AlexKentsisMDPhD

PubMed

• Toward a Unified Theory of Why Young People Develop Cancer.
  Alex Kentsis> ;Cold Spring Harbor Perspectives in Medicine. 2024 May 1
• Childhood cancer mutagenesis caused by transposase-derived PGBD5.
  Makiko Yamada, Ross R Keller, Rodrigo Lopez Gutierrez, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Ho...> ;Science Advances. 2024 Mar 22
• overexpression synergizes with the loss ofand is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia.
  André Almeida, Sara T'Sas, Luca Pagliaro, Igor Fijalkowski, Wouter Sleeckx, Hannah Van Steenberge, Raffaella Zamponi, Béatrice Lintermans, Wouter Van Loocke, Bruno Pal...> ;Hemasphere. 2024 Mar 1
• 2 citations
  A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML.
  Tao Dao, Guangyan Xiong, Sung Soo Mun, Jeremy Meyerberg, Tatyana Korontsvit, Jingyi Xiang, Ziyou Cui, Aaron Y Chang, Casey Jarvis, Winson Cai, Hanzhi Luo, Aspen Pierso...> ;Blood. 2024 Feb 8
• 1 citations
  Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy.
  Kazansky, Y., Cameron, D., Mueller, H., Demarest, P., Zaffaroni, N., Arrighetti, N., Zuco, V., Kuwahara, Y., Somwar, R., Ladanyi, M., Qu, R., de Stanchina, E., Dela Cr...> ;Cancer Discovery. 2024 Feb 5
• Human iPSC modeling recapitulatessympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma.
  Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Inés Fernandez Maestre, Adrianna Amaro, Vaness...> ;Iscience. 2024 Jan 19
• 1 citations
  Epigenetic Cooperativity as a Therapeutic Vulnerability in Cancer.
  Yaniv Kazansky, Alex Kentsis> ;Cancer Research. 2023 Dec 1
• 1 citations
  SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
  Sarah Perlee, Sota Kikuchi, Tomoyoshi Nakadai, Takeshi Masuda, Sumio Ohtsuki, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo, Paolo Cifani, Alex Kentsis, Robert ...> ;EMBO Reports. 2023 Oct 9
• Integrative Proteogenomics Using ProteomeGenerator2.
  Nathaniel Kwok, Zita Aretz, Sumiko Takao, Zheng Ser, Paolo Cifani, Alex Kentsis> ;Journal of Proteome Research. 2023 Aug 4
• A transposase-derived gene required for human brain development.
  Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, Sara Lewis, Daniel Cameron, Phillip Demarest, Anika Nabila, Junfei Zhao, Paul Bergin, Casie Reed, Makiko...> ;Biorxiv. 2023 May 23
• 1 citations
  RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
  Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han...> ;Nature Communications. 2023 Apr 21
• 2 citations
  The tumor microenvironment and immune targeting therapy in pediatric renal tumors.
  Amy B Hont, Benoit Dumont, Kathryn S Sutton, John Anderson, Alex Kentsis, Jarno Drost, Andrew L Hong, Arnauld Verschuur> ;Pediatric Blood & Cancer. 2023 May 1
• Quantitative Cell Proteomic Atlas: Pathway-Scale Targeted Mass Spectrometry for High-Resolution Functional Profiling of Cell Signaling.
  Paolo Cifani, Alex Kentsis> ;Journal of Proteome Research. 2022 Oct 7
• 1 citations
  Myb drives B-cell neoplasms and myeloid malignancies in vivo.
  Tim Pieters, André Almeida, Sara T'Sas, Kelly Lemeire, Tino Hochepied, Geert Berx, Alex Kentsis, Steven Goossens, Pieter Van Vlierberghe> ;Blood Advances. 2022 May 24
• Automated Multidimensional Nanoscale Chromatography for Ultrasensitive Targeted Mass Spectrometry.
  Paolo Cifani, Alex Kentsis> ;Methods in Molecular Biology. 2022 Jan 1
• 38 citations
  The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
  Emily B Heikamp, Jill A Henrich, Florian Perner, Eric M. Wong, Charlie Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah Uckelmann,...> ;Blood. 2021 Sep 28
• 1 citations
  Corrigendum to "The C-terminal Domain of piggyBac Transposase is not Required for DNA Transposition" [J. Mol. Biol. 433 (2021) 166805].
  Laura Helou, Linda Beauclair, Hugues Dardente, Peter Arensburger, Nicolas Buisine, Yan Jaszczyszyn, Florian Guillou, Thierry Lecomte, Alex Kentsis, Yves Bigot> ;Journal of Molecular Biology. 2021 Jun 12
• 16 citations
  Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.
  Leonie Smeenk, Sophie Ottema, Roger Mulet-Lazaro, Anja Ebert, Marije Havermans, Andrea Arricibita Varea, Michaela Fellner, Dorien Pastoors, Stanley van Herk, Claudia A...> ;Cancer Discovery. 2021 May 12
• 25 citations
  Integrative analysis reveals unique structural and functional features of the Smc5/6 complex
  You Yu, Shibai Li, Zheng Ser, Tanmoy Sanyal, Koyi Choi, Bingbing Wan, Huihui Kuang, Andrej Sali, Alex Kentsis, Dinshaw J. Patel, Xiaolan Zhao> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 May 11
• 11 citations
  Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics.
  Paolo Cifani, Zhi Li, Danmeng Luo, Mark Grivainis, Andrew M. Intlekofer, David Fenyö, Alex Kentsis> ;Journal of Proteome Research. 2021 Mar 22
• 66 citations
  Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors.
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Cancer. 2021 Feb 15
• 31 citations
  Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
  Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G. Kharas, Rober...> ;Elife. 2021 Feb 2
• 6 citations
  The piggyBac-derived protein 5 (PGBD5) transposes both the closely and the distantly related piggyBac-like elements Tcr-pble and Ifp2.
  Laura Helou, Linda Beauclair, Hugues Dardente, Benoît Piégu, Louis Tsakou-Ngouafo, Thierry Lecomte, Alex Kentsis, Pierre Pontarotti, Yves Bigot> ;Journal of Molecular Biology. 2021 Apr 2
• 6 citations
  The C-terminal Domain of piggyBac Transposase Is Not Required for DNA Transposition.
  Laura Helou, Linda Beauclair, Hugues Dardente, Peter Arensburger, Nicolas Buisine, Yan Jaszczyszyn, Florian Guillou, Thierry Lecomte, Alex Kentsis, Yves Bigot> ;Journal of Molecular Biology. 2021 Apr 2
• 1 citations
  Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors.
  Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodriguez-Fos, Santiago Gonzalez, Montserra...> ;Nature Genetics. 2020 Nov 1
• Join now to see all

Journal Articles

• DPP8/DPP9 Inhibitor-Induced Pyroptosis for Treatment of Acute Myeloid Leukemia  
  Alex Kentsis, MD, Nature
• High sensitivity quantitative proteomics using accumulated ion monitoring and automated multidimensional nano-flow chromatography  
  Cifani P, Kentsis A, Mol Cell Proteomics, 1/18/2017
• Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors  
  Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung KL, Schult..., Science Transl Med, 1/1/2017
• A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition  
  Mathias MD, Ortiz MV, Magnan H, Ambati SR, Slotkin EK, Chou AJ, Walsh MF, Offit K, Moskowitz C, Kentsis A, Wexler LH, Biomark Res, 1/1/2017
• Genomics of primary chemoresistance and remission induction failure in pediatric and adult acute myeloid leukemia  
  Brown F, Cifani P, Drill E, He J, Still E, Zhong S, Balasubramanian S, Pavlick D, Yilmazel B, Knapp K, Alonzo TA, Meshinchi S, Stone R, Kornblau SM, Marcucci G, Gamis ..., Br J Haematol, 1/1/2017
• Towards comprehensive and quantitative proteomics for diagnostic and therapy of human disease  
  Cifani P, Kentsis A, Proteomics, 1/1/2017
• PGBD5 promotes site-specific oncogenic mutations in human tumors  
  Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gö..., Nature Genetics, 1/1/2017
• Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma  
  Ortiz MV, Magnan H, Slotkin EK, Ambati SR, Chou AJ, Wexler LH, Meyers PA, Walsh MF, Heaton T, Girardi LN, Wolden SL, Price AP, Kennedy JA, Zehir A, Hameed M, Berger MF..., J Pediatr Hematol Oncol, 1/1/2017
• ProteoModlR for functional proteomic analysis  
  Cifani P, Shakiba M, Chhangawala S, Kentsis A, BMC Bioinformatics, 1/1/2017
• Forward genetic screen of human transposase genomic rearrangements  
  Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gonen M, Villasante CM, Armstrong SA, Bauer DE, Weng Z, Kentsis A, BMC Genomics, 1/1/2016
• Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center  
  Ortiz MV, Kobos R, Walsh M, Slotkin EK, Roberts S, Berger MF, Hameed M, Solit D, Ladanyi M, Shukla N, Kentsis A, Pediatric Blood and Cancer, 1/1/2016
• Osteosarcoma with apparent Ewing sarcoma gene rearrangement  
  Mathias M, Chou AJ, Meyers P, Shukla N, Hameed M, Agaram N, Wang L, Berger MF, Walsh M, Kentsis A, J Hematol Oncol, 1/1/2016
• Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization  
  Sabath DE, Bender MA, Sankaran VG, Vamos E, Kentsis A, Yi HS, Greisman HA, J Mol Diagn, 1/1/2016
• Transposon mapping using flanking sequence exponential anchored (FLEA) PCR  
  Henssen A, Carson J, Kentsis A, Protocol Exchange, 1/22/2015
• Native proteome extraction protocol using poloxamer-based adaptive focused sonication  
  Dhabaria A, Cifani P, Reed C, Kentsis A, Protocol Exchange, 1/14/2015
• Fabrication of nanoelectrospray emitters for LC-MS  
  Cifani P, Dhabaria A, Kentsis A, Protocol Exchange, 1/9/2015
• Fabrication of capillary columns with integrated frits for mass spectrometry  
  Dhabaria A, Cifani P, Kentsis A, Protocol Exchange, 1/2/2015
• Targeting oncogenic interleukin-7 receptor signaling with N-acetylcysteine in T-cell acute lymphoblastic leukemia  
  Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S,..., Br J Haematol, 1/1/2015
• Genomic DNA transposition induced by human PGBD5  
  Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A, eLife, 1/1/2015
• Therapeutic re-activation of protein phosphatase 2A in acute myeloid leukemia  
  Ramaswamy K, Spitzer B, Kentsis A, Front Oncol, 1/1/2015
• High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the ...  
  Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB, J Hematol Oncol, 1/1/2015
• A high-efficiency cellular extraction system for biological proteomics  
  Dhabaria A, Cifani P, Reed C, Steen H, Kentsis A, J Proteome Res, 1/1/2015
• Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer  
  Muntel J, Xuan Y, Berger ST, Reiter L, Bachur R, Kentsis A, Steen H, J Proteome Res, 1/1/2015
• MStern blotting - high throughput PVDF membrane-based proteomic sample preparation for 96-well plates  
  Berger ST, Ahmed S, Muntel J, Cuevas Polo N, Bachur R, Kentsis A, Steen J, Steen H, Mol Cell Proteomics, 1/1/2015
• Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia  
  Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, Verplank L, An F, Burba..., J Clin Invest, 1/1/2014
• Join now to see all

Books/Book Chapters

• Nathan & Oski’s Hematology of Infancy and Childhood, and Orkin: Oncology of Infancy and Childhood 
  Chapter: Genetics and Epigenetics of Childhood Cancers. 
  Kentsis A, Roberts CW2013

Lectures

• Therapeutic Disassembly of Leukemogenic Enhancer Complexes 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Mechanism and function of human piggybac transposable element derived PGBD5 
  Big Sky, MT - 1/1/2017
• Functional proteomics of therapy resistance and aberrant gene control in acute myeloid leukemia 
  Cambridge, MA - 1/1/2017
• On the Causes of Childhood Cancer: Mechanisms and Therapy of Site-Specific Oncogenic Mutations by the Human DNA Transposase PGBD5 
  Johns Hopkins University School of Medicine - 1/1/2017
• Recent discoveries, therapies, and clinical implementation of rational pediatric oncology 
  Weill Cornell Medical College, New York, NY - 1/1/2017
• Towards Comprehensive and Quantitative Proteomics for Diagnosis and Therapy of Childhood Disease 
  Boston, MA - 1/1/2016
• Human Tumorigenesis Induced by an Endogenous DNA Transposase in Embryonal Tumors 
  New York, NY - 1/1/2016
• Human Tumorigenesis Induced by an Endogenous DNA Transposase in Renal Tumors 
  Toronto, Canada - 1/1/2016
• Functional proteomics of acute myeloid leukemia 
  Orlando, FL - 1/1/2015
• Therapeutic targeting of leukemogenic interleukin-7 receptor in acute lymphoblastic leukemia 
  Dallas, TX - 1/1/2014
• Functional proteomics for improved therapy of acute myeloid leukemia 
  Philadelphia, PA - 1/1/2014
• Tumorigenesis by endogenous DNA transposons in rhabdoid tumors 
  Washington, DC - 1/1/2014
• Urine proteomics of renal tumors for discovery of new prognostic markers and therapeutic targets 
  Bethesda, MD - 1/1/2013
• Urine proteomics for discovery of markers of human disease 
  Boston, MA - 1/1/2013
• Toward translational proteomics 
  Children’s Hospital Boston, Boston, MA - 1/1/2011
• Enzyme-linked immunosorbent assay of urine leucine-rich alpha-2-glycoprotein discriminates patients with acute appendicitis and correlates with appendicitis severity 
  Denver, CO - 1/1/2011
• Urine proteomics for profiling of human disease using high accuracy mass spectrometry 
  Erice, Sicily - 1/1/2010
• Discovery and validation of urine markers of acute pediatrics appendicitis using high accuracy mass spectrometry 
  Baltimore, MD - 1/1/2009
• Protein stability calculations using Monte Carlo and graph manifold learning 
  New York, NY - 1/1/2006
• Control of biochemical reactions through supramolecular RING domain self-assembly 
  Erice, Sicily - 1/1/2003
• Biochemical properties of promyelocytic leukemia protein PML 
  San Francisco, CA - 1/1/2002
• Join now to see all

Other

• Whole-genome sequencing in medicine: New knowledge, new responsibilities. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/24/2012
• Proteomics 2011. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/29/2011
• Patients and genes: Getting personal through information technology. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/30/2010
• Personalized rational medicine for all. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/22/2010
• Smart cancer drugs need smart clinical trials. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/5/2010
• Self-organization of biological systems, Ph.D. Dissertation. 
  Kentsis A
  New York University, New York, NY - 1/1/2004
• Folding and specification of native protein structure, S.M. Thesis. 
  Kentsis A
  University of Chicago, Chicago, IL - 1/1/1998
• Between light and eye: Goethe’s science of color and the polar phenomenology of nature. 
  Kentsis A
• Join now to see all