YanaGeorgeNajjarMD

PubMed

• Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy inV600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective coh...
  Xue Bai, Ahmed Shaheen, Charlotte Grieco, Paolo D d'Arienzo, Florentia Mina, Juliane A Czapla, Aleigha R Lawless, Eleonora Bongiovanni, Umberto Santaniello, Helena Zap...> ;Eclinicalmedicine. 2024 May 1
• Automated Quantitative CD8+ Tumor-Infiltrating Lymphocytes and Tumor Mutation Burden as Independent Biomarkers in Melanoma Patients Receiving Front-Line Anti-PD-1 Immu...
  Hong Wang, Lindsey Seigh, Dylan Fortman, Arivarasan Karunamurthy, Douglas Hartman, Ibrahim Abukhiran, Yana G Najjar, Liron Pantanowitz, Hassane M Zarour, John M Kirkwo...> ;The Oncologist. 2024 Apr 24
• Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy.
  Hicks, W., Gattie, L., Traylor, J., McBrayer, S., Richardson DO, T., Davar, D., Najjar, Y., Abdullah, K.> ;Biorxiv. 2024 Jan 23
• 4 citations
  Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations.
  Butterfield, L., Najjar, Y.> ;Nature Reviews. Immunology. 2023 Dec 6
• Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy inV600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective coh...
  Xue Bai, Ahmed Shaheen, Charlotte Grieco, Paolo D d'Arienzo, Florentia Mina, Juliane A Czapla, Aleigha R Lawless, Eleonora Bongiovanni, Umberto Santaniello, Helena Zap...> ;Eclinicalmedicine. 2023 Nov 1
• Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma.
  Ryan C Augustin, Sarah Newman, Aofei Li, Marion Joy, Maureen Lyons, Mary P Pham, Peter Lucas, Katelyn Smith, Cindy Sander, Brian Isett, Diwakar Davar, Yana G Najjar, H...> ;Journal for Immunotherapy of Cancer. 2023 Oct 1
• Tumor cell p38 inhibition to overcome immunotherapy resistance.
  Jason J Luke, Rebekah E Dadey, Ryan C Augustin, Sarah Newman, Krishna B Singh, Rose Doerfler, Sarah Behr, Patrice Lee, Brian Isett, Christopher Deitrick, Aofei Li, Mar...> ;Research Square. 2023 Aug 19
• 3 citations
  Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study.
  Ryan C Augustin, Ziyu Huang, Fei Ding, Shuyan Zhai, Jennifer McArdle, Anthony Santisi, Michael Davis, Cindy Sander, Diwakar Davar, John M Kirkwood, Greg M Delgoffe, Al...> ;Frontiers in Oncology. 2023 Jan 1
• 4 citations
  Plasma glycoproteomic biomarkers identify metastatic melanoma patients with reduced clinical benefit from immune checkpoint inhibitor therapy.
  Chad Pickering, Paul Aiyetan, Gege Xu, Alan Mitchell, Rachel Rice, Yana G Najjar, Joseph Markowitz, Lisa M Ebert, Michael P Brown, Gonzalo Tapia-Rico, Dennie Frederick...> ;Frontiers in Immunology. 2023 Jan 1
• 2 citations
  Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes.
  Lilit Karapetyan, Hassan M AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P MacFawn, Zachary J Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Ka...> ;Frontiers in Immunology. 2023 Jan 1
• Hereditary Cancer Syndromes-A Broader Clinical Spectrum Than Previously Understood?
  Susrutha Puthanmadhom Narayanan, Yana G Najjar> ;JAMA Oncology. 2022 Nov 1
• Aggressive Stereotactic Radiosurgery Coupled With Immune and Targeted Therapy for Recurrent Melanoma Brain Metastases: A Case Report and Literature Review.
  Zhishuo Wei, Kaitlin Waite, Hansen Deng, Yana Najjar, Ajay Niranjan, L Dade Lunsford> ;Cureus. 2022 Jul 1
• 5 citations
  A retrospective analysis of the impact of the COVID-19 pandemic on staging at presentation of patients with invasive melanoma.
  Saba S Shaikh, Xi Yang, Dylan D Fortman, Hong Wang, Diwakar Davar, Jason J Luke, Hassane Zarour, John M Kirkwood, Yana G Najjar> ;Journal of the American Academy of Dermatology. 2022 Oct 1
• 3 citations
  Phase I trial of pembrolizumab plus vemurafenib and cobimetinib in patients with metastatic melanoma.
  Saba S Shaikh, Yan Zang, Janel Hanmer, Hong Wang, Yan Lin, Diwakar Davar, Hassane M Zarour, John M Kirkwood, Yana G Najjar> ;Frontiers in Oncology. 2022 Jan 1
• 16 citations
  Immune-Related Adverse Events in PD-1 Treated Melanoma and Impact Upon Anti-Tumor Efficacy: A Real World Analysis
  Melissa L. Bastacky, Hong Wang, Dylan Fortman, Zahra Rahman, Gerard P. Mascara, Timothy Brenner, Yana G. Najjar, Jason J. Luke, John M. Kirkwood, Hassane M. Zarour, Di...> ;Frontiers in Oncology. 2021 Nov 26
• 1 citations
  Search for effective treatments in patients with advanced refractory melanoma continues: can novel intratumoral therapies deliver?
  Yana G. Najjar> ;Journal for Immunotherapy of Cancer. 2021 Jul 1
• 644 citations
  Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
  Diwakar Davar, Amiran K. Dzutsev, John A. McCulloch, Richard R. Rodrigues, Joe Marc Chauvin, Robert M. Morrison, Richelle DeBlasio, Carmine Menna, Quanquan Ding, Ornel...> ;Science. 2021 Feb 5
• 14 citations
  Neoadjuvant Pembrolizumab and High-Dose IFNα-2b in Resectable Regionally Advanced Melanoma
  Yana G. Najjar, Dustin McCurry, Huang Lin, Yan Lin, Yan Zang, Diwakar Davar, Arivarasan Karunamurthy, Joseph J. Drabick, Rogerio I. Neves, Lisa H. Butterfield, Marc S....> ;Clinical Cancer Research. 2021 Mar 22
• 55 citations
  Characteristics of the Tumor Microenvironment That Influence Immune Cell Functions: Hypoxia, Oxidative Stress, Metabolic Alterations.
  Ryan C. Augustin, Greg M. Delgoffe, Yana G. Najjar> ;Cancers. 2020 Dec 17
• 2 citations
  Thick Melanoma Is Associated with Low Melanoma Knowledge and Low Perceived Health Competence, but Not Delays in Care
  Sophia Zhang, Rebecca Liu, Nalyn Siripong, John M. Kirkwood, Matthew P. Holtzman, Diwakar Davar, Yana G. Najjar, Keely Marshall, Stephanie R. Jackson Cullison, Neil A....> ;Journal of the American Academy of Dermatology. 2020 Aug 1
• Metastatic Melanoma With Sebocyte-Like Melanocytes and Widespread Visceral Involvement.
  Li-Wei Chang, Viktoryia Kazlouskaya, Jenna R Bordelon, Marion A. Hughes, Yana G. Najjar, Yuri L Bunimovich, Arivarasan Karunamurthy, Jonhan Ho> ;Dermatology Practical & Conceptual. 2020 Apr 20
• 5 citations
  Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review.
  Peter Mohr, Felix Kiecker, Virtudes Soriano, Olivier Dereure, Karmele Mujika, Philippe Saiag, Jochen Utikal, Rama Koneru, Caroline Robert, Florencia Cuadros, Matias Ch...> ;Melanoma Management. 2019 Oct 4
• 11 citations
  An updated analysis of 4 randomized ECOG trials of high‐dose interferon in the adjuvant treatment of melanoma
  Yana G. Najjar, Maneka Puligandla, Sandra J. Lee, John M. Kirkwood> ;Cancer. 2019 Sep 1
• 128 citations
  Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.
  Yana G. Najjar, Ashley V. Menk, Cindy Sander, Uma Rao, Arivarasan Karunamurthy, Roma Bhatia, Shuyan Zhai, John M. Kirkwood, Greg M. Delgoffe> ;JCI Insight. 2019 Mar 7
• 35 citations
  Next-generation sequencing-based molecular characterization of primary urinary bladder adenocarcinoma
  Somak Roy, Dinesh Pradhan, Wayne L. Ernst, Stephanie Mercurio, Yana G. Najjar, Rahul A. Parikh, Anil V. Parwani, Reetesh K. Pai, Rajiv Dhir, Marina N. Nikiforova> ;Modern Pathology. 2017 May 26
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Lectures

• A phase I study of neoadjuvant combination immunotherapy in locally/regionally advanced melanoma. 
  2019 ASCO Annual Meeting - 6/1/2019