AlexanderKolevzonMD

Psychiatry • New York, NY

Child & Adolescent Psychiatry

Professor, Psychiatry and Pediatrics, Icahn School of Medicine

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Office
1425 Madison Ave
New York, NY 10029
Phone+1 212-659-9134

Fax+1 212-996-8931
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Education & Training

Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalFellowship, Child and Adolescent Psychiatry, 2003 - 2005
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Psychiatry, 2000 - 2003
Tel Aviv University SacklerClass of 2000

Certifications & Licensure

NY State Medical License 2001 - 2025
FL State Medical License 2015 - 2017
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Child & Adolescent Psychiatry

Clinical Trials

Trichuris Suis Ova in Autism Spectrum Disorders Start of enrollment: 2012 Nov 01
Completed
Phase 1
Clinical Trial in 22q13 Deletion Syndrome(Phelan-McDermid Syndrome) Start of enrollment: 2012 Feb 01
Completed
Phase 2
A Safety Study of NNZ-2566 in Patients With Fragile X Syndrome Start of enrollment: 2014 Jan 01
Completed
Phase 2
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors Start of enrollment: 2014 Aug 01
Completed
Phase 2
A Pilot Treatment Study of Insulin-Like Growth Factor-1 (IGF-1) in Autism Spectrum Disorder Start of enrollment: 2014 May 01
Terminated
Phase 2
Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome Start of enrollment: 2015 May 01
Recruiting
Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome Start of enrollment: 2016 Apr 29
Completed
Phase 2
AMO-01 to Treat Adolescents and Adults With Phelan-McDermid Syndrome (PMS) and Co-morbid Epilepsy Start of enrollment: 2018 May 30
Completed
Phase 2
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures. Start of enrollment: 2018 May 22
Recruiting
FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures. Start of enrollment: 2016 Mar 28
Recruiting
ADNP Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing ADNP-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures. Start of enrollment: 2017 Nov 14
Recruiting
Growth Hormone Treatment in Children With Phelan McDermid Syndrome Start of enrollment: 2019 Sep 13
Completed
Phase 2
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Publications & Presentations

PubMed

Caregiver perspectives on patient-focused drug development for Phelan-McDermid syndrome.
Luciana Gizzo, Geraldine Bliss, Chrystal Palaty, Alexander Kolevzon> ;Orphanet Journal of Rare Diseases. 2024 Mar 26
Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome.
Ariela S Buxbaum Grice, Laura Sloofman, Tess Levy, Hannah Walker, Gauri Ganesh, Miguel Rodriguez de Los Santos, Pardis Armini, Joseph D Buxbaum, Alexander Kolevzon, An...> ;Medrxiv. 2024 Jan 31
Gait Abnormalities in Children with Phelan-McDermid Syndrome.
Yitzchak Frank, Tess Levy, Reymundo Lozano, Kate Friedman, Slayton Underwood, Ana Kostic, Hannah Walker, Alexander Kolevzon> ;Journal of Child Neurology. 2023 Dec 1
3 citations
An adapted clinical global Impression of improvement for use in Angelman syndrome: Validation analyses utilizing data from the NEPTUNE study.
Pamela Ventola, Judith Jaeger, Christopher J Keary, Alexander Kolevzon, Maxwell Adams, Bina Keshavan, Celia Zinger-Salmun, Cesar Ochoa-Lubinoff> ;European Journal of Paediatric Neurology. 2023 Nov 1
1 citations
Development of webcam-collected and artificial-intelligence-derived social and cognitive performance measures for neurodevelopmental genetic syndromes.
Thomas W Frazier, Robyn M Busch, Patricia Klaas, Katherine Lachlan, Shafali Jeste, Alexander Kolevzon, Eva Loth, Jacqueline Harris, Leslie Speer, Tom Pepper, Kristin A...> ;American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 2023 Sep 1
5 citations
Updated consensus guidelines on the management of Phelan-McDermid syndrome.
Siddharth Srivastava, Mustafa Sahin, Joseph D Buxbaum, Elizabeth Berry-Kravis, Latha Valluripalli Soorya, Audrey Thurm, Jonathan A Bernstein, Afua Asante-Otoo, William...> ;American Journal of Medical Genetics. Part A. 2023 Aug 1
2 citations
Gaboxadol in angelman syndrome: A double-blind, parallel-group, randomized placebo-controlled phase 3 study.
Christopher Keary, Lynne M Bird, Marie-Claire de Wit, Shivkumar Hatti, Gali Heimer, Helen Heussler, Alexander Kolevzon, Adera Mathews, Cesar Ochoa-Lubinoff, Wen-Hann T...> ;European Journal of Paediatric Neurology. 2023 Nov 1
Prospective phenotyping of CHAMP1 disorder indicates that coding mutations may not act through haploinsufficiency.
Tess Levy, Thariana Pichardo, Hailey Silver, Bonnie Lerman, Jessica Zweifach, Danielle Halpern, Paige M Siper, Alexander Kolevzon, Joseph D Buxbaum> ;Human Genetics. 2023 Sep 1
2 citations
Development of informant-report neurobehavioral survey scales for PTEN hamartoma tumor syndrome and related neurodevelopmental genetic syndromes.
Frazier, T., Busch, R., Klaas, P., Lachlan, K., Jeste, S., Kolevzon, A., Loth, E., Harris, J., Speer, L., Pepper, T., Anthony, K., Graglia, J., Delagrammatikas, C., Be...> ;American Journal of Medical Genetics. Part A. 2023 Jul 1
1 citations
ADNP Syndrome: A Qualitative Assessment of Symptoms, Therapies, and Challenges.
Jarrett Fastman, Alexander Kolevzon> ;Children. 2023 Mar 20
15 citations
Comorbidities in autism spectrum disorder and their etiologies.
Vahe Khachadourian, Behrang Mahjani, Sven Sandin, Alexander Kolevzon, Joseph D Buxbaum, Abraham Reichenberg, Magdalena Janecka> ;Translational Psychiatry. 2023 Feb 25
3 citations
Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome.
Michael S Breen, Xuanjia Fan, Tess Levy, Rebecca M Pollak, Brett Collins, Aya Osman, Anna S Tocheva, Elizabeth Berry-Kravis, Latha Soorya, Audrey Thurm, Craig M Powell...> ;HGG Advances. 2023 Jan 12
3 citations
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.
Stephen K Siecinski, Stephanie N Giamberardino, Marina Spanos, Annalise C Hauser, Jason R Gibson, Tara Chandrasekhar, Maria Del Pilar Trelles, Carol M Rockhill, Michel...> ;Autism Research. 2023 Mar 1
7 citations
An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose ketamine in children with ADNP syndrome.
Alexander Kolevzon, Tess Levy, Sarah Barkley, Sandra Bedrosian-Sermone, Matthew Davis, Jennifer Foss-Feig, Danielle Halpern, Katherine Keller, Ana Kostic, Christina La...> ;HGG Advances. 2022 Oct 13
2 citations
Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.
Kimberly L H Carpenter, Naomi O Davis, Marina Spanos, Maura Sabatos-DeVito, Rachel Aiello, Grace T Baranek, Scott N Compton, Helen L Egger, Lauren Franz, Soo-Jeong Kim...> ;Journal of Autism and Developmental Disorders. 2022 Oct 12
Enhancing Child and Adolescent Psychiatry Recruitment Through a Medical Student Mentorship Network: A Qualitative Study.
Anita Kishore, Madeline DiGiovanni, Kevin Lee Sun, Alexander Kolevzon, Laelia Benoit, Andrés Martin> ;Academic Psychiatry. 2023 Apr 1
3 citations
CHAMP1 disorder is associated with a complex neurobehavioral phenotype including autism, ADHD, repetitive behaviors and sensory symptoms.
Tess Levy, Bonnie Lerman, Danielle Halpern, Yitzchak Frank, Christina Layton, Jessica Zweifach, Paige M Siper, Joseph D Buxbaum, Alexander Kolevzon> ;Human Molecular Genetics. 2022 Aug 17
6 citations
Cancer risk in individuals with autism spectrum disorder.
Q Liu, W Yin, J J Meijsen, A Reichenberg, J R Gådin, A J Schork, H-O Adami, A Kolevzon, S Sandin, F Fang> ;Annals of Oncology. 2022 Jul 1
1 citations
Brief Report: Assessment of a Caregiver-Implemented Intervention for Improving Social Communication Skills in Toddlers and Young Children with Autism.
Audrey A Rouhandeh, Christine Honsberger, Nathaniel A Shanok, Erin Brooker Lozott, Tess Levy, Alexander Kolevzon, Joseph D Buxbaum, Marlene Sotelo, Jennifer Foss-Feig,...> ;Journal of Autism and Developmental Disorders. 2024 Feb 1
12 citations
Clinical trial of insulin-like growth factor-1 in Phelan-McDermid syndrome.
A Kolevzon, M S Breen, P M Siper, D Halpern, Y Frank, H Rieger, J Weismann, M P Trelles, B Lerman, R Rapaport, J D Buxbaum> ;Molecular Autism. 2022 Apr 8
2 citations
Intra-topic latency as an automated behavioral marker of treatment response in autism spectrum disorder.
Elizabeth P McKernan, Manoj Kumar, Adriana Di Martino, Lisa Shulman, Alexander Kolevzon, Catherine Lord, Shrikanth Narayanan, So Hyun Kim> ;Scientific Reports. 2022 Feb 28
4 citations
A proof-of-concept study of growth hormone in children with Phelan-McDermid syndrome.
S Sethuram, T Levy, J Foss-Feig, D Halpern, S Sandin, P M Siper, H Walker, J D Buxbaum, R Rapaport, A Kolevzon> ;Molecular Autism. 2022 Jan 29
5 citations
Neural Markers of Auditory Response and Habituation in Phelan-McDermid Syndrome.
Emily L Isenstein, Hannah E Grosman, Sylvia B Guillory, Yian Zhang, Sarah Barkley, Christopher S McLaughlin, Tess Levy, Danielle Halpern, Paige M Siper, Joseph D Buxba...> ;Frontiers in Neuroscience. 2022 Jan 1
2 citations
Social visual attentional engagement and memory in Phelan-McDermid syndrome and autism spectrum disorder: a pilot eye tracking study.
Sylvia B Guillory, Victoria Z Baskett, Hannah E Grosman, Christopher S McLaughlin, Emily L Isenstein, Emma Wilkinson, Jordana Weissman, Bari Britvan, M Pilar Trelles, ...> ;Journal of Neurodevelopmental Disorders. 2021 Dec 4
4 citations
Parent-reported measure of repetitive behavior in Phelan-McDermid syndrome.
Siddharth Srivastava, Emma Condy, Erin Carmody, Rajna Filip-Dhima, Kush Kapur, Jonathan A. Bernstein, Elizabeth Berry-Kravis, Craig M. Powell, Latha Soorya, Audrey Thu...> ;Journal of Neurodevelopmental Disorders. 2021 Nov 5
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Press Mentions

Clinical Trial for Rare Genetic Disease Gets Assistance from Artificial IntelligenceNovember 4th, 2022
Ketamine Promising for Rare Condition Linked to AutismSeptember 13th, 2022
Ketamine May Be Effective in Treating Children with ADNP SyndromeSeptember 12th, 2022
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Grant Support

OPEN Label Risperidone In Children And Adolescents With Autistic DisorderNational Center For Research Resources2009
Effect Of Fluoxetine Orally Dissolving Tablet (ODT) On Repetitive BehaviorsNational Center For Research Resources2008

Hospital Affiliations

The Mount Sinai HospitalNew York, New York
Mount Sinai MorningsideNew York, New York
Mount Sinai WestNew York, New York
Mount Sinai Hospital of QueensAstoria, New York
Mount Sinai BrooklynBrooklyn, New York
Mount Sinai Beth IsraelNew York, New York