X. LongZhengMDPhD

PubMed

• 2 citations
  Mechanisms of inhibition of human monoclonal antibodies in immune thrombotic thrombocytopenic purpura.
  Konstantine Halkidis, Chan Meng, Szumam Liu, Leland Mayne, Don L Siegel, Zheng, X., X Long Zheng> ;Blood. 2023 Jun 15
• Altered cleavage of human factor VIII at the B-domain and acidic region 3 interface enhances expression after gene therapy in hemophilia A mice.
  Giang N Nguyen, Jonathan R Lindgren, Maria C Seleme, Samita Kafle, Catherine B Zander, X Long Zheng, Denise E Sabatino> ;Journal of Thrombosis and Haemostasis. 2023 Aug 1
• 3 citations
  Longitudinal Assessment of Plasma Syndecan-1 Predicts 60-Day Mortality in Patients with COVID-19.
  Quan Zhang, Zhan Ye, Antonia Bignotti, X Long Zheng> ;Journal of Clinical Medicine. 2023 Jan 10
• 2 citations
  Effects of convalescent plasma infusion on the ADAMTS13-von Willebrand factor axis and endothelial integrity in patients with severe and critical COVID-19.
  Quan Zhang, Zhan Ye, Paul McGowan, Christopher Jurief, Andrew Ly, Antonia Bignotti, Noritaka Yada, X Long Zheng> ;Research and Practice in Thrombosis and Haemostasis. 2023 Jan 1
• A novel mechanism underlying allosteric regulation of ADAMTS-13 revealed by hydrogen-deuterium exchange plus mass spectrometry.
  Vikram G Pillai, X Long Zheng> ;Research and Practice in Thrombosis and Haemostasis. 2023 Jan 1
• Changes in Plasma Levels of ADAMTS13 and von Willebrand Factor in Patients Undergoing Elective Joint Arthroplasty.
  Jun Kit He, Samuel Schick, Marshall Williams, Bradley Wills, Martim Pinto, Gean Viner, Eugene Brabston, Amit Momaya, X Long Zheng, Brent Ponce> ;Journal of Clinical Medicine. 2022 Oct 30
• 4 citations
  ADAMTS13 Biomarkers in Management of Immune Thrombotic Thrombocytopenic Purpura.
  Jingrui Sui, Liang Zheng, X Long Zheng> ;Archives of Pathology & Laboratory Medicine. 2023 Aug 1
• 10 citations
  Race, rituximab, and relapse in TTP.
  Shruti Chaturvedi, Ana G Antun, Andrew M Farland, Ryan Woods, Ara Metjian, Yara A Park, Gustaaf de Ridder, Briana Gibson, Raj S Kasthuri, Darla K Liles, Frank Akwaa, T...> ;Blood. 2022 Sep 22
• 1 citations
  Protein arginine methyltransferase 1 in the generation of immune megakaryocytes: A perspective review.
  Xinyang Zhao, Zechen Chong, Yabing Chen, X Long Zheng, Qian-Fei Wang, Yueying Li> ;The Journal of Biological Chemistry. 2022 Nov 1
• ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish.
  Liang Zheng, Liyun Cao, X Long Zheng> ;Journal of Thrombosis and Haemostasis. 2022 Oct 1
• 2 citations
  ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura.
  Konstantine Halkidis, X Long Zheng> ;Journal of Thrombosis and Haemostasis. 2022 Oct 1
• 1 citations
  How should caplacizumab be used for treatment of immune thrombotic thrombocytopenic purpura?
  Lucy Zheng, X Long Zheng> ;Annals of Blood. 2023 Jun 30
• 1 citations
  A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations.
  Liang Zheng, Jake Hill, Lucy Zheng, M A Karim Rumi, X Long Zheng> ;Journal of Clinical and Translational Pathology. 2022 Jan 1
• 3 citations
  Low ADAMTS-13 predicts adverse outcomes in hospitalized patients with suspected heparin-induced thrombocytopenia.
  Meng Chan, Xinyang Zhao, X. Long Zheng> ;Research and Practice in Thrombosis and Haemostasis. 2021 Aug 1
• 12 citations
  The Standard of Care for Immune Thrombotic Thrombocytopenic Purpura Today
  X. Long Zheng> ;Journal of Thrombosis and Haemostasis. 2021 Jun 1
• 1 citations
  Plasma Levels of Big Endothelin-1 Are Associated with Renal Insufficiency and In-Hospital Mortality of Immune Thrombotic Thrombocytopenic Purpura.
  Ruinan Lu, X. Long Zheng> ;Thrombosis and Haemostasis. 2021 May 13
• 2 citations
  A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura
  Konstantine Halkidis, Don L. Siegel, X. Long Zheng> ;Journal of Thrombosis and Haemostasis. 2021 Apr 9
• 5 citations
  Identification of Biomarkers in Patients with Thrombotic Thrombocytopenic Purpura Presenting with Large and Small Ischemic Stroke.
  Chen Lin, Raima A. Memon, Jingrui Sui, X. Long Zheng> ;Cerebrovascular Diseases Extra. 2021 Feb 18
• 4 citations
  Cerebral Infarction in Immune Thrombotic Thrombocytopenic Purpura Is Associated with Old Age, Hypertension, Smoking, and Anti-ADAMTS13 Ig, But Not with Mortality.
  Raima A. Memon, Jingrui Sui, Chen Lin, X. Long Zheng> ;TH Open. 2021 Jan 13
• 15 citations
  Plasma levels of S100A8/A9, histone/DNA complexes, and cell-free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura.
  Jingrui Sui, Ruinan Lu, Konstantine Halkidis, Nicole K. Kocher, Wenjing Cao, Marisa B. Marques, X. Long Zheng> ;Journal of Thrombosis and Haemostasis. 2021 Jan 3
• 3 citations
  Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura.
  Malay Kumar Basu, Felipe Massicano, Lijia Yu, Konstantine Halkidis, Vikram G. Pillai, Wenjing Cao, Liang Zheng, X. Long Zheng> ;Thrombosis and Haemostasis. 2021 Apr 1
• 7 citations
  Elevated plasma levels of syndecan-1 and soluble thrombomodulin predict adverse outcomes in thrombotic thrombocytopenic purpura
  Ruinan Lu, Jingrui Sui, X. Long Zheng> ;Blood Advances. 2020 Nov 10
• 147 citations
  ISTH guidelines for treatment of thrombotic thrombocytopenic purpura.
  X. Long Zheng, Sara K. Vesely, Spero R. Cataland, Paul Coppo, Brian Geldziler, Alfonso Iorio, Masanori Matsumoto, Reem A. Mustafa, Menaka Pai, Gail Rock, Lene Russell,...> ;Journal of Thrombosis and Haemostasis. 2020 Oct 1
• 108 citations
  ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura
  X. Long Zheng, Sara K. Vesely, Spero R. Cataland, Paul Coppo, Brian Geldziler, Alfonso Iorio, Masanori Matsumoto, Reem A. Mustafa, Menaka Pai, Gail Rock, Lene Russell,...> ;Journal of Thrombosis and Haemostasis. 2020 Oct 1
• 20 citations
  Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura.
  X. Long Zheng, Sara K. Vesely, Spero R. Cataland, Paul Coppo, Brian Geldziler, Alfonso Iorio, Masanori Matsumoto, Reem A. Mustafa, Menaka Pai, Gail Rock, Lene Russell,...> ;Journal of Thrombosis and Haemostasis. 2020 Oct 1
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Journal Articles

• Understanding thrombotic microangiopathies in children  
  Joly BS, Zheng XL and Veyradier A, Inten Care Med, 1/24/2018
• Low Plasma ADAMTS13 Activity is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Pediatric Trauma  
  Russell RT, McDaniel JK, Cao WJ, Shroyer M, Wagener BM, Zheng XL (corr. au.), JF Pittet, Thromb Haemost, 1/1/2018
• Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A  
  Nguyen GN, George LA, Siner JI, Davidson RJ, Zander CB, Zheng XL, Arruda VR, Camire RM, Sabatino DE, J Thromb Haemost, 1/1/2017
• Conformational quiescence of ADAMTS13 prevents proteolytic promiscuity: comment  
  Cao WJ, and Zheng XL, J Thromb Haemost, 1/1/2017
• Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid hemorrhage  
  Kumar M, Cao WJ, McDaniel JK, Pham HP, Raju D, Nawalinski K, Frangos S, Kung S, Zager E, Kasner SE, Levine JM, Zheng XL, Thromb Haemost, 1/1/2017
• Thrombotic Thrombocytopenic Purpura: Pathogenesis, Diagnosis, and Potential Novel Therapeutics  
  Saha M, McDaniel JK, Zheng XL, J Thromb Haemost, 1/1/2017
• Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma  
  Ping Z., Soni A., Williams AL, Pham HP, Basu MK, and Zheng XL, TH Open, 1/1/2017
• Platelet transactivation by monocytes promotes thrombosis in heparin induced thrombocytopenia  
  Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L, Blood, 1/1/2016
• Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe haemophilia A  
  Williams LA, Drwiega JC, Cao W, Pham HP, Bertoli LF, and Zheng XL, Haemophilia, 1/1/2016
• High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome  
  Casina VC, Hu W, Mao JH, Lu RN, Hanby HA, Pickens B, Kan ZY, Lim WK, Mayne L, Ostertag EM, Kacir S, Siegel DL, Englander SW, Zheng XL, Proc Natl Acad Sci USA, 1/4/2015
• ADAMTS13 and its variants promote angiogenesis via upregulation of VEGF and VEGFR2  
  Lee M1, Keener J, Xiao J, Zheng XL, Rodgers GM, Cell Mol Life Sci, 1/1/2015
• Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease  
  Lu RN, Yang S, Wu HM, Zheng XL, J Thromb Haemost, 1/1/2015
• ADAMTS13 and VWF interactions  
  Zander C. Cao WJ, Zheng XL, Curr Opin Hematol, 1/1/2015
• Carboxyl-terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large VWF string formation under flow in a free thiol-dependent manner  
  Bao J., Xiao J., Mao J., and Zheng X.L., Arteroscler Thromb Vascul Biol, 1/1/2014
• Structure-function and cofactor-dependent regulation of ADAMTS13 protease  
  Zheng X.L., J Thromb Hemost, 1/1/2013
• Biochemistry and physiological function of ADAMTS7  
  Hanby H.H. and Zheng X.L., Adv Biochem, 1/1/2013
• Gain-of-function ADAMTS13 variants that are resistant to inhibition by autoantibodies in patients with acquired idiopathic thrombotic thrombocytopenic purpura  
  Jian C., Xiao J., Gong L., Skipwith C.G., Jin S-Y, Kwaan H-C, and Zheng X.L., Blood, 1/1/2012
• Genetic ablation of Adamts13 gene dramatically accelerates the early atherosclerosis in a murine model  
  Jin S-Y., Tohyama J., Bauer R.C., Cao N.N, Rader D.J., and Zheng X.L., Thromb Vasc Biol, 1/1/2012
• ADAMTS13, TTP, and Beyond (Editorial)  
  Zheng X.L., Hereditary Genet, 1/1/2012
• Toward A Definition of "Fresh" Whole Blood: An In-vitro Characterization of Coagulation Properties in Refrigerated Whole Blood for Transfusion  
  Jobes,D. Wolfe, Y. O'Neill,D. Calder, J. Jones, L. Sesok-Pizzini,D, and Zheng X.L., Transfusion, 1/1/2011
• Analysis of Morphology of Platelet Aggregates Formed on Collagen Under Laminar Blood Flow  
  Colace T., Falls E,. Zheng X.L., Diamond S.L., Ann Biomed Eng, 1/1/2011
• A Shear Based Assay for Assessing Plasma ADAMTS13 Activity in Patients With Thrombotic Thrombocytopenic Purpura  
  Han Y., Xiao J., Falls E., and Zheng X.L., Transfusion, 1/1/2011
• Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis  
  Xiao J., Jin S-Y., Xue J., Sorvillo N., Voorberg J., and Zheng X.L., Arterioscler, 1/1/2011
• ADAMTS13 testing-Why bother?  
  Zheng X.L., Blood, 1/1/2010
• Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor  
  Jin S.Y., Skipwith C.G., and Zheng X.L., Blood, 1/1/2010
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Books/Book Chapters

• Transfusion Medicine, Apheresis, and Hemostasis: Review Questions and Case Studies 
  Chapter: Interpretation of data 
  Zheng XLEditors: Huy P. Pham, Lance A. Williams III.Edition 1st,2017
• ADAMTS13: Biology and Disease 
  Chapter: Structure-function of ADAMTS13 
  Zheng XLEditors: Rodgers.Springer2015

Abstracts/Posters

• Longitudinal Assessment of Plasma ADAMTS13 Biomarkers Helps Predict Recurrence of Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Plasma Levels of Histone-DNA Complex and Cell-Free DNA Predict Mortality in Patients with Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• African American Race Is Associated with Decreased Relapse-Free Survival in Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

• TTP: from bench to bedside 
  San Francisco, CA - 1/1/2018
• aHUS: Evidence Based Guidelines in Therapeutic Apheresis 
  Dallas, TX - 1/1/2018
• HUS: Dual Presentation Diagnosis and Treatment 
  Westchester Medical Center, Valhalla, NY - 1/1/2018
• TMA: from zebrafish to men 
  1/1/2018
• A journey from Obstetrician to pathologist 
  1/1/2018
• Thrombotic thrombocytopenic purpura (TTP) - from Bench to Bedside 
  Montgomery, AL - 1/1/2017
• A Novel Zebrafish Model of Thrombotic Thrombocytopenic Purpura (TTP) Created by CRISPR/Cas, 
  1/1/2017
• ADAMTS13, TTP, and beyond 
  Fort Lauderdale, FL - 1/1/2017
• Pathogenesis of thrombotic thrombocytopenic purpura: lesson from zebrafish to men. 
  China - 1/1/2017
• Atypical hemolytic uremic syndrome 
  Nashville, TN - 1/1/2017
• TMA-from bench to bedside 
  UNC-Chapel Hill, NC - 1/1/2017
• Diagnosis and differential diagnosis of thrombotic microangiopathy 
  Los Angeles, CA - 1/1/2017
• What do we know about TTP? 
  Hospital of University of Alabama at Birmingham, AL - 1/1/2016
• Thrombotic thrombocytopenic purpura-diagnosis, mechanism, and novel therapeutics 
  University of Michigan, Ann Arbor, MI - 1/1/2016
• Interaction between VWF and ADAMTS13 under flow 
  Montpellier, France - 1/1/2016
• Novel therapeutics for acquired autoimmune TTP 
  Stoweflake, VT - 1/1/2016
• Novel therapeutics for acquired thrombotic thrombocytopenic purpura 
  Birmingham, AL - 1/1/2016
• Hemostasis, hematology, and transfusion medicine research (RED) club, ADAMTS13, beyond TTP 
  1/1/2016
• New Horizon-Discovery in TTP 
  Memphis, TN - 1/1/2016
• Novel therapeutics for acquired TTP 
  University of Alabama at Birmingham, AL - 1/1/2015
• Thrombotic Microangiopathy-Molecular Mechanism and Novel Therapeutics 
  Vanderbilt University, Nashville, TN - 1/1/2014
• Molecular Mechanism and Novel Therapeutics of Thrombotic Thrombocytopenic Purpura 
  Cleveland Clinic, OH - 1/1/2014
• Proteolysis of von Willebrand factor by ADAMTS13 under fluid shear stress. 
  Amsterdam, Netherlands - 1/1/2013
• Structure-function and regulation of ADAMTS13 protease 
  Amsterdam, Netherland - 1/1/2013
• Novel Therapeutics for Thrombotic Thrombocytopenic Purpura 
  Sol Sherry Thrombosis Center, Temple University School of Medicine, Philadelphia, PA - 1/1/2012
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