Yang-xinFuMD

PubMed

• STING licensing of type I dendritic cells potentiates antitumor immunity.
  Wang, J., Li, S., Wang, M., Wang, X., Chen, S., Sun, Z., Ren, X., Huang, G., Yan, N., Gao, J., Sumer, B., Fu, Y.> ;Science Immunology. 2024 Feb 16
• 2 citations
  DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability.
  Yaping Huang, Changzheng Lu, Hanzhi Wang, Liya Gu, Yang-Xin Fu, Guo-Min Li> ;Nature Communications. 2023 Aug 28
• Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8T cells.
  Xue Wang, Longchao Liu, Tao Yue, Zhichen Sun, Joonbeom Bae, Kuo-Fu Tseng, Anli Zhang, Jian Qiao, Yang-Xin Fu> ;Signal Transduction and Targeted Therapy. 2023 Jul 12
• 4 citations
  Blockade of trans PD-L1 interaction with CD80 augments antitumor immunity.
  Yuankun Zhang, Qingxiao Song, Kaniel Cassady, Michael Lee, Haidong Tang, Moqian Zheng, Bixin Wang, Dustin E Schones, Yang-Xin Fu, Arthur D Riggs, Paul J Martin, Ru Fen...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr 18
• 19 citations
  IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8T cells to overcome immunotherapy resistance in cancer.
  Joonbeom Bae, Longchao Liu, Casey Moore, Eric Hsu, Anli Zhang, Zhenhua Ren, Zhichen Sun, Xue Wang, Jiankun Zhu, Jiao Shen, Jian Qiao, Yang-Xin Fu> ;Nature Cell Biology. 2022 Dec 1
• 79 citations
  Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity.
  Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D Sumer, Bo Li, Yang-Xin Fu,...> ;Nature Communications. 2022 Sep 6
• 9 citations
  T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies.
  Fanlin Li, Huihui Zhang, Wanting Wang, Puyuan Yang, Yue Huang, Junshi Zhang, Yaping Yan, Yuan Wang, Xizhong Ding, Jie Liang, Xinyue Qi, Min Li, Ping Han, Xiaoqing Zhan...> ;Nature Communications. 2022 Jul 26
• 7 citations
  Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
  Kyung-Min Lee, Chang-Ching Lin, Alberto Servetto, Joonbeom Bae, Vishal Kandagatla, Dan Ye, GunMin Kim, Dhivya R Sudhan, Saurabh Mendiratta, Paula I González Ericsson, ...> ;Cancer Immunology Research. 2022 Jul 1
• 1 citations
  Author Correction: The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.
  Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu,...> ;Nature Communications. 2022 Jun 22
• 14 citations
  Concurrent delivery of immune checkpoint blockade modulates T cell dynamics to enhance neoantigen vaccine-generated antitumor immunity.
  Longchao Liu, Jiahui Chen, Hongyi Zhang, Jianfeng Ye, Casey Moore, Changzheng Lu, Yan Fang, Yang-Xin Fu, Bo Li> ;Nature Cancer. 2022 Apr 1
• 20 citations
  A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.
  Yunjia Zhang, Boxun Li, Sergio Cananzi, Chuanhui Han, Lei-Lei Wang, Yuhua Zou, Yang-Xin Fu, Gary C Hon, Chun-Li Zhang> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Mar 15
• 36 citations
  AXL targeting restores PD-1 blockade sensitivity ofmutant NSCLC through expansion of TCF1CD8 T cells.
  Huiyu Li, Zhida Liu, Longchao Liu, Hongyi Zhang, Chuanhui Han, Luc Girard, Hyunsil Park, Anli Zhang, Chunbo Dong, Jianfeng Ye, Austin Rayford, Michael Peyton, Xiaoguan...> ;Cell Reports. Medicine. 2022 Mar 15
• 29 citations
  Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity.
  Zhenhua Ren, Anli Zhang, Zhichen Sun, Yong Liang, Jianfeng Ye, Jian Qiao, Bo Li, Yang-Xin Fu> ;The Journal of Clinical Investigation. 2022 Feb 1
• 28 citations
  A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors.
  Diyuan Xue, Benjamin Moon, Jing Liao, Jingya Guo, Zhuangzhi Zou, Yanfei Han, Shuaishuai Cao, Yang Wang, Yang-Xin Fu, Hua Peng> ;Science Immunology. 2022 Jan 7
• KP372-1-Induced AKT Hyperactivation Blocks DNA Repair to Synergize With PARP Inhibitor RucaparibInhibiting FOXO3a/GADD45α Pathway.
  Lingxiang Jiang, Yingchun Liu, Xiaolin Su, Jiangwei Wang, Ye Zhao, Soumya Tumbath, Jessica A Kilgore, Noelle S Williams, Yaomin Chen, Xiaolei Wang, Marc S Mendonca, Ta...> ;Frontiers in Oncology. 2022 Jan 1
• 5 citations
  Broad neutralization against SARS-CoV-2 variants induced by a next-generation protein vaccine V-01
  Shiyu Sun, Xi Chen, Jingjing Lin, Junwen Ai, Jiaming Yang, Zhenxiang Hu, Yang Xin Fu, Hua Peng> ;Cell Discovery. 2021 Nov 30
• 24 citations
  Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells.
  Longchao Liu, Jiahui Chen, Joonbeom Bae, Huiyu Li, Zhichen Sun, Casey Moore, Eric Hsu, Chuanhui Han, Jian Qiao, Yang Xin Fu> ;Nature Biomedical Engineering. 2021 Nov 1
• 5 citations
  Characterization of ovarian cancer-derived extracellular vesicles by surface-enhanced Raman spectroscopy.
  Nina M Ćulum, Tyler T. Cooper, Gilles A. Lajoie, Thamara Dayarathna, Stephen H. Pasternak, Jiahui Liu, Yang Xin Fu, Lynne-Marie Postovit, François Lagugné-Labarthet> ;The Analyst. 2021 Oct 29
• 32 citations
  Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance.
  Xuezhi Cao, Yong Liang, Zhenxiang Hu, Huiyu Li, Jiaming Yang, Eric Hsu, Jiankun Zhu, Jin Zhou, Yang Xin Fu> ;Nature Communications. 2021 Oct 7
• 12 citations
  Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma
  Raquibul Hannan, Osama Mohamad, Alberto Diaz de Leon, Subrata Manna, Laurentiu M. Pop, Ze Zhang, Samantha Mannala, Alana Christie, Scott Christley, Nancy L. Monson, Da...> ;Clinical Cancer Research. 2021 Sep 22
• 2 citations
  Author Correction: Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2.
  Shiyu Sun, Yueqi Cai, Tian-Zhang Song, Yang Pu, Lin Cheng, Hairong Xu, Jing Sun, Chaoyang Meng, Yifan Lin, Haibin Huang, Fang Zhao, Silin Zhang, Yu Gao, Jian-Bao Han, ...> ;Cell Research. 2021 Sep 20
• 28 citations
  Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity.
  Jingya Guo, Yong Liang, Diyuan Xue, Jiao Shen, Yueqi Cai, Jiankun Zhu, Yang Xin Fu, Hua Peng> ;Cell Research. 2021 Aug 10
• 34 citations
  Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors
  Anli Zhang, Zhenhua Ren, Kuo-fu Tseng, Xiaojuan Liu, Huiyu Li, Changzheng Lu, Yueqi Cai, John D. Minna, Yang Xin Fu> ;Science Translational Medicine. 2021 Aug 4
• 25 citations
  Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Preclinical Models Enhances Single-Agent Immune Checkpoint Blockade.
  Casey Moore, Ching Cheng Hsu, Wei Min Chen, Benjamin P C Chen, Chuanhui Han, Michael D. Story, Todd A. Aguilera, Laurentiu M. Pop, Raquibul Hannan, Yang Xin Fu, Debabr...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Aug 1
• 81 citations
  Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
  Anthony B. Rodriguez, J. David Peske, Amber N. Woods, Katie M. Leick, Ileana S. Mauldin, Max O. Meneveau, S. Young, Robin S. Lindsay, Marit M. Melssen, Salwador Cyrano...> ;Cell Reports. 2021 Jul 20
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