XuemeiCaiMD

Neurology • Boston, MA

Neurocritical Care

Physician

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Office
Tufts Medical Center 800 Washington St
Box #314
Boston, MA 02111
Phone+1 617-636-1840

Fax+1 941-584-9093
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Summary

Dr. Xuemei Cai is a neurologist in Boston, MA and is affiliated with Tufts Medical Center. She received her medical degree from Harvard Medical School and has been in practice 8 years. She specializes in neurocritical care and is experienced in stroke, critical care medicine, interventional neuroradiology / endovascular neurosurgery, cerebrovascular disease, and intracranial hemorrhage.

Education & Training

Pfizer, IncFellowship, Neuroscience Clinical Translational Fellowship, 2015 - 2017
Brigham and Women's Hospital/Harvard Medical SchoolFellowship, Neurocritical Care, 2013 - 2015
Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 2010 - 2013
Massachusetts General HospitalInternship, Internal Medicine, 2009 - 2010
Harvard Medical SchoolClass of 2009
University of ArizonaB.S., Biochemistry and Molecular Biophysics, Molecular and Cellular Biology, Summa Cum Laude, 2001 - 2005
University of ArizonaB.A., East Asian Studies, Summa Cum Laude, 2001 - 2005

Certifications & Licensure

MA State Medical License 2013 - 2026
PA State Medical License 2014 - 2015
American Board of Psychiatry and Neurology Neurology
UCNSNeurocritical Care

Awards, Honors, & Recognition

Resident-Teacher of the Year Award Partners Neurology Residency, 2013
Annual Meeting Resident Scholarship American Academic of Neurology, 2012
Joseph B. Martin Scholarship Harvard Medical School, 2009
Louis W. Gilbert Award Harvard Medical School, 2007
Von Liebig Research Scholarship 2006
Merrill P. Freeman Graduation Medal University of Arizona, 2005
Charles O Hucker Award University of Arizona, College of Humanities, 2005
University of Arizona Foundation Award University of Arizona, College of Science, 2005
Van De Verde Research Scholarship University of Arizona, College of Science, 2004
Excellence in the Biological Sciences Award University of Arizona, Department of Science, 2004
Galileo Circle Scholarship Galileo Circle Foundation, 2003
Phi Beta Kappa 2002
Deans Honor List University of Arizona, 2002
Flinn Scholarship Flinn Foundation, 2001
National Merit Scholarship National Merit Scholarship Corporation, 2001
John P. Schaefer Scholarship University of Arizona, 2000
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Clinical Trials

Nurses' Health Study (Cardiovascular Component) Start of enrollment: 1980 Aug 01
Active, not recruiting
The Spot Sign for Predicting and Treating ICH Growth Study Start of enrollment: 2010 Nov 01
Completed
Phase 2
Progesterone for the Treatment of Traumatic Brain Injury III Start of enrollment: 2010 Mar 01
Terminated
Phase 3
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Start of enrollment: 2010 May 28
Terminated
Phase 3
Antihypertensive Treatment of Acute Cerebral Hemorrhage-II Start of enrollment: 2011 May 15
Terminated
Phase 3
Glyburide Advantage in Malignant Edema and Stroke Pilot Start of enrollment: 2011 May 26
Completed
Phase 1, Phase 2
A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients Start of enrollment: 2011 Jan 01
Completed
Phase 2
Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial Start of enrollment: 2012 Dec 01
Completed
Not Applicable
High-Dose Deferoxamine in Intracerebral Hemorrhage Start of enrollment: 2013 Mar 18
Terminated
Phase 2
Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Start of enrollment: 2013 Jun 13
Completed
Phase 2
Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2 Start of enrollment: 2009 Feb 01
Completed
Phase 2
An Open Label, Expanded Access Protocol With SAGE-547 for Super-Refractory Status Epilepticus
No longer available
Safety and Tolerability of PF-05230907 in Intracerebral Hemorrhage Start of enrollment: 2016 Nov 01
Terminated
Phase 1
Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers Start of enrollment: 2016 Mar 28
Completed
Phase 1
Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke Start of enrollment: 2016 Jul 18
Completed
Phase 2
Safety and Tolerability of PF-06818883 in Healthy Subjects Start of enrollment: 2016 Nov 11
Terminated
Phase 1
A Study to Evaluate the Safety and Tolerability of PF-06939926 Gene Therapy in Duchenne Muscular Dystrophy Start of enrollment: 2018 Jan 23
Active, not recruiting
Phase 1
Singe Dose, First in Human Study of PF- 06946860 in Healthy Adult Subjects Start of enrollment: 2018 Jul 30
Completed
Phase 1
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Publications & Presentations

PubMed

Monitoring Activity and Gait in Children (MAGIC) using digital health technologies.
Junrui Di, Pirinka Georgiev Tuttle, Lukas Adamowicz, Wenyi Lin, Hao Zhang, Dimitrios Psaltos, Jessica Selig, Jiawei Bai, F Isik Karahanoglu, Paul Sheriff, Vijitha Seel...> ;Pediatric Research. 2024 Mar 21
1 citations
Can Gait Characteristics Be Represented by Physical Activity Measured with Wrist-Worn Accelerometers?
Wenyi Lin, Fikret Isik Karahanoglu, Dimitrios Psaltos, Lukas Adamowicz, Mar Santamaria, Xuemei Cai, Charmaine Demanuele, Junrui Di> ;Sensors. 2023 Oct 18
SciKit digital health package for accelerometry-measured physical activity: comparisons to existing solutions and investigations of age effects in healthy adults.
Lin, W., Karahanoglu, F., Demanuele, C., Khan, S., Santamaria, M., Di, J., Adamowicz, L., Cai, X.> ;Frontiers in Digital Health. 2023 Jan 1
4 citations
Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics
Thao Pham, Cristianne Fernandez, Giles Blaney, Kristen T. Tgavalekos, Angelo Sassaroli, Xuemei Cai, Steve Bibu, Joshua Kornbluth, Sergio Fantini> ;Frontiers in Neurology. 2021 Nov 16
3 citations
The impact of chronotype on circadian rest-activity rhythm and sleep characteristics across the week
Chris Brooks, Nina Shaafi Kabiri, Jaspreet Bhangu, Xuemei Cai, Eve H. Pickering, Michael Kelley Erb, Sanford Auerbach, Paolo Bonato, Tara L. Moore, Farzad Mortazavi, K...> ;Chronobiology International. 2021 Jun 16
10 citations
Assessment of Sit-to-Stand Transfers during Daily Life Using an Accelerometer on the Lower Back.
Lukas Adamowicz, F. Isik Karahanoglu, Christopher Cicalo, Hao Zhang, Charmaine Demanuele, Mar Santamaria, Xuemei Cai, Shyamal Patel> ;Sensors. 2020 Nov 19
2 citations
Toxin-Induced Acute Delirium.
Alice Cai, Xuemei Cai> ;Neurologic Clinics. 2020 Nov 1
Age and environment-related differences in gait in healthy adults using wearables.
Matthew D Czech, Dimitrios Psaltos, Hao Zhang, Tomasz Adamusiak, Monica Calicchio, Amey Kelekar, Andrew Messere, Koene R A Van Dijk, Vesper Ramos, Charmaine Demanuele,...> ;NPJ Digital Medicine. 2020 Jan 1
7 citations
Multimodal Wearable Sensors to Measure Gait and Voice.
Dimitrios Psaltos, Kara Chappie, Fikret Isik Karahanoglu, Rachel Chasse, Charmaine Demanuele, Amey Kelekar, Hao Zhang, Vanessa Marquez, Tairmae Kangarloo, Shyamal Pate...> ;Digital Biomarkers. 2019 Oct 29
Thromboembolic risks of recombinant factor VIIa Use in warfarin-associated intracranial hemorrhage: a case-control study.
H-Y CS Xuemei C G KR M BL V HG A SF K FS> ;BMC Neurol. 2012
11 citations
Aggressiveness of care following intracerebral hemorrhage in women and men
Rahul Guha, Amelia K. Boehme, Stacie L Demel, Janet J. Li, Xuemei Cai, Michael L. James, Sebastian Koch, Carl D. Langefeld, Charles J Moomaw, Jennifer Osborne, Padmini...> ;Neurology. 2017 Jul 25
[Application of laparoscopic transection of median hepatic fissure in difficult laparoscopic liver resections].
Cai LX, He SL, Wei FQ, Yu YC, Cai XJ> ;Zhonghua Yi Xue Za Zhi. 2016-09-13
14 citations
Management of Posterior Reversible Encephalopathy Syndrome Induced by Carfilzomib in a Patient With Multiple Myeloma
Xuemei Cai, Shamik Bhattacharyya, Anna Plitt, Pooja Raibagkar, Jamie Nicole LaBuzetta, Stephen M. Schleicher, Nikhil C. Munshi, Joshua P. Klein> ;Journal of Clinical Oncology. 2016 Jan 10
1 citations
ATS Core Curriculum 2015: Part IV. Adult Critical Care Medicine
Jason T. Poston, Jakob I. McSparron, Margaret M. Hayes, Tessa W Damm, Jayshil J. Patel, Brooke K. Decker, Engi F. Attia, Basxak Çoruh, Xuemei Cai, W. Taylor Kimberly, ...> ;Annals of the American Thoracic Society. 2015 Dec 11
8 citations
The Evaluation and Management of Adult Intracerebral Hemorrhage.
Xuemei Cai, Jonathan Rosand> ;Seminars in Neurology. 2015 Nov 23
Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China.
Han Z, Liu Y, Wang G, He Y, Hu S, Li Y, Shi W, Wu J, Wang S, Liu H, Cai X> ;Transbound Emerg Dis. 2015-10-01
12 citations
Effects of waterlogging after pollination on the physicochemical properties of starch from waxy maize
Dalei Lu, Xuemei Cai, Yaxing Shi, Jiuran Zhao, Weiping Lu> ;Food Chemistry. 2015 Jul 15
57 citations
Patient Preferences and Surrogate Decision Making in Neuroscience Intensive Care Units
Xuemei Cai, Jennifer Robinson, Susanne Muehlschlegel, Douglas B. White, Robert G. Holloway, Kevin N. Sheth, Liana Fraenkel, David Y. Hwang> ;Neurocritical Care. 2015 May 20
9 citations
Case Misclassification in Studies of Spinal Manipulation and Arterial Dissection
Xuemei Cai, Ali Razmara, Jessica K. Paulus, Karen M Switkowski, Pari Fariborz, Sergey Goryachev, Leonard W. D'Avolio, Edward Feldmann, David E. Thaler> ;Journal of Stroke and Cerebrovascular Diseases. 2014 Sep 1
9 citations
Dyscalculia, Dysgraphia, and Left-Right Confusion from a Left Posterior Peri-Insular Infarct
Shamik Bhattacharyya, Xuemei Cai, Joshua P. Klein> ;Behavioural Neurology. 2014 Apr 10
233 citations
Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage
H. Bart Brouwers, Yuchiao Chang, Guido J. Falcone, Xuemei Cai, Alison M. Ayres, Thomas W.K. Battey, Anastasia Vashkevich, Kristen A. McNamara, Valerie Valant, Kristin ...> ;JAMA Neurology. 2014 Feb 1
Author response.
Cai X Han S Feske S Chou S> ;Neurology. 2013 Nov 19
Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary a...
Ma X, Gu J, Zhang Z, Jing L, Xu M, Dai X, Jiang Y, Li Y, Bao L, Cai X, Ding Y, Wang J, Li Y, Li Y> ;Eur J Clin Nutr. 2013-12-01
The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.
Zhang SS, Yang H, Luo KJ, Huang QY, Chen JY, Yang F, Cai XL, Xie X, Liu QW, Bella AE, Hu RG, Wen J, Hu Y, Fu JH> ;Br. J. Cancer. 2013-11-26
Pathogenicity and distribution of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs.
Hu SP, Zhang Z, Liu YG, Tian ZJ, Wu DL, Cai XH, He XJ> ;Transbound Emerg Dis. 2013-08-01
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Journal Articles

Coherent Hemodynamics Spectroscopy: Initial Applications in the Neurocritical Care Unit
Tgavalekos K, Sassaroli A, Cai X, Kornbluth J, Fantini S, Optical Tomography and Spectroscopy of Tissue XII, Proc of SPIE, 1/1/2017
Dyscalculia, Dysgraphia, and Left-Right Confusion from a Left Posterior Peri-Insular Infarct
Bhattacharyya, S; Cai X; Klein JP, Behavioural Neurology, 4/11/2014
Vascular sequelae of aortic arch thrombo-emboli
Cai X, Khalpey Z, Gates JD, Gravereaux E, Grand Rounds, 1/1/2008

Books/Book Chapters

The NeuroICU Board Review.
Chapter: Neuro-Pharmacology.
Daneshmand A, Hajizadeh A, Cai XEditors: Saef Izzy, David Lerner, Kiwon Lee.McGraw Hill Global Education, New York, NY2017
A Student�s Guide to First-Year Composition.
Chapter: Power: A Song to Keep the World Alive.
Cai XUniversity of Pennsylvania Press2004

Abstracts/Posters

Intensive Measurement of Circadian Rhythm in Alzheimer�s Disease: A Feasibility Study.
Kabiri NS, Cote AC, Dupee BN, Detheridge C, Wager T, Ward S, Cai X, Bhangu J, Thomas KC, AD-PD Conference, Torino, Italy, 1/1/2018
Do Women Receive Less Aggressive Care Following Intracerebral Hemorrhage?
Chaturvedi S, Koch S, Sekar P, Moomaw C, Osborne J, Boehme A, Demel S, Li J, Woodrich E, Bracho J, James M, Sheth K, Cai X, Langefeld C, Woo D, Stroke; International Stroke Conference, 1/1/2016
Prothrombin Complex Concentrate Decreases Time to Surgery but Does Not Reduce Mortality in Warfarin-Associated Subdural Hemorrhage.
Otite F, Cai X, Bressette L, Henderson G, Sorond F, Feske S, Chou S, Society of Critical Care Medicine�s 43rd Critical Care Congress, 1/1/2014
Prothrombin Complex Concentrate Rapidly Reverses Coagulopathy but does not Alter Mortality in Warfarin-associated Intracerebral Hemorrhage.
Cai X, Orzell S, Suh S, Bresette L, Sorond F, Henderson G, Feske S, Chou S, International Stroke Conference, 1/1/2013
Dissection in the Veterans� Administration (DIVA): Re-examining Spinal Manipulation and Cervical Artery Dissection.
Thaler D, Cai X, Razmara A, Switkowski K, Goryachev S, D'Avolio, Fiore L, Fariborz P, Feldmann E, American Neurological Association Annual Meeting, 1/1/2012
Imminent Osmotic Myelinolysis: Reversal of Neurological Symptoms with Re-Lowering of Serum Sodium.
Cai X, Nguyen R, Herrington T, Varian K, Warren L, Feske S, Seifter J, Neurocritical Care Society Meeting, 1/1/2012
Small but consequential: a case of deep intracerebral hemorrhage (ICH) caused by distal lenticulostriate artery aneurysm.
Cai X, Han S, Chou S H-Y, 64th Annual American Academy of Neurology Meeting, 1/1/2012
Prothrombin Complex Concentrate use in Warfarin-Associated Intracerebral Hemorrhage is not Associated with higher Thromboembolic Risks.
Chou S H-Y, Konigsberg RG, Cai X, Bresette L, Sorond FA, Henderson GV, Ropper AH, Feske SK, Neurocritical Care; Neurocritical Care Society Meeting, 1/1/2010
Prothrombin Complex Concentrate use in Warfarin-Associated Intracrebral Hemorrhage is not Associated with Higher Thromboembolic Risks.
Chou S H-Y, Konigsberg R, Cai X, Bresette L, Henderson GV, Sorond FA, Ropper AH, Feske SK, Critical Care Med; 38th Critical Care Congress, 1/1/2009
Thromboembolic Risk of Activated Factor VIIa use in Acute Intracerebral Hemorrhage with Coagulopathy.
Chou S H-Y,Cai X, Konigsberg R, Henderson GV, Sorond FA, Ropper AH, Feske SK, Neurocritical Care; Neurocritical Care Society Meeting, 1/1/2009
Thromboembolic Risks of Activated Factor VIIa Use in Warfarin-Associated Intracerebral Hemorrhage.
Chou S H-Y,Cai X, Konigsberg R, Bresette L, Henderson GV, Sorond FA, Ropper AH, Feske SK, Critical Care Med; 38th Critical Care Congress, 1/1/2009
Role of Neuroinflammatory Markers in Ischemia Diabetic Wound Healing.
Pradhan L, Cai X, Anderson N, Jain M, Malek J, Contreras M, Veves A, Lo Gerfo F, Journal of Surgical Research; Annual Academic Surgical Congress Meeting, 1/1/2007
Chaperone Rich Cell Lysates (CRCL) Activate Innate Immune Responses.
Cai X, Zeng Y, Larmonier N, Katsanis E, Keystone Symposium, 1/1/2005
Tumor-Derived Chaperone Rich Cell Lysates (CRCL) Activate Macrophage-Associated Innate Immunity.
Cai X, Romanoski A, Marron M, Katsanis E, 96th Annual Meeting of the American Association for Cancer Research, 1/1/2005
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Lectures

The New Standards for Acute Stroke Treatment
Sturdy Memorial Hospital, Attleboro, MA - 1/1/2016
Acute Ischemic Stroke Management
Massachusetts General Hospital, Boston, MA - 1/1/2015
Brain Death
Denver, CO - 1/1/2015
Acute Neurology for the Oncologist
Massachusetts General Hospital, Boston, MA - 1/1/2014
Acute Neurological Emergencies in Oncology
Dana Farber Cancer Institute and Brigham and Women�s Hospital, Boston, MA - 1/1/2012
Hyperspectral Imaging and Molecular Analysis of a New Rabbit Model of Diabetic Ischemic Wound Healing.
1/1/2007
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Other

A Clinical Update of Intracerebral Hemorrhage.
Cai, A, Cai, X, NeurologyTimes
http://www.neurologytimes.com/headache-and-migraine/clinical-update-intracerebral-hemorrhage
1/13/2017
Massachusetts General Hospital Guidelines for the Management of Adult Intracerebral Hemorrhage.
Cai X, Rosand J, Goldstein J, Romero J, Patel A, Schlunk F
http://www2.massgeneral.org/stopstroke/protocolAdultHemorrhage.aspx
1/1/2015
Step 1 Qmax
Cai X, USMLERx Step 1 Website
http://www.usmlerx.com