JonathanDanielMorenoMDPhD, FACC(He/Him)
Cardiology • Saint Louis, MOHeart Failure & Transplantation
Division of Cardiology | Department of Medicine; Washington University in St. Louis; E: jmoreno@wustl.edu | W: jonathanmoreno.com
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Office
Campus Box 8086
660 South Euclid Ave
Saint Louis, MO 63110Phone+1 314-652-4100- Is this information wrong?
Summary
- I am a phyisican scientist and heart failure specialist at Washington University in St. Louis.
My research interests include computational modeling of drug / ion channel interactions, inherited cardiomyopathies, and prediction of pharmacotherapy.
From a clinical standpoint, I am interested in advanced heart failure therapies, temporary MCS, cardiogenic shock and critical care cardiology.
Clinical Expertise
- Echocardiography, Cardiac critical care, Inherited cardiomyopathies, Cardiology, Cardiac arrhythmias, Mathematical modeling, Drug development, Computational biology, Internal medicine, Channelopathies
Education & Training
Washington University in St. Louis School of MedicinePost-Doctoral Fellowship, Biomedical Engineering, 2017 - 2020- Washington University/B-JH/SLCH ConsortiumFellowship, Advanced Heart Failure and Transplant Cardiology, 2018 - 2019
- Washington University/B-JH/SLCH ConsortiumFellowship, Cardiovascular Disease, 2015 - 2017
- Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 2013 - 2015
Weill Cornell MedicineClass of 2013
Weill Cornell Medical College of Cornell UniversityPh.D., Computational Biology, 2008 - 2011- University of Massachusetts AmherstB.S., Biochemistry and Molecular Biology, Summa Cum Laude, 2006
- University of Massachusetts AmherstB.S., Chemical Engineering, Summa Cum Laude, 2006
Certifications & Licensure
MO State Medical License 2014 - 2025- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
- American Board of Internal Medicine Cardiovascular Disease
- Diplomate of the National Board of EchocardiographyAdult Comprehensive Echocardiography
Awards, Honors, & Recognition
- Burton E. Sobel Award for Excellence in Cardiovascular Research Washington University in St. Louis, 2019
- Knowlton Incentive for Excellence Award Barnes Jewish Hospital Foundation, 2017
- Gregory J. Gurtner, MD Internal Medicine Residency Research Award Washington University, St. Louis, 2014
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Publications & Presentations
PubMed
- A Curious Case of Left Ventricular Outflow Tract Velocity Time Integral Alternans With an Intra-Aortic Balloon Pump: Physiology in Action.Vardhan, S., Moreno, J.> ;The American Journal of Cardiology. 2024 Mar 6
- A Reinterpretation of the Relationship Between Persistent and Resurgent Sodium Currents.Brown, S., Lawson, R., Ransdell, J., Moreno, J.> ;Biorxiv. 2023 Dec 22
- Bacterial sodium channels as gene therapy for cardiac arrhythmia: slow (activation and inactivation kinetics) and steady wins the race.Jonathan D Moreno, Seth H Weinberg> ;American Journal of Physiology. Heart and Circulatory Physiology. 2023 Dec 1
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Journal Articles
- Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardiaYang, PC; Moreno, JD; Jeng, MT, Noskov, S; and Clancy, CE. Response to Wiliams et al, J Physiol, 1/1/2016
- Ranolazine for congenital and acquired late INa linked arrhythmias: in silico pharmacologic screeningMoreno, JD; Yang, PC; Bankston, JR; Grandi, E; Bers, DM; Kass, RS; Clancy, CE, Circ Res, 1/1/2013
- Pathophysiology of the cardiac late Na current and its potential as a drug targetMoreno, JD; Clancy, CE, Journal of Molecular and Cellular Cardiology, 1/1/2012
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Books/Book Chapters
Abstracts/Posters
- A multiscale model to predict antiarrhythmic drug effects on cardiac rhythms.Moreno, JD; Zhu, ZI; Yang, PC; Bankston, JR; Jeng, MT; Kang, C; Wang, L; Christini, DJ; Ripplinger, CM; Kass, RS; Clancy, CE, Gordon Research Conference, “Cardiac Arrhythmia Mechanisms”, Galveston, TX, 1/1/2011
- Using a Human-Centered Design Approach to Develop and Implement User-Centric Performance Support Tools for Hypertension control in Sub-Saharan Africa.Vedanthan, R; Marwah, V; Moreno, JD; Sachs, S; Pronyk, P; Fuster, VF, 4th NIH Conference on Dissemination and Implementation Research, Washington, DC, 1/1/2011
- A multiscale model to predict antiarrhythmic drug effects on cardiac rhythms.Moreno, JD; Zhu, ZI; Yang, PC; Bankston, JR; Jeng, MT; Kang, C; Wang, L; Christini, DJ; Ripplinger, CM; Kass, RS; Clancy, CE, Medical Student Research Day, Weill Cornell Medical College, 1/1/2011
Lectures
- Pulmonary Artery Pulsatility Index predicts RV failure, duration of inotropes and death after LVAD implantation in a large, high acuity cohort.San Diego, CA - 1/1/2017
- Antiarrhythmic implications of ranolazine.Ventura, CA - 1/1/2013
- Prediction of the emergent effects of drugs on cardiac electrical activity: an in silico approach.Washington University, St. Louis, MO - 1/1/2013
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Other
- Insured Need Not Apply.Moreno, JD; Patel, SH, Cornell Daily Sun’s “What’s Up Doc?” opinion section
1/18/2010 - Volunteer Brigades in the Fight Against CVD.Moreno, JD; Patel, SH, Cornell Daily Sun’s “What’s Up Doc?” opinion section
1/10/2010 - Synergistic effects of combined elicitation on the accumulation of taxanes in Taxus cell suspension cultures. An Honors Research ThesisMoreno JD
Commonwealth College, University of Massachusetts, Amherst - 1/1/2006
Press Mentions
Past Pandemics Remind Us Covid Will Be an Era, Not a Crisis That FadesOctober 12th, 2021- What Happened to All of Those COVID Contract Tracers?August 26th, 2021
- Why Vermont Made All Minorities Eligible for the Vaccine Before White People Under 50April 13th, 2021
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Grant Support
- Effects of Mechanical Forces on Cardiac Excitability in Heart Disease2018 CIMED Pilot and Feasibility Award2018–Present
- Development of a cloud-based, in-silico drug testing system for the treatment of cardiac arrhythmiaAmazon Web Services (AWS): Cloud credits for research2018–2019
Research History
- Cardiovascular Disease Initiative, UN Millennium Villages ProjectCardiovascular disease (CVD) is the second leading cause of death in Africa, and the leading cause of death in those aged 45 or older. This initiative developed a framework for CVD prevention, which acts on a population level as well as an individual level, in a resource-poor setting.2008 - 2011
- PhD Research, Colleen Clancy, PhD (mentor)My thesis research focused on using experimental function and clinical data to build a theoretical framework to simulate measured properties of drug channel interactions to make predictions about emergent effects of antiarrhythmic drugs on cardiac cells and tissues.2008 - 2011
- Commonwealth Honors College Research Fellowship and Undergraduate Thesis WorkPaclitaxel is a novel anticancer agent used to treat breast, lung, ovarian, and Kaposi’s sarcoma. My senior thesis studied the effects of adding chemical elicitors to plant cell culture as a way of upregulating the accumulation of both paclitaxel and precursor taxanes in cell culture.2003 - 2006
Professional Memberships
- Member
- Member
- International Society for Heart and Lung TransplantationMember
- Heart Failure Society of AmericaMember
Hospital Affiliations
Barnes-Jewish HospitalSaint Louis, Missouri- Barnes-Jewish West County HospitalSaint Louis, Missouri
External Links
- Website:http://jonathanmoreno.com
- LinkedInhttps://www.linkedin.com/in/morenomdphd/
- Google Scholarhttps://scholar.google.com/citations?user=G5Zm8aAAAAAJ&hl=en&oi=ao
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