ZhiqiangBradWangMD

Molecular Genetics, Anatomic Pathology, Clinical Pathology

Senior Staff, Department of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202

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Office
2799 W Grand Blvd
Henry Ford Hospital Pathology
Detroit, MI 48202
Phone+1 313-916-2738
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Education & Training

UPMC Medical EducationFellowship, Molecular Genetic Pathology, 2009 - 2010
Methodist Hospital (Houston)Residency, Pathology-Anatomic and Clinical, 2005 - 2009
Shandong Medical UniversityClass of 1986

Certifications & Licensure

MI State Medical License 2017 - 2027
FL State Medical License 2010 - 2018
American Board of Pathology Pathology - Anatomic/Pathology - Clinical
American Board of Pathology Pathology - Molecular Genetic

Publications & Presentations

PubMed

4 citations
B Cells Are Required to Generate Optimal Anti-Melanoma Immunity in Response to Checkpoint Blockade.
Shubhra Singh, Jason Roszik, Neeraj Saini, Vipul Kumar Singh, Karishma Bavisi, Zhiqiang Wang, Long T Vien, Zixi Yang, Suprateek Kundu, Richard E Davis, Laura Bover, Ad...> ;Frontiers in Immunology. 2022 Jan 1
6 citations
Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry
Jared Henderson, Ondrej Havranek, Man Chun John Ma, Vaclav Herman, Kristyna Kupcova, Tereza Chrbolkova, Mariana Pacheco-Blanco, Zhiqiang Wang, Justin M Comer, Tomasz Z...> ;Cytometry. Part A. 2021 Jun 24
11 citations
IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma
Shubhra Singh, Zhilan Xiao, Karishma Bavisi, Jason Roszik, Brenda Melendez, Zhiqiang Wang, Mark J. Cantwell, Richard E. Davis, Greg Lizee, Patrick Hwu, Sattva S. Neela...> ;Journal of Immunology. 2021 Apr 15
52 citations
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E. Davis, Pei Lin, P. Leif Bergsagel, Elisabet E. Manasanch, Stephen T. C. Wo...> ;Cell Metabolism. 2021 Jan 5
63 citations
Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
Huan Liu, Jin He, Su Pin Koh, Yuping Zhong, Zhiqiang Liu, Zhiqiang Wang, Yujin Zhang, Zongwei Li, Bjorn T. Tam, Pei Lin, Min Xiao, Ken H. Young, Behrang Amini, Michael...> ;Science Translational Medicine. 2019 May 29
43 citations
BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment
Sujan Piya, Hong Mu, Seemana Bhattacharya, Philip L. Lorenzi, R. Eric Davis, Teresa McQueen, Vivian Ruvolo, Natalia Baran, Zhiqiang Wang, Yimin Qian, Craig M. Crews, M...> ;The Journal of Clinical Investigation. 2019 May 1
37 citations
CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity.
Fuliang Chu, Haiyan S. Li, Xindong Liu, JingJing Cao, Wencai Ma, Ying Ma, Jinsheng Weng, Zheng Zhu, Xiaoyun Cheng, Zhiqiang Wang, Jingwei Liu, Zi Yang Jiang, Amber U L...> ;Leukemia. 2019 Apr 25
50 citations
Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma.
Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Hans C. Lee, Zuzana Berkova, Allison Berger, Marc L. Hyer, Nibedita Chattopadhyay, Sakeena Sye...> ;Blood. 2019 Apr 4
9 citations
Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191.
Haiwen Ni, Fazal Shirazi, Veerabhadran Baladandayuthapani, Heather Lin, Isere Kuiatse, Hua Wang, Richard J. Jones, Zuzana Berkova, Yasumichi Hitoshi, Stephen M. Ansell...> ;Clinical Cancer Research. 2018 Dec 15
352 citations
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Tina Cascone, Jodi A. McKenzie, Rina M. Mbofung, Simone Punt, Zhe Wang, Chunyu Xu, Leila Williams, Zhiqiang Wang, Christopher A. Bristow, Alessandro Carugo, Michael Pe...> ;Cell Metabolism. 2018 May 1
58 citations
Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma
Xiaohui Zhang, Hans C. Lee, Fazal Shirazi, Veerabhadran Baladandayuthapani, Heather Lin, Isere Kuiatse, Hua Wang, Richard J. Jones, Zuzana Berkova, Ram Kumar Singh, Ji...> ;Leukemia. 2018 Mar 27
Truncated protein tyrosine phosphatase receptor type O suppresses AKT signaling through IQ motif containing GTPase activating protein 1 and confers sensitivity to bort...
Hua Wang, Veerabhadran Baladandayuthapani, Zhiqiang Wang, Heather Lin, Zuzana Berkova, Richard E. Davis, Lin Yang, Robert Z. Orlowski> ;Oncotarget. 2017 Dec 7
7 citations
Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.
Rodrigo Jacamo, R. Eric Davis, Xiaoyang Ling, Sonali Sonnylal, Zhiqiang Wang, Wencai Ma, Min Zhang, Peter P. Ruvolo, Vivian Ruvolo, Rui Yu Wang, Teresa McQueen, Scott ...> ;Oncotarget. 2017 Jul 6
48 citations
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.
Hans C. Lee, Hua Wang, Veerabhadran Baladandayuthapani, Heather Lin, Jin He, Richard J. Jones, Isere Kuiatse, Dongmin Gu, Zhiqiang Wang, Wencai Ma, John Soon Yew Lim, ...> ;British Journal of Haematology. 2017 Apr 1
50 citations
Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK
Ekaterina Kim, Christian Hurtz, Stefan Koehrer, Zhiqiang Wang, Sriram Balasubramanian, Betty Y. Chang, Markus Müschen, R. Eric Davis, Jan A. Burger> ;Blood. 2017 Mar 2
126 citations
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
Jo Ishizawa, Kensuke Kojima, Dhruv Chachad, Peter P. Ruvolo, Vivian Ruvolo, Rodrigo Jacamo, Gautam Borthakur, Hong Mu, Zhihong Zeng, Yoko Tabe, Joshua E. Allen, Zhiqia...> ;Science Signaling. 2016 Feb 16
26 citations
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185
Yoko Tabe, Kensuke Kojima, Shinichi Yamamoto, Kazumasa Sekihara, Hiromichi Matsushita, Richard E. Davis, Zhiqiang Wang, Wencai Ma, Jo Ishizawa, Saiko Kazuno, Michael K...> ;Plos One. 2015 Sep 4
40 citations
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression
Yong Lu, Mingjun Zhang, Siqing Wang, Bangxing Hong, Zhiqiang Wang, Haiyan Li, Yuhuan Zheng, Jing Yang, Richard E. Davis, Jianfei Qian, Jian Hou, Qing Yi> ;Nature Communications. 2014 Jun 24
422 citations
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
Jason R. Westin, Fuliang Chu, Min Zhang, Luis Fayad, Larry W. Kwak, Nathan Fowler, Jorge E. Romaguera, Fredrick B. Hagemeister, Michelle A. Fanale, Felipe Samaniego, L...> ;The Lancet. Oncology. 2014 Jan 1
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Hospital Affiliations

Henry Ford HospitalDetroit, Michigan