YoussefZeidanMDPhD

PubMed

• Post-lumpectomy radiation therapy boost in breast cancer patients: evidence revisited.
  Majd Kayali, Joseph Abi Jaoude, Paul Ramia, Hazem Assi, Fady Geara, Philip Poortmans, Youssef H. Zeidan> ;Ecancermedicalscience. 2021 Mar 1
• Noninvasive assessment of radiation-induced renal injury in mice.
  Anis Ahmad, Junwei Shi, Saba Ansari, Jumana Afaghani, Judith Molina, Alan Pollack, Sandra Merscher, Youssef H. Zeidan, Alessia Fornoni, Brian Marples> ;International Journal of Radiation Biology. 2021 Mar 15
• Don't Miss the Devil in the Details.
  Youssef H. Zeidan, Philip Poortmans> ;International Journal of Radiation Oncology Biology Physics. 2020 Nov 18
• De-intensifying Radiation Therapy in HER-2 Positive Breast Cancer: To Boost or Not to Boost?
  Joseph Abi Jaoude, Majd Kayali, Evandro de Azambuja, Maha Makki, Hani Tamim, Arafat Tfayli, Nagi S. El Saghir, Fady Geara, Martine Piccart, Philip Poortmans, Youssef H...> ;International Journal of Radiation Oncology Biology Physics. 2020 Nov 15
• Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities.
  Patrick Azzam, Manal Mroueh, Marina Francis, Alaa Abou Daher, Youssef H. Zeidan> ;Ecancermedicalscience. 2020 Nov 3
• Efficacy and safety-in analysis of short-course radiation followed by mFOLFOX-6 plus avelumab for locally advanced rectal adenocarcinoma.
  Ali Shamseddine, Youssef H. Zeidan, Ziad El Husseini, Malek Kreidieh, Monita Al Darazi, Rim Turfa, Joseph Kattan, Ibrahim Khalifeh, Deborah Mukherji, Sally Temraz, Kho...> ;Radiation Oncology. 2020 Oct 7
• Neoadjuvant chemotherapy and Avelumab in early stage resectable nonsmall cell lung cancer.
  Arafat Tfayli, Majd Al Assaad, Ghina Fakhri, Reem Akel, Hanine Atwi, Hady Ghanem, Fadi El Karak, Fadi Farhat, Kamal Al Rabi, Pierre Sfeir, Pierre Youssef, Ziad Mansour...> ;Cancer Medicine. 2020 Sep 29
• Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced rectal adenocarcinoma.
  Ali Shamseddine, Youssef H. Zeidan, Malek Kreidieh, Ibrahim Khalifeh, Rim Turfa, Joseph Kattan, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al A...> ;BMC Cancer. 2020 Sep 1
• 2 citations
  Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate.
  Marina Francis, Alaa Abou Daher, Patrick Azzam, Manal Mroueh, Youssef H. Zeidan> ;International Journal of Molecular Sciences. 2020 Jun 24
• Proton Therapy as a Bridging Treatment in CAR T-Cell Therapy for Relapsed and Refractory Large B-Cell Lymphoma: Is There a Role?
  Omran Saifi, Mohamed A. Kharfan-Dabaja, Youssef H. Zeidan, Jennifer L. Peterson, William G. Rule, S.C. Lester, Bradford S. Hoppe> ;International journal of particle therapy. 2020 Jun 3
• 1 citations
  Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B.
  Alaa Abou Daher, Marina Francis, Patrick Azzam, Anis Ahmad, Assaad A. Eid, Alessia Fornoni, Brian Marples, Youssef H. Zeidan> ;The FASEB Journal. 2020 Jun 1
• 3 citations
  Post-Mastectomy Radiation Therapy in Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer Patients: Analysis of the HERA Trial.
  Joseph Abi Jaoude, Evandro de Azambuja, Maha Makki, Hani Tamim, Arafat Tfayli, Fady Geara, Martine Piccart, Philip Poortmans, Youssef H. Zeidan> ;International Journal of Radiation Oncology Biology Physics. 2020 Mar 1
• Post-mastectomy radiation therapy in breast cancer patients with 1-3 positive lymph nodes: No one size fits all.
  Majd Kayali, Joseph Abi Jaoude, Arafat Tfayli, Nagi S. El Saghir, Philip Poortmans, Youssef H. Zeidan> ;Critical Reviews in Oncology Hematology. 2020 Jan 18
• 1 citations
  Craniocervical Rosai-Dorfman Disease Involving the Vertebral Artery: Case Report and Literature Review
  Wassim Baassiri, Charbel Moussalem, Elie Massaad, Youssef H. Zeidan, Houssein Darwish> ;World Neurosurgery. 2020 Jan 1
• 2 citations
  Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
  Fatima Mohsen Mroueh, Mohamed H. Noureldein, Youssef H. Zeidan, Suzan S. Boutary, Sara Abou Merhi Irani, Stephanie Eid, Mary E Haddad, Rasha Barakat, Frédéric Harb, Jo...> ;The FASEB Journal. 2019 Nov 25
• 21 citations
  SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
  Alla Mitrofanova, Shamroop K. Mallela, Gloria Michelle Ducasa, Tae Hyun Yoo, Eden Rosenfeld-Gur, Iris D. Zelnik, Julia Molina, J. Varona Santos, Mengyuan Ge, Alexis Sl...> ;Nature Communications. 2019 Jun 19
• 5 citations
  The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.
  Malek Kreidieh, Youssef H. Zeidan, Ali Shamseddine> ;Journal of Oncology. 2019 Apr 28
• 5 citations
  Assessing Radiosensitivity of Bladder Cancer in vitro: A 2D vs. 3D Approach.
  Larry Bodgi, Hisham F. Bahmad, Tarek Araji, Joelle Al Choboq, Jolie Bou-Gharios, Katia Cheaito, Youssef H. Zeidan, Toufic Eid, Fady Geara, Wassim Abou-Kheir> ;Frontiers in Oncology. 2019 Mar 19
• 3 citations
  Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Ca...
  Fady Geara, Toufic Eid, Nicolas Zouain, Ranim Thebian, Therese Youssef Andraos, Chirine Chehab, Paul Ramia, Bassem Youssef, Youssef H. Zeidan> ;American Journal of Clinical Oncology. 2018 Dec 1
• 4 citations
  Predictors of Cardiac Sparing in Deep Inspiration Breath-Hold for Patients With Left Sided Breast Cancer.
  Abbas Mkanna, Osama Mohamad, Paul Ramia, Ranim Thebian, Maha Makki, Hani Tamim, Wassim Jalbout, Bassem Youssef, Toufic Eid, Fady Geara, B. Shahine, Youssef H. Zeidan> ;Frontiers in Oncology. 2018 Nov 27
• In Reply to Belkacemi and Tsoutsou.
  Youssef H. Zeidan, Joyce G. Habib, Evandro de Azambuja, Ian R. Campbell, M. Andersson, Ana Lluch, Angelo Di Leo, Prudence A. Francis> ;International Journal of Radiation Oncology Biology Physics. 2018 Oct 1
• 12 citations
  Postmastectomy Radiation Therapy in Women with T1-T2 Tumors and 1 to 3 Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial
  Youssef H. Zeidan, Joyce G. Habib, Lieveke Ameye, Marianne Paesmans, Evandro de Azambuja, Richard D. Gelber, Ian R. Campbell, Bo Nordenskjöld, Jorge Gutiérez, Michael ...> ;International Journal of Radiation Oncology Biology Physics. 2018 Jun 1
• 3 citations
  E6-Associated Protein Dependent Estrogen Receptor Regulation of Protein Kinase A Regulatory Subunit R2A Expression in Neuroblastoma
  Jean Pierre Obeid, Youssef H. Zeidan, Nawal Zafar, Jimmy El Hokayem> ;Molecular Neurobiology. 2018 Feb 1
• 9 citations
  Translational Aspects of Sphingolipid Metabolism in Renal Disorders.
  Alaa Abou Daher, Tatiana El Jalkh, Assaad A. Eid, Alessia Fornoni, Brian Marples, Youssef H. Zeidan> ;International Journal of Molecular Sciences. 2017 Nov 25
• 5 citations
  Optimizing tumor immune response through combination of radiation and immunotherapy
  Alissar El Chediak, Ali Shamseddine, Larry Bodgi, Jean-Pierre Obeid, Fady B. Geara, Youssef H. Zeidan> ;Medical Oncology. 2017 Aug 21
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Journal Articles

• Intraoperative Radiation Therapy for Parotid Cancer: A Single Institution Experience  
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Int J Radiat Oncol Biol Phys, 4/1/2012
• Intraoperative Radiation Therapy for Advanced Cervical Metastasis: A Single Institution Experience  
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Radiat Oncol, 6/15/2011
• The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation  
  Zeidan YH and Hannun YA, Current Molecular Medicine, 7/1/2010
• Eccrine Porocarcinoma with Metastasis to the Parotid Gland: Treatment with Intensity-Modulated Radiation Therapy Case Report  
  Zeidan YH, Zauls JA, Bilic M, Lentsch EJ, and Sharma AK, Journal of Medical Case Reports, 5/22/2010
• Defective acid sphingomyelinase pathway with pseudomonas aeruginosa infection in cystic fibrosis  
  Yu H, Zeidan YH, Wu BX, Flotte T, Jenkins RW, Hannun YA and Virella-Lowell I, Am J Respir Cell Mol Biol, 9/1/2009
• Downregulation of Neutral Ceramidase by Gemcitabine: Implications for Cell Cycle Regulation  
  Wu BX, Zeidan YH and Hannun YA, Biochim Biophys Acta, 8/1/2009
• Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats  
  Nahas Z, Jiang Y, Zeidan YH, Bielawska A, Szulc Z, Devane L, Kalivas P, Hannun YA, Behavioural Brain Research, 1/30/2009
• Integrin Associated Lyn Kinase Promotes Survival by Suppressing Acid Sphingomyelinase Activity  
  Chudakova D, Zeidan YH, Wheeler B, Yu J, Novgorodov SA, Kindy MS, Hannun YA, and Gudz TI, J Biol Chem, 10/24/2008
• Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia /reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells  
  Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, and Hsu YT, J Biol Che, 9/1/2008
• Molecular Targeting of Acid Ceramidase: Implications to Cancer Therapy  
  Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA, Current Drug Targets, 8/1/2008
• Remodeling of Cellular Cytoskeleton by the Acid Sphingomyelinase/Ceramide Pathway  
  Zeidan YH, Jenkins RW and Hannun YA, J Cell Biol, 4/21/2008
• Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells  
  Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS, Cancer Chemother Pharmacol, 2/1/2008
• A Novel Role for PKCdelta-mediated phosphorylation of ASMase in UV-Induced Mitochondrial Injury  
  Zeidan YH, Obeid LM and Hannun YA, FASEB Journal, 1/1/2008
• Acid ceramidase inhibition: a novel target for cancer therapy  
  Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tava..., Frontiers in Bioscience, 1/1/2008
• Isc1 regulates sphingolipid metabolism in yeast mitochondria  
  Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA, Biochim Biophys Acta, 11/1/2007
• "Translational Aspects in Sphingolipid Research"  
  Zeidan YH and Hannun YA, Trends in Molecular Medicine, 8/1/2007
• Activation of acid sphingomyelinase by PKC-mediated phosphorylation  
  Zeidan YH and Hannun YA, J Biol Chem, 1/1/2007
• Involvement of sphingolipids in apoptin-induced cell killing  
  Liu X., Zeidan Y H, Elojeimy S., Holman D. H., El-Zawahry A. M., Guo G. W., Bielawska A., Bielawski J., Szulc Z., Rubinchik S., Dong J. Y., Keane T. E., Tavassoli M., ..., Moecular Therapy, 1/1/2006
• New insights on the use of desipramine as an inhibitor for acid ceramidase  
  Elojeimy S., Holman D. H., Liu X., El-Zawahry A., Villani M., Cheng J. C., Mahdy A., Zeidan Y., Bielwaska A., Hannun Y. A., and Norris J. S., FEBS Letters, 1/1/2006
• Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 productionJ Biol Chem  
  Zeidan YH, Pettus B. J., Elojeimy S., Taha T., Obeid L. M., Kawamori T., Norris J. S., and Hannun Y. A., J Biol Chem, 1/1/2006
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Books/Book Chapters

• Gene Therapy 
  Chapter: Implementation of acid ceramidase inhibitors as adjuncts to increase the efficacy of cancer therapy. 
  Page 58 - 65Liu Xiang, Elojeimy Saeed, Turner Lorianne S, Mahdy Ayman EM, Zeidan Youssef, Bielawska Alicja, Bielawski Jacek, Dong Jian-Yun, El-Zawahry Ahmed M, Guo Gui-wen, Hannun...Editors: Ochiai T, Shimada H, Tagawa M.Medical View, Co., Ltd., Chiba, Japan2007
• Sphigolipid Biology 
  Chapter: Overview of Acid and Neutral Sphingomyelinases in Cell Regulation. 
  Zeidan Youssef, Marchesini Norma and Hannun YusufEditors: Hirabayashi, Yoshio; Igarashi, Yasuyuki; Merrill, Alfred H. Jr..Springer2006

Abstracts/Posters

• Survival Benefit for Adjuvant Radiation Therapy in Minor Salivary Gland Tumors.
  Y. Zeidan, Y. An, L. Pekelis, C. Kong and Q. Le, ASTRO 2014 Multidisciplinary Head and Neck Cancer Symposium, Phoenix, AZ, 2/1/2014
• Botulinum Toxin Injection Confers Radioprotection In Murine Salivary Glands.
  Y. Zeidan, N. Xiao, H. Cao, C. Kong,, Q. Le and D. Sirjani, ASTRO 55th Annual Meeting, Atlanta, GA, 9/1/2013
• Prospective Analysis of Measured Oral Mucosal Dose and Oral Mucositis (OM) in Head and Neck Cancer (HNC) Patients During IMRT.
  Z. Wang, C. Chan, L. Wang, E. Mok, Y. Zeidan, N. Lee-Enriquez, L. Xing, W. Hara and Q. Le, ASTRO 55th Annual Meeting, Atlanta, GA, 9/1/2013
• Postoperative Radiation Therapy for Minor Salivary Glands Carcinomas of the Head and Neck: Long Term Outcomes.
  Y. Zeidan, J. D. Murphy, C. Chan, Y. An, M. Kaplan, A. Colevas, C. Kong, Q. Le, ASTRO 54th Annual Meeting, Boston, MA, 10/1/2012
• Intraoperative Radiation Therapy for Parotid Cancer: A Single Institution Experience.
  Zeidan YH, Shiue K, Weed D, Johnstone PA, Freeman S, Krowiak E, Borrowdale R, Huntley T, Yeh A, Radiological Society of North America, Chicago, IL, 12/1/2010
• Loss of Acid Sphingomyelinase Induction by Pseudomonas aeruginosa in Cystic Fibrosis.
  Zeidan Y, Hong Yu, Yusuf Hannun and Isabel Virella-Lowell, 30th European Cystic Fibrosis Conference, Belek, Turkey, 6/1/2007
• Activation of Acid Sphingomyelinase by PKCdelta-Mediated Phosphorylation.
  Zeidan Y and Yusuf A Hannun, Fourth International Charleston Ceramide Conference, Pacific Grove, CA, 5/7/2007
• Acid Ceramidase but not Acid Sphingomyelinase is required for TNF-alpha Induced PGE2 Production.
  Zeidan Y, Benjamin Pettus, Toshihiko Kawamori, Tarek Taha, Saeed Elojeimy, Kazuyuki Kitatani, James Norris, Lina Obeid and Yusuf Hannun, 40th Southeastern Regional Lipid Conference, Cashiers, NC, 11/2/2005
• Activation of Acid Sphingomyelinase by Phorbol Ester: Dependence on PKC.
  Zeidan Y, Norma Marchesini, Patrick Roddy, Lina Obeid and Yusuf Hannun, FEBS Advaced Course "Lipid-Protein Interaction in Signaling and Membrane Traffic", Chieti, Italy, 6/10/2005
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