Youssef Zeidan MD PhD

PubMed

• Radiation therapy in clinically node positive HER2 positive breast cancer after primary systemic therapy and breast conserving surgery: pooled analysis of TRYPHAENA an...
  Mohamad El-Jammal, Omran Saifi, Jose Bazan, Youssef H Zeidan
  BMC Cancer. 2025-06-04
• Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced microsatellite stable rectal adenocarcinoma: The Averectal study.
  Ali Shamseddine, Rim Turfa, Laudy Chehade, Youssef H Zeidan, Ziad El Husseini
  European Journal of Cancer. 2025-06-03
• Radiation-Induced Nephrotoxicity: Role of Sphingomyelin Phosphodiesterase Acid-like 3b.
  Anis Ahmad, Shamroop Kumar Mallela, Saba Ansari, Mohammed Alnukhali, Misha Ali
  International Journal of Radiation Oncology, Biology, Physics. 2025-04-01

Journal Articles

• Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced microsatellite stable rectal adenocarcinoma: The Averectal study  
  Ali Shamseddine 1, Rim Turfa 2, Laudy Chehade 3, Youssef H Zeidan 4, Ziad El Husseini 3, Malek Kreidieh 3, Youssef Bouferraa 3, Charbel Elias 3, Joseph Kattan 5, Ibrah..., European Journal of Cancer, 4/25/2025
• Intraoperative Radiation Therapy for Parotid Cancer: A Single Institution Experience  
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Int J Radiat Oncol Biol Phys, 4/1/2012
• Intraoperative Radiation Therapy for Advanced Cervical Metastasis: A Single Institution Experience  
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Radiat Oncol, 6/15/2011
• The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation  
  Zeidan YH and Hannun YA, Current Molecular Medicine, 7/1/2010
• Eccrine Porocarcinoma with Metastasis to the Parotid Gland: Treatment with Intensity-Modulated Radiation Therapy Case Report  
  Zeidan YH, Zauls JA, Bilic M, Lentsch EJ, and Sharma AK, Journal of Medical Case Reports, 5/22/2010
• Defective acid sphingomyelinase pathway with pseudomonas aeruginosa infection in cystic fibrosis  
  Yu H, Zeidan YH, Wu BX, Flotte T, Jenkins RW, Hannun YA and Virella-Lowell I, Am J Respir Cell Mol Biol, 9/1/2009
• Downregulation of Neutral Ceramidase by Gemcitabine: Implications for Cell Cycle Regulation  
  Wu BX, Zeidan YH and Hannun YA, Biochim Biophys Acta, 8/1/2009
• Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats  
  Nahas Z, Jiang Y, Zeidan YH, Bielawska A, Szulc Z, Devane L, Kalivas P, Hannun YA, Behavioural Brain Research, 1/30/2009
• Integrin Associated Lyn Kinase Promotes Survival by Suppressing Acid Sphingomyelinase Activity  
  Chudakova D, Zeidan YH, Wheeler B, Yu J, Novgorodov SA, Kindy MS, Hannun YA, and Gudz TI, J Biol Chem, 10/24/2008
• Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia /reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells  
  Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, and Hsu YT, J Biol Che, 9/1/2008
• Molecular Targeting of Acid Ceramidase: Implications to Cancer Therapy  
  Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA, Current Drug Targets, 8/1/2008
• Remodeling of Cellular Cytoskeleton by the Acid Sphingomyelinase/Ceramide Pathway  
  Zeidan YH, Jenkins RW and Hannun YA, J Cell Biol, 4/21/2008
• Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells  
  Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS, Cancer Chemother Pharmacol, 2/1/2008
• A Novel Role for PKCdelta-mediated phosphorylation of ASMase in UV-Induced Mitochondrial Injury  
  Zeidan YH, Obeid LM and Hannun YA, FASEB Journal, 1/1/2008
• Acid ceramidase inhibition: a novel target for cancer therapy  
  Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tava..., Frontiers in Bioscience, 1/1/2008
• Isc1 regulates sphingolipid metabolism in yeast mitochondria  
  Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA, Biochim Biophys Acta, 11/1/2007
• "Translational Aspects in Sphingolipid Research"  
  Zeidan YH and Hannun YA, Trends in Molecular Medicine, 8/1/2007
• Activation of acid sphingomyelinase by PKC-mediated phosphorylation  
  Zeidan YH and Hannun YA, J Biol Chem, 1/1/2007
• Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 productionJ Biol Chem  
  Zeidan YH, Pettus B. J., Elojeimy S., Taha T., Obeid L. M., Kawamori T., Norris J. S., and Hannun Y. A., J Biol Chem, 1/1/2006
• New insights on the use of desipramine as an inhibitor for acid ceramidase  
  Elojeimy S., Holman D. H., Liu X., El-Zawahry A., Villani M., Cheng J. C., Mahdy A., Zeidan Y., Bielwaska A., Hannun Y. A., and Norris J. S., FEBS Letters, 1/1/2006
• Involvement of sphingolipids in apoptin-induced cell killing  
  Liu X., Zeidan Y H, Elojeimy S., Holman D. H., El-Zawahry A. M., Guo G. W., Bielawska A., Bielawski J., Szulc Z., Rubinchik S., Dong J. Y., Keane T. E., Tavassoli M., ..., Moecular Therapy, 1/1/2006
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Books/Book Chapters

• Gene Therapy 
  Chapter: Implementation of acid ceramidase inhibitors as adjuncts to increase the efficacy of cancer therapy. 
  Page 58 - 65Liu Xiang, Elojeimy Saeed, Turner Lorianne S, Mahdy Ayman EM, Zeidan Youssef, Bielawska Alicja, Bielawski Jacek, Dong Jian-Yun, El-Zawahry Ahmed M, Guo Gui-wen, Hannun...Editors: Ochiai T, Shimada H, Tagawa M.Medical View, Co., Ltd., Chiba, Japan2007
• Sphigolipid Biology 
  Chapter: Overview of Acid and Neutral Sphingomyelinases in Cell Regulation. 
  Zeidan Youssef, Marchesini Norma and Hannun YusufEditors: Hirabayashi, Yoshio; Igarashi, Yasuyuki; Merrill, Alfred H. Jr..Springer2006

Abstracts/Posters

• Survival Benefit for Adjuvant Radiation Therapy in Minor Salivary Gland Tumors.
  Y. Zeidan, Y. An, L. Pekelis, C. Kong and Q. Le, ASTRO 2014 Multidisciplinary Head and Neck Cancer Symposium, Phoenix, AZ, 2/1/2014
• Botulinum Toxin Injection Confers Radioprotection In Murine Salivary Glands.
  Y. Zeidan, N. Xiao, H. Cao, C. Kong,, Q. Le and D. Sirjani, ASTRO 55th Annual Meeting, Atlanta, GA, 9/1/2013
• Prospective Analysis of Measured Oral Mucosal Dose and Oral Mucositis (OM) in Head and Neck Cancer (HNC) Patients During IMRT.
  Z. Wang, C. Chan, L. Wang, E. Mok, Y. Zeidan, N. Lee-Enriquez, L. Xing, W. Hara and Q. Le, ASTRO 55th Annual Meeting, Atlanta, GA, 9/1/2013
• Postoperative Radiation Therapy for Minor Salivary Glands Carcinomas of the Head and Neck: Long Term Outcomes.
  Y. Zeidan, J. D. Murphy, C. Chan, Y. An, M. Kaplan, A. Colevas, C. Kong, Q. Le, ASTRO 54th Annual Meeting, Boston, MA, 10/1/2012
• Intraoperative Radiation Therapy for Parotid Cancer: A Single Institution Experience.
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Radiological Society of North America, Chicago, IL, 12/1/2010
• Loss of Acid Sphingomyelinase Induction by Pseudomonas aeruginosa in Cystic Fibrosis.
  Zeidan Y, Hong Yu, Yusuf Hannun and Isabel Virella-Lowell, 30th European Cystic Fibrosis Conference, Belek, Turkey, 6/1/2007
• Activation of Acid Sphingomyelinase by PKCdelta-Mediated Phosphorylation.
  Zeidan Y and Yusuf A Hannun, Fourth International Charleston Ceramide Conference, Pacific Grove, CA, 5/7/2007
• Acid Ceramidase but not Acid Sphingomyelinase is required for TNF-alpha Induced PGE2 Production.
  Zeidan Y, Benjamin Pettus, Toshihiko Kawamori, Tarek Taha, Saeed Elojeimy, Kazuyuki Kitatani, James Norris, Lina Obeid and Yusuf Hannun, 40th Southeastern Regional Lipid Conference, Cashiers, NC, 11/2/2005
• Activation of Acid Sphingomyelinase by Phorbol Ester: Dependence on PKC.
  Zeidan Y, Norma Marchesini, Patrick Roddy, Lina Obeid and Yusuf Hannun, FEBS Advaced Course "Lipid-Protein Interaction in Signaling and Membrane Traffic", Chieti, Italy, 6/10/2005
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