JonathanDanielMorenoMDPhD

Cardiology Saint Louis, MO

Heart Failure & Transplantation

Division of Cardiology | Department of Medicine; Washington University in St. Louis; E: jmoreno@wustl.edu | W: jonathanmoreno.com

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Office Address

Campus Box 8086
660 South Euclid Ave
Saint Louis, MO 63110
Phone
(314) 360-1578
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Summary

I am a phyisican scientist at Washington University in St. Louis. I have completed my clinical fellowship in cardiovascular disease, and will specialize in heart failure and cardiac transplant. I am currently pursuing my post-doctoral research in the laboratory of Jon Silva, PhD (Biomedical Engineering, Wash U.).

My research interests include computational modeling of drug / ion channel interactions, inherited cardiomyopathies, and prediction of pharmacotherapy.

Skills & Expertise

Echocardiography, Cardiac critical care, Inherited cardiomyopathies, Cardiology, Cardiac arrhythmias, Mathematical modeling, Drug development, Computational biology, Internal medicine, Channelopathies

Education & Training

Washington UniversityPostDoctoralFellowship
Washington University - Barnes-Jewish HospitalFellowship
Washington University - Barnes-Jewish HospitalFellowship
Washington University - Barnes-Jewish HospitalResidency
Weill Cornell Medical College of Cornell UniversityMedicalSchool
Weill Cornell Medical College of Cornell UniversityOtherTraining
University of Massachusetts, AmherstOtherTraining
University of Massachusetts, AmherstOtherTraining

Certifications & Licensure

MO State Medical License 2014 - 2021
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease
Diplomate of the National Board of EchocardiographyAdult Comprehensive Echocardiography

Awards, Honors, & Recognition

Burton E. Sobel Award for Excellence in Cardiovascular Research Washington University in St. Louis, 2019
Knowlton Incentive for Excellence Award Barnes Jewish Hospital Foundation, 2017
Gregory J. Gurtner, MD Internal Medicine Residency Research Award Washington University, St. Louis, 2014
Intern of the Month Washington University, 2013
Ida Sophia Scudder, M.D. Award for Excellence in Public Service, a Pioneer in Diversity Award Weill Cornell Medical College, 2011
Commonwealth Honors College Research Fellowship 2003-2004
21st Century Leadership Award University of Massachusetts, Amherst
William F. Field Class of 2006 Alumni Scholar University of Massachusetts, Amherst
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Publications & Presentations

PubMed
Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation. Zhu W, Mazzanti A, Voelker TL, Hou P, Moreno JD, Angsutararux P, Naegle KM, Priori SG, Silva JR> ;Circulation research.
The Combination of Tricuspid Annular Plane Systolic Excursion and HeartMate Risk Score Predicts Right Ventricular Failure After Left Ventricular Assist Device Implanta... Raymer DS, Moreno JD, Sintek MA, Nassif ME, Sparrow CT, Adamo L, Novak EL, LaRue SJ, Vader JM> ;ASAIO journal (American Society for Artificial Internal Organs : 1992). 2018-04-26
Mechanisms and models of cardiac sodium channel inactivation. Mangold KE, Brumback BD, Angsutararux P, Voelker TL, Zhu W, Kang PW, Moreno JD, Silva JR> ;Channels (Austin). 2017 Nov 2
{"__content__"=>"Regulation of Na channel inactivation by the DIII and DIV voltage-sensing domains.", "sup"=>{"__content__"=>"+"}} Hsu EJ, Zhu W, Schubert AR, Voelker T, Varga Z, Silva JR> ;The Journal of general physiology. 2017-02-23
Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE> ;J Physiol. 2016 Nov 01
Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. Moreno JD, Lewis TJ, Clancy CE> ;PLoS One. 2016
In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE> ;J Physiol. 2016 Feb 01
Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE> ;Circ Res. 2013 Sep 13
Computational approaches to understand cardiac electrophysiology and arrhythmias. Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE> ;Am J Physiol Heart Circ Physiol. 2012 Oct 01
Pathophysiology of the cardiac late Na current and its potential as a drug target. Moreno JD, Clancy CE> ;J Mol Cell Cardiol. 2012 Mar
A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE> ;Sci Transl Med. 2011 Aug 31
Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Moreno JD, Clancy CE> ;Drug Discov Today Dis Models. 2009 Fall
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Journal Articles
Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia Yang, PC; Moreno, JD; Jeng, MT, Noskov, S; and Clancy, CE. Response to Wiliams et al, J Physiol, 1/1/2016
Ranolazine for congenital and acquired late INa linked arrhythmias: in silico pharmacologic screening Moreno, JD; Yang, PC; Bankston, JR; Grandi, E; Bers, DM; Kass, RS; Clancy, CE, Circ Res, 1/1/2013
Pathophysiology of the cardiac late Na current and its potential as a drug target Moreno, JD; Clancy, CE, Journal of Molecular and Cellular Cardiology, 1/1/2012
A multiscale model to predict the effects of class I antiarrhythmic drugs on ventricular rhythms Moreno, JD; Zhu, ZI; Yang, PC; Bankston, JR; Jeng, MT; Kang, C; Wang, L; Ripplinger, CM; Christini, DC; Kass, RS; Clancy, CE, Science Translational Medicine, 1/1/2011
Cardiac Dynamics In-Silico: Pharmacological Targeting of Long QT3 Syndrome Moreno, JD; Bankston, JR; Kass, RS; Clancy, CE, Biophys J, 1/1/2010
Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy Moreno, JD; Clancy, CE, Drug Discovery Today: Disease Models, 1/1/2010
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Title
Cardiac Intensive Care Chapter: Right Ventricular Infarction
Moreno, JD, and Brown, DL
Editors: Brown, DL..Elsevier
Edition 3,
Encyclopedia of Computational Neuroscience. Chapter: Cardiac Excitable Tissue Pathology (Ion Channels).
Moreno, JD; Roberts BN; Clancy CE
Editors: SpringerReference.com.
2013

Abstracts/Posters
A multiscale model to predict antiarrhythmic drug effects on cardiac rhythms. Moreno, JD; Zhu, ZI; Yang, PC; Bankston, JR; Jeng, MT; Kang, C; Wang, L; Christini, DJ; Ripplinger, CM; Kass, RS; Clancy, CE, Gordon Research Conference, “Cardiac Arrhythmia Mechanisms”, Galveston, TX, 1/1/2011
Using a Human-Centered Design Approach to Develop and Implement User-Centric Performance Support Tools for Hypertension control in Sub-Saharan Africa. Vedanthan, R; Marwah, V; Moreno, JD; Sachs, S; Pronyk, P; Fuster, VF, 4th NIH Conference on Dissemination and Implementation Research, Washington, DC, 1/1/2011
A multiscale model to predict antiarrhythmic drug effects on cardiac rhythms. Moreno, JD; Zhu, ZI; Yang, PC; Bankston, JR; Jeng, MT; Kang, C; Wang, L; Christini, DJ; Ripplinger, CM; Kass, RS; Clancy, CE, Medical Student Research Day, Weill Cornell Medical College, 1/1/2011

Lectures
Pulmonary Artery Pulsatility Index predicts RV failure, duration of inotropes and death after LVAD implantation in a large, high acuity cohort. San Diego, CA - 1/1/2017
Antiarrhythmic implications of ranolazine. Ventura, CA - 1/1/2013
Prediction of the emergent effects of drugs on cardiac electrical activity: an in silico approach. Washington University, St. Louis, MO - 1/1/2013
The Heart-to-Heart Community Outreach Campaign: A community-based participatory research study to assess the prevalence of cardiovascular disease in underserved New Yo... Weill Cornell Medical College - 1/1/2012
Heart Disease: Knowing your risk and tips for prevention. 1/1/2012
Cardiac Dyanmics in silico: Pharmacology through High Performance Computing. Weill Cornell Medical College - 1/1/2011
Cardiac Dynamics in-silico: Pharmacological Targeting of Long QT3 Syndrome. San Francisco, CA - 1/1/2010
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Other
Insured Need Not Apply. Moreno, JD; Patel, SH, Cornell Daily Sun’s “What’s Up Doc?” opinion section
1/18/2010
Volunteer Brigades in the Fight Against CVD. Moreno, JD; Patel, SH, Cornell Daily Sun’s “What’s Up Doc?” opinion section
1/10/2010
Synergistic effects of combined elicitation on the accumulation of taxanes in Taxus cell suspension cultures. An Honors Research Thesis Moreno JD
Commonwealth College, University of Massachusetts, Amherst - 1/1/2006

Press Mentions

President Gutmann Kicks off 15th World Congress of BioethicsJune 21, 2020
Nuremberg Code Addresses Experimentation, Not VaccinesJune 08, 2020
Inside America’s Mask Crunch: A Slow Government Reaction and an Industry Wary of LiabilityApril 03, 2020
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Grant Support

Effects of Mechanical Forces on Cardiac Excitability in Heart Disease2018 CIMED Pilot and Feasibility Award2018–Present
Development of a cloud-based, in-silico drug testing system for the treatment of cardiac arrhythmiaAmazon Web Services (AWS): Cloud credits for research2018–2019

Research History

Cardiovascular Disease Initiative, UN Millennium Villages ProjectCardiovascular disease (CVD) is the second leading cause of death in Africa, and the leading cause of death in those aged 45 or older. This initiative developed a framework for CVD prevention, which acts on a population level as well as an individual level, in a resource-poor setting.2008 - 2011
PhD Research, Colleen Clancy, PhD (mentor)My thesis research focused on using experimental function and clinical data to build a theoretical framework to simulate measured properties of drug channel interactions to make predictions about emergent effects of antiarrhythmic drugs on cardiac cells and tissues.2008 - 2011
Commonwealth Honors College Research Fellowship and Undergraduate Thesis WorkPaclitaxel is a novel anticancer agent used to treat breast, lung, ovarian, and Kaposi’s sarcoma. My senior thesis studied the effects of adding chemical elicitors to plant cell culture as a way of upregulating the accumulation of both paclitaxel and precursor taxanes in cell culture.2003 - 2006

Professional Memberships

American College of Cardiology - ACCMember
Heart Rhythm Society - HRSMember
International Society for Heart and Lung TransplantationMember

Hospital Affiliations

Barnes-Jewish HospitalSaint Louis, Missouri

QuickSite

http://www.JonathanMorenoMD.com

External Links

Website:http://jonathanmoreno.com
LinkedInhttps://www.linkedin.com/in/morenomdphd/
Google Scholarhttps://scholar.google.com/citations?user=G5Zm8aAAAAAJ&hl=en&oi=ao