ZhihengHeMDPhD

PubMed

• Editorial: Immune regulatory functions of biologically active compounds from fungi.
  Di Wang, Zhiheng He, Yu Li, Ning Wang> ;Frontiers in Immunology. 2023 Jan 1
• 21 citations
  The N-glycome regulates the endothelial-to-hematopoietic transition
  Dionna M. Kasper, Jared Hintzen, Yinyu Wu, Joey J. Ghersi, Hanna K. Mandl, Kevin E. Salinas, William Armero, Zhiheng He, Ying Sheng, Yixuan Xie, Daniel W. Heindel, Eon...> ;Science. 2020 Dec 4
• 4 citations
  Inter-clinician eConsults without programmatic incentives or requirements: a qualitative study of primary care provider perspectives.
  Leah Zallman, Carolyn Fisher, Sofia Ladner, Kira Mengistu, Alison B Rapaport, David H. Bor, Zhiheng He, Joel Sawady, Robert Stavert, Rachel Nardin, Adarsha S. Bajracha...> ;Family Practice. 2020 Sep 5
• 3 citations
  Thyrotoxicosis after massive triiodothyronine (LT3) overdose: a coast-to-coast case series and review.
  Zhiheng H. He, Yan Li, Nitin Trivedi, Sabrina Gill, James V. Hennessey> ;Drugs in Context. 2020 Jan 15
• 48 citations
  Residual β cell function and monogenic variants in long-duration type 1 diabetes patients.
  Marc Gregory Yu, Hillary A. Keenan, Hetal Shah, Scott G. Frodsham, David M. Pober, Zhiheng He, Emily Wolfson, Stephanie D’Eon, Liane J. Tinsley, Susan Bonner-Weir, Mar...> ;The Journal of Clinical Investigation. 2019 Aug 1
• 22 citations
  Low iodine diet in differentiated thyroid cancer: a review
  Josephine H. Li, Zhiheng H. He, Vivek Bansal, James V. Hennessey> ;Clinical Endocrinology. 2016 Jan 1
• 12 citations
  Cardiovascular Disease Protection in Long-Duration Type 1 Diabetes and Sex Differences
  Zhiheng H. He, Stephanie D’Eon, Liane J. Tinsley, Shane Fitzgerald, Stephanie M. Hastings, Mogher Khamaisi, Jennifer K. Sun, Sara J. Turek, Ernst J. Schaefer, George L...> ;Diabetes Care. 2015 May 1
• 24 citations
  Modulating Notch Signaling to Enhance Neovascularization and Reperfusion in Diabetic Mice
  Lan Cao, Praveen R. Arany, Jaeyun Kim, José Rivera-Feliciano, Yuan-Shuo Wang, Zhiheng He, Christian Rask-Madsen, George L. King, David J. Mooney> ;Biomaterials. 2010 Dec 1
• 21 citations
  Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cβ2 in the regulation of physiologic developmental hypertrophy and heart function
  Debra L. Rigor, Natalya Bodyak, Soochan Bae, Jun H. Choi, Li Zhang, Dmitry Ter-Ovanesyan, Zhiheng He, Julie R. McMullen, Tetsuo Shioi, Seigo Izumo, George L. King, Pet...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2009 Jan 2
• 53 citations
  Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin through IRS1/Phosphoinositide 3-Kinase/Akt-2 Pathway
  Pedro Geraldes, Kunimasa Yagi, Yuzuru Ohshiro, Zhiheng He, Yasuhiro Maeno, Junko Yamamoto-Hiraoka, Christian Rask-Madsen, Su Wol Chung, Mark A. Perrella, George L. King> ;The Journal of Biological Chemistry. 2008 Dec 5
• 18 citations
  Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells
  Keiji Isshiki, Zhiheng He, Yasuhiro Maeno, Ronald C.W. Ma, Yutaka Yasuda, Tatsuya Kuroki, Gregory S. White, Mary E. Patti, Gordon C. Weir, George L. King> ;Kidney International. 2008 Dec 1
• 44 citations
  Effects of Insulin Replacements, Inhibitors of Angiotensin, and PKCβ's Actions to Normalize Cardiac Gene Expression and Fuel Metabolism in Diabetic Rats
  Emi Arikawa, Ronald C.W. Ma, Keiji Isshiki, Ivan Luptak, Zhiheng He, Yutaka Yasuda, Yasuhiro Maeno, Mary-Elizabeth Patti, Gordon C. Weir, Robert A. Harris, Victor A. Z...> ;Diabetes. 2007 May 1
• 36 citations
  Regulation of progranulin expression in myeloid cells.
  Colin H. P. Ong, Zhiheng He, Leonid Kriazhev, Xiaochuan Shan, Roger G. E. Palfree, Andrew Bateman> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2006 Dec 1
• 76 citations
  Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and I...
  Zhiheng He, Darren M. Opland, Kerrie J. Way, Kohjiro Ueki, Natalya Bodyak, Peter M. Kang, Seigo Izumo, Rohit N. Kulkarni, Bo Wang, Ronglih Liao, C. Ronald Kahn, George...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 Apr 1
• 5 citations
  Differential expression of human telomerase catalytic subunit mRNA by in situ hybridization in pheochromocytomas.
  Zuojie Luo, Jianling Li, Yinfen Qin, Yan Ma, Xinghuan Liang, Jing Xian, Decheng Lu, Minyi Wei, Jack Y. Yang, Mary Qu Yang, Zhiheng He> ;Endocrine Pathology. 2006 Jan 1
• 8 citations
  Can Protein Kinase C β–Selective Inhibitor, Ruboxistaurin, Stop Vascular Complications in Diabetic Patients?
  Zhiheng He, George L. King> ;Diabetes Care. 2005 Nov 1
• 57 citations
  Molecular targets of diabetic cardiovascular complications.
  Fatima K. Ahmad, Zhiheng He, George L. King> ;Current Drug Targets. 2005 May 31
• 54 citations
  Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium
  Zhiheng He, Kerrie J. Way, Emi Arikawa, Eva Chou, Darren M. Opland, Allen C. Clermont, Keiji Isshiki, Ronald C.W. Ma, Joshua A. Scott, Frederick J. Schoen, Edward P. F...> ;The Journal of Biological Chemistry. 2005 Apr 22
• 23 citations
  Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.
  Yizhen Xu, Zhiheng He, George L. King> ;Current Diabetes Reports. 2005 Apr 1
• 284 citations
  Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
  P. Christian Schulze, Jun Yoshioka, Tomosaburo Takahashi, Zhiheng He, George L. King, Richard T. Lee> ;The Journal of Biological Chemistry. 2004 Jul 16
• 26 citations
  Protein Kinase Cβ Isoform Inhibitors A New Treatment for Diabetic Cardiovascular Diseases
  Zhiheng He, George L. King> ;Circulation. 2004 Jul 6
• 109 citations
  Microvascular complications of diabetes
  Zhiheng He, George L. King> ;Endocrinology and Metabolism Clinics of North America. 2004 Mar 1
• 85 citations
  Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
  Zhen Y. Jiang, Zhiheng He, Benjamin L. King, Tatsuya Kuroki, Darren M. Opland, Kiyoshi Suzuma, Izumi Suzuma, Kohjiro Ueki, Rohit N. Kulkarni, C. Ronald Kahn, George L....> ;The Journal of Biological Chemistry. 2003 Aug 22
• 398 citations
  Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
  Zhiheng He, Andrew Bateman> ;Journal of Molecular Medicine. 2003 Aug 19
• 162 citations
  Biological activities and signaling pathways of the granulin/epithelin precursor.
  Tommaso Zanocco-Marani, Andrew Bateman, Gaetano Romano, Barbara Valentinis, Zhiheng He, Renato Baserga> ;Cancer Research. 1999 Oct 15
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Journal Articles

• Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and i...  
  He, Zhiheng, ATVB
• Modulating Notch Signaling to Enhance Neovascularization and Reperfusion in Diabetic Mice  
  Cao L., Arany P., Kim J., Rivera-Feliciano J., Wang YS, He Z, Rask-Madsen C., King GL, Mooney DJ., Biomaterials, 1/1/2010
• Phosphinositide 3 Kinase Akt Signalling Pathway Interacts with Protein Kinase Cbeta2 in the Regulation of Physiologic Developmental Hypertrophy and Heart Function  
  Rigor DL, Bodyak N, Bae S, Choi JH, Zhang L, Ter-Ovanesyan D, He Z, McMullen JR, Shioi T, Izumo S, King GL, Kang PM, American Journal of Physiology, Heart and Circulatory Physiology, 1/1/2009
• Regulation of Suppressor of Cytokine Signalling 2 Expression by Insulin and Its Inhibitory Actions on IGF-1's Mitogenic Effect in Renal Mesangial Cells  
  Isshiki K*, He Z*, Maeno Y, Yasuda Y, Kuroki T, Ma RC, White GS, Patti ME. Weir GC, and King GL, Kidney International, 1/1/2008
• Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin through IRS1/PI3-kinase/AKT-2 Pathway  
  Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL, Journal of Biological Chemistry, 1/1/2008
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  Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, and King GL, Diabetes, 1/1/2007
• Regulation of VEGF Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia  
  He Z., Opland DM., Way KJ., Ueki K., Bodyak N., Kang PM., Izumo S, Kulkarni RN., Wang B., Liao R., Kahn CR. and King GL., Arteriosclerosis, Thrombosis, and Vascular Biology, 1/1/2006
• Regulation of Progranulin Expression in Myeloid Cells  
  Ong CH., He Z., Kriazhev L., Shan X., Palfree RG. And Bateman A., American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, 1/1/2006
• Differential Expression of Human Telomerase Catalytic Subunit MRNA by in Situ Hybridization in Pheochromocytomas  
  Luo Z, Li J, Qin Y, Ma Y, Liang X, Xian J, Lu D, Wei M, Yang JY, Yang MQ, and He Z, Endocrine Pathology, 1/1/2006
• PKC-isoform-dependent Regulation of CTGF Expression by Angiotensin II, Potential Mechanism for Diabetic Cardiomyopathy and Fibrosis  
  He Z., Way KJ., Arikawa E., Opland DM., Clermont A, Scott J, Feener E and King GL., Journal of Biological Chemistry, 1/1/2005
• Introduction of Hyperglycemia and Dyslipidemia in the Pathogenesis of Diabetic Vascular Complications  
  Xu Y., He Z. and King GL., Current Diabetes Reports, 1/1/2005
• Molecular Targets of Diabetic Cardiovascular Complications  
  Ahmad FK., He Z. and King GL., Current Drug Targets, 1/1/2005
• Can Protein Kinase C Beta-selective Inhibitor, Ruboxistaurin, Stop Vascular Complications in Diabetic Patients?  
  He Z., King GL., Diabetes Care, 1/1/2005
• Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein  
  Schulze PC., Yoshioka J., Takahashi T., He Z., King GL., Lee RT., Journal of Biological Chemistry, 1/1/2004
• Microvascular Complications of Diabetes  
  He Z. and King GL., Endocrinology and Metabolism Clinic of North America, 1/1/2004
• PKCbeta Isoform Inhibitors, a New Treatment for Diabetic Cardiovascular Diseases  
  He Z. and King GL., Circulation, 1/1/2004
• Progranulin Is a Mediator of the Wound Response  
  He Z., Ong CHP., Halper J. and Bateman A., Nature Medicine, 1/1/2003
• Progranulin (Acrogranin//PC Cell-derived Growth Factor/epithelin Precursor) Is Expressed in the Placenta, Epidermis, Microvasculature and Brain during Murine Development  
  Daniel R., Daniels E., He Z. and Bateman A., Developmental Dynamics, 1/1/2003
• Characterization of Insulin's Multiple Signaling Pathways in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis  
  Jiang ZY., He Z., King BL., Kuroki T., Opland DM., Suzuma K., Suzuma I., Ueki K., Kulkarni RN., Kahn CR. and King GL., Journal of Biological Chemistry, 1/1/2003
• Mechanisms of Cardiovascular Complications in Diabetes and Potential New Pharmacological Therapies  
  He Z., Rask-Madsen C. and King GL., European Heart Journal, 1/1/2003
• Progranulin (Granulin-epithelin Precursor, PC-cell-derived Growth Factor, Acrogranin) Mediates Tissue Repair and Tumorigenesis  
  He Z. and Bateman A., Journal of Molecular Medicine, 1/1/2003
• Progranulin (PC-cell-derived Growth Factor/acrogranin) Regulates Invasion and Cell Survival  
  He Z., Ismail A., Kriazhev L., Sadvakassova G. & Bateman A., Cancer Research, 1/1/2002
• Cellular Localization of Gene Expression for Progranulin  
  Daniel R.*, He Z.*, Paige C., Halper J. and Bateman A., Journal of Histochemistry & Cytochemistry, 1/1/2000
• Progranulin Gene Expression Regulates Epithelial Cell Growth and Promotes Tumor Growth in Vivo  
  He Z. and Bateman A., Cancer Research, 1/1/1999
• Biological Activities and Signalling Pathways of the Granulin/Epithelin Precursor  
  Zanocco-Marani, T., Bateman, A., Valentinis, B., Romano, G., He, Z. and Baserga, R., Cancer Research, 1/1/1999
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Books/Book Chapters

• Clinical Decision Support: Endocrinology 
  He Z. & Hennessey JV.Editors: Rosen CJ, Adler RA, Braverman LE and Leung A, Clemmons DR, Klibanski A, Thomas A.Decision Support in Medicine, LLC, Wilmington, DE2013
• Contemporary Cardiology, Diabetes and Cardiovascular Disease 
  Chapter: Effects of Diabetes and Insulin Resistance on Endothelial Functions 
  Page 25 - 46He Z., Naruse K. and King GL.Editors: Michael T. Johnstone and Aristidis Veves.Humana PressEdition 2nd,2005
• Diabetes and Cardiovascular Disease: Integrating Science and Clinical Medicine 
  Chapter: PKC in Diabetic Vascular Complications 
  He Z., Ma RC. and King GL.Editors: Steven P. Marso and David M. Stern.Lippincott Williams & WilkinsEdition 1st,2004
• International Textbook of Diabetes Mellitus 
  Chapter: Pathogenesis of Diabetic Microvascular Complications 
  Page 1135 - 1159He Z., Rask-Madesen C. and King GL.Editors: R.A. De Fronzo, Ele Ferrannini, Harry Keen and Paul Zimmet.John Wiley & SonsEdition 3rd,2004
• Joslin's Diabetes Mellitus 
  Chapter: Hyperglycemia and Diabetic Microvascular Complications 
  Page 823 - 837Rask-Madsen C., He Z. and King GL.Editors: C. Ronald Kahn.Lippincott Williams & WilkinsEdition 14th,2004
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Abstracts/Posters

• Thyroid Uptake to Urinary Iodine/Creatinine Ratio May be a Predictor of Disease Outcomes for Differentiated Thyroid Cancer (DTC)
  He ZH, Bansal V, & Hennessey JV, ICE/ENDO Endocrine Society Annual Conference, Chicago, 6/22/2014
• Protective Effects of Gender and HDL on Cardiovascular Disease (CVD) In Patients with 50 or More Years of Type 1 Diabetes
  He Z., Keenan HA., Sun JK, Turek SJ., Hastings SM., & King GL., Diabetes, 1/1/2013
• Effect of Incidental Ingestion of Massive Dose of Liothyronine Sodium due to a Compounding Pharmacy Error
  He Z. & Hennessey JV., New England-AACE 4th Annual Meeting, Dedham, MA, 10/27/2012

Lectures

• Elimination of Disparity of Diabetes Care in an Asian American-Tailored Program in a Tertiary Care Diabetes Center 
  Boston, MA - 6/16/2014
• Physical Activity Raises HDLc and Protects from CVD in Male Medalists 
  Boston, MA - 6/15/2014
• Differential Factors for Diabetic Nephropathy and Retinopathy 
  Boston, MA - 6/16/2014