ZhiyongYangMD

PubMed

• A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins.
  Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang, Hanping Feng> ;Microbial Cell Factories. 2023 Sep 25
• 2 citations
  Aflibercept more effectively weans patients with neovascular age-related macular degeneration off therapy compared with bevacizumab.
  Xuan Cao, Jaron Castillo Sanchez, Tapan P Patel, Zhiyong Yang, Chuanyu Guo, Danyal Malik, Anuoluwapo Sopeyin, Silvia Montaner, Akrit Sodhi> ;The Journal of Clinical Investigation. 2023 Jan 17
• 4 citations
  Aqueous proteins help predict the response of patients with neovascular age-related macular degeneration to anti-VEGF therapy.
  Xuan Cao, Jaron Castillo Sanchez, Aumreetam Dinabandhu, Chuanyu Guo, Tapan P Patel, Zhiyong Yang, Ming-Wen Hu, Lijun Chen, Yuefan Wang, Danyal Malik, Kathleen Jee, Yas...> ;The Journal of Clinical Investigation. 2022 Jan 18
• 4 citations
  Nocturnal Variability of Intraocular Pressure Monitored with Contact Lens Sensor is associated with Visual Field Loss in Glaucoma.
  Zhiyong Yang, Kaweh Mansouri, Sasan Moghimi, Robert N. Weinreb> ;Journal of Glaucoma. 2021 Mar 1
• 47 citations
  A probiotic yeast-based immunotherapy against Clostridioides difficile infection.
  Kevin Chen, Yixuan Zhu, Yongrong Zhang, Therwa Hamza, Hua Yu, Ashley Saint Fleur, James E. Galen, Zhiyong Yang, Hanping Feng> ;Science Translational Medicine. 2020 Oct 28
• 8 citations
  Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity.
  Xuejiao Dong, Lisi Wei, Xueheng Guo, Zhiyong Yang, Chuan Wu, Peiyu Li, Lu Lu, Hai Qi, Yan Shi, Xiaoyu Hu, Li Wu, Liangyi Chen, Wanli Liu> ;Journal of Immunology. 2019 Jun 1
• 10 citations
  Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity
  Yongrong Zhang, Shan Li, Zhiyong Yang, Lianfa Shi, Hua Yu, Rosangela Salerno-Goncalves, Ashley Saint Fleur, Hanping Feng> ;Cellular and Molecular Gastroenterology and Hepatology. 2018 Jan 1
• 3 citations
  Expression of Exogenous Genes in Murine Primary B Cells and B Cell Lines Using Retroviral Vectors.
  Zhiyong Yang, Christopher D.C. Allen> ;Methods in Molecular Biology. 2018 Jan 1
• 8 citations
  The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model
  Yongrong Zhang, Zhiyong Yang, Si Gao, Therwa Hamza, Harris G. Yfantis, Michael M. Lipsky, Hanping Feng> ;Anaerobe. 2017 Dec 1
• 96 citations
  Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons
  Derek S. Welsbie, Katherine L. Mitchell, Vinod Jaskula-Ranga, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit K Patel, Scott E. Martin, Ping Wu Zhang...> ;Neuron. 2017 Jun 21
• Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells.
  Christophe J Langouet-Astrie, Zhiyong Yang, Sraavya M Polisetti, Derek S Welsbie, William W Hauswirth, Donald J Zack, Shannath L Merbs, Raymond A Enke> ;Experimental Eye Research. 2016 Oct 1
• 16 citations
  Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection.
  Zhiyong Yang, Lianfa Shi, Hua Yu, Yongrong Zhang, Kevin Chen, Ashley Saint Fleur, Guang Bai, Hanping Feng> ;Pathogens and Disease. 2016 Aug 7
• 21 citations
  Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile.
  Krunal K. Mehta, Elena E. Paskaleva, Xia Wu, Navdeep Grover, Ruchir V. Mundra, Kevin Chen, Yongrong Zhang, Zhiyong Yang, Hanping Feng, Jonathan S. Dordick, Ravi S. Kane> ;Biotechnology and Bioengineering. 2016 Jun 20
• 32 citations
  Does the Location of Bruch's Membrane Opening Change Over Time? Longitudinal Analysis Using San Diego Automated Layer Segmentation Algorithm (SALSA).
  Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Naama Hammel, Zhiyong Yang, Robert N. Weinreb, Linda M. Zangwill> ;Investigative Ophthalmology & Visual Science. 2016 Feb 1
• 15 citations
  Glucosyltransferase activity of Clostridium difficile Toxin B is essential for disease pathogenesis
  Zhiyong Yang, Yongrong Zhang, Tuxiong Huang, Hanping Feng> ;Gut Microbes. 2015 Jun 19
• 21 citations
  Evaluation of Postural Control in Patients with Glaucoma Using a Virtual Reality Environment
  Alberto Diniz-Filho, Erwin R. Boer, Carolina P. B. Gracitelli, Ricardo Y. Abe, Nienke van Driel, Zhiyong Yang, Felipe A. Medeiros> ;Ophthalmology. 2015 Jun 1
• 57 citations
  Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography
  Zhiyong Yang, Andrew J. Tatham, Robert N. Weinreb, Felipe A. Medeiros, Ting Liu, Linda M. Zangwill> ;Plos One. 2015 May 15
• 29 citations
  Identification of Toxemia in Patients with Clostridium difficile Infection
  Hua Yu, Kevin Chen, Jianguo Wu, Zhiyong Yang, Lianfa Shi, Lydia L. Barlow, David M. Aronoff, Kevin W. Garey, Tor C. Savidge, Erik C. von Rosenvinge, Ciaran P. Kelly, H...> ;Plos One. 2015 Apr 17
• 74 citations
  Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab
  Zhiyong Yang, Jeremy Ramsey, Therwa Hamza, Yongrong Zhang, Shan Li, Harris G. Yfantis, Dong Lee, Lorraine D. Hernandez, Wolfgang Seghezzi, Jamie M. Furneisen, Nicole D...> ;Infection and Immunity. 2015 Feb 1
• 28 citations
  Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis
  Shan Li, Lianfa Shi, Zhiyong Yang, Yongrong Zhang, Gregorio Pérez-Cordón, Tuxiong Huang, Jeremy Ramsey, Numan Oezguen, Tor C. Savidge, Hanping Feng> ;Infection and Immunity. 2015 Feb 1
• 49 citations
  Diagnostic ability of retinal nerve fiber layer imaging by swept-source optical coherence tomography in glaucoma.
  Zhiyong Yang, Andrew J. Tatham, Linda M. Zangwill, Robert N. Weinreb, Chunwei Zhang, Felipe A. Medeiros> ;American Journal of Ophthalmology. 2015 Jan 1
• 57 citations
  Relationship between Ganglion Cell Layer Thickness and Estimated Retinal Ganglion Cell Counts in the Glaucomatous Macula
  Chunwei Zhang, Andrew J. Tatham, Robert N. Weinreb, Linda M. Zangwill, Zhiyong Yang, James Zexi Zhang, Felipe A. Medeiros> ;Ophthalmology. 2014 Dec 1
• 52 citations
  Assessment of Choroidal Thickness in Healthy and Glaucomatous Eyes Using Swept Source Optical Coherence Tomography
  Chunwei Zhang, Andrew J. Tatham, Felipe A. Medeiros, Linda M. Zangwill, Zhiyong Yang, Robert N. Weinreb> ;Plos One. 2014 Oct 8
• 23 citations
  Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions
  Dana Ferraris, Zhiyong Yang, Derek S. Welsbie> ;Future Medicinal Chemistry. 2013 Oct 31
• 16 citations
  RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors
  Ling Zhang, Karl J. Wahlin, Yuanyuan Li, Tomohiro Masuda, Zhiyong Yang, Donald J. Zack, Noriko Esumi> ;Molecular Vision. 2013 Jun 17
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Journal Articles

• An Autoimmune Disease Variant of IgG1 Modulates B Cell Activation and Differentiation  
  Zhiyong Yang, MD, Science Magazine