AimeeWen YiKaoMD

Neurology • San Francisco, CA

Assistant Professor, Neurology, UCSF School of Medicine

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Office
505 Parnassus Ave
San Francisco, CA 94143
Phone+1 415-353-2273

Fax+1 415-353-2898
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Education & Training

University of California (San Francisco)Residency, Neurology, 2001 - 2004
Beth Israel Deaconess Medical CenterInternship, Internal Medicine, 2000 - 2001
University of Iowa Roy J. and Lucille A. Carver College of MedicineClass of 2000

Certifications & Licensure

CA State Medical License 2002 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Publications & Presentations

PubMed

Second international symposium on the chaperone code, 2023.
Johannes Buchner, Milad J Alasady, Sarah J Backe, Brian S J Blagg, Richard L Carpenter, Giorgio Colombo, Ioannis Gelis, Daniel T Gewirth, Lila M Gierasch, Walid A Hour...> ;Cell Stress & Chaperones. 2024 Feb 1
2 citations
The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
Austin L Wang, Edwina A Mambou, Aimee W Kao> ;Human Molecular Genetics. 2024 Jan 20
Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Paul J Sampognaro, Shruti Arya, Giselle M Knudsen, Emma L Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S Craik, Matthew P Jacobson, Aimee W...> ;Molecular Neurodegeneration. 2023 May 30
8 citations
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Paul J Sampognaro, Shruti Arya, Giselle M Knudsen, Emma L Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S Craik, Matthew P Jacobson, Aimee W...> ;Molecular Neurodegeneration. 2023 May 2
3 citations
Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
Andrea R Argouarch, Nina Schultz, Andrew C Yang, Yeongjun Jang, Kristle Garcia, Celica G Cosme, Christian I Corrales, Alissa L Nana, Anna M Karydas, Salvatore Spina, L...> ;Stem Cell Reviews and Reports. 2022 Dec 1
2 citations
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.
Marcus Y Chin, Kean-Hooi Ang, Julia Davies, Carolina Alquezar, Virginia G Garda, Brendan Rooney, Kun Leng, Martin Kampmann, Michelle R Arkin, Aimee W Kao> ;ACS Chemical Neuroscience. 2022 May 18
22 citations
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Carolina Alquezar, Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy H. Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth A. Dombroski,...> ;Science Advances. 2021 Nov 5
18 citations
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C Courtney, Jiasheng Zhang, Amanda R. Mason, Kathy H. ...> ;Molecular Neurodegeneration. 2021 Aug 3
20 citations
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.
Marcus Y. Chin, Anand Patwardhan, Kean-Hooi Ang, Austin L Wang, Carolina Alquezar, Mackenzie Welch, Phi T. Nguyen, Michael Grabe, Anna V. Molofsky, Michelle R. Arkin, ...> ;ACS Sensors. 2021 Jun 8
132 citations
Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
Carolina Alquezar, Shruti Arya, Aimee W. Kao> ;Frontiers in Neurology. 2021 Jan 7
2 citations
Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.
Sushmitha Gururaj, Paul J. Sampognaro, Andrea R. Argouarch, Aimee W. Kao> ;Frontiers in Neuroscience. 2020 Dec 14
13 citations
Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia.
Andy J Liu, Adam M. Staffaroni, Julio C Rojas-Martinez, Nicholas T. Olney, Carolina Alquezar-Burillo, Peter A. Ljubenkov, Renaud La Joie, Jamie Fong, Joanne Taylor, An...> ;JAMA Neurology. 2020 Mar 1
4 citations
Protons in small spaces: Discrete simulations of vesicle acidification.
Apeksha Singh, Frank V. Marcoline, Salome Veshaguri, Aimee W. Kao, Marcel P. Bruchez, Joseph A. Mindell, Dimitrios Stamou, Michael Grabe> ;Plos Computational Biology. 2019 Dec 23
48 citations
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea R. Argouarch, Chao Wang, Cindy Shen Huang, Peter Dongmin Sohn, Kathryn R. Bowles,...> ;Stem Cell Reports. 2019 Nov 12
20 citations
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie K. Andersen, Aimee W. Kao, Eric Verdin> ;NPJ Aging and Mechanisms of Disease. 2019 Oct 2
20 citations
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.
Victoria J. Butler, Fuying Gao, Christian I. Corrales, Wilian A. Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P. Jacobson, Gio...> ;Plos Genetics. 2019 Aug 9
21 citations
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.
Victoria J. Butler, Wilian A. Cortopassi, Sushmitha Gururaj, Austin L Wang, Olivia M Pierce, Matthew P. Jacobson, Aimee W. Kao> ;Biochemistry. 2019 May 17
38 citations
Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.
Victoria J. Butler, Wilian A. Cortopassi, Andrea R. Argouarch, Sam L. Ivry, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao> ;Journal of Molecular Biology. 2019 Mar 1
21 citations
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Victoria J. Butler, Dominique A. Salazar, David Soriano-Castell, Miguel Alves-Ferreira, Frank J.A. Dennissen, Mihir Vohra, Juan A. Oses-Prieto, Kathy H. Li, Austin L W...> ;Human Molecular Genetics. 2019 May 1
40 citations
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Shauna H. Yuan, Nobuhiko Hiramatsu, Qing Liu, Xuehan Victoria Sun, David Lenh, Priscilla Chan, Karen Chiang, Edward H. Koo, Aimee W. Kao, Irene Litvan, Jonathan H. Lin> ;Human Molecular Genetics. 2018 Nov 15
11 citations
Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
Yi Li, Matthew J. Barkovich, Celeste M. Karch, Ryan M. Nillo, Chun Chieh Fan, Iris J. Broce, Chin Hong Tan, Daniel Cuneo, Christopher P. Hess, William P. Dillon, Orit ...> ;Scientific Reports. 2018 Sep 6
The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.
Tsung-Yuan Hsu, Victoria J. Butler, Aimee W. Kao> ;Methods in Molecular Biology. 2018 Jan 1
195 citations
Clinicopathological correlations in behavioural variant frontotemporal dementia.
David C. Perry, Jesse A. Brown, Katherine L. Possin, Samir Datta, Andrew Trujillo, Anneliese Radke, Anna Karydas, John Kornak, Ana C. Sias, Gil D. Rabinovici, Maria Lu...> ;Brain. 2017 Dec 1
11 citations
Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.
Nicholas T. Olney, Carolina Alquezar, Eliana Marisa Ramos, Alissa L. Nana, Jamie Fong, Anna Karydas, Joanne Taylor, Melanie L. Stephens, Andrea R. Argouarch, Victoria ...> ;Acta Neuropathologica. 2017 Aug 21
159 citations
Progranulin, lysosomal regulation and neurodegenerative disease
Aimee W. Kao, Andrew S. McKay, Param Priya Singh, Anne Brunet, Eric J. Huang> ;Nature Reviews. Neuroscience. 2017 Apr 24
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