AjayNirulaMD

PubMed

• 18 citations
  A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis.
  Jay Tuttle, Edit Drescher, Jesus Abraham Simón-Campos, Paul Emery, Maria Greenwald, Alan Kivitz, Hyungmin Rha, Pia Yachi, Christina Kiley, Ajay Nirula> ;The New England Journal of Medicine. 2023 May 18
• Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.
  Kara W Chew, Carlee Moser, Eric S Daar, David A Wohl, Jonathan Z Li, Robert W Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Manish C Choudhary, Rin...> ;Nature Communications. 2023 Jan 19
• 16 citations
  Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial.
  Manish C Choudhary, Kara W Chew, Rinki Deo, James P Flynn, James Regan, Charles R Crain, Carlee Moser, Michael D Hughes, Justin Ritz, Ruy M Ribeiro, Ruian Ke, Joan A D...> ;Nature Microbiology. 2022 Nov 1
• 23 citations
  Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.
  Kara W Chew, Carlee Moser, Eric S Daar, David A Wohl, Jonathan Z Li, Robert W Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Manish C Choudhary, Rin...> ;Nature Communications. 2022 Aug 22
• 4 citations
  The anti-SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination.
  Robert J Benschop, Jay L Tuttle, Lin Zhang, Josh Poorbaugh, Nicole L Kallewaard, Peter Vaillancourt, Melissa Crisp, Thi Ngoc Vy Trinh, Joshua J Freitas, Stephanie Beas...> ;Science Translational Medicine. 2022 Jul 27
• 7 citations
  Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection.
  Julie Boucau, Kara W Chew, Manish C Choudhary, Rinki Deo, James Regan, James P Flynn, Charles R Crain, Michael D Hughes, Justin Ritz, Carlee Moser, Joan A Dragavon, Ar...> ;Cell Reports. Medicine. 2022 Jul 19
• 1 citations
  COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccine.
  Gregory Huhn, Josh Poorbaugh, Lin Zhang, Stephanie Beasley, Ajay Nirula, Jennifer Brothers, Sharon Welbel, James Wilson, Sheena Gillani, Kathleen M Weber, Ralph Morack...> ;Plos One. 2022 Jan 1
• 7 citations
  Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection.
  Julie Boucau, Kara W Chew, Manish Choudhary, Rinki Deo, James Regan, James P Flynn, Charles R Crain, Michael D Hughes, Justin Ritz, Carlee Moser, Joan A Dragavon, Arzh...> ;Medrxiv. 2021 Dec 30
• 7 citations
  Bamlanivimab reduces nasopharyngeal SARS-CoV-2 RNA levels but not symptom duration in non-hospitalized adults with COVID-19: A Phase 2 Randomized Clinical Trial.
  Kara W Chew, Carlee Moser, Eric S Daar, David A Wohl, Jonathan Z Li, Robert Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Carlos Malvestutto, Paul ...> ;Medrxiv. 2021 Dec 21
• 19 citations
  A randomized, placebo-controlled clinical trial of bamlanivimab and etesevimab together in high-risk ambulatory patients with COVID-19 and validation of the prognostic...
  Michael Dougan, Masoud Azizad, Bharat Mocherla, Robert L. Gottlieb, Peter Chen, Corey Hebert, Russell Perry, Joseph Boscia, Barry Heller, Jason Morris, Chad Crystal, A...> ;Clinical Infectious Diseases. 2021 Oct 28
• 10 citations
  A Quantitative Modeling and Simulation Framework to Support Candidate and Dose Selection of Anti-SARS-CoV-2 Monoclonal antibodies to Advance Bamlanivimab into a First-...
  Emmanuel Chigutsa, Eric Burroughs Jordie, Matthew M. Riggs, Ajay Nirula, Ahmed Elmokadem, Tim Knab, Jenny Y. Chien> ;Clinical Pharmacology and Therapeutics. 2021 Oct 22
• 131 citations
  Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial
  Myron S. Cohen, Ajay Nirula, Mark J. Mulligan, Richard M. Novak, Mary A. Marovich, Catherine Yen, Alexander Stemer, Stockton Mayer, David A. Wohl, Blair Brengle, Brian...> ;JAMA. 2021 Jul 6
• 639 citations
  Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
  Robert L. Gottlieb, Ajay Nirula, Peter Chen, Joseph Boscia, Barry Heller, Jason Morris, Gregory D. Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, P...> ;JAMA. 2021 Feb 16
• 13 citations
  Emergence of SARS-CoV-2 Resistance with Monoclonal Antibody Therapy
  Manish Chandra Choudhary, Kara W Chew, Rinki Deo, James P. Flynn, James Regan, Charles R Crain, Carlee Moser, Michael Hughes, Justin Ritz, Ruy M. Ribeiro, Ruian Ke, Jo...> ;Medrxiv. 2021 Sep 15
• 19 citations
  First-in-Human Study of Bamlanivimab in a Randomized Trial of Hospitalized Patients With COVID-19.
  Peter Chen, Gourab Datta, Ying Grace Li, Jenny Y. Chien, Karen L. Price, Emmanuel Chigutsa, Patricia Brown-Augsburger, Josh Poorbaugh, Jeffrey Fill, Robert J. Benschop...> ;Clinical Pharmacology and Therapeutics. 2021 Oct 16
• 403 citations
  Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19.
  Michael Dougan, Ajay Nirula, Masoud Azizad, Bharat Mocherla, Robert L. Gottlieb, Peter Chen, Corey Hebert, Russell Perry, Joseph Boscia, Barry Heller, Jason Morris, Ch...> ;The New England Journal of Medicine. 2021 Jul 14
• 16 citations
  Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together.
  Lin Zhang, Josh Poorbaugh, Michael Dougan, Peter Chen, Robert L Gottlieb, Gregory Huhn, Stephanie Beasley, Montanea Daniels, Thi Ngoc Vy Trinh, Melissa Crisp, Joshua J...> ;Frontiers in Immunology. 2021 Jan 1
• Neutralizing Antibody LY-CoV555 for Outpatient Covid-19. Reply.
  Nirula A, Shen L, Skovronsky DM> ;The New England journal of medicine. 2020-12-30
• A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.
  ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benf...> ;The New England journal of medicine. 2020-12-22
• 9 citations
  Safety and Efficacy of Poseltinib, Bruton's Tyrosine Kinase Inhibitor, in Patients With Rheumatoid Arthritis: A Randomized, Double-blind, Placebo-controlled, 2-part Ph...
  Mark C. Genovese, Alberto Spindler, Akira Sagawa, Won Park, Anna Dudek, Alan Kivitz, Jeannie Chao, Lai Shan Melanie Chan, Jennifer Witcher, William Barchuk, Ajay Nirula> ;The Journal of Rheumatology. 2020 Dec 15
• 826 citations
  SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19.
  Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory D. Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, A...> ;The New England Journal of Medicine. 2021 Jan 21
• 114 citations
  Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19.
  Jonathan T. Sims, Venkatesh Krishnan, Ching Yun Chang, Sarah M. Engle, Giacomo Casalini, George H. Rodgers, Nicoletta Bivi, Brian J. Nickoloff, Robert J. Konrad, Steph...> ;The Journal of Allergy and Clinical Immunology. 2021 Jan 1
• 185 citations
  Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.
  Justin Stebbing, Venkatesh Krishnan, Stephanie de Bono, Silvia Ottaviani, Giacomo Casalini, Peter J. Richardson, Vanessa Monteil, Volker M. Lauschke, Ali Mirazimi, Son...> ;EMBO Molecular Medicine. 2020 Aug 7
• 30 citations
  Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis
  Lewis Tomalin, Chris B. Russell, Sandra Garcet, David Adrian Ewald, Paul Klekotka, Ajay Nirula, Hanne Norsgaard, Mayte Suárez-Fariñas, James G. Krueger> ;The Journal of Allergy and Clinical Immunology. 2020 Mar 1
• 31 citations
  Bispecific antibodies: The next generation of targeted inflammatory bowel disease therapies.
  Laurent Peyrin-Biroulet, S.J. Demarest, Ajay Nirula> ;Autoimmunity Reviews. 2019 Feb 1
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Journal Articles

• Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID ‐19 patients  
  Justin Stebbing Venkatesh Krishnan Stephanie de Bono Silvia Ottaviani Giacomo Casalini Peter J Richardson Vanessa Monteil Volker M Lauschke Ali Mirazimi ..., EMBO Molecular Medicine