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Office
75 Francis St
Boston, MA 02115
Summary
- I am an academic physician-scientist, clinical nephrologist, full-time faculty member in the Division of Renal Medicine at Brigham and Women’s Hospital, Associate Professor of Medicine at Harvard Medical School, and an Associate Editor of Journal of the American Society of Nephrology. My lab (www.leaflab.org) conducts patient-oriented and translational research in acute kidney injury (AKI), investigating novel risk factors for its development and therapies for its prevention.
Clinical Expertise
- Acute renal failure, Sepsis, Calcium, Dysregulated Mineral Metabolism, Phosphates, acute kidney injury
Education & Training
- Brigham and Women's Hospital/Massachusetts General HospitalFellowship, Nephrology, 2011 - 2015
- Harvard Medical SchoolMMSc, Clinical Research, 2012 - 2014
- New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 2008 - 2011
- New York University School of MedicineClass of 2008
- University of PennsylvaniaBA, Psychology, 2000 - 2004
Certifications & Licensure
- MA State Medical License 2013 - 2025
- NY State Medical License 2009 - 2012
Awards, Honors, & Recognition
- Best Clinical/Translational Cancer Immunotherapy Paper Award Society for Immunotherapy of Cancer, 2022
- Editors' Choice Article (one of the top five original publications in 2020) Journal of the American Society of Nephrology, 2021
- Chair's Research Award Brigham and Women's Hospital, Department of Medicine, 2019
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Clinical Trials
- Vitamin D Repletion in Stone Formers With Hypercalciuria Start of enrollment: 2010 Sep 01
- Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis Start of enrollment: 2013 Feb 01
- Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury Start of enrollment: 2017 Apr 03
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Publications & Presentations
PubMed
- 4 citationsIntroduction: Cross-Talk Between the Kidneys and Remote Organ Systems in AKI.David E. Leaf
Seminars in Nephrology. 2019-01-01 - 26 citationsElevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injuryDavid E. Leaf, Myles Wolf, Leonard Stern
Nephrology, Dialysis, Transplantation. 2010-04-01 - 75 citationsTherapeutic advances in COVID-19.Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey
Nature Reviews. Nephrology. 2023-01-01
Lectures
- To Treat or Not to Treat: Medication Toxicity and Clinical ConundrumsAmerican Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/7/2019
- Intradialytic HypertensionGrand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
- Left ventricular assist devices and renal functionGrand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
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Press Mentions
- Research Spotlight: Radiology Test Can Be Used to Diagnose Immune Checkpoint Inhibitor-Associated Acute Kidney InjurySeptember 5th, 2024
- Smoking, Diabetes and Obesity – Not Preexisting Heart Disease – Bigger Risk of COVID-19 DeathOctober 12th, 2022
- Analysis Questions Tocilizumab in Ventilated COVID PatientsMarch 3rd, 2022
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Grant Support
- Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney InjuryNIH/NIDDK2022–2026
- Deferoxamine for the Prevention of Acute Kidney InjuryNIH/NIDDK2020–2025
- Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessNIH/NHLBI2019–2023
- Dysregulated Mineral Metabolism and Acute Kidney InjuryNIH/NIDDK2015–2020
- Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney InjuryASN Foundation for Kidney Research Carl W. Gottschalk Research Scholar Grant2018–2019
- Dysregulated Mineral Metabolism in Critically Ill Patients with Severe AKINIH/NIDDK2015–2017
- Dysregulated Mineral Metabolism in Acute Kidney InjuryNIH/NIDDK2013–2015
Committees
- Member, Mass General Brigham Institutional Review Board 2018 - 2022
Professional Memberships
- Fellow
- American Society of OnconephrologyFounding Member
External Links
- Leaf Labhttp://www.leaflab.org
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