YuxingXiaMDPhD

PubMed

• The model student: GPT-4 performance on graduate biomedical science exams.
  Daniel Stribling, Yuxing Xia, Maha K Amer, Kiley S Graim, Connie J Mulligan, Rolf Renne> ;Scientific Reports. 2024 Mar 7
• Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
  Lloyd, G., Dhillon, J., Gorion, K., Riffe, C., Fromholt, S., Giasson, B., Borchelt, D., Xia, Y.> ;Molecular Neurodegeneration. 2024 Feb 16
• 3 citations
  Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.
  Stephan Quintin, Grace M Lloyd, Giavanna Paterno, Yuxing Xia, Zachary Sorrentino, Brach M Bell, Kimberly-Marie Gorion, Edward B Lee, Stefan Prokop, Benoit I Giasson> ;The Journal of Biological Chemistry. 2023 Jul 1
• 3 citations
  Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation.
  Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasson> ;Frontiers in Neuroscience. 2023 Jan 1
• 2 citations
  Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation.
  Yuxing Xia, Brach M Bell, Benoit I Giasson> ;International Journal of Molecular Sciences. 2023 May 5
• 1 citations
  Role of Ubiquilin-2 in Proteostasis and Tau Aggregation in Tauopathies.
  Yuxing Xia> ;The Journal of Neuroscience. 2022 Aug 10
• 4 citations
  Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.
  Yuxing Xia, Stefan Prokop, Brach M Bell, Kimberly-Marie M Gorion, Cara L Croft, Guilian Xu, Cara J Riffe, Alyssa N Manaois, Kevin H Strang, Stephan S Quintin, Giavanna...> ;Communications Biology. 2022 May 12
• 75 citations
  "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies.
  Yuxing Xia, Stefan Prokop, Benoit I. Giasson> ;Molecular Neurodegeneration. 2021 Jun 5
• 52 citations
  Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
  Yuxing Xia, Stefan Prokop, Kimberly-Marie M. Gorion, Justin D. Kim, Zachary A. Sorrentino, Brach M. Bell, Alyssa N. Manaois, Paramita Chakrabarty, Peter Davies, Benoit...> ;Acta Neuropathologica Communications. 2020 Jun 22
• 50 citations
  Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum‐associated protein degradation
  Yuxing Xia, Linda H. Yan, Bo Huang, Mujun Liu, Xionghao Liu, Cao Huang> ;Journal of Neurochemistry. 2014 Apr 1
• 19 citations
  Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations
  Yuxing Xia, Zachary A. Sorrentino, Justin D. Kim, Kevin H. Strang, Cara J. Riffe, Benoit I. Giasson> ;The Journal of Biological Chemistry. 2019 Nov 29
• 7 citations
  Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction.
  Yuxing Xia, Benoit I. Giasson, Lith H. Nasif> ;Journal of Neurochemistry. 2021 Mar 26
• 4 citations
  Targeted proteolytic products of τ and α-synuclein in neurodegeneration.
  Yuxing Xia, Grace M. Lloyd, Benoit I. Giasson> ;Essays in Biochemistry. 2021 Nov 30
• 13 citations
  Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation.
  Yuxing Xia, Brach M. Bell, Benoit I. Giasson> ;Scientific Reports. 2021 Aug 23
• 9 citations
  Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
  Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara J. Riffe, Susan Fromholt, Yuxing Xia, Benoit I. Giasson, David R. Borchelt> ;Molecular Neurodegeneration. 2021 Sep 9
• 11 citations
  Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.
  Ethan W Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop, Benoit I. Giasson> ;Acta Neuropathologica Communications. 2021 Aug 28
• 28 citations
  β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins
  Wanxia He, Jinxuan Hu, Yuxing Xia, Riqiang Yan> ;The Journal of Biological Chemistry. 2014 Jul 25
• 29 citations
  Precision therapeutic targets for COVID-19.
  Zachary A. Krumm, Grace M. Lloyd, Connor Francis, Duane Mitchell, Todd E. Golde, Benoit I. Giasson, Yuxing Xia, Lith H. Nasif> ;Virology Journal. 2021 Mar 29
• 1 citations
  Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates.
  Yuxing Xia, Zhijuan Chen, Guilian Xu, David R. Borchelt, Jacob I. Ayers, Benoit I. Giasson> ;Neuroscience Letters. 2021 Jan 18
• Therapeutic potential of miRNAs in Duchenne muscular dystrophy and other neuromuscular diseases
  Yuxing Xia> ;The Journal of Physiology. 2021 Mar 1
• 11 citations
  Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease.
  Grace M. Lloyd, Jorge A. Trejo-Lopez, Yuxing Xia, Karen N. McFarland, Sarah Lincoln, Nilufer Ertekin-Taner, Benoit I. Giasson, Anthony T. Yachnis, Stefan Prokop> ;Acta Neuropathologica Communications. 2020 Mar 12
• 15 citations
  Carboxy-terminal truncations of mouse α-synuclein alter aggregation and prion-like seeding.
  Zachary A. Sorrentino, Yuxing Xia, Kimberly-Marie M. Gorion, Ethan W Hass, Benoit I. Giasson> ;FEBS Letters. 2020 Apr 1
• 41 citations
  Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.
  Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie M. Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawre...> ;Acta Neuropathologica Communications. 2019 Sep 2
• 29 citations
  Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.
  Zachary A. Sorrentino, Yuxing Xia, Cory C. Funk, Cara J. Riffe, Nicola J. Rutherford, Carolina Ceballos Diaz, Amanda N. Sacino, Nathan D. Price, Todd E. Golde, Benoit ...> ;Neurobiology of Disease. 2018 Sep 6
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Abstracts/Posters

• A novel SPAM mouse model of tauopathy develops robust tau inclusions and early hyperphosphorylation
  Xia Y, Prokop S, Gorion K, Cunningham D, Riffe C, Croft C, Xu G, Bell B, Manaois A, Strang KH, Giasson B, Alzheimer's Research and Dementia, 16 (S12)