ZoranBrkanacMD

Psychiatry • Seattle, WA

Child & Adolescent Psychiatry

Associate Professor, Psychiatry & Behavioral Sciences, University of Washington School of Medicine

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Office
4800 Sand Point Way Ne
Seattle, WA 98105
Phone+1 206-987-2000
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Education & Training

University of WashingtonFellowship, Child and Adolescent Psychiatry, 2001 - 2003
University of Zagreb Faculty of MedicineClass of 1993
University of WashingtonResidency, Psychiatry

Certifications & Licensure

WA State Medical License 1999 - 2025
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Child & Adolescent Psychiatry

Publications & Presentations

PubMed

Human whole-exome genotype data for Alzheimer's disease.
Yuk Yee Leung, Adam C Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Ka...> ;Nature Communications. 2024 Jan 23
14 citations
Family-based exome sequencing and case-control analysis implicate CEP41 as an ASD gene.
Ashok Patowary, So Yeon Won, Shin Ji Oh, Ryan R. Nesbitt, Marilyn Archer, Deborah A. Nickerson, Wendy H. Raskind, Raphael Bernier, Ji Eun Lee, Zoran Brkanac> ;Translational Psychiatry. 2019 Jan 15
26 citations
Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism.
Moran Rubinstein, Ashok Patowary, Ian B. Stanaway, E McCord, Ryan R. Nesbitt, Marilyn Archer, Todd Scheuer, Deborah A. Nickerson, Wendy H. Raskind, Ellen M. Wijsman, R...> ;Molecular Psychiatry. 2018 Feb 1
34 citations
Suppression and facilitation of human neural responses
Michael-Paul Schallmo, Alex Kale, Rachel Millin, Anastasia V. Flevaris, Zoran Brkanac, Richard A.E. Edden, Raphael Bernier, Scott O. Murray> ;Elife. 2018 Jan 29
28 citations
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants
Jan Rehker, Johanna Rodhe, Ryan R. Nesbitt, Evan A. Boyle, Beth Martin, Jenny Lord, Ilker Karaca, Adam C. Naj, Frank Jessen, Seppo Helisalmi, Hilkka Soininen, Mikko Hi...> ;Plos One. 2017 Oct 6
26 citations
Next Generation Sequencing Mitochondrial DNA Analysis in Autism Spectrum Disorder.
Ashok Patowary, Ryan R. Nesbitt, Marilyn Archer, Raphael Bernier, Zoran Brkanac> ;Autism Research. 2017 Apr 17
5 citations
PBAP: a pipeline for file processing and quality control of pedigree data with dense genetic markers.
Alejandro Q. Nato, Nicola H. Chapman, Harkirat Sohi, Hiep D. Nguyen, Zoran Brkanac, Ellen M. Wijsman> ;Bioinformatics. 2015 Dec 1
10 citations
Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.
Mohamad Saad, Zoran Brkanac, Ellen M. Wijsman> ;Genes, Brain, and Behavior. 2015 Nov 1
102 citations
R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family clinical, genetic, and neuropathological study
Olena Korvatska, James B. Leverenz, Suman Jayadev, Pamela J. McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O. Dorschne...> ;JAMA Neurology. 2015 Aug 1
38 citations
Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes
Nicola H. Chapman, Alejandro Q. Nato, Raphael Bernier, Katy Ankenman, Harkirat Sohi, Jeff Munson, Ashok Patowary, Marilyn Archer, Elizabeth Blue, Sara Jane Webb, Hilar...> ;Human Genetics. 2015 Jul 24
331 citations
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
Carlos Cruchaga, Celeste M. Karch, Sheng Chih Jin, Bruno A. Benitez, Y Cai, Rita Guerreiro, Oscar Harari, Joanne Norton, John P. Budde, Sarah Bertelsen, AT Jeng, B Coo...> ;Nature. 2014 Jan 23
9 citations
Identification of rare variants from exome sequence in a large pedigree with autism.
Elizabeth E. Marchani, Nicola H. Chapman, Charles Cheung, Katy Ankenman, Ian B. Stanaway, Hilary Coon, Deborah A. Nickerson, Raphael Bernier, Zoran Brkanac, Ellen M. W...> ;Human Heredity. 2012 Jan 1
19 citations
Evidence for involvement of GNB1L in autism.
Ying-Zhang Chen, Mark Matsushita, Santhosh Girirajan, Mark Lisowski, Elizabeth Sun, Youngmee Sul, Raphael Bernier, Annette Estes, Geraldine Dawson, Nancy J. Minshew, G...> ;American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2012 Jan 1
237 citations
Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes
Santhosh Girirajan, Zoran Brkanac, Bradley P. Coe, Carl Baker, Laura Vives, Tiffany H. Vu, Neil Shafer, Raphael Bernier, Giovanni Battista Ferrero, Margherita Silengo,...> ;Plos Genetics. 2011 Nov 10
88 citations
Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample
Beate Peter, Wendy H. Raskind, Mark Matsushita, Mark Lisowski, Tiffany H. Vu, Virginia W. Berninger, Ellen M. Wijsman, Zoran Brkanac> ;Journal of Neurodevelopmental Disorders. 2011 Mar 1
28 citations
The Effect of Algorithms on Copy Number Variant Detection
Debby W. Tsuang, Steven P. Millard, Benjamin Ely, Peter B. Chi, Kenneth Wang, Wendy H. Raskind, Sulgi Kim, Zoran Brkanac, Chang En Yu> ;Plos One. 2010 Dec 30
33 citations
IFRD1 Is a Candidate Gene for SMNA on Chromosome 7q22-q23
Zoran Brkanac, David H. Spencer, Jay Shendure, Peggy D. Robertson, Mark Matsushita, Tiffany H. Vu, Thomas D. Bird, Maynard V. Olson, Wendy H. Raskind> ;American Journal of Human Genetics. 2009 May 15
6 citations
Pharmacology and genetics of autism: implications for diagnosis and treatment
Zoran Brkanac, Wendy H. Raskind, Bryan H. King> ;Personalized Medicine. 2008 Nov 10
21 citations
Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci.
Zoran Brkanac, Nicola H. Chapman, Robert P. Igo, Mark Matsushita, Kathleen Nielsen, Virginia W. Berninger, Ellen M. Wijsman, Wendy H. Raskind> ;Behavior Genetics. 2008 Jul 8
69 citations
Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia
Zoran Brkanac, Nicola H. Chapman, Mark Matsushita, Lani S. Chun, Kathleen Nielsen, Elizabeth Cochrane, Virginia W. Berninger, Ellen M. Wijsman, Wendy H. Raskind> ;American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2007 Jun 5
32 citations
Genomewide scan for real-word reading subphenotypes of dyslexia: Novel chromosome 13 locus and genetic complexity
Robert P. Igo, Nicola H. Chapman, Virginia W. Berninger, Mark Matsushita, Zoran Brkanac, Joseph H. Rothstein, Ted Holzman, Kathleen Nielsen, Wendy H. Raskind, Ellen M....> ;American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2006 Jan 5
36 citations
Genetic Determinants of Addiction to Opioids and Cocaine
Andrew J. Saxon, Michael R. Oreskovich, Zoran Brkanac> ;Harvard Review of Psychiatry. 2005 Jul 1
46 citations
A genome scan in multigenerational families with dyslexia : identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency
Wendy H. Raskind, Robert P. Igo, Nicola H. Chapman, Virginia W. Berninger, Jennifer B. Thomson, Mark Matsushita, Zoran Brkanac, Ted Holzman, M Brown, Ellen M. Wijsman> ;Molecular Psychiatry. 2005 Jul 1
58 citations
Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q.
Nicola H. Chapman, Robert P. Igo, Jennifer B. Thomson, Mark Matsushita, Zoran Brkanac, Ted Holzman, Virginia W. Berninger, Ellen M. Wijsman, Wendy H. Raskind> ;American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2004 Nov 15
184 citations
Missense Mutations in the Regulatory Domain of PKCγ: A New Mechanism for Dominant Nonepisodic Cerebellar Ataxia
Dong Hui Chen, Zoran Brkanac, Christophe L. M. J. Verlinde, Xiao Jian Tan, Laura Bylenok, David Nochlin, Mark Matsushita, Hillary Lipe, John Wolff, Magali Fernandez, P...> ;American Journal of Human Genetics. 2003 Apr 1
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Grant Support

Next Generation Mendelian Genetics In Familial Alzheimer DiseaseNational Institute On Aging2011–2012
Next Generation Gene Discovery In Familial AutismNational Institute Of Mental Health2011–2012
Molecular Genetics Of Executive Function In DyslexiaEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009

Hospital Affiliations

Seattle Children's HospitalSeattle, Washington