AlanJ.SimmonsMD

Internal Medicine • Mchenry, IL

Hospital Medicine/Hospitalist

Physician

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Office
4309 W Medical Center Dr
MOB A102
Mchenry, IL 60050
Phone+1 815-338-6600
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Summary

Dr. Alan Simmons, MD is a board certified internist in Mchenry, Illinois. He is currently licensed to practice medicine in Illinois, Kentucky, and Tennessee. He is affiliated with Northwestern Medicine McHenry.

Education & Training

University of TennesseeResidency, Internal Medicine, 2008 - 2011
Vanderbilt University Medical CenterInternship, Transitional Year, 2007 - 2008
University of Louisville School of MedicineClass of 2007

Certifications & Licensure

IL State Medical License 2014 - 2026
KY State Medical License 2010 - 2025
TN State Medical License 2009 - 2024
American Board of Internal Medicine Internal Medicine

Publications & Presentations

PubMed

Direct Detection of Isolevuglandins in Tissues using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence.
Cassandra Warden, Alan J. Simmons, Lejla Pasic, Sean S. Davies, Justin H. Layer, Raymond L. Mernaugh, Annet Kirabo> ;Journal of Visualized Experiments. 2021 Jul 5
49 citations
Combinatorial Transcriptional Profiling of Mouse and Human Enteric Neurons Identifies Shared and Disparate Subtypes In Situ.
Aaron A. May-Zhang, Eric Tycksen, Austin N. Southard-Smith, Karen K. Deal, Joseph T. Benthal, Dennis P. Buehler, Mike Adam, Alan J. Simmons, James R. Monaghan, Brittan...> ;Gastroenterology. 2021 Feb 1
6 citations
Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms
Mary Catherine Macedonia, Julia L. Drewes, Nicholas O. Markham, Alan J. Simmons, Joseph T. Roland, Paige N. Vega, Cherie’ R. Scurrah, Robert J. Coffey, Martha J. Shrub...> ;NPJ Biofilms and Microbiomes. 2020 Sep 24
99 citations
Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation
Amrita Banerjee, Charles A. Herring, Bob Chen, Hyeyon Kim, Alan J. Simmons, Austin N. Southard-Smith, Margaret M. Allaman, James R. White, Mary C. Macedonia, Eliot T. ...> ;Gastroenterology. 2020 Dec 1
13 citations
An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.
Douglas K. Brubaker, Manu P. Kumar, Evan L. Chiswick, Cecil Gregg, Alina Starchenko, Paige N. Vega, Austin N. Southard-Smith, Alan J. Simmons, Elizabeth A. Scoville, L...> ;Science Signaling. 2020 Aug 4
17 citations
Dual indexed library design enables compatibility of in-Drop single-cell RNA-sequencing with exAMP chemistry sequencing platforms
Austin N. Southard-Smith, Alan J. Simmons, Bob Chen, Angela L. Jones, Marisol A. Ramirez Solano, Paige N. Vega, Cherie’ R. Scurrah, Yue Zhao, Michael J. Brenan, Jiekun...> ;BMC Genomics. 2020 Jul 2
240 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
6 citations
Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress...
Xiaodun Yang, Sarah M. Graff, Cody N. Heiser, Kung-Hsien Ho, Bob Chen, Alan J. Simmons, Austin N. Southard-Smith, Gregory David, David A. Jacobson, Irina Kaverina, Chr...> ;Diabetes. 2020 Apr 3
17 citations
Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach.
Jimin Min, Paige N. Vega, Amy C. Engevik, Janice A. Williams, Qing Yang, Loraine M. Patterson, Alan J. Simmons, R. Jarrett Bliton, Joshua W Betts, Ken S. Lau, Scott T....> ;Nature Communications. 2019 Dec 5
92 citations
High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension.
Jane F. Ferguson, Luul A. Aden, Natalia R. Barbaro, Justin P Van Beusecum, Liang Xiao, Alan J. Simmons, Cassandra Warden, Lejla Pasic, Lauren E. Himmel, Mary Kay Washi...> ;JCI Insight. 2019 Nov 5
13 citations
Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.
Marika Manolopoulou, Brittany K. Matlock, Stellor Nlandu-Khodo, Alan J. Simmons, Ken S. Lau, Melanie Phillips-Mignemi, Alla V. Ivanova, Catherine E. Alford, David K. F...> ;American Journal of Physiology. Renal Physiology. 2019 May 1
29 citations
Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.
Jing Liu, Amrita Banerjee, Charles A. Herring, Jonathan Attalla, Ruiying Hu, Yanwen Xu, Qiujia Shao, Alan J. Simmons, Prasanna K. Dadi, Sui Wang, David A. Jacobson, Bi...> ;Developmental Cell. 2019 Jan 7
6 citations
Single-Cell Mass Cytometry of Archived Human Epithelial Tissue for Decoding Cancer Signaling Pathways
Cherie’ R. Scurrah, Alan J. Simmons, Ken S. Lau> ;Methods in Molecular Biology. 2019 Jan 1
25 citations
Quantitative assessment of cell population diversity in single-cell landscapes.
Qi Liu, Charles A. Herring, Quanhu Sheng, Jie Ping, Alan J. Simmons, Bob Chen, Amrita Banerjee, Wei Li, Guoqiang Gu, Robert J. Coffey, Yu Shyr, Ken S. Lau> ;Plos Biology. 2018 Oct 22
115 citations
Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.
Charles A. Herring, Amrita Banerjee, Eliot T. McKinley, Alan J. Simmons, Jie Ping, Joseph T. Roland, Jeffrey L. Franklin, Qi Liu, Michael J. Gerdes, Robert J. Coffey, ...> ;Cell Systems. 2017 Nov 15
25 citations
The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.
Dana Almohazey, Yuan-Hung Lo, Claire V Vossler, Alan J. Simmons, Jonathan J. Hsieh, Edie B Bucar, Michael A. Schumacher, Kathryn E. Hamilton, Ken S. Lau, Noah F. Shroy...> ;Cell Death and Differentiation. 2017 Mar 17
6 citations
Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges.
Alan J. Simmons, Ken S. Lau> ;Molecular & Cellular Oncology. 2017 Jan 1
18 citations
Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks
Alan J. Simmons, Cherie’ R. Scurrah, Eliot T. McKinley, Charles A. Herring, Jonathan M. Irish, M. Kay Washington, Robert J. Coffey, Ken S. Lau> ;Science Signaling. 2016 Oct 11
Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.
Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS> ;Mol. Syst. Biol.. 2016-08-29
5 citations
Multiscale analysis of the murine intestine for modeling human diseases
Jesse Lyons, Charles A. Herring, Amrita Banerjee, Alan J. Simmons, Ken S. Lau> ;Integrative Biology. 2015 Jul 6
Hunger Does Not Motivate Reward in Women Remitted from Anorexia Nervosa.
Wierenga, C. E.,Bischoff-Grethe, A.,Melrose, A. J.,Irvine, Z.,Torres, L.,Bailer, U. F.,Simmons, A.,Fudge, J. L.,McClure, S. M.,Ely, A.,Kaye, W. H.> ;Biol. Psychiatry. 2014 Dec 08
Combat-exposed war veterans at risk for suicide show hyperactivation of prefrontal cortex and anterior cingulate during error processing.
Matthews S, Spadoni A, Knox K, Strigo I, Simmons A> ;Psychosom Med. 2012-06-01
169 citations
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.
Abdullah Yalcin, Brian F. Clem, Alan Simmons, Andrew N. Lane, Kristin K. Nelson, Amy L. Clem, Erin Brock, Deanna Siow, Binks W. Wattenberg, Sucheta Telang, Jason Chesney> ;The Journal of Biological Chemistry. 2009 Sep 4
Initial evidence of a failure to activate right anterior insula during affective set shifting in posttraumatic stress disorder.
Simmons, A.,Strigo, I. A.,Matthews, S. C.,Paulus, M. P.,Stein, M. B.> ;Psychosom Med. 2009 Apr 29
46 citations
Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response
Murali Gururajan, Alan Simmons, Trivikram Dasu, Brett T. Spear, Christopher Calulot, Darrell A. Robertson, David L. Wiest, John G. Monroe, Subbarao Bondada> ;Journal of Immunology. 2008 Oct 1
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Press Mentions

Not so Great Expectations: Pain in HIV Related to Brain’s Expectations of ReliefNovember 4th, 2021
Lumpy Flint Figurines May Be Some of the Earliest Depictions of Real PeopleJuly 13th, 2020

Professional Memberships

Society of Hospital Medicine - SHM
Member

Hospital Affiliations

Northwestern Medicine McHenryMchenry, Illinois