CarlJDeSelmMDPhD

Radiation Oncology • Saint Louis, MO

Assistant Professor

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Office
Washington University in St. Louis
Center for Human Immunotherapy and Immunology
Saint Louis, MO 63108
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Summary

Carl DeSelm Lab

Developing cellular immunotherapies for difficult cancers.

Education & Training

Memorial Sloan Kettering Cancer CenterTranslational Research, 2017 - 2018
Memorial Sloan Kettering Cancer CenterResidency, Radiation Oncology, 2013 - 2017
Washington University/B-JH/SLCH ConsortiumInternship, Internal Medicine, 2012 - 2013
Washington University in St. Louis School of MedicineClass of 2012

Certifications & Licensure

IL State Medical License 2020 - 2026
MO State Medical License 2018 - 2025
NY State Medical License 2013 - 2019
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

Agilent 2020 Early Career Professor Award Agilent, 2020
Early Independence Award (DP5) NIH

Publications & Presentations

PubMed

Chimeric antigen receptor macrophages target and resorb amyloid plaques.
Alexander B Kim, Qingli Xiao, Ping Yan, Qiuyun Pan, Gaurav Pandey, Susie Grathwohl, Ernesto Gonzales, Isabella Xu, Yoonho Cho, Hans Haecker, Slava Epelman, Abhinav Diw...> ;JCI Insight. 2024 Feb 6
1 citations
Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer.
Jacobs, M., Wong, P., Zhou, A., Becker-Hapak, M., Marin, N., Marsala, L., Foster, M., Foltz, J., Cubitt, C., Tran, J., Russler-Germain, D., Neal, C., Kersting-Schadek,...> ;Clinical Cancer Research. 2023 Oct 13
1 citations
BAP1 promotes osteoclast function by metabolic reprogramming.
Nidhi Rohatgi, Wei Zou, Yongjia Li, Kevin Cho, Patrick L Collins, Eric Tycksen, Gaurav Pandey, Carl J DeSelm, Gary J Patti, Anwesha Dey, Steven L Teitelbaum> ;Nature Communications. 2023 Sep 22
1 citations
Prostate cancer immunotherapy: Improving clinical outcomes with a multi-pronged approach.
Dhivya Sridaran, Elliot Bradshaw, Carl DeSelm, Russell Pachynski, Kiran Mahajan, Nupam P Mahajan> ;Cell Reports. Medicine. 2023 Oct 17
2 citations
Initial clinical experience building a dual CT- and MR-guided adaptive radiotherapy program.
Alex T Price, Joshua P Schiff, Eric Laugeman, Borna Maraghechi, Matthew Schmidt, Tong Zhu, Francisco Reynoso, Yao Hao, Taeho Kim, Eric Morris, Xiaodong Zhao, Geoffrey ...> ;Clinical and Translational Radiation Oncology. 2023 Sep 1
1 citations
Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease.
Qiuyun Pan, Ping Yan, Alexander B Kim, Qingli Xiao, Gaurav Pandey, Hans Haecker, Slava Epelman, Abhinav Diwan, Jin-Moo Lee, Carl J DeSelm> ;Biorxiv. 2023 May 3
Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation.
Alexander B Kim, Ssu-Yu Chou, Solomon Kang, Eric Kwon, Matthew Inkman, Jeff Szymanski, Neal Andruska, Cian Colgan, Jin Zhang, Joanna C Yang, Nathan Singh, Carl J DeSelm> ;Blood Advances. 2023 Sep 26
3 citations
p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy.
Douglas V Faget, Xianmin Luo, Matthew J Inkman, Qihao Ren, Xinming Su, Kai Ding, Michael R Waters, Ganesh Kumar Raut, Gaurav Pandey, Paarth B Dodhiawala, Renata Ramalh...> ;Cancer Discovery. 2023 Jun 2
Oligometastatic Rectal Adenocarcinoma Treated With Short-Course Radiation Therapy and Chemotherapy With Nonoperative Intent of the Primary for Locoregional Complete Re...
Joshua P Schiff, Re-I Chin, Amit Roy, Lily Mahapatra, Hayley B Stowe, Neal Andruska, Yi Huang, Matthew Mutch, Ryan C Fields, William G Hawkins, Maria Doyle, Will Chapm...> ;Practical Radiation Oncology. 2022 May 5
9 citations
The Current and Future Role of Radiation Therapy in the Era of CAR T-cell Salvage.
Carl J. DeSelm> ;The British Journal of Radiology. 2021 Aug 10
63 citations
CARD8 is an inflammasome sensor for HIV-1 protease activity.
Qiankun Wang, Hongbo Gao, Kolin M. Clark, Christian Shema Mugisha, Keanu Davis, Jack P. Tang, Gray H. Harlan, Carl J. DeSelm, Rachel M. Presti, Sebla B. Kutluay, Liang...> ;Science. 2021 Feb 4
206 citations
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.
Samarth Hegde, Varintra E. Krisnawan, Brett H. Herzog, Chong Zuo, Marcus A. Breden, Brett L. Knolhoff, Graham D. Hogg, Jack P. Tang, John M. Baer, Cedric Mpoy, Kyung B...> ;Cancer Cell. 2020 Mar 16
44 citations
Early experience using salvage radiotherapy for relapsed/refractory non‐Hodgkin lymphomas after CD19 chimeric antigen receptor (CAR) T cell therapy
Brandon S. Imber, Michel Sadelain, Carl J. DeSelm, Connie Lee Batlevi, Renier J. Brentjens, Parastoo B. Dahi, Sergio Giralt, Jae H. Park, Craig S. Sauter, Michael Scor...> ;British Journal of Haematology. 2020 Mar 5
7 citations
Overall Survival of Breast Cancer Patients With Locoregional Failures Involving Internal Mammary Nodes.
A.J. Xu, Carl J. DeSelm, Alice Y. Ho, Erin F. Gillespie, Lior Z. Braunstein, Atif J. Khan, Beryl McCormick, Simon N. Powell, Oren Cahlon> ;Advances in Radiation Oncology. 2019 Mar 1
27 citations
A 3-Dimensional Mapping Analysis of Regional Nodal Recurrences in Breast Cancer.
Carl J. DeSelm, T. Jonathan Yang, Oren Cahlon, Jamie Tisnado, Atif J. Khan, Erin F. Gillespie, Simon N. Powell, Alice Y. Ho> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Mar 1
158 citations
Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape.
Carl J. DeSelm, M. Lia Palomba, Joachim Yahalom, Mohamad Hamieh, Justin Eyquem, Vinagolu K. Rajasekhar, Michel Sadelain> ;Molecular Therapy. 2018 Nov 7
13 citations
Potential abscopal response to dual checkpoint blockade in RCC after reirradiation using dose-painting SBRT.
Quincey LaPlant, Carl J. DeSelm, Natalie A. Lockney, James J. Hsieh, Yoshiya Yamada> ;Practical Radiation Oncology. 2017 Nov 1
57 citations
CAR T-cell therapy for pancreatic cancer.
Carl J. DeSelm, Zachary Tano, Anna M. Varghese, Prasad S. Adusumilli> ;Journal of Surgical Oncology. 2017 Jul 1
104 citations
Proton Beam Reirradiation for Recurrent Head and Neck Cancer: Multi-institutional Report on Feasibility and Early Outcomes
Paul B. Romesser, Oren Cahlon, Eli D. Scher, Eugen B. Hug, Kevin Sine, Carl J. DeSelm, J.L. Fox, Dennis Mah, Madhur Garg, John Han-Chih Chang, Nancy Y. Lee> ;International Journal of Radiation Oncology, Biology, Physics. 2016 May 1
3 citations
Correction: AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake (PLoS One.(2014)9:4 (e92948)Doi: 10.1371/journ...
Ramachandran Rashmi, Carl J. DeSelm, Cynthia Helms, Anne M. Bowcock, Buck E. Rogers, Janet S. Rader> ;Plos One. 2016 May 1
39 citations
Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma
Jeremy Setton, James Han, D. Kannarunimit, Yen-Ruh Wuu, Stephen A. Rosenberg, Carl J. DeSelm, Suzanne L. Wolden, C. Jillian Tsai, Sean McBride, Nadeem Riaz, Nancy Y. Lee> ;Oral Oncology. 2016 Feb 1
17 citations
Low incidence of radionecrosis in children treated with conventional radiation therapy and intrathecal radioimmunotherapy
Kim Kramer, Neeta Pandit-Taskar, Pat Zanzonico, Suzanne L. Wolden, John L. Humm, Carl J. DeSelm, Mark M. Souweidane, Jason S. Lewis, Nai-Kong V. Cheung> ;Journal of Neuro-Oncology. 2015 May 6
62 citations
AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.
Ramachandran Rashmi, Carl J. DeSelm, Cynthia Helms, Anne M. Bowcock, Buck E. Rogers, Janet L Rader, Perry W. Grigsby, Julie K. Schwarz> ;Plos One. 2014 Apr 4
14 citations
Paxillin contracts the osteoclast cytoskeleton
Wei Zou, Carl J. DeSelm, Thomas J. Broekelmann, Robert P. Mecham, Scott B. Vande Pol, Kyunghee Choi, Steven L. Teitelbaum> ;Journal of Bone and Mineral Research. 2012 Dec 1
9 citations
Halofuginone prevents estrogen-deficient osteoporosis in mice.
Carl J. DeSelm, Wei Zou, Steven L. Teitelbaum> ;Journal of Cellular Biochemistry. 2012 Oct 1
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Abstracts/Posters

Early Experience Using Radiotherapy As a Salvage Treatment for Relapsed or Refractory Non-Hodgkin Lymphomas Following CD19 Chimeric Antigen Receptor Modified T-Cell Th...
Carl DeSelm, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
MSKCC Early Experience Using Radiotherapy As a Bridging Strategy for Relapsed Diffuse Large B Cell Lymphoma before CD19 CAR T Therapy
Carl DeSelm, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019