David Leaf, MD, Nephrology, Boston, MA

DavidEvanLeafMDMMSc, FASN

NephrologyBoston, MA

Acute Renal Failure, Critical Care, Renal Metabolism

Assistant Professor of Medicine, Harvard Medical School; Director of Clinical and Translational Research in Acute Kidney Injury, Division of Renal Medicine, Brigham and Women's Hospital

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  • I am an academic physician-scientist, clinical nephrologist, and full-time faculty member in the Division of Nephrology at Brigham and Women’s Hospital. My research focuses on novel risk factors and interventions for acute kidney injury (AKI). In particular, I am interested in dysregulated mineral metabolism as a risk factor and potential contributor to AKI, and the role of vitamin D metabolites as novel therapeutic agents for AKI prevention.

    Lab website: www.leaflab.org

Skills & Expertise

  • Calcium, Phosphates, Dysregulated Mineral Metabolism, Sepsis, Acute renal failure

Education & Training

  • Brigham and Women's Hospital
    Brigham and Women's HospitalFellowship
  • Harvard Medical School
    Harvard Medical SchoolOtherTraining
  • New York Presbyterian Hospital -  Columbia Campus
    New York Presbyterian Hospital - Columbia CampusResidency
  • NYU School of Medicine
    NYU School of MedicineMedicalSchool
  • University of Pennsylvania
    University of PennsylvaniaOtherTraining

Certifications & Licensure

  • MA State Medical License
    MA State Medical License 2013 - 2021
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

  • Chair’s Research Award Brigham and Women's Hospital, Department of Medicine, 2015
  • Teaching Award for Excellence as a Tutorial Leader Harvard Medical School, 2013-2014
  • Excellence in Research New York Presbyterian Hospital, Columbia Campus, 2011
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Clinical Trials

Publications & Presentations



  • To Treat or Not to Treat: Medication Toxicity and Clinical Conundrums 
    American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/7/2019
  • Evidence for and against the use of renal replacement therapy for contrast-induced nephropathy prophylaxis among high-risk patients 
    Journal Club, Division of Nephrology, Brigham and Women's Hospital
  • Intradialytic Hypertension 
    Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
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Press Mentions

  • Genetic Variant May Help Predict Risk of Kidney Damage After Heart SurgeryJune 02, 2016
  • AKI Diagnostic Testing May Be ExcessiveJanuary 20, 2016

Grant Support

  • Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessNIH/NHLBI2019–2023
  • Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney InjuryASN Foundation for Kidney Research Carl W. Gottschalk Research Scholar Grant2018–2020
  • Dysregulated Mineral Metabolism and Acute Kidney InjuryNIH/NIDDK2015–2020
  • Dysregulated Mineral Metabolism in Critically Ill Patients with Severe AKINIH/NIDDK2015–2017
  • Dysregulated Mineral Metabolism in Acute Kidney InjuryNIH/NIDDK2013–2015

Professional Memberships