DavidEvanLeafMDMMSc, FASN

Acute Renal Failure, Critical Care, Renal Metabolism

Associate Professor of Medicine, Harvard Medical School; Director of Clinical and Translational Research in Acute Kidney Injury, Division of Renal Medicine, Brigham and Women's Hospital; Associate Editor, Journal of the American Society of Nephrology

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Office
75 Francis St
Boston, MA 02115
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Summary

I am an academic physician-scientist, clinical nephrologist, full-time faculty member in the Division of Renal Medicine at Brigham and Women’s Hospital, Associate Professor of Medicine at Harvard Medical School, and an Associate Editor of Journal of the American Society of Nephrology. My lab (www.leaflab.org) conducts patient-oriented and translational research in acute kidney injury (AKI), investigating novel risk factors for its development and therapies for its prevention.

Clinical Expertise

Acute renal failure, Sepsis, Calcium, Dysregulated Mineral Metabolism, Phosphates, acute kidney injury

Education & Training

Brigham and Women's Hospital/Massachusetts General HospitalFellowship, Nephrology, 2011 - 2015
Harvard Medical SchoolMMSc, Clinical Research, 2012 - 2014
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 2008 - 2011
New York University School of MedicineClass of 2008
University of PennsylvaniaBA, Psychology, 2000 - 2004

Certifications & Licensure

MA State Medical License 2013 - 2025
NY State Medical License 2009 - 2012

Awards, Honors, & Recognition

Best Clinical/Translational Cancer Immunotherapy Paper Award Society for Immunotherapy of Cancer, 2022
Editors' Choice Article (one of the top five original publications in 2020) Journal of the American Society of Nephrology, 2021
Chair's Research Award Brigham and Women's Hospital, Department of Medicine, 2019
Outstanding Reviewer Award Clinical Journal of the American Society of Nephrology, 2018
Chair’s Research Award Brigham and Women's Hospital, Department of Medicine, 2015
Teaching Award for Excellence as a Tutorial Leader Harvard Medical School, 2013-2014
Excellence in Research New York Presbyterian Hospital, Columbia Campus, 2011
Andrew Alan Friedland Memorial Award for Excellence in Internal Medicine NYU School of Medicine, 2008
Honors in Physiology and Neuroscience Basic Science Research NYU School of Medicine, 2008
Phi Beta Kappa University of Pennsylvania, 2004
Summa Cum Laude University of Pennsylvania, 2004
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Clinical Trials

Vitamin D Repletion in Stone Formers With Hypercalciuria Start of enrollment: 2010 Sep 01
Completed
Phase 4
Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis Start of enrollment: 2013 Feb 01
Completed
Phase 2
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury Start of enrollment: 2017 Apr 03
Completed
Phase 2
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury Start of enrollment: 2021 Apr 13
Recruiting
Phase 2
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Publications & Presentations

PubMed

Platelet Factor 4 Antibodies and Severe AKI.
Charlotte Thomas, Rafia Ali, Isabel Park, Helena Kim, Samuel Short, Sarah Kaunfer, Lavanya Durai, Osman A Yilmam, Tushar Shenoy, Elisabeth M Battinelli, Hanny Al-Samka...> ;Kidney360. 2023 Dec 1
Author Correction: Therapeutic advances in COVID-19.
Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R Lawler, Meghan E Sise, David E Leaf> ;Nature Reviews. Nephrology. 2023 Apr 1
Reply to 'Use of convalescent plasma in the treatment of COVID-19'.
Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R Lawler, Meghan Sise, David E Leaf> ;Nature Reviews. Nephrology. 2023 Apr 1
10 citations
Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI.
Shruti Gupta, Clara Garcia-Carro, Jason M Prosek, Ilya Glezerman, Sandra M Herrmann, Pablo Garcia, Ala Abudayyeh, Nuttha Lumlertgul, A Bilal Malik, Sebastian Loew, Paz...> ;Journal for Immunotherapy of Cancer. 2022 Sep 1
5 citations
Sex-related differences in mortality, acute kidney injury, and respiratory failure among critically ill patients with COVID-19.
Stephanie M Toth-Manikowski, Jillian Caldwell, Min Joo, Jinsong Chen, Natalie Meza, Jacob Bruinius, Shruti Gupta, Mary Hannan, Mustafa Kagalwalla, Samantha Madrid, Mic...> ;Medicine. 2021 Dec 17
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan K...> ;JAMA.
Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators, Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Bégin P, van ...> ;JAMA.
49 citations
Therapeutic advances in COVID-19.
Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R Lawler, Meghan E Sise, David E Leaf> ;Nature Reviews. Nephrology. 2023 Jan 1
10 citations
Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.
Alexi Vasbinder, Chelsea Meloche, Tariq U Azam, Elizabeth Anderson, Tonimarie Catalan, Husam Shadid, Hanna Berlin, Michael Pan, Patrick O'Hayer, Kishan Padalia, Pennel...> ;Circulation. Cardiovascular Quality and Outcomes. 2022 Oct 1
15 citations
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury.
Ben Sprangers, David E Leaf, Camillo Porta, Maria José Soler, Mark A Perazella> ;Nature Reviews. Nephrology. 2022 Dec 1
1 citations
Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.
Ashwin Sunderraj, Chloe Cho, Xuan Cai, Shruti Gupta, Rupal Mehta, Tamara Isakova, David E Leaf, Anand Srivastava> ;Critical Care Explorations. 2022 Sep 1
7 citations
Acute kidney injury in patients receiving pembrolizumab combination therapy versus pembrolizumab monotherapy for advanced lung cancer.
Shruti Gupta, Ian A Strohbehn, Qiyu Wang, Paul E Hanna, Rituvanthikaa Seethapathy, Jason M Prosek, Sandra M Herrmann, Ala Abudayyeh, A Bilal Malik, Sebastian Loew, Chr...> ;Kidney International. 2022 Oct 1
9 citations
Hispanic ethnicity and mortality among critically ill patients with COVID-19.
Ana C Ricardo, Jinsong Chen, Stephanie M Toth-Manikowski, Natalie Meza, Min Joo, Shruti Gupta, Deepa G Lazarous, David E Leaf, James P Lash> ;Plos One. 2022 Jan 1
2 citations
Controlled Study of Decision-Making Algorithms for Kidney Replacement Therapy Initiation in Acute Kidney Injury.
Yvelynne P Kelly, Kavita Mistry, Salman Ahmed, Shimon Shaykevich, Sonali Desai, Stuart R Lipsitz, David E Leaf, Ernest I Mandel, Emily Robinson, Gearoid McMahon, Peter...> ;Clinical Journal of the American Society of Nephrology. 2022 Feb 1
7 citations
Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19.
Adam B Keene, Andrew J Admon, Samantha K Brenner, Shruti Gupta, Deepa Lazarous, David E Leaf, Hayley B Gershengorn, , Hayek, S., Tehranian, S.> ;Journal of Intensive Care Medicine. 2022 Apr 1
1 citations
Protocol to assess performance of crisis standards of care guidelines for clinical triage.
Louis T. Merriam, Maheetha Bharadwaj, Julia L. Jezmir, David E. Leaf, Edy Y. Kim> ;STAR Protocols. 2021 Dec 17
9 citations
Immune-related adverse events and kidney function decline in patients with genitourinary cancers treated with immune checkpoint inhibitors
Harish Seethapathy, Sarah Street, Ian A. Strohbehn, Meghan Lee, Sophia H. Zhao, Nifasha Rusibamayila, Donald F. Chute, Xin Gao, M.D. Michaelson, Osama E. Rahma, Toni K...> ;European Journal of Cancer. 2021 Nov 1
25 citations
Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine.
Sanjay R V Gadi, Patricia A. R. Brunker, Hanny Al-Samkari, David B. Sykes, Rebecca R. Saff, Janet Lo, Pavan K. Bendapudi, David E. Leaf, Rebecca Karp Leaf> ;Transfusion. 2021 Nov 1
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kum...> ;The New England journal of medicine. 2021-08-04
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson...> ;The New England journal of medicine. 2021-08-04
10 citations
Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019.
Matthew M. Churpek, Shruti Gupta, Alexandra B. Spicer, Salim S. Hayek, Anand Srivastava, Lili Chan, Michal L. Melamed, Samantha K. Brenner, Jared Radbel, Farah Madhani...> ;Critical Care Explorations. 2021 Aug 1
9 citations
Performance of Crisis Standards of Care Guidelines in a Cohort of Critically Ill COVID-19 Patients in the United States.
Hayek, S., Kim, E. Y., Julia L. Jezmir, Maheetha Bharadwaj, Alexander Chaitoff, Bradford Diephuis, Conor P. Crowley, Sandeep P. Kishore, Eric Goralnick, Louis T. Merri...> ;Cell Reports. Medicine. 2021 Jul 28
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
Arabi YM, Gordon AC, Derde LPG, Nichol AD, Murthy S, Beidh FA, Annane D, Swaidan LA, Beane A, Beasley R, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, B...> ;Intensive care medicine. 2021-07-12
16 citations
Incidence and Predictors of CKD and Estimated GFR Decline in Patients Receiving Immune Checkpoint Inhibitors.
Donald F. Chute, Sophia Zhao, Ian A. Strohbehn, Nifasha Rusibamayila, Harish Seethapathy, Meghan Lee, Shruti Gupta, David E. Leaf, Osama E. Rahma, Zsofia D. Drobni, To...> ;American Journal of Kidney Diseases. 2021 Jun 23
10 citations
Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.
Allon N. Friedman, John Guirguis, Rajat Kapoor, Shruti Gupta, David E. Leaf, Lava Timsina> ;Obesity. 2021 Jun 9
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Lectures

To Treat or Not to Treat: Medication Toxicity and Clinical Conundrums
American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/7/2019
Intradialytic Hypertension
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Left ventricular assist devices and renal function
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Rhabdomyolysis-induced acute kidney injury
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Mechanisms of hypokalemia induced by therapeutic hypothermia
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Relationship between ICU design and mortality
Grand Rounds, Department of Medicine, New York Presbyterian Hospital, Columbia Campus
Mechanisms of action of acetazolamide in the treatment and prophylaxis of acute mountain sickness
Grand Rounds, Division of Nephrology, NYU Medical Center
Chess, Education, and Intelligence
Grand Rounds, Department of Psychiatry, NYU Medical Center
Effect of Vitamin D Repletion on Urinary Calcium Excretion among Stone Formers
Selected Oral Presentation, American Society of Nephrology, Kidney Week, Philadelphia
Effect of Vitamin D Repletion on Urinary Calcium Excretion among Stone Formers
Invited oral presentation, Research of Calculus Kinetics (R.O.C.K.) Society, Boston
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Press Mentions

Smoking, Diabetes and Obesity – Not Preexisting Heart Disease – Bigger Risk of COVID-19 DeathOctober 12th, 2022
Analysis Questions Tocilizumab in Ventilated COVID PatientsMarch 3rd, 2022
Expert Discusses AKI Incidence, Now on a ‘Downward Trend,’ in COVID-19 HospitalizationsAugust 24th, 2021
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Grant Support

Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney InjuryNIH/NIDDK2022–2026
Deferoxamine for the Prevention of Acute Kidney InjuryNIH/NIDDK2020–2025
Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessNIH/NHLBI2019–2023
Dysregulated Mineral Metabolism and Acute Kidney InjuryNIH/NIDDK2015–2020
Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney InjuryASN Foundation for Kidney Research Carl W. Gottschalk Research Scholar Grant2018–2019
Dysregulated Mineral Metabolism in Critically Ill Patients with Severe AKINIH/NIDDK2015–2017
Dysregulated Mineral Metabolism in Acute Kidney InjuryNIH/NIDDK2013–2015