YogenthiranSaunthararajahMD

PubMed

• 6 citations
  Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer.
  Stephanie Gomez, Olivia L Cox, Reddick R Walker 3rd, Uzma Rentia, Melissa Hadley, Elisa Arthofer, Noor Diab, Erin E Grundy, Tomas Kanholm, James I McDonald, Julie Koby...> ;Journal for Immunotherapy of Cancer. 2022 Nov 1
• 4 citations
  Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas.
  Nikolaus von Knebel Doeberitz, Daniel Paech, Dominik Sturm, Stefan Pusch, Sevin Turcan, Yogen Saunthararajah> ;International Journal of Cancer. 2022 Nov 1
• 2 citations
  Functional characterization of NPM1-TYK2 fusion oncogene.
  Sudhakiranmayi Kuravi, Riley W Baker, Muhammad Umair Mushtaq, Irfan Saadi, Tara L Lin, Carolyn J Vivian, Anusha Valluripalli, Sunil Abhyankar, Siddhartha Ganguly, Wei ...> ;NPJ Precision Oncology. 2022 Jan 18
• 1 citations
  Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.
  Sunisa Kongkiatkamon, Simona Pagliuca, Vera Adema, Yasunobu Nagata, Cassandra M Kerr, Wencke Walter, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Heesun J. Rogers, M...> ;Leukemia. 2021 Nov 29
• 26 citations
  The Similarity of Class II HLA Genotypes Defines Patterns of Autoreactivity in Idiopathic Bone Marrow Failure Disorders.
  Simona Pagliuca, Carmelo Gurnari, Hassan Awada, Ashwin Kishtagari, Sunisa Kongkiatkamon, Laila Terkawi, Misam Zawit, Yihong Guan, Thomas LaFramboise, Babal K. Jha, Bhu...> ;Blood. 2021 Nov 5
• 8 citations
  Clinical Trials Assessing Hypomethylating Agents Combined with Other Therapies: Causes for Failure and Potential Solutions.
  Phaedon D. Zavras, Aditi Shastri, Mendel Goldfinger, Amit Verma, Yogen Saunthararajah> ;Clinical Cancer Research. 2021 Sep 22
• 7 citations
  PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation.
  Xiaorong Gu, Francis Enane, Rita Tohme, Caroline Schuerger, Tomas Radivoyevitch, Yvonne Parker, Eric Zuberi, Bartlomiej P Przychodzen, Babal K. Jha, Daniel J. Lindner,...> ;Cell Reports. 2021 Sep 21
• 2 citations
  A non-cytotoxic regimen of decitabine to treat refractory T-cell large granular lymphocytic leukemia
  Misam Zawit, Carmelo Gurnari, Simona Pagliuca, Hassan Awada, Jaroslaw P. Maciejewski, Yogen Saunthararajah> ;Clinical Case Reports. 2021 Sep 1
• 37 citations
  Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.
  Lindsay Stetson, Dheepa Balasubramanian, Susan Pereira Ribeiro, Tammy Stefan, Kalpana Gupta, Xuan Xu, Slim Fourati, Anne Roe, Zachary Jackson, Robert Schauner, Ashish ...> ;Leukemia. 2021 Jul 9
• 9 citations
  Thioredoxin reductase is a major regulator of metabolism in leukemia cells.
  Sheelarani Karunanithi, Ruifu Liu, Yongchun Hou, Giancarlo Gonzalez, Natasha Oldford, Anne Roe, Nethrie Idipilly, Kalpana Gupta, Chandra Sekhar Amara, Satwikreddy Putl...> ;Oncogene. 2021 Jul 8
• 10 citations
  Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma.
  Metis Hasipek, Dale Grabowski, Yihong Guan, Raghunandan Reddy Alugubelli, Anand D. Tiwari, Xiaorong Gu, Gabriel DeAvila, Ariosto S. Silva, Mark B. Meads, Yvonne Parker...> ;Cancers. 2021 May 28
• 17 citations
  Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.
  Noah J. Daniels, Courtney E Hershberger, Xiaorong Gu, Caroline Schueger, William M. DiPasquale, Jonathan Brick, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Richard ...> ;Cell Reports. 2021 Apr 13
• 1 citations
  β-Hemoglobinopathies lead the way.
  Yogen Saunthararajah> ;Blood. 2021 Mar 25
• 5 citations
  Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia
  Vera Adema, Jack Khouri, Ying Ni, Heesun J. Rogers, Cassandra M Kerr, Hassan Awada, Yasunobu Nagata, Teodora Kuzmanovic, Anjali S. Advani, Aaron T. Gerds, Sudipto Mukh...> ;Leukemia & Lymphoma. 2021 Feb 23
• 1 citations
  Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations.
  Hassan Awada, Cassandra M Kerr, Arda Durmaz, Vera Adema, Carmelo Gurnari, Simona Pagliuca, Misam Zawit, Sunisa Kongkiatkamon, Heesun J. Rogers, Yogen Saunthararajah, M...> ;Leukemia. 2021 Feb 18
• 6 citations
  A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
  Brian T. Hill, Deepa Jagadeesh, Brad Pohlman, Robert M. Dean, Neetha Parameswaran, Joel Chen, Tomas Radivoyevitch, Ashley Morrison, Sherry Fada, Meredith Dever, Shelle...> ;Seminars in Hematology. 2021 Jan 1
• 7 citations
  DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone ...
  Jack Khouri, Beth Faiman, Dale Grabowski, Reda Z. Mahfouz, Shahper N. Khan, Wei Wei, Jason Valent, Robert M. Dean, Christy J. Samaras, Babal K. Jha, Hillard M. Lazarus...> ;Seminars in Hematology. 2021 Jan 1
• 3 citations
  Epigenetic modifier directed therapeutics to unleash healthy genes in unhealthy cells.
  Babal K. Jha, Yogen Saunthararajah> ;Seminars in Hematology. 2021 Jan 1
• 5 citations
  Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation.
  Yogen Saunthararajah> ;Haematologica. 2020 Jun 5
• 3 citations
  Liver background uptake of [ 18 F]FLT in PET imaging
  Olga A. Sergeeva, Yifan Zhang, Jonathan Kenyon, Galen A. Miller-Atkins, Maxim Sergeev, Emily Verbus, Renuka Iyer, Sandra Sexton, Vladimir Kepe, Norbert Avril, Yogen Sa...> ;American Journal of Nuclear Medicine and Molecular Imaging. 2020 Oct 15
• 24 citations
  Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
  Yihong Guan, Edward F Greenberg, Metis Hasipek, Shi Chen, Xiaochen Liu, Cassandra M Kerr, Daniel Gackowski, Ewelina Zarakowska, Tomas Radivoyevitch, Xiaorong Gu, Belin...> ;Communications Biology. 2020 Sep 7
• 15 citations
  A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
  Davendra Sohal, Smitha S. Krishnamurthi, Rita Tohme, Xiaorong Gu, Daniel J. Lindner, Terry H. Landowski, John J. Pink, Tomas Radivoyevitch, Sherry Fada, Zhenghong Lee,...> ;American Journal of Cancer Research. 2020 Sep 1
• 57 citations
  Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network.
  Xiaorong Gu, Rita Tohme, Benjamin Tomlinson, Nneha Sakre, Metis Hasipek, Lisa Durkin, Caroline Schuerger, Dale Grabowski, Asmaa M. Zidan, Tomas Radivoyevitch, Changjin...> ;Leukemia. 2021 Apr 1
• 1 citations
  Cytoplasmic dislocation of NPM1 and PU.1 in NPM1-mutated leukaemia is obscured by paraformaldehyde fixation.
  Xiaorong Gu, Yogen Saunthararajah> ;British Journal of Haematology. 2020 Feb 29
• 10 citations
  Extended experience with a non-cytotoxic DNMT1-targeting regimen of decitabine to treat myeloid malignancies.
  Hassan Awada, Reda Z. Mahfouz, Ashwin Kishtagari, Teodora Kuzmanovic, Cassandra M Kerr, Bhumika J. Patel, Valeria Visconte, Tomas Radivoyevitch, Alan E. Lichtin, Hetty...> ;British Journal of Haematology. 2020 Mar 1
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Abstracts/Posters

• CUL1: Novel Therapeutic Target in Myeloid Neoplasms Harboring -7/Del(7q)
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Large Granular Lymphocytic Leukemia Coexists with Clonal Hematopoiesis of Indeterminate PotentialClinically Relevant Abstract
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Feedback Responses of the Pyrimidine Metabolism Network Mediate Resistance to Decitabine and 5-Azacytidine
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Iron Catalyzed Hydrogen Sulfide and Its Prevalence during Oxidative Events in Sickle Cell Disease
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Extended Experience with a Very Low Dose, Metronomic, Subcutaneous Decitabine Regimen Intended to Deplete DNMT1 without Cytotoxicity
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Eltrombopag Creates a Transient Chemical Phenocopy of TET2 Loss of Function That Contributes to Hematopoietic Precursor ExpansionClinically Relevant Abstract
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• FA Gene Carrier Status Predisposes to Myeloid Neoplasms and Bone Marrow Failure in AdultsClinically Relevant Abstract
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Integrated Analysis of Copy-Number Alterations and Gene Mutations in 2,000 Patients with Myeloid Neoplasms
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Single Arm, Phase II Study of Eltrombopag to Enhance Platelet Count Recovery in Older Patients with Acute Myeloid Leukemia (AML) Undergoing Remission Induction Therapy
  Yogenthiran Saunthararajah, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

• A First-in-Class Inhibitor of ISWI-Mediated (ATP-Dependent) Transcription Repression Releases Terminal-Differentiation in AML Cells While Sparing Normal Hematopoiesis 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• The LSD1 Inhibitor RN-1 Increases I-Globin . Expression in Baboons By Targeting an Early Event Responsible for I-Globin Repression 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Ultimate Precision: Targeting Cancer but Not Normal Self-Replication 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018