Alexander Gerhard Miethke MD

Pediatric Gastroenterology•Cincinnati, OH

Pediatric Hepatology and Liver Transplantation

Assistant Professor, Pediatrics, University of Cincinnati College of Medicine

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3333 Burnet AvenueGastroenterology & Nutrition Ml 2010Cincinnati, OH 45229
Phone+1 513-636-4415
Fax+1 513-636-7805

Education & Training

Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Transplant Hepatology, 2008 - 2009
Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Gastroenterology, 2005 - 2008
Cincinnati Children's Hospital Medical CenterResidency, Pediatrics, 2002 - 2005
Humboldt University of Berlin - Charite Faculty of MedicineClass of 2000

Certifications & Licensure

KY State Medical License 2024 - 2026
OH State Medical License 2002 - 2026
IN State Medical License 2024 - 2025
MI State Medical License 2016 - 2020
American Board of Pediatrics Pediatric Gastroenterology
American Board of Pediatrics Pediatric Transplant Hepatology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

A Prospective Database of Infants With Cholestasis Start of enrollment: 2004 Apr 21
RECRUITING
Biliary Atresia Study in Infants and Children Start of enrollment: 2006 May 16
RECRUITING
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) Start of enrollment: 2007 Nov 30
SUSPENDED
Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Start of enrollment: 2010 Oct 01
Completed
Phase 1
Longitudinal Study of Mitochondrial Hepatopathies Start of enrollment: 2010 Aug 18
SUSPENDED
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome Start of enrollment: 2014 Nov 24
Completed
Phase 2
Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis Start of enrollment: 2014 Mar 01
Completed
Phase 2
A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC) Start of enrollment: 2019 Jul 09
Completed
Phase 3
MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Start of enrollment: 2017 Feb 20
RECRUITING
Roles: Principal Investigator, Contact
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Start of enrollment: 2017 Jan 17
RECRUITING
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.
Susan M White, Annelotte P Wondergem, Isa Breet, Maren Dittmaier, Katrina Bell
European Journal of Human Genetics. 2025-07-19
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies.
Ramesh Kudira, Zi F Yang, Immaculeta Osuji, Michelle S M A Damen, Annika Yang Vom Hofe
Journal of Hepatology. 2025-06-20
Pediatric endoscopic ultrasound-guided liver biopsy: 3-year experience.
Talia S Schwartz, Marialena Mouzaki, Lara Berklite, Oscar F Lopez-Nunez, Alexander Miethke
Journal of Pediatric Gastroenterology and Nutrition. 2025-05-01

Journal Articles

Putting It All Together: Established and Emerging MRI Techniques for Detecting and Measuring Liver Fibrosis
Stavra A Xanthakos, Eric Diaz, Jonathan R Dillman, Alexander Miethke, Pediatric Radiology

Press Mentions

Gucy1α1 Acts as Fibrosis Biomarker in Multiple OrgansJanuary 30th, 2025
Deleterious Variants in ABCC12 Are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model OrganismsMarch 23rd, 2021

Grant Support

The role of regulatory T cells in Biliary AtresiaNIH/NIDDK2012–Present