YumiImaiMD

PubMed

• Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy.
  Brianna R Brennecke, USeong Yang, Siming Liu, Fatma S Ilerisoy, Beyza N Ilerisoy, Aditya Joglekar, Lucy B Kim, Spencer J Peachee, Syreine L Richtsmeier, Samuel B Steph...> ;Frontiers in Endocrinology. 2023 Jan 1
• 10 citations
  Lipid Droplets' Role in the Regulation of β-Cell Function and β-Cell Demise in Type 2 Diabetes.
  Xin Tong, Siming Liu, Roland Stein, Yumi Imai> ;Endocrinology. 2022 Mar 1
• 11 citations
  Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
  Susheel K Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R Chheda, Chen Kang, David M Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E Gerber, Wojciech J ...> ;Nature Communications. 2022 Feb 10
• 1 citations
  Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes.
  Yumi Imai, Scott A Soleimanpour, Jeffery S Tessem> ;Frontiers in Endocrinology. 2022 Jan 1
• 1 citations
  Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data.
  Yumi Imai> ;The Journal of Clinical Investigation. 2021 Dec 15
• 2 citations
  Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy.
  Jaeyong Cho, Yoji Tsugawa, Yumi Imai, Takeshi Imai> ;Biochemical and Biophysical Research Communications. 2021 Sep 24
• 12 citations
  A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.
  Mark Li, Fan Shao, Qingwen Qian, Wenjie Yu, Zeyuan Zhang, Biyi Chen, Dan Su, Yuwei Guo, An-Vi Phan, Long-Sheng Song, Samuel B. Stephens, Julien A. Sebag, Yumi Imai, Li...> ;Molecular Therapy. Nucleic Acids. 2021 Jul 16
• 8 citations
  Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function.
  Casey J. Bauchle, Kristen E. Rohli, Cierra K. Boyer, Vidhant Pal, Jonathan V. Rocheleau, Siming Liu, Yumi Imai, Eric B. Taylor, Samuel B. Stephens> ;Diabetes. 2021 May 26
• 8 citations
  Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria
  , , , , , , , , , , , , , , , , , > ;JCI Insight. 2021 May 10
• 1 citations
  My journey from Japan to becoming a physician-scientist in the United States.
  Yumi Imai> ;The Journal of Clinical Investigation. 2021 May 3
• 5 citations
  Genetic deletion of miR-204 improves glycemic control despite obesity in db/db mice
  Ravinder Reddy Gaddam, Young-Rae Kim, Quixia Li, Julia S. Jacobs, Mohanad Gabani, Akansha Mishra, Joseph A. Promes, Yumi Imai, Kaikobad Irani, Ajit Vikram> ;Biochemical and Biophysical Research Communications. 2020 Nov 5
• 11 citations
  L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.
  Jaeyong Cho, Yukio Horikawa, Mayumi Enya, Jun Takeda, Yoichi Imai, Yumi Imai, Hiroshi Handa, Takeshi Imai> ;Communications Biology. 2020 Sep 8
• 6 citations
  UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner
  Jaeyong Cho, Masaki Hiramoto, Yuka Masaike, Satoshi Sakamoto, Yoichi Imai, Yumi Imai, Hiroshi Handa, Takeshi Imai> ;Biochemical and Biophysical Research Communications. 2020 Jun 30
• 9 citations
  Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells.
  Siming Liu, Joseph A Promes, Akansha Mishra, Samuel B Stephens, Eric B Taylor, Anthony J Burand Jr, William I Sivitz, Brian D Fink, James A Ankrum, Yumi Imai, Harata, M.> ;Diabetes. 2020 Jun 1
• 2 citations
  Adipose Triglyceride Lipase is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells.
  Siming Liu, Joseph A Promes, Akansha Mishra, Samuel B Stephens, Eric B Taylor, Anthony J Burand Jr, William I Sivitz, Brian D Fink, James A Ankrum, Yumi Imai, Harata, M.> ;Diabetes. 2020 Mar 31
• 38 citations
  Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
  Yumi Imai, Ryan S. Cousins, Siming Liu, Brian M. Phelps, Joseph A. Promes> ;Annals of the New York Academy of Sciences. 2020 Feb 1
• 1 citations
  Characterization of Islet Leukocyte Populations in Human and Murine Islets by Flow Cytometry
  Matthew J. Butcher, Michelle B. Trevino, Yumi Imai, Elena V. Galkina> ;Methods in Molecular Biology. 2020 Jan 1
• 5 citations
  Lentiviral Mediated Gene Silencing in Human Pseudoislet Prepared in Low Attachment Plates
  Siming Liu, Joseph A. Promes, Anthony J. Burand, James A. Ankrum, Yumi Imai> ;Journal of Visualized Experiments. 2019 May 14
• 40 citations
  Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
  Anca D. Dobrian, Margaret A. Morris, David A. Taylor-Fishwick, Theodore R. Holman, Yumi Imai, Raghu Mirmira, Jerry L. Nadler> ;Pharmacology & Therapeutics. 2019 Mar 1
• 13 citations
  Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets.
  Siming Liu, Joseph A. Promes, Anthony J. Burand, James A. Ankrum, Yumi Imai> ;Physiological Reports. 2018 Oct 1
• 20 citations
  Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic β-cell function and energetics in high fat fed obese mice.
  Yumi Imai, Brian D. Fink, Joseph A. Promes, Chaitanya A. Kulkarni, Robert J. Kerns, William I. Sivitz> ;Pharmacology Research & Perspectives. 2018 Jun 1
• 20 citations
  12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets
  Kaiwen Ma, An Xiao, So Hyun Park, Lindsey Glenn, Laura Jackson, Tatvam Barot, Jessica R. Weaver, David A. Taylor-Fishwick, Diane K. Luci, David J. Maloney, Raghavendra...> ;The Journal of Clinical Endocrinology and Metabolism. 2017 Aug 1
• 2 citations
  Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice.
  Sichen Liu, Emily M. Smith, Timothy H. King, Lindsey Glenn, Michelle B. Trevino, So Hyun Park, Yui Machida, Ciriaco Villaflor, Wojciech J. Grzesik, Margaret A. Morris,...> ;Journal of Diabetes Mellitus. 2016 Sep 13
• 87 citations
  Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis
  Divya P. Kumar, Amon Asgharpour, Faridoddin Mirshahi, So Hyun Park, Sichen Liu, Yumi Imai, Jerry L. Nadler, John R. Grider, Karnam S. Murthy, Arun J. Sanyal> ;The Journal of Biological Chemistry. 2016 Mar 25
• 35 citations
  Lipids and immunoinflammatory pathways of beta cell destruction.
  Yumi Imai, Anca D. Dobrian, Margaret A. Morris, David A. Taylor-Fishwick, Jerry L. Nadler> ;Diabetologia. 2016 Feb 11
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