 1
9 citations
Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO...
Lori M Laffel, Thomas Danne, Georgeanna J Klingensmith, William V Tamborlane, Steven Willi, Philip Zeitler, Dietmar Neubacher, Jan Marquard> ;The Lancet. Diabetes & Endocrinology. 2023 Mar 1
DKA Prevention and Insulin Pumps: Lessons Learned From a Large Pediatric Pump Practice.
Elizabeth Ann Doyle, Stuart Alan Weinzimer, William Tamborlane> ;The Science of Diabetes Self-Management and Care. 2022 Dec 1
5 citations
The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study.
Lynne L Levitsky, Kimberly L Drews, Morey Haymond, Rose A Glubitosi-Klug, Lorraine E Levitt Katz, Mihai Mititelu, William Tamborlane, Jeanie B Tryggestad, Ruth S Weins...> ;Journal of Diabetes and Its Complications. 2022 Nov 1
1 citations
Commentary on CDC data showing an increased risk for pediatric diabetes with COVID-19 infection.
Jasmine Gujral, William Tamborlane, Laura Nally> ;Journal of Diabetes. 2022 Sep 1
6 citations
A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 dia...
Allan L Reiss, Booil Jo, Ana Maria Arbelaez, Eva Tsalikian, Bruce Buckingham, Stuart A Weinzimer, Larry A Fox, Allison Cato, Neil H White, Michael Tansey, Tandy Aye, W...> ;Nature Communications. 2022 Aug 30
113 citations
American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Lawrence Blonde, Guillermo E Umpierrez, S Sethu Reddy, Janet B McGill, Sarah L Berga, Michael Bush, Suchitra Chandrasekaran, Ralph A DeFronzo, Daniel Einhorn, Rodolfo ...> ;Endocrine Practice. 2022 Oct 1
20 citations
Once-Weekly Exenatide in Youth With Type 2 Diabetes.
William V Tamborlane, Raafat Bishai, David Geller, Naim Shehadeh, Dalia Al-Abdulrazzaq, Evelina Mánica Vazquez, Eva Karoly, Tünde Troja, Orlando Doehring, Debra Carter...> ;Diabetes Care. 2022 Aug 1
5 citations
SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance.
Alfonso Galderisi, William Tamborlane, Simeon I Taylor, Najya Attia, Carlo Moretti, Fabrizio Barbetti> ;Pediatrics. 2022 Jul 1
2 citations
Youth with type 2 diabetes have a high rate of treatment failure after discontinuation of insulin: A Pediatric Diabetes Consortium study.
Risa M Wolf, Peiyao Cheng, Robin L Gal, Lindsey C Beaulieu, Craig Kollman, Elvira Isganaitis, Sheela Magge, Lucy D Mastrandrea, Georgeanna J Klingensmith, William Tamb...> ;Pediatric Diabetes. 2022 Jun 1
21 citations
Efficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study.
William V Tamborlane, Lori M Laffel, Naim Shehadeh, Elvira Isganaitis, Michelle Van Name, Jayantha Ratnayake, Cecilia Karlsson, Ensio Norjavaara> ;The Lancet. Diabetes & Endocrinology. 2022 May 1
6 citations
Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study.
Michelle A Van Name, Lauren G Kanapka, Linda A DiMeglio, Kellee M Miller, Anastasia Albanese-O'Neill, Persis Commissariat, Sarah D Corathers, Kara R Harrington, Marisa...> ;Journal of Diabetes Science and Technology. 2023 Jul 1
12 citations
Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study.
Rose A Gubitosi-Klug, Barbara H Braffett, Ionut Bebu, Mary L Johnson, Kaleigh Farrell, David Kenny, Victoria R Trapani, Lynne Meadema-Mayer, Elsayed Z Soliman, Rodica ...> ;Diabetes Care. 2022 Mar 1
1 citations
Tobacco use patterns and clinical outcomes in the T1D exchange.
Carla J Rash, Sheila M Alessi, Nicole Foster, William Tamborlane, Michelle A Van Name, Julie A Wagner> ;Journal of Diabetes and Its Complications. 2022 Feb 1
8 citations
Racial and Ethnic Disparities in Comorbidities in Youth With Type 2 Diabetes in the Pediatric Diabetes Consortium (PDC).
Fida Bacha, Peiyao Cheng, Robin L. Gal, Lindsey C. Beaulieu, Craig Kollman, Anne L. Adolph, Ashley H. Shoemaker, Risa M. Wolf, Georgeanna J. Klingensmith, William V. T...> ;Diabetes Care. 2021 Aug 30
5 citations
Case Report: Managing Pregnancy With Type 1 Diabetes Using a Do-It-Yourself Artificial Pancreas System
Apoorva Ravindranath Waikar, Tanima Arora, Meagan Haynes, William V. Tamborlane, Laura M. Nally> ;Clinical Diabetes. 2021 Jun 9
5 citations
A Pilot Study of Youth With Type 1 Diabetes Initiating Use of a Hybrid Closed-Loop System While Receiving a Behavioral Economics Intervention.
Laura M. Nally, Julie Wagner, Jennifer L. Sherr, Eileen Tichy, Kate Weyman, Meredith K. Ginley, Kristyn Zajac, Marcia Desousa, Veronika Shabanova, Nancy M. Petry, Will...> ;Endocrine Practice. 2021 Jun 1
16 citations
Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes
Rose Gubitosi-Klug, Xiaoyu Gao, Rodica Pop-Busui, Ian H. de Boer, Neill White, Lloyd Paul Aiello, Ryan Miller, Jerry P. Palmer, William V. Tamborlane, Amisha Wallia, M...> ;Diabetes Care. 2021 May 12
14 citations
Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes.
Stephanie N. DuBose, Zoey Li, Jennifer L. Sherr, Roy W. Beck, William V. Tamborlane, Viral N. Shah> ;Journal of Diabetes Science and Technology. 2021 May 1
4 citations
Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.
Dean P. Hainsworth, Xiaoyu Gao, Ionut Bebu, Arup Das, Lisa Olmos de Koo, Andrew J. Barkmeier, William V. Tamborlane, John M. Lachin, Lloyd Paul Aiello, Diabetes Contro...> ;Ophthalmology. 2021 Apr 1
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Lectures

60th Annual Advanced Postgraduate Course
American Diabetes Association, New York, New York - 2/22/2013
Diabetic Retinopathy--From Children to Adults
William V. Tamborlane, MD - 6/15/2014
Warming Up to Sensors: Does Site Warming Improve Continuous Glucose Monitoring Performance?
New Haven, CT - 6/15/2014

Press Mentions

In Memoriam: Robert S. Sherwin, MD, 1942-2023April 19th, 2023
The New Machinery of Medicine: How Gene Sequencing and High-Performance Computing Are Revolutionizing CareMay 11th, 2022
Wins for AstraZeneca: Diabetes Drug Approved for Teens, Covid Vaccine Effective Against Delta VariantJuly 23rd, 2021
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Grant Support

Career Development Programs In Diabetes Research For Pediatric EndocrinologistsNational Institute Of Diabetes And Digestive And Kidney Diseases2011
Training In Pediatric Endocrinology And Diabetes ResearchNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Training In Pediatric Endocrinology/Diabetes ResearchNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2006
Outcomes Of Type 1 Diabetes In ChildrenNational Center For Research Resources2005
Implantable Insulin PUMPNational Center For Research Resources2005
Epidemiology Of Diabetes Interventions And ComplicationsNational Center For Research Resources2004–2005
Pediatric Endocrine/Diabetes Physician ScientistsNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2005
Pediatric Pharmacology Research UnitEunice Kennedy Shriver National Institute Of Child Health &Human Development1999–2003
Yale Center In The Children'S Glucose Sensor NetworkEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2002
Tolerability And Pharmacokinetics Of Inhaled Insulin In Children 6 To 11 YearsNational Center For Research Resources2000–2002
Metformin Hydrochloride For Treatment Of Adolescents With Type 2 DiabetesNational Center For Research Resources2000–2002
Implantable PUMP System And Insulin In Patient Unable To Achieve Glycemic ControlNational Center For Research Resources2000–2002
Efficacy Of Metformin Hydrochloride PLUS Insulin Compared To Insulin MonotherapyNational Center For Research Resources2000–2002
Efficacy And Safety Of Inhaled Insulin Compared To Subcutaneous Human InsulinNational Center For Research Resources2000–2002
Compassionate Use Of Inhaled Insulin In ONE AdolescentNational Center For Research Resources1999–2002
Nocturnal Hypoglycemia Effect On Sleep Patterns Of Diabetic ChildrenNational Center For Research Resources1998–2002
Hormonal, Symptomatic And Neurophysiologic Response To Sugar Intake In ChildrenNational Center For Research Resources1998–2002
Mechanisms Of Glucose Intolerance In Children With IDDMNational Center For Research Resources1996–2002
Effects Of Puberty On Glucose KineticsNational Center For Research Resources1996–2002
Effects Of Hospitalization On Diabetes ManagementNational Center For Research Resources1996–2002
Diabetes Prevention Trial--Type I Diabetes (Dpt 1)National Center For Research Resources1996–2002
Mechanism Of Glucose Intolerance In Preadolescent/Adolescent Children With IDDMNational Center For Research Resources2000–2001
Responses To Hypoglycemia In Insulin Dependent Diabetes MellitusNational Center For Research Resources1998–2001
Epidemiology Of Diabetes Intervention And Complications (EDIC)National Center For Research Resources1998–2001
Effects Of Puberty On Glucose KineticsNational Center For Research Resources1996–2001
Diabetes Prevention Trial Type I Diabetes (Dpt 1)National Center For Research Resources1999–2000
Response To Hypoglycemia In Insulin Dependent Diabetes MellitusNational Center For Research Resources1998–2000
Long Term Effects Of Hospitalization On Diabetes ManagementNational Center For Research Resources1996–2000
Evaluation Of Forearm Lancet DeviceNational Center For Research Resources1998–1999
Comparison Of Humalog (Insulin Lispro) Vs. Human Regular InsulinNational Center For Research Resources1998–1999
Insulin Lispro VS Velsulin BR In Patients With Type 1 Diabetes Using InsulinNational Center For Research Resources1997–1999
Mechanism Of Glucose Intolerance In Preadolescent And Adolescent ChildrenNational Center For Research Resources1996–1999
Puberty Effects On Metabolism And Body CompositionEunice Kennedy Shriver National Institute Of Child Health &Human Development1998
Effects Of Puberty On Glucose Kinetics During ChildhoodNational Center For Research Resources1997
Hormonal, Symptomatic, And Neurophysiologic Response To Sugar Intake In ChildrenNational Center For Research Resources1996–1997
Epidemiology Of Diabetes Intervention And ComplicationsNational Center For Research Resources1996–1997
Effects Of Puberty On Metabolism And Body CompositionEunice Kennedy Shriver National Institute Of Child Health &Human Development1993–1997
Responses To Hypoglycemia In Insulin Dependent Diabetes MellitusNational Center For Research Resources1996
Diabetes Prevention Trial--Type I Diabetes (Dpt 1)National Center For Research Resources1996
Counterregulatory Responses To HypoglycemiaNational Center For Research Resources1996
Diabetes Control And ComplicationsNational Institute Of Diabetes And Digestive And Kidney Diseases1995
Diabetes Control And Complications TrialNational Institute Of Diabetes And Digestive And Kidney Diseases1989–1994
Diabetes Control And Complications Trial (DCCT)National Institute Of Diabetes And Digestive And Kidney Diseases1986–1988
Diabetes Control &Complications Trial (DCCT)National Institute Of Diabetes And Digestive And Kidney Diseases1986
Insulin Treatment Of Pregnant DiabeticsNational Center For Research Resources1985
Insulin Treatment Of Juvenile Diabetes With Portable Infusion SystemNational Center For Research Resources1985
Control Of Hyperglycemia By Pulsed Insulin Infusion In DiabetesNational Center For Research Resources1985
Diabetes Control And Complications Trial (DCCT)Nat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985