YairLotanMD

Surgical Oncology

Professor of Urology, Chief of Urologic Oncology Southwestern Medical School; Medical Director of the Urology Clinic at Parkland Health & Hospital System

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Office
5323 Harry Hines Boulevard
Dallas, TX 75390
Phone+1 214-645-2800

Fax+1 214-645-8772
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Education & Training

University of Texas Southwestern Medical CenterResidency, Urology, 1999 - 2003
University of Texas Southwestern Medical CenterResidency, Surgery, 1997 - 1999
Baylor College of MedicineClass of 1997

Certifications & Licensure

TX State Medical License 1999 - 2024
American Board of Urology Urology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012

Clinical Trials

Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy Start of enrollment: 2014 May 01
Recruiting
Phase 3
Clinical Evaluation of a Test for Monitoring the Recurrence of Bladder Cancer Start of enrollment: 2016 Dec 01
Completed
Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance Start of enrollment: 2019 Mar 11
Recruiting
Phase 3
Gemcitabine Versus Water Irrigation in Upper Tract Urothelial Carcinoma Start of enrollment: 2021 Nov 29
Recruiting
Phase 3
Roles: Contact, Principal Investigator
Measuring Surgical Recovery After Radical Cystectomy Start of enrollment: 2015 Apr 30
Recruiting
Roles: Contact
STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA Start of enrollment: 2019 Sep 11
Active, not recruiting
Not Applicable
Roles: Principal Investigator, Contact
STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA Start of enrollment: 2019 Sep 11
Active, not recruiting
Not Applicable
Roles: Principal Investigator, Contact
A Novel Multiplex ELISA Assay for Evaluating Patients With Gross Hematuria for Bladder Cancer Start of enrollment: 2016 Dec 30
Recruiting
Roles: Contact
Bladder Cancer Screening Trial Start of enrollment: 2023 May 05
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve Start of enrollment: 2021 Apr 22
Recruiting
Phase 1, Phase 2
Roles: Contact
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Publications & Presentations

PubMed

Clinical Trial Protocol for "Replace Cysto": Replacing Invasive Cystoscopy with Urine Testing for Non-muscle-invasive Bladder Cancer Surveillance-A Multicenter, Random...
Todd A MacKenzie, A Aziz Ould Ismail, Laura Jensen, Gregory J Tsongalis, Florian R Schroeck, Robert Grubb, Yair Lotan> ;European Urology Open Science. 2024 May 1
Racial Differences in the Detection Rate of Bladder Cancer Using Blue Light Cystoscopy: Insights from a Multicenter Registry.
Seyedeh-Sanam Ladi-Seyedian, Alireza Ghoreifi, Badrinath Konety, Kamal Pohar, Jeffrey M Holzbeierlein, John Taylor, Max Kates, Brian Willard, Jennifer M Taylor, Joseph...> ;Cancers. 2024 Mar 24
The optimal number of induction chemotherapy cycles in clinically lymph node-positive bladder cancer.
Markus von Deimling, Laura S Mertens, Marc Furrer, Roger Li, Guus A H Tendijck, Jacob Taylor, Felice Crocetto, Moritz Maas, Andrea Mari, Renate Pichler, Marco Moschini...> ;BJU International. 2024 Mar 12
Alignment of molecular subtypes across multiple bladder cancer subtyping classifiers.
Moritz J Reike, Joep J de Jong, Tarek A Bismar, Stephen A Boorjian, Omar Y Mian, Jonathan L Wright, Marc A Dall'Era, Hristros Z Kaimakliotis, Yair Lotan, Joost L Boorm...> ;Urologic Oncology. 2024 Mar 12
The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.
Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J H Shih, Zhongc...> ;Nature Communications. 2024 Feb 14
Reply to Khurshid R. Ghani's letter to editor regarding the article "Early experience with UGN-101 for the treatment of upper tract urothelial cancer: a multicenter ev...
Solomon Woldu, Yair Lotan> ;Urologic Oncology. 2024 Mar 1
Standardization of the evaluation and surveillance of patients with BCG unresponsive high grade non-muscle invasive bladder cancer clinical trials.
Lee, B., Smith, A., Lotan, Y., Agarwal, P., Black, P., Dickstein, R., Kamat, A., Narayan, V., Porten, S., Psutka, S., Svatek, R., Williams, S., Woldu, S.> ;Urologic Oncology. 2024 Feb 1
Interruptions in bladder cancer care during the COVID-19 public health emergency.
John L Gore, Kristin Follmer, Jason Reynolds, Michael Nash, Christopher B Anderson, James W F Catto, Karim Chamie, Siamak Daneshmand, Rian Dickstein, Tullika Garg, Sco...> ;Urologic Oncology. 2024 Apr 1
Protocol of the Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO) study: a pragmatic, prospective multicenter observational cohort study of r...
John L Gore, Erika M Wolff, Bryan A Comstock, Kristin M Follmer, Michael G Nash, Anirban Basu, Stephanie Chisolm, Douglas B MacLean, Jenney R Lee, Yair Lotan, Sima P P...> ;BMC Cancer. 2023 Nov 18
Water intake and recurrent urinary tract infections prevention: economic impact analysis in seven countries.
Juliane Zemdegs, Alison Iroz, Mariacristina Vecchio, Stephane Roze, Yair Lotan> ;BMC Health Services Research. 2023 Nov 3
Clinical Application of Digital and Computational Pathology in Renal Cell Carcinoma: A Systematic Review.
Zine-Eddine Khene, Solène-Florence Kammerer-Jacquet, Pierre Bigot, Noémie Rabilloud, Laurence Albiges, Vitaly Margulis, Renaud De Crevoisier, Oscar Acosta, Nathalie Ri...> ;European Urology Oncology. 2023 Nov 2
4 citations
Impact of the extent of lymph node dissection on survival outcomes in clinically lymph node-positive bladder cancer.
Markus von Deimling, Marc Furrer, Laura S Mertens, Andrea Mari, Noor van Ginkel, Mara Bacchiani, Moritz Maas, Renate Pichler, Roger Li, Marco Moschini, Alberto Bianchi...> ;BJU International. 2024 Mar 1
The effect of cisplatin-based neoadjuvant chemotherapy on the renal function of patients undergoing radical cystectomy.
Matthew D Ho, Anna J Black, Homayoun Zargar, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen,...> ;Canadian Urological Association Journal = Journal De L'association Des Urologues Du Canada. 2023 Oct 1
Corrigendum to "Route of Administration for UGN-101 and Impact on Oncological and Safety Outcomes" [Eur. Urol. Focus (2023)].
Jennifer Linehan, Josh Gottlieb, Solomon L Woldu, Craig Labbate, Kyle Rose, Wade Sexton, Hristos Kaimakliotis, Joseph Jacob, Rian Dickstein, Alan Nieder, Marc Bjurlin,...> ;European Urology Focus. 2024 Jan 1
1 citations
Prospective Randomized Trial of Single-UseReusable Cystoscope for Ureteral Stent Removal.
Brett A Johnson, Jay D Raman, Sara L Best, Yair Lotan> ;Journal of Endourology. 2023 Oct 1
1 citations
First analysis of the safety and efficacy of UGN-101 in the treatment of ureteral tumors.
Joseph M Jacob, Solomon L Woldu, Jennifer Linehan, Craig Labbate, Kyle M Rose, Wade J Sexton, Isamu Tachibana, Hristos Kaimakliotis, Alan Nieder, Marc A Bjurlin, Mitch...> ;Urologic Oncology. 2024 Jan 1
Development and Multicenter Case-Control Validation of Urinary Comprehensive Genomic Profiling for Urothelial Carcinoma Diagnosis, Surveillance, and Risk-Prediction.
Keyan Salari, Debasish Sundi, Jason J Lee, Shulin Wu, Chin-Lee Wu, Gabrielle DiFiore, Q Robert Yan, Andrew Pienkny, Chi K Lee, Daniel Oberlin, Greg Barme, Joel Piser, ...> ;Clinical Cancer Research. 2023 Sep 15
Clinical value of cholinesterase in patients treated with radical nephroureterectomy for upper urinary tract carcinoma.
Markus von Deimling, David D'Andrea, Benjamin Pradere, Ekaterina Laukhtina, Takafumi Yanagisawa, Tatsushi Kawada, Muhammad Majdoub, Pawel Rajwa, Maximilian Pallauf, Ni...> ;World Journal of Urology. 2023 Jul 1
4 citations
Route of Administration for UGN-101 and Impact on Oncological and Safety Outcomes.
Jennifer Linehan, Josh Gottlieb, Solomon L Woldu, Craig Labbate, Kyle Rose, Wade Sexton, Hristos Kaimakliotis, Joseph Jacob, Rian Dickstein, Alan Nieder, Marc Bjurlin,...> ;European Urology Focus. 2023 Nov 1
1 citations
The ablative effect of mitomycin reverse thermal gel: Expanding the role for nephron preservation therapy in low grade upper tract urothelial carcinoma.
Hristos Z Kaimakliotis, Isamu Tachibana, Solomon Woldu, Craig Labbate, Joseph Jacob, Katie Murray, Kyle Rose, Wade Sexton, Rian Dickstein, Jennifer Linehan, Alan Niede...> ;Urologic Oncology. 2023 Sep 1
Optimal Prostate Cancer Diagnostic Pathways for Men With Prostatomegaly in the MRI Era.
Samuel A Gold, Ramy Goueli, Thomaz Rodrigues Mostardeiro, Gianpaolo P Carpinito, Alfarooq El-Eishy, Ryan Mauck, Solomon L Woldu, Douglas W Strand, Yair Lotan, Claus G ...> ;Urology. 2023 Sep 1
1 citations
Carboplatin Induction Chemotherapy in Clinically Lymph Node-positive Bladder Cancer.
Markus von Deimling, Laura S Mertens, Bas W G van Rhijn, Yair Lotan, Philippe E Spiess, Siamak Daneshmand, Peter C Black, Maximilian Pallauf, David D'Andrea, Marco Mos...> ;European Urology Open Science. 2023 May 1
2 citations
Mitomycin Gel (UGN-101) as a Kidney-sparing Treatment for Upper Tract Urothelial Carcinoma in Patients with Imperative Indications and High-grade Disease.
Kyle M Rose, Katie S Murray, Craig Labbate, Solomon Woldu, Jennifer Linehan, Joseph Jacob, Hristos Kaimakliotis, Rian Dickstein, Adam Feldman, Surena F Matin, Yair Lot...> ;European Urology Focus. 2023 Sep 1
2 citations
Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging.
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan> ;BMC Medicine. 2023 Apr 5
Diagnostic Imaging in the Evaluation of Asymptomatic Microhematuria: Systematic Review and Meta-analysis.
Jacob I Taylor, Lesley H Souter, Daniel A Barocas, Stephen A Boorjian, Jay D Raman, Yair Lotan> ;The Journal of Urology. 2023 Jun 1
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Journal Articles

Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018
Ashish M Kamat, Yair Lotan, European Urology

Other

Clinical presentation, diagnosis, and staging of bladder cancer
Lotan Y, Choueiri TK
http://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-of-bladder-cancer
UpToDate, Wolters Kluwer Health - 2012-08-23

Authored Content

Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
Re: Who Should Be Investigated for Hematuria? Results of a Contemporary Prospective Observational Study of 3556 PatientsApril 2018
Re: Who Should Be Investigated for Hematuria? Results of a Contemporary Prospective Observational Study of 3556 PatientsApril 2018
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Press Mentions

UroAmp Detects Bladder Cancer 12 Years Before Clinical Signs, Says StudyMay 2nd, 2023
Genomic Urine Test Detects Bladder Cancer from DNA up to 12 Years Before Clinical Signs and Symptoms AppearMay 1st, 2023
The Discovery of New Biomarkers Could Lead to Early Detection of Bladder CancerApril 28th, 2023
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