Zain Ismail Khalpey MD PhD, FACS, FETCS
Adult Cardiac Surgery, Aortic Surgery, Cardiopulmonary Transplantation, Minimally Invasive Cardiac Surgery
Director of Artificial Heart Program, Cardiothoracic Surgery Network Director Artificial Intelligence Director, Mechanical Circulatory & Extracorporeal Life Support, Robotic Cardiac Surgery Program, Ai Lab Honor Health, Scottsdale, AZ
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10210 N 92nd St Ste 300Scottsdale, AZ 85258
Phone+1 480-882-7750
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Summary
- Dr. Zain Khalpey is a thoracic surgeon in Tucson, AZ and is affiliated with multiple hospitals in the area, including Brigham and Women's Hospital, TMC HealthCare, Banner - University Medical Center Tucson, Southern Arizona Veterans Affairs Health Care System, Banner - University Medical Center South, and Northwest Medical Center. He received his medical degree from Guy's, King's and St Thomas' School of Medical Education and has been in practice 21 years. He specializes in adult cardiac surgery, aortic surgery, cardiopulmonary transplantation, and minimally invasive cardiac surgery and is experienced in thoracotomy, cardiac transplant surgery, and prosthesis design.
Education & Training
Mass General Brigham/Brigham and Women's Hospital/Children's HospitalFellowship, Thoracic Surgery - Independent, 2010 - 2012- Mass General Brigham/Brigham and Women's HospitalResidency, Surgery, 2006 - 2010
Guy's, King's and St Thomas' School of Medical EducationClass of 1998
Certifications & Licensure
AZ State Medical License 2012 - 2027
MA State Medical License 2008 - 2027
NY State Medical License 2012 - 2026
American Board of Thoracic Surgery Thoracic and Cardiac Surgery
Clinical Trials
- Cardiogenesis Transmyocardial Revascularization Registry Start of enrollment: 2013 May 01
- Safety and Efficacy Study of Amniotic Membrane Patch to Treat Postoperative Atrial Fibrillation Start of enrollment: 2014 Jul 01
Publications & Presentations
PubMed
- Digital Twin-Guided Virtual Clinical Trials for Predicting and Preventing Postoperative Atrial Fibrillation in Cardiac Surgery.Zain Khalpey, Nicholas King
Cureus. 2026-04-01 - Machine Learning-Based Data Extraction Tools in Healthcare: A Systematic Review.Zain Khalpey, Matthew Rorvig, Zacharya I Khalpey, Ujjawal Kumar, Feras H Khaliel
Cureus. 2026-04-01 - Small Language Models for Developing Agentic AI in Healthcare: A Comprehensive Systematic Review and Critical Analysis.Zain Khalpey, Nicholas King, Alyssa Abraham
Cureus. 2026-04-01
Press Mentions
Phoenix Hospital Performs Groundbreaking Procedure on Heart Failure PatientSeptember 22nd, 2025- Sarah R. Baroody, MD, an Ophthalmologist with Eye Care of DanburyAugust 5th, 2021
- Zain Khalpey, MD, PhD, a Cardiothoracic Surgeon with Northwest Cardiology at Northwest Medical CenterAugust 5th, 2021
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