WinstonXiaYanMD

PubMed

• 1037 citations
  Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
  Kira S. Makarova, Yuri I. Wolf, Jaime Iranzo, Sergey Shmakov, Omer S. Alkhnbashi, Stan J. J. Brouns, Emmanuelle Charpentier, David R. Cheng, Daniel H. Haft, Philippe H...> ;Nature Reviews. Microbiology. 2020 Feb 1
• 142 citations
  CRISPR-Cas in mobile genetic elements: counter-defence and beyond.
  Guilhem Faure, Sergey Shmakov, Winston X. Yan, David R. Cheng, David Scott, Joseph E. Peters, Kira S. Makarova, Eugene V. Koonin> ;Nature Reviews. Microbiology. 2019 Aug 1
• 255 citations
  Functionally diverse type V CRISPR-Cas systems
  Winston X. Yan, Pratyusha Hunnewell, Lauren E. Alfonse, Jason M. Carte, Elise Keston-Smith, Shanmugapriya Sothiselvam, Anthony J. Garrity, Shaorong Chong, Kira S. Maka...> ;Science. 2019 Jan 4
• 274 citations
  Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein.
  Winston X. Yan, Shaorong Chong, Huaibin Zhang, Kira S. Makarova, Eugene V. Koonin, David R. Cheng, David Scott> ;Molecular Cell. 2018 Apr 19
• 94 citations
  A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action
  Shiran Abadi, Winston X. Yan, David Amar, Itay Mayrose> ;Plos Computational Biology. 2017 Oct 16
• 110 citations
  CRISPR-Cas9–based treatment of myocilin-associated glaucoma
  Ankur Jain, Gulab Zode, Ramesh B. Kasetti, Fei A. Ran, Winston X. Yan, Tasneem Putliwala Sharma, Kevin Bugge, Charles Searby, John H. Fingert, Feng Zhang, Abbot F. Cla...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct 17
• 260 citations
  Engineered Cpf1 variants with altered PAM specificities
  Linyi Gao, David Benjamin Turitz Cox, Winston X. Yan, John C. Manteiga, Martin W. Schneider, Takashi Yamano, Hiroshi Nishimasu, Osamu Nureki, Nicola Crosetto, Feng Zhang> ;Nature Biotechnology. 2017 Jun 5
• 220 citations
  BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks.
  Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David A. Scott, Martin W. Schneider, Tomasz Kallas, Joaquin Custodio, Erik L. G. Wernersson, Yinqing Li, Linyi Gao,...> ;Nature Communications. 2017 May 12
• 586 citations
  Diversity and evolution of class 2 CRISPR-Cas systems
  Sergey Shmakov, Aaron Smargon, David A. Scott, David Benjamin Turitz Cox, Neena Pyzocha, Winston X. Yan, Omar O. Abudayyeh, Jonathan S. Gootenberg, Kira S. Makarova, Y...> ;Nature Reviews. Microbiology. 2017 Mar 1
• 767 citations
  In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
  Christopher E. Nelson, Chady H. Hakim, David G. Ousterout, Pratiksha I. Thakore, Eirik A. Moreb, Ruth M. Castellanos Rivera, Sarina Madhavan, Xiufang Pan, F. Ann Ran, ...> ;Science. 2016 Jan 22
• 727 citations
  In vivo gene editing in dystrophic mouse muscle and muscle stem cells
  Mohammadsharif Tabebordbar, Kexian Zhu, Jason Cheng, Wei Leong Chew, Jeffrey J. Widrick, Winston X. Yan, Claire Maesner, Elizabeth Y Wu, Ru Xiao, F. Ann Ran, Le Cong, ...> ;Science. 2016 Jan 22
• 1543 citations
  Rationally Engineered Cas9 Nucleases With Improved Specificity
  Ian Slaymaker, Linyi Gao, Bernd Zetsche, David Scott, Winston X. Yan, Feng Zhang> ;Science. 2016 Jan 1
• 281 citations
  Crystal Structure of Staphylococcus aureus Cas9
  Hiroshi Nishimasu, Le Cong, Winston X. Yan, F. Ann Ran, Bernd Zetsche, Yinqing Li, Arisa Kurabayashi, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki> ;Cell. 2015 Aug 27
• 1792 citations
  In vivo genome editing using Staphylococcus aureus Cas9
  F. Ann Ran, Le Cong, Winston X. Yan, David A. Scott, Jonathan S. Gootenberg, Andrea J. Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira S. Makarova, Eugene V. Kooni...> ;Nature. 2015 Apr 9
• 47 citations
  Reducing the gradient artefact in simultaneous EEG-fMRI by adjusting the subject's axial position.
  Karen J. Mullinger, Winston X. Yan, Richard Bowtell> ;Neuroimage. 2011 Feb 1
• 48 citations
  Physical modeling of pulse artefact sources in simultaneous EEG/fMRI.
  Winston X. Yan, Karen J. Mullinger, Gerda B. Geirsdottir, Richard Bowtell> ;Human Brain Mapping. 2009 Oct 12
• 44 citations
  Understanding gradient artefacts in simultaneous EEG/fMRI
  Winston X. Yan, Karen J. Mullinger, Matthew J. Brookes, Richard Bowtell> ;Neuroimage. 2009 Jun 1
• 25 citations
  Source localisation in concurrent EEG/fMRI: applications at 7T.
  Matthew J. Brookes, Jiri Vrba, Karen J. Mullinger, Gerða Björk Geirsdóttir, Winston X. Yan, Claire M. Stevenson, Richard Bowtell, Peter G. Morris> ;Neuroimage. 2009 Apr 1
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Journal Articles

• BLISS Is a Versatile and Quantitative Method for Genome-Wide Profiling of DNA Double-Strand Breaks  
  Winston Yan, MD, Nature