Brian Capell MD PhD, FAAD
Assistant Professor of Dermatology and Genetics
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3400 Civic Center BlvdPerelman Center for Advanced Medicine, Suite 1-330SPhiladelphia, PA 19104
Phone+1 215-662-2737
Fax+1 215-615-3424
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Summary
- Brian C. Capell, M.D., Ph.D. is a board-certified dermatologist and physician-scientist at the University of Pennsylvania whose research focuses on how epigenetic mechanisms encode cellular memory in the skin to regulate inflammation, aging, and cancer. Trained in the laboratories of Francis Collins and Shelley Berger, his work has defined key chromatin regulators as central controllers of epithelial differentiation and immune crosstalk. His laboratory integrates genomics, spatial profiling, and translational models to develop epigenetic and metabolic therapies for inflammatory skin disease and skin cancers.
Education & Training
University of Pennsylvania Health SystemResidency, Dermatology, 2010 - 2013
Pennsylvania Hospital of the University of Pennsylvania Health SystemInternship, Internal Medicine, 2009 - 2010
New York University School of MedicineClass of 2009
Certifications & Licensure
PA State Medical License 2009 - 2026
American Board of Dermatology Dermatology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017
Publications & Presentations
PubMed
- Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.Nina Kuprasertkul, Alyssa F Moore, Carina A D'souza, Julia Chini, Eun-Kyung Ko
The Journal of Clinical Investigation. 2026-04-15 - Stress vesicles link epidermal mechanotransduction to stem cell differentiation.Sixia Huang, Paola Kuri, Jonathan Zou, Adriana Blanco, Maxwell Marshall
Nature Communications. 2026-01-23 - 1 citationsUTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.Gina N Pacella, Nina Kuprasertkul, Lydia Bao, Sijia Huang, Carina D'souza
Proceedings of the National Academy of Sciences of the United States of America. 2025-05-20
Authored Content
- Histone Modifiers: Dynamic Regulators of the Cutaneous TranscriptomeSeptember 2015
Press Mentions
The Ironclad Promise of FerroptosisJanuary 25th, 2023- Study Reveals “Seeds of Skin Cancer” – Gene Mutations Associated with Early Stages of Skin CancerDecember 24th, 2020
Helping Skin Cells Differentiate May Help Treat Skin CancerAugust 21st, 2019
Grant Support
- Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermisUNIVERSITY OF PENNSYLVANIA2020–2025
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