DmitriyZamarinMDPhD

Gynecologic Cancer

Section Head, Gynecologic Medical Oncology

Overview of Dr. Zamarin

I am a medical oncologist specializing in the care of women with gynecologic cancers, including cervical, ovarian, and endometrial cancers. My clinical and laboratory research is focused on the development of novel ways to use the immune system to treat cancer. In addition, I have a special interest in genetically engineered oncolytic viruses, an emerging class of immune therapeutic drugs. By manipulating the oncolytic viruses and the immune system, I’m exploring different ways to enhance the immune recognition of tumors and to develop novel treatment strategies for gynecologic cancers.

Office
Icahn School of Medicine at Mount Sinai
1470 Madison Ave
New York, NY 10029
Book by Phone+1(786) 541-1289
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 2010 - 2014
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Internal Medicine, 2008 - 2010
Icahn School of Medicine at Mount SinaiClass of 2008

Certifications & Licensure

FL State Medical License 2021 - Present
NJ State Medical License 2019 - 2025
NY State Medical License 2009 - 2025
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Liz Tilberis Early Career Award Ovarian Cancer Research Alliance
GOG Foundation Scholar Investigator Award GOG Foundation, 2019
MSKCC Academic Excellence Recognition Award Memorial Sloan Kettering Cancer Center, 2018
Judith Liebenthal Robinson Ovarian Cancer Foundation Award Foundation for Women's Cancers, 2015
Bladder Cancer Awareness Network Young Investigator Award Bladder Cancer Awareness Network, 2014
Conquer Cancer Foundation ASCO Young Investigator Award Conquer Cancer Foundation, 2013
Celgene Future Leaders in Hematology Award Celgene, 2012
Damon Runyon Foundation Fellowship Award Damon Runyon Foundation, 2012
American Society of Hematology Abstract Achievement Award American Society of Hematology, 2011
Department of Medicine Award for excellence in research Mount Sinai School of Medicine, 2010
Alpha Omega Alpha Mount Sinai School of Medicine, 2008
Barry Coller Award for Excellence in Clinical Medicine Mount Sinai School of Medicine, 2008
Harold Elster Memorial Prize for Highest Academic Standing Mount Sinai School of Medicine, 2008
Graduate Student Conference Travel Awards Mount Sinai School of Medicine, 2004-2008
Award for Best Doctoral Dissertation Mount Sinai School of Medicine, 2006
Teaching Assistant Award Mount Sinai School of Medicine, 2005
American Society for Virology Travel Award American Society for Virology, 2005
Academic Excellence Award Mount Sinai School of Medicine, 2003
Student Service Award Mount Sinai School of Medicine, 2002
Summa Cum Laude Manhattan College, 2000
Phi Beta Kappa Manhattan College, 1999
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Clinical Trials

A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab With or Without Ipilimumab in Patients With Ovarian Cancer Start of enrollment: 2017 Aug 04
Active, not recruiting
Phase 1
Study of Pembrolizumab Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors Start of enrollment: 2019 Feb 20
Active, not recruiting
Early Phase 1
Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer Start of enrollment: 2020 Apr 09
Active, not recruiting
Phase 3
ZW25 in Women With Endometrial Cancers Start of enrollment: 2020 Aug 12
Completed
Phase 2
A Study of MEDI9253 in Combination With Durvalumab in Select Solid Tumors Start of enrollment: 2020 Dec 02
Active, not recruiting
Phase 1
Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery Start of enrollment: 2021 Apr 02
Active, not recruiting
Phase 2
Phase 1a/1b Study of STK-012 Monotherapy and in Combination With Pembrolizumab in Patients With Solid Tumors Start of enrollment: 2022 Jan 25
Recruiting
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

1 citations
Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling.
Fang, Y., Xiao, X., Wang, J., Dasari, S., Pepin, D., Nephew, K., Mitra, A., Zamarin, D.> ;NPJ Precision Oncology. 2024 Jan 8
APR-246 increases tumor antigenicity independent of p53.
Judith Michels, Divya Venkatesh, Cailian Liu, Sadna Budhu, Hong Zhong, Mariam M George, Daniel Thach, Zhong-Ke Yao, Ouathek Ouerfelli, Hengrui Liu, Brent R Stockwell, ...> ;Life Science Alliance. 2024 Jan 1
1 citations
Breaking the barriers in cancer care: The next generation of herpes simplex virus-based oncolytic immunotherapies for cancer treatment.
Nikhil I Khushalani, Kevin J Harrington, Alan Melcher, Praveen K Bommareddy, Dmitriy Zamarin> ;Molecular Therapy Oncolytics. 2023 Dec 19
Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function.
Hwang, S., Awasthi, D., Jeong, J., Sandoval, T., Chae, C., Ramos, Y., Tan, C., Falco, M., McBain, I., Mishra, B., Ivashkiv, L., Zamarin, D., Cantillo, E., Chapman-Davi...> ;Research Square. 2023 Dec 14
Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.
Kahn, R., Selenica, P., Boerner, T., Roche, K., Xiao, Y., Sia, T., Maio, A., Kemel, Y., Sheehan, M., Salo-Mullen, E., Breen, K., Zhou, Q., Iasonos, A., Grisham, R., O'...> ;Gynecologic Oncology. 2024 Jan 1
Transforming ovarian cancer care by targeting minimal residual disease.
Amir A Jazaeri, Rachel Grisham, Anne Knisely, Stefani Spranger, Dmitriy Zamarin, R Tyler Hillman, Barrett C Lawson, Kathleen H Burns, Sanghoon Lee, Shannon N Westin, E...> ;Med. 2023 Nov 10
Tumor lenvatinib addiction and withdrawal rebound response in patients with advanced endometrial cancer.
Clarissa Lam, Debra Sarasohn, Britta Weigelt, Dmitriy Zamarin> ;Gynecologic Oncology Reports. 2023 Oct 1
2 citations
Phase IIa Study of PLX2853 in Gynecologic Cancers With Known ARID1A Mutation and Phase Ib/IIa Study of PLX2853/Carboplatin in Platinum-Resistant Epithelial Ovarian Can...
Linda R Duska, Dmitriy Zamarin, Erica Hamilton, Amit Oza, Gini Fleming, Alexander Spira, Oladapo O Yeku, Debra L Richardson, Jackie Walling, Kerry Inokuchi, Bernice Ma...> ;JCO Precision Oncology. 2023 Sep 1
Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets.
Claire F Friedman, Vignesh Ravichandran, Kathryn Miller, Chad Vanderbilt, Qin Zhou, Alexia Iasonos, Malavika Vivek, Pamela Mishra, Mario M Leitao Jr, Vance Broach, Yuk...> ;Clinical Cancer Research. 2023 Nov 14
A phase 2 study of dasatinib in recurrent clear cell carcinoma of the ovary, fallopian tube, peritoneum or endometrium: NRG oncology/gynecologic oncology group study 0...
Roisin E O'Cearbhaill, Austin Miller, Robert A Soslow, Heather A Lankes, Deborah DeLair, Sheila Segura, Shweta Chavan, Dmitriy Zamarin, Robert DeBernardo, Kathleen Moo...> ;Gynecologic Oncology. 2023 Sep 1
Correction: Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in micemultichannel image segmenta...
Chrysafis Andreou, Konstantinos Plakas, Naxhije Berisha, Mathieu Gigoux, Lauren E Rosch, Rustin Mirsafavi, Anton Oseledchyk, Suchetan Pal, Dmitriy Zamarin, Taha Mergho...> ;Nanoscale Horizons. 2023 Jul 24
4 citations
Phase I Study of a Multivalent WT1 Peptide Vaccine (Galinpepimut-S) in Combination with Nivolumab in Patients with WT1-Expressing Ovarian Cancer in Second or Third Rem...
Beryl L Manning-Geist, Sacha Gnjatic, Carol Aghajanian, Jason Konner, Sarah H Kim, Debra Sarasohn, Krysten Soldan, William P Tew, Nicholas J Sarlis, Dmitriy Zamarin, S...> ;Cancers. 2023 Feb 25
Impact of immune infiltration signatures on prognosis in endometrial carcinoma is dependent on the underlying molecular subtype.
Kimberly Dessources, Lorenzo Ferrando, Qin C Zhou, Alexia Iasonos, Nadeem R Abu-Rustum, Jorge S Reis-Filho, Nadeem Riaz, Dmitriy Zamarin, Britta Weigelt> ;Gynecologic Oncology. 2023 Apr 1
Shedding Light on PARP Inhibitor Response through Functional Imaging.
Ying L Liu, Dmitriy Zamarin> ;Clinical Cancer Research. 2023 Apr 14
1 citations
Cancer trials as opportunities to serve and learn from individuals with human immunodeficiency virus.
Christina E Henson, Daniel J Morton, Jyoti S Mayadev, Stuart J Wong, Dmitriy Zamarin> ;Cancer. 2023 Mar 1
44 citations
Ovarian cancer mutational processes drive site-specific immune evasion.
Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L P Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Boj...> ;Nature. 2022 Dec 1
4 citations
Durvalumab with or without tremelimumab in patients with persistent or recurrent endometrial cancer or endometrial carcinosarcoma: A randomized open-label phase 2 study.
Maria M Rubinstein, Eric Rios Doria, Jason Konner, Stuart Lichtman, Qin Zhou, Alexia Iasonos, Debra Sarasohn, Tiffany Troso-Sandoval, Claire Friedman, Roisin O'Cearbha...> ;Gynecologic Oncology. 2023 Feb 1
Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in micemultichannel image segmentation.
Chrysafis Andreou, Konstantinos Plakas, Naxhije Berisha, Mathieu Gigoux, Lauren E Rosch, Rustin Mirsafavi, Anton Oseledchyk, Suchetan Pal, Dmitriy Zamarin, Taha Mergho...> ;Nanoscale Horizons. 2022 Nov 21
30 citations
Single-cell genomic variation induced by mutational processes in cancer.
Tyler Funnell, Ciara H O'Flanagan, Marc J Williams, Andrew McPherson, Steven McKinney, Farhia Kabeer, Hakwoo Lee, Sohrab Salehi, Ignacio Vázquez-García, Hongyu Shi, Em...> ;Nature. 2022 Dec 1
7 citations
Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Sarah Ehmann, Dib Sassine, Alli M Straubhar, Aaron M Praiss, Carol Aghajanian, Kaled M Alektiar, Vance Broach, Karen A Cadoo, Elizabeth L Jewell, Amir Momeni Boroujeni...> ;Gynecologic Oncology. 2022 Dec 1
2 citations
State of the Biomarker Science in Ovarian Cancer: A National Cancer Institute Clinical Trials Planning Meeting Report.
Josee-Lyne Ethier, Katherine C Fuh, Rebecca Arend, Gottfried E Konecny, Panagiotis A Konstantinopoulos, Kunle Odunsi, Elizabeth M Swisher, Elise C Kohn, Dmitriy Zamarin> ;JCO Precision Oncology. 2022 Oct 1
2 citations
GermlineDeletion as a Driver of Uterine Cancer: An Atypical Presentation.
Anastasia Navitski, Duaa H Al-Rawi, Vicky Makker, Britta Weigelt, Dmitriy Zamarin, Ying Liu, Angela G Arnold, M Herman Chui, Diana L Mandelker, Michael Walsh, Deborah ...> ;JCO Precision Oncology. 2022 Oct 1
6 citations
High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer.
Charles W Ashley, Pier Selenica, Juber Patel, Michelle Wu, Josip Nincevic, Yulia Lakhman, Qin Zhou, Ronak H Shah, Michael F Berger, Arnaud Da Cruz Paula, David N Brown...> ;Clinical Cancer Research. 2023 Jan 17
12 citations
Microsatellite Instability-High Endometrial Cancers with MLH1 Promoter Hypermethylation Have Distinct Molecular and Clinical Profiles.
Beryl L Manning-Geist, Ying L Liu, Kelly A Devereaux, Arnaud Da Cruz Paula, Qin C Zhou, Weining Ma, Pier Selenica, Ozge Ceyhan-Birsoy, Lea A Moukarzel, Timothy Hoang, ...> ;Clinical Cancer Research. 2022 Oct 3
29 citations
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.
Xiaoxiao Ma, Nadeem Riaz, Robert M Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W R Fitzgerald, Hui Jiang, ...> ;Nature Genetics. 2022 Jul 1
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Journal Articles

A Phase 1 Dose-Escalation Study of Intraperitoneal Cisplatin, intravenous/intraperitoneal Paclitaxel, Bevacizumab, and Olaparib for Newly Diagnosed Ovarian Cancer
Karen A Cadoo, Roisin E O'Cearbhaill, Dmitriy Zamarin, Paul J Sabbatini, William P Tew, Carol Aghajanian, Jason A Konner, Gynecologic Oncology

Press Mentions

Key Advances and Advocacy Are Themes at SGO Annual MeetingMarch 21st, 2023
Dmitriy Zamarin, MD, PhD, on Novel Therapies for Cervical CancerMarch 23rd, 2022
Gynecologic Cancer Awareness Month: 2021 Immunotherapy Research UpdatesSeptember 3rd, 2021
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Grant Support

GOG Foundation Scholar Investigator AwardGOG Foundation2019–2024
Profiling co‑evolution of ovarian cancer and its immune microenvironmentOvarian Cancer Research Alliance2020–2022
Chromatin remodeling and immunotherapy in ovarian cancerOvarian Cancer Research Alliance2020–2022
Novel approaches to locoregional and systemic immunotherapy for ovarian cancerCongressionally Directed Medical Research Programs: Ovarian Cancer Academy (OCA)2016–2021

Committees

Chair, Translational Science, NRG Oncology Cervical Cancer Committee 2018 - Present
Member, NRG Oncology Developmental Therapeutics Committee 2018 - Present
Member, Institutional Biosafety Committee 2016 - Present
Member, Protocol Development Committee 2015 - Present
Member, Pharmacy and Therapeutics Committee, MSKCC 2014 - Present