LesleyADoughtyMD

Pediatrics • Cincinnati, OH

Pediatric Critical Care Medicine

Associate Professor, Pediatrics, University of Cincinnati College of Medicine

Join to view full profile

Dr. Doughty is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Doughty's full profile

Already have an account?

Office
3333 Burnet Ave
Ml 2005
Cincinnati, OH 45229
Phone+1 513-636-4259
Is this information wrong?

Education & Training

UPMC Medical EducationFellowship, Pediatric Critical Care Medicine, 1993 - 1996
Tripler Army Medical CenterResidency, Pediatrics, 1988 - 1991
Geisel School of Medicine at DartmouthClass of 1988

Certifications & Licensure

TX State Medical License 2023 - 2025
OH State Medical License 2005 - 2025
KS State Medical License 2023 - 2024
RI State Medical License 1998 - 2006
PA State Medical License 1993 - 1998
HI State Medical License 1991 - 1994
American Board of Pediatrics Pediatric Critical Care Medicine

Publications & Presentations

PubMed

12 citations
Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest.
Fink, E., Kochanek, P., Panigrahy, A., Beers, S., Berger, R., Bayir, H., Pineda, J., Newth, C., Topjian, A., Press, C., Maddux, A., Willyerd, F., Hunt, E., Siems, A., ...> ;JAMA Network Open. 2022 Sep 1
6 citations
Serum Biomarkers of Regeneration and Plasticity are Associated with Functional Outcome in Pediatric Neurocritical Illness: An Exploratory Study.
Catherine Madurski, Jessica M. Jarvis, Sue R. Beers, Amy J. Houtrow, Amy K. Wagner, Anthony Fabio, Chunyan Wang, Craig M. Smith, Lesley Doughty, Keri Janesko-Feldman, ...> ;Neurocritical Care. 2021 Mar 4
43 citations
Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States.
Gertz, S. J., Gertz, S. J., , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;Critical Care Medicine. 2020 May 1
25 citations
Early Protocolized Versus Usual Care Rehabilitation for Pediatric Neurocritical Care Patients: A Randomized Controlled Trial.
Ericka L. Fink, Sue R. Beers, Amy J. Houtrow, Rudolph Richichi, Cheryl Burns, Lesley Doughty, Roberto Ortiz-Aguayo, Catherine Madurski, Cynthia Valenta, Maddie Chrisma...> ;Pediatric Critical Care Medicine. 2019 Jun 1
1 citations
Cytokine Help for Diagnosing Community-Acquired Pneumonia.
Susan R. Conway, Lesley Doughty> ;Pediatric Critical Care Medicine. 2017 Apr 1
49 citations
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.
Joseph A. Carcillo, Bradley Podd, Rajesh K. Aneja, Scott L. Weiss, Mark W. Hall, Timothy T. Cornell, Thomas P. Shanley, Lesley Doughty, Trung C. Nguyen> ;Pediatric Critical Care Medicine. 2017 Mar 1
2 citations
Adaptive immune function in critical illness.
Lesley Doughty> ;Current Opinion in Pediatrics. 2016 Jun 1
24 citations
Acute renal replacement therapy in pediatrics.
Rajit K. Basu, Derek S. Wheeler, Stuart L. Goldstein, Lesley Doughty> ;International Journal of Nephrology. 2011 Jun 1
2 citations
The Accreditation Council for Graduate Medical Education proposed work hour regulations.
Denise M. Goodman, Margaret K. Winkler, Richard T. Fiser, Shamel Abd-Allah, Mudit Mathur, Niurka Rivero, Irwin K. Weiss, Bradley M. Peterson, David N. Cornfield, Richa...> ;Pediatric Critical Care Medicine. 2011 Jan 1
57 citations
Toward a clinically feasible gene expression-based subclassification strategy for septic shock: Proof of concept
Hector R. Wong, Derek S. Wheeler, Ken Tegtmeyer, Sue E. Poynter, Jennifer M. Kaplan, Ranjit S. Chima, Erika Stalets, Rajit K. Basu, Lesley Doughty> ;Critical Care Medicine. 2010 Oct 1
111 citations
Admission angiopoietin levels in children with septic shock.
John S. Giuliano, Patrick Lahni, Kelli Harmon, Hector R. Wong, Lesley Doughty, Joseph A. Carcillo, Basilia Zingarelli, Vikas P. Sukhatme, Samir M. Parikh, Derek S. Whe...> ;Shock. 2007 Dec 1
22 citations
Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
Derek S. Wheeler, Patrick Lahni, Kelli Odoms, Brian R. Jacobs, Joseph A. Carcillo, Lesley Doughty, Hector R. Wong> ;Inflammation Research. 2007 May 1
21 citations
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.
Chun-Shiang Chung, Yaping Chen, Patricia S. Grutkoski, Lesley Doughty, Alfred Ayala> ;Apoptosis. 2007 Mar 16
19 citations
Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.
Lesley Doughty, S Carlton, Benjamin T. Galen, Indranie Cooma-Ramberan, C. S. Chung, Alfred Ayala> ;Shock. 2006 Aug 1
152 citations
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
Doreen E. Wesche-Soldato, Chun-Shiang Chung, Joanne Lomas-Neira, Lesley Doughty, Stephen H. Gregory, Alfred Ayala> ;Blood. 2005 Oct 1
105 citations
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
Joseph A. Carcillo, Lesley Doughty, Danny Kofos, Reginald F. Frye, Sandra S. Kaplan, Howell Sasser, Gilbert J. Burckart> ;Intensive Care Medicine. 2003 Apr 16
63 citations
Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessme...
Joanne L. Lomas, Chun-Shiang Chung, Patricia S. Grutkoski, Brian W. LeBlanc, Liz M. Lavigne, Jonathan S. Reichner, Stephen H. Gregory, Lesley Doughty, William G. Cioff...> ;Shock. 2003 Apr 1
PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK
Alfred Ayala, Yanli Ding, Rebecca J. Rhee, Lesley Doughty, Patrician S. Grutkoski, Chun-Shiang Chung> ;Recent Research Developments in Immunology. 2003 Jan 12
57 citations
Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis.
Yong Y. Han, Lesley Doughty, Danny Kofos, Howell Sasser, Joseph A. Carcillo> ;Pediatric Critical Care Medicine. 2003 Jan 1
127 citations
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
Alfred Ayala, Chun-Shiang Chung, Joanne L. Lomas, Grace Y. Song, Lesley Doughty, Stephen H. Gregory, William G. Cioffi, Brian W. LeBlanc, Jonathan S. Reichner, H. Hank...> ;The American Journal of Pathology. 2002 Dec 1
43 citations
sFas and sFas Ligand and Pediatric Sepsis-Induced Multiple Organ Failure Syndrome
Lesley Doughty, Robert S. B. Clark, Sandra S. Kaplan, Howell Sasser, Joseph A. Carcillo> ;Pediatric Research. 2002 Dec 1
38 citations
The Tissue Factor and Plasminogen Activator Inhibitor Type-1 Response in Pediatric Sepsis-induced Multiple Organ Failure*
Jerril Green, Lesley Doughty, Sandra S. Kaplan, Howell Sasser, Joseph A. Carcillo> ;Thrombosis and Haemostasis. 2002 Feb 1
26 citations
Plasma concentrations of defensins and lactoferrin in children with severe sepsis.
Neal J. Thomas, Joseph A. Carcillo, Lesley Doughty, Howell Sasser, R. Phillip Heine> ;The Pediatric Infectious Disease Journal. 2002 Jan 1
57 citations
A Role for IFN-αβ in Virus Infection-Induced Sensitization to Endotoxin
Lesley Doughty, Khuong B. Nguyen, Joan E. Durbin, Christine A. Biron> ;Journal of Immunology. 2001 Feb 15
216 citations
Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox.
Khuong B. Nguyen, Leslie P. Cousens, Lesley Doughty, Gary C. Pien, Joan E. Durbin, Christine A. Biron> ;Nature Immunology. 2000 Jul 1
Join now to see all

Grant Support

Interferon-Mediated Reprogramming Of Toll-Like Receptor SignalingNational Institute Of General Medical Sciences2010–2011
Interferon-Mediated Reprogramming Of Toll-Like Receptor SignalingNational Institute Of General Medical Sciences2008–2009
Viral Modulation Of The Inflammatory ResponseNational Institute Of General Medical Sciences2004–2008
Viral Modulation Of The Inflammatory ResponseNational Institute Of General Medical Sciences2004

Hospital Affiliations

Cincinnati Children's Hospital Medical CenterCincinnati, Ohio