AlanHShihMD

PubMed

• Discontinuation Syndrome With JAK2 Selective Agents: Case Presentation and Mechanistic Insights.
  Farina, K., Becker, M., Kelly, B., Yu, A., Handa, S., Tremblay, D., Marcellino, B., Salib, C., Mascarenhas, J., Shih, A., Feld, J.> ;JCO Precision Oncology. 2024 Jan 1
• Murine Modeling of Myeloproliferative Neoplasms.
  Karie Chen, Alan H. Shih> ;Hematology/oncology Clinics of North America. 2021 Apr 1
• 25 citations
  Safety and Efficacy: Clinical Experience of Venetoclax in Combination With Hypomethylating Agents in Both Newly Diagnosed and Relapsed/Refractory Advanced Myeloid Mali...
  Jonathan Feld, Douglas Tremblay, Mikaela Dougherty, Tina Czaplinska, Gillian Sanchez, Claudia Brady, Marina Kremyanskaya, Michal Bar-Natan, Alla Keyzner, Bridget K. Ma...> ;Hemasphere. 2021 Mar 9
• 17 citations
  Venetoclax and hypomethylating agent combination therapy in acute myeloid leukemia secondary to a myeloproliferative neoplasm.
  Douglas Tremblay, Jonathan Feld, Mikaela Dougherty, Tina Czaplinska, Gillian Sanchez, Marina Kremyanskaya, Michal Bar-Natan, Alan H. Shih, Alla Keyzner, John Mascarenhas> ;Leukemia Research. 2020 Sep 22
• 13 citations
  Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML
  Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L. Glass, Alan H. Shih, Ruud Delwel, Ross L. Levine, Christopher E. Mason, Ari Melnick> ;Cancer Discovery. 2020 Sep 16
• 31 citations
  Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
  Cihangir Duy, Matt Teater, Francine E. Garrett-Bakelman, Tak C. Lee, Cem Meydan, Jacob L. Glass, Meng Li, Johannes C. Hellmuth, Helai P. Mohammad, Kimberly N. Smithema...> ;Cancer Discovery. 2019 Jul 1
• 17 citations
  Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer
  Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher Famulare, Alan H. Shih, Cameron Brennan, Xue Gao, Yaozhu Pan, Shuangping ...> ;Cancer Discovery. 2019 Mar 12
• 126 citations
  Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.
  Lynn Quek, Muriel D. David, Alison Kennedy, Marlen Metzner, Michael Amatangelo, Alan Shih, Bilyana Stoilova, Cyril Quivoron, Maël Heiblig, Christophe Willekens, Véroni...> ;Nature Medicine. 2018 Jul 16
• 178 citations
  Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
  Andrew M. Intlekofer, Alan H. Shih, Abbas Nazir, Ariën S. Rustenburg, Steven K. Albanese, Minal Patel, Christopher Famulare, Fabian Correa, Naofumi Takemoto, Vidushi D...> ;Nature. 2018 Jun 27
• 14 citations
  JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
  McKenney, A., Lau, A., Somasundara, A., Spitzer, B., Intlekofer, A., Ahn, J., Shank, K., Rapaport, F., Patel, M., Papalexi, E., Shih, A., Chiu, A., Freinkman, E., Akba...> ;The Journal of Clinical Investigation. 2018 Feb 1
• 6 citations
  Corrigendum: JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition(J Clin Invest. (2018) 128:2 (789–804) DOI: 10.1172/JCI94516)
  Anna Sophia McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M. Intlekofer, Jihae Ahn, Kaitlyn Shank, Franck Rapaport, Minal Pa...> ;The Journal of Clinical Investigation. 2018 Feb 1
• 62 citations
  Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
  Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, Justin T. Whitfield, Kaitlyn Shank, Franck Rapaport, Rebecca Maher, Elodie Pronier, Sara C. Meyer, Francine E. Garrett-Bak...> ;Cancer Cell. 2018 Jan 8
• 99 citations
  TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Discovery. 2018 Jan 1
• 109 citations
  Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition.
  James J. Harding, Maeve A. Lowery, Alan H. Shih, Juan M. Schvartzman, Shengqi Hou, Christopher Famulare, Minal Patel, Mikhail Roshal, Richard K. G. Do, Ahmet Zehir, Da...> ;Cancer Discovery. 2018 Jan 1
• 265 citations
  Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response
  Michael Amatangelo, Lynn Quek, Alan Shih, Eytan M. Stein, Mikhail Roshal, Muriel D. David, Benoit S. Marteyn, Noushin Farnoud, Stéphane de Botton, Olivier A. Bernard, ...> ;Blood. 2017 Aug 10
• 15 citations
  Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells
  Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Franck Rapaport, Benjamin H. Durham, Francine E. Garrett-Bakelman, Elodie Pronier, Al...> ;Blood. 2017 Mar 30
• 73 citations
  Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.
  Alan H. Shih, Cem Meydan, Kaitlyn Shank, Francine E. Garrett-Bakelman, Patrick S. Ward, Andrew M. Intlekofer, Abbas Nazir, Eytan M. Stein, Kristina M. Knapp, Jacob L. ...> ;Cancer Discovery. 2017 May 1
• 100 citations
  A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations
  Dali Han, Xingyu Lu, Alan H. Shih, Ji Nie, Qiancheng You, Meng Michelle Xu, Ari Melnick, Ross L. Levine, Chuan He> ;Molecular Cell. 2016 Aug 18
• 138 citations
  Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
  Satoshi Inoue, Wanda Y. Li, Alan Tseng, Isabel Beerman, Andrew J. Elia, Sean C. Bendall, François Lemonnier, Ken Kron, David W. Cescon, Zhenyue Hao, Evan F. Lind, Naoy...> ;Cancer Cell. 2016 Aug 8
• 21 citations
  Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles
  Megan A. Hatlen, Kanika Arora, Vladimir Vacic, Ewa A. Grabowska, Willey Liao, Bridget Riley-Gillis, Dayna M. Oschwald, Lan Wang, Jacob E. Joergens, Alan H. Shih, Franc...> ;The Journal of Experimental Medicine. 2016 Jan 11
• 107 citations
  CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms
  Sara C. Meyer, Matthew D. Keller, Sophia Chiu, Priya Koppikar, Olga A. Guryanova, Franck Rapaport, Ke Xu, Katia Manova, Dmitry Pankov, Richard J. O'Reilly, Maria Klepp...> ;Cancer Cell. 2015 Jul 13
• 162 citations
  Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
  Alan H. Shih, Yanwen Jiang, Cem Meydan, Kaitlyn Shank, Suveg Pandey, Laura Barreyro, Iléana Antony-Debré, Agnes Viale, Nicholas D. Socci, Yongming Sun, Alexander Rober...> ;Cancer Cell. 2015 Apr 13
• 200 citations
  DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
  Raajit K. Rampal, Altuna Alkalin, Jozef Madzo, Aparna Vasanthakumar, Elodie Pronier, Jay P. Patel, Yushan Li, Jihae Ahn, Omar Abdel-Wahab, Alan Shih, Chao Lu, Patrick ...> ;Cell Reports. 2014 Dec 11
• 82 citations
  Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis
  Jozef Madzo, Hui Liu, Alexis Rodriguez, Aparna Vasanthakumar, Sriram Sundaravel, Donne Bennett D. Caces, Timothy J. Looney, Li Zhang, Janet B. Lepore, Trisha A. Macrae...> ;Cell Reports. 2014 Jan 16
• 247 citations
  Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
  Omar Abdel-Wahab, Jie Gao, Mazhar Adli, Anwesha Dey, Thomas Trimarchi, Young Rock Chung, Cem Kuscu, Todd Hricik, Delphine Ndiaye-Lobry, Lindsay M. LaFave, Richard Koch...> ;The Journal of Experimental Medicine. 2013 Nov 18
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Journal Articles

• Acquired Resistance to IDH Inhibition Through Trans or Cis Dimer-Interface Mutations  
  Martin S Tallman, Eytan M Stein, Alan H Shih, Maria E Arcila, Andrew M Intlekofer, Craig B Thompson, Mikhail Roshal, Nature