Gregory D Cascino MD FAAN, FANA, FACNS, FAES

Epilepsy, Neurophysiology

Whitney MacMillan, Jr. Professor of Neuroscience, Mayo Clinic Alix School of Medicine; Enterprise Director of Epilepsy; Mayo Clinic Rochester, MN

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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511

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Summary

I am a neurologist with an expertise in epilepsy and clinical neurophysiology. I have a special interest in drug-resistant epilepsy including the identification of surgically remediable epileptic syndromes.

Clinical Expertise

Magnetic resonance imaging, Epilepsy, Electroencephalography, Healthcare outcomes research, Temporal lobe epilepsy, Single photon emission computerized tomography, Status epilepticus

Education & Training

Mass General Brigham/Massachusetts General HospitalFellowship, Clinical Neurophysiology, 1985 - 1986
Mass General Brigham/Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1982 - 1985
Duke University HospitalResidency, Internal Medicine, 1979 - 1982
Rush Medical College of Rush University Medical CenterClass of 1979
Northwestern UniversityBachelors, 1972 - 1975

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Certifications & Licensure

FL State Medical License 2026 - Present
AZ State Medical License 2002 - 2027
WI State Medical License 1986 - 2027
MN State Medical License 1988 - 2026
ND State Medical License 2012 - 2017
American Board of Internal Medicine Internal Medicine
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Epilepsy

Awards, Honors, & Recognition

J. Kiffin Penry Excellence in Epilepsy Care Award 2013 American Epilepsy Society
President’s Award American Academy of Neurology, 2020
CMS Meaningful Use Stage 2 Certification Mayo Clinic Electronic Notes, Mayo Clinic, 2014-2017

Clinical Trials

Epilepsy Phenome/Genome Project
COMPLETED

Publications & Presentations

PubMed

3 citations
Focal to bilateral tonic-clonic seizures in newly diagnosed focal epilepsy.
Shruti Agashe, Gregory D Cascino, Orrin Devinsky, Sarah Barnard, Barry Gidal
Epilepsia. 2025-04-01
9 citations
Drug-resistant temporal lobe epilepsy with temporal encephaloceles: How far to resect.
Kelsey M Smith, Kiran M Kanth, Karl N Krecke, Eva C Alden, Jay S Patel
Epilepsy & Behavior. 2023-11-01
4 citations
Seizure control in women with epilepsy undergoing assisted reproductive technology.
Aisha A Abdulrazaq, Alessandra J Ainsworth, Jeffrey W Britton, Chandra C Shenoy, Samir N Babayev
Epilepsia. 2023-10-01

Journal Articles

De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies
EuroEPINOMICS-RES Consortium; Epilepsy Phenome/Genome Project; Epi4K Consortium, Am J Hum Genet., 9/24/2014
Teaching NeuroImages: EEG pattern associated with a skull osteolytic lesion in breast cancer
O'Gorman C, Cascino GD, Neurology, 9/1/2014
Prevalence and Spectrum of Electroencephalogram Identified Epileptiform Activity among Patients with Long QT Syndrome
Anderson JH, Bos JM, Cascino GD, Ackerman MJ, Heart Rhythm, 1/1/2014

Books/Book Chapters

Epilepsy Continuum Volume 19, Number 3
Editors: Cascino GD, St. Louis EK.Philadelphia, PA2013
Epilepsy Case Studies: Pearls for Patient Care
Editors: Tatum WO, Sirven JI, Cascino GD.Springer, New York, NY2013
Adult Epilepsy
Editors: Cascino GD, Sirven JI.Wiley-Blackwell, Oxford, UK2011

Abstracts/Posters

“Intractable focal epilepsy in women of child bearing age: reproduction and the effect of epilepsy surgery”.
Fabris R (fellow), Marsh WR, Meyer F, Cascino T, Cascino GD, Annual Meeting of the American Epilepsy Society, Washington, DC, 12/1/2013
“Automated voxel-based SPM-SPECT analysis in MRI-negative temporal lobe epilepsy”.
Sulc V, Brinkmann B, Hanson D, Jones D, Horinek D, Cascino G, Wong-Kisiel L, Britton J, So E, Worrell G, Annual Meeting of the American Epilepsy Society, Washington, DC, 12/1/2013
“Factors contributing to the yield of asymmetric bilateral implantations of intracranial electrodes”.
Lee R, Mandrekar J, Worrell G, Cascino G, Wetjen N, Meyer F, Wirrell E, Marsh R, So E, Annual Meeting of the American Epilepsy Society, Washington, DC, 12/1/2013

Lectures

“Update in Neuroimaging in Epilepsy” Essentials and Beyond.”
Cancun, QR, Mexico - 11/1/2014
“Diagnostic and Management Challenges in Epilepsy: Now and in the Future”
Cancun, QR, Mexico - 11/1/2014
“Diagnosis of Seizures: Video Demonstration.”
10/1/2014

Other

Surgical treatment of epilepsy in adults.
Cascino GD, UpToDate
6/30/2014
Epilepsy surgery and electronic devices.
Cascino GD, Theodore WH, Epilepsy Continuum
Philadelphia, PA - 6/1/2010
Epilepsy Quintessentials
Cascino GD. (chair), American Academy of Neurology
http://aan.com
1/1/2004

Press Mentions

HMP Global Announces Lineup of Expert Faculty for Neurology Week 2021June 10th, 2021
Mortality Risk Found to Be Reduced by Two-Thirds Following Epilepsy SurgeryMay 10th, 2016