VarmanTSamuelMDPhD

PubMed

• Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and over...
  Sakuma, I., Gaspar, R., Luukkonen, P., Kahn, M., Zhang, D., Murray, S., Golla, J., Shulman, G., Zhang, X., Vatner, D., Samuel, V., Petersen, K.> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Dec 26
• Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
  Utpal B Pajvani, Carrie J Shawber, Varman T Samuel, Andreas L Birkenfeld, Gerald I Shulman, Jan Kitajewski, Domenico Accili> ;Nature Medicine. 2024 Feb 1
• 2 citations
  Deletion ofgene causes early growth retardation and insulin resistance in mice.
  Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T Samuel, Karrie D Dudek, Anna B Osipovich, Jeffrey Sklar, Gerald I Shulman, Magnuson, M. A., Mark A Magnuson> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Dec 6
• 21 citations
  Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation.
  Kun Lyu, Dongyan Zhang, Joongyu D. Song, Xiruo Li, Rachel J. Perry, Varman T. Samuel, Gerald I. Shulman> ;JCI Insight. 2021 Feb 22
• 5 citations
  Membrane-bound-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice.
  Abudukadier Abulizi, Daniel F Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Dongyan Zhang, Mario Kahn, Kun Lyu, Alaa Sirwi, Gary W Cline, M Mahmood Hussain, P...> ;Journal of Lipid Research. 2020 Dec 1
• 42 citations
  Metabolic control analysis of hepatic glycogen synthesis in vivo.
  Yuichi Nozaki, Max C. Petersen, Dongyan Zhang, Daniel F. Vatner, Rachel J. Perry, Abudukadier Abulizi, Sofie Haedersdal, Xian-Man Zhang, Gina M. Butrico, Varman T. Sam...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Apr 7
• 7 citations
  Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
  Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier ...> ;Cell Reports. 2019 Dec 10
• 55 citations
  Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides.
  Varman T. Samuel, Gerald I. Shulman> ;The New England Journal of Medicine. 2019 Nov 6
• 6 citations
  Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε
  Varman T. Samuel, Max C. Petersen, Brandon M. Gassaway, Daniel F. Vatner, Jesse Rinehart, Gerald I. Shulman> ;Hepatology. 2019 Dec 1
• 8 citations
  Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action
  Abudukadier Abulizi, Joao Paulo Camporez, Michael J. Jurczak, Kasper F. Høyer, Dongyan Zhang, Gary W. Cline, Varman T. Samuel, Gerald I. Shulman, Daniel F. Vatner> ;FASEB Journal. 2019 Apr 28
• 8 citations
  Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.
  Abudukadier Abulizi, Joao Paulo Camporez, Dongyan Zhang, Varman T. Samuel, Gerald I. Shulman, Daniel F. Vatner> ;Metabolism. 2019 Apr 1
• 5 citations
  PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
  Sara A. Beddow, Arijeet K. Gattu, Daniel F. Vatner, Lauren Paolella, Abdulelah Alqarzaee, Nedda Tashkandi, Violeta B. Popov, Christopher D. Church, Matthew S. Rodeheff...> ;Endocrinology. 2019 Jan 1
• 48 citations
  PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.
  Brandon M. Gassaway, Max C. Petersen, Yulia V. Surovtseva, Karl W. Barber, Joshua B. Sheetz, Hans R. Aerni, Jane S. Merkel, Varman T. Samuel, Gerald I. Shulman, Jesse ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Sep 18
• 46 citations
  Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents
  Daniel F. Vatner, Leigh Goedeke, Joao Paulo Camporez, Kun Lyu, Ali Nasiri, Dongyan Zhang, Sanjay Bhanot, Susan Murray, Glenn S. Gerhard, Gerald I. Shulman, Varman T. S...> ;Diabetologia. 2018 Mar 1
• 416 citations
  Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
  Varman T. Samuel, Gerald I. Shulman> ;Cell Metabolism. 2018 Jan 9
• 105 citations
  Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
  Kasper W. ter Horst, Pim W. Gilijamse, Ruth I. Versteeg, Mariëtte T. Ackermans, Aart J. Nederveen, Susanne E. la Fleur, Johannes A. Romijn, Max Nieuwdorp, Dongyan Zhan...> ;Cell Reports. 2017 Jun 6
• 38 citations
  Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.
  Hui-Young Lee, Jae Sung Lee, Tiago C. Alves, Warren Ladiges, Peter S. Rabinovitch, Michael J. Jurczak, Cheol Soo Choi, Gerald I. Shulman, Varman T. Samuel> ;Diabetes. 2017 Aug 1
• 146 citations
  Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
  Max C. Petersen, Anila K. Madiraju, Brandon M. Gassaway, Michael Marcel, Ali Nasiri, Gina M. Butrico, Melissa Marcucci, Dongyan Zhang, Abudukadier Abulizi, Xian-Man Zh...> ;The Journal of Clinical Investigation. 2016 Nov 1
• 135 citations
  The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
  Mark A. Herman, Varman T. Samuel> ;Trends in Endocrinology and Metabolism. 2016 Oct 1
• 37 citations
  Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.
  Anila K. Madiraju, Tiago C. Alves, Xiaojian Zhao, Gary W. Cline, Dongyan Zhang, Sanjay Bhanot, Varman T. Samuel, Richard G. Kibbey, Gerald I. Shulman> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Jun 14
• 14 citations
  Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.
  Violeta B. Popov, François R Jornayvaz, Emin O. Akgul, Shoichi Kanda, Michael J. Jurczak, Dongyan Zhang, Abulizi Abudukadier, Sachin Majumdar, Blas A. Guigni, Kitt Fal...> ;FASEB Journal. 2016 Mar 1
• 14 citations
  The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.
  Xuan Li, Jae-Joon Jung, Lei Nie, Mahmoud Razavian, Jiasheng Zhang, Varman T. Samuel, Mehran M. Sadeghi> ;American Journal of Physiology. Heart and Circulatory Physiology. 2016 Feb 26
• 727 citations
  The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.
  Varman T. Samuel, Gerald I. Shulman> ;The Journal of Clinical Investigation. 2016 Jan 4
• 32 citations
  Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)
  Dominik Pesta, Rachel J. Perry, Fitsum Guebre-Egziabher, Dongyan Zhang, Michael J. Jurczak, Antje Fischer-Rosinsky, Martin A. Daniels, Diana M. Willmes, Sanjay Bhanot,...> ;Aging. 2015 Dec 5
• 14 citations
  3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats.
  Daniel F. Vatner, Jaclyn Snikeris, Violeta B. Popov, Rachel J. Perry, Yasmeen Rahimi, Varman T. Samuel> ;Plos One. 2015 Oct 20
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Journal Articles

• PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats  
  Arijeet K Gattu, Varman T Samuel, Violeta Popov, Daniel F Vatner, Gary Cline, Endocrinology
• PKCε Contributes to Lipid-Induced Insulin Resistance Through Cross Talk with p70S6K and Through Previously Unknown Regulators of Insulin Signaling  
  Max C Petersen, Varman T Samuel, Proceedings of the National Academy of Sciences