Amit Vikram Khera MD

Preventive Cardiology

Cardiologist and preventive genomics, Massachusetts General Hospital Group leader, MGH Center for Genomic Medicine Associate Director, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard Assistant Professor, Harvard Medical School

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185 Cambridge StreetSimches Research Building | CPZN 6.256Boston, MA 02114

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Summary

Amit V. Khera, MD MSc, is a cardiologist, human geneticist, and population biologist at Massachusetts General Hospital (MGH), group leader within the MGH Center for Genomic Medicine, Associate Director of the Program in Medical and Population Genetics and Merkin Institute Fellow at the Broad Institute of MIT and Harvard, and Assistant Professor at Harvard Medical School.

He received his MD with Alpha Omega Alpha distinction from the Perelman School of Medicine at the University of Pennsylvania and went on to complete clinical training in Internal Medicine and cardiology at Brigham and Women's Hospital and MGH. He completed a Masters of Science at the Harvard School of Public Health and a postdoctoral research fellowship with Dr. Sekar Kathiresan in human genetics at the Broad Institute of MIT and Harvard prior to accepting a faculty position.

His research program (kheralab.org) uses genetic variation as a tool to uncover new biology and enable enhanced clinical care informed by inherited susceptibility.

He has developed expertise in epidemiology, clinical medicine, and human genetics. Among his scientific contributions, he pioneered use of a new approach to quantify genetic risk (‘genome-wide polygenic scores’) for common diseases, developed biomarkers that provide new biologic insights, and analyzed large-scale gene sequencing data to highlight key pathways driving risk and identify molecular subtypes of cardiometabolic diseases.

Dr. Khera has authored more than 80 scientific publications, including lead-authored publications in the New England Journal of Medicine, Journal of the American Medical Association, Cell, Nature Reviews Genetics, Nature Genetics, Journal of the American College of Cardiology, and Circulation. His work has been recognized as among the top ten research advances by the American Heart Association (in both 2016 and 2018), and he is the 2019 recipient of the Douglas P. Zipes Distinguished Young Scientist Award from the American College of

Khera Lab

We use genetic variation to better understand the causes of cardiovascular and other important diseases and to enable a new era of personalized genomic medicine

Education & Training

Harvard T.H. Chan School of Public HealthMSc, Epidemiology, 2015 - 2017
Mass General Brigham/Massachusetts General HospitalFellowship, Cardiovascular Disease, 2013 - 2016
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 2010 - 2013
Perelman School of Medicine at the University of PennsylvaniaClass of 2010

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Certifications & Licensure

MA State Medical License 2013 - 2028
American Board of Internal Medicine Cardiovascular Disease

Publications & Presentations

PubMed

1 citations
Inherited risk of coronary artery disease: redefining care with imaging and genetics.
Nick S R Lan, Girish Dwivedi, Graham S Hillis, Derek P Chew, Bu B Yeap
Nature Reviews. Cardiology. 2026-08-01
Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.
Jianfeng Xu, Zhuqing Shi, Sumeet A Khetarpal, Ashley J Mulford, Osama Siddiqui
Circulation. Genomic and Precision Medicine. 2026-06-01
6 citations
Inherited Genetic Risk of Liver Fibrosis in Lean Versus Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Kaleb Tesfai, Luis Antonio Díaz, Juan Pablo Arab, Marco Arrese, Francisco Idalsoaga
Alimentary Pharmacology & Therapeutics. 2026-03-01

Journal Articles

Genome-Wide Polygenic Scores for Common Diseases Identify Individuals with Risk Equivalent to Monogenic Mutations
Amit V Khera, Steven A Lubitz, Sekar Kathiresan, Patrick T Ellinor, Krishna G Aragam, Pradeep Natarajan, Nature

Press Mentions

Predicting Long-Term Risk of CVD in US Adults with the PREVENT EquationsJune 11th, 2025
The Latest Thinking on Inherited High CholesterolDecember 1st, 2024
Alzheimer’s: A New Method Can Spot the Disease Before Any Symptoms AppearSeptember 1st, 2022