AndrewLeeMD

PubMed

• 2 citations
  Backbone and ILVM methyl resonance assignments of human thymidylate synthase in apo and substrate bound forms.
  Jeffrey P. Bonin, Andrew L. Lee> ;Biomolecular NMR Assignments. 2021 Jan 24
• 82 citations
  Mapping allosteric communications within individual proteins.
  Jian Wang, Abha Jain, Leanna R. McDonald, Craig Gambogi, Andrew L. Lee, Nikolay V. Dokholyan> ;Nature Communications. 2020 Jul 31
• 12 citations
  Isotopic Labeling of Formate Dehydrogenase Perturbs the Protein Dynamics.
  Chethya Ranasinghe, Philip Pagano, Paul J. Sapienza, Andrew L. Lee, Amnon Kohen, Christopher M. Cheatum> ;The Journal of Physical Chemistry. B. 2019 Nov 7
• 8 citations
  Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
  Jeffrey P Bonin, Paul J Sapienza, Emily Wilkerson, Dennis Goldfarb, Li Wang, Laura Herring, Xian Chen, Michael B Major, Andrew L Lee> ;Biophysical Journal. 2019 Sep 17
• 8 citations
  Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
  Paul J. Sapienza, Konstantin I. Popov, David D. Mowrey, Bradley T. Falk, Nikolay V. Dokholyan, Andrew L. Lee> ;Biochemistry. 2019 Jul 18
• 8 citations
  Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase
  Andrew L. Lee, Paul J. Sapienza> ;Frontiers in Molecular Biosciences. 2018 May 25
• 12 citations
  Protein Mass Effects on Formate Dehydrogenase.
  Chethya Ranasinghe, Qi Guo, Paul J. Sapienza, Andrew L. Lee, Daniel M. Quinn, Christopher M. Cheatum, Amnon Kohen> ;Journal of the American Chemical Society. 2017 Nov 27
• 7 citations
  Widespread perturbation of function, structure, and dynamics by a conservative single-Atom substitution in thymidylate synthase
  Paul J. Sapienza, Andrew L. Lee> ;Biochemistry. 2016 Sep 30
• 14 citations
  Chemical shift imprint of intersubunit communication in a symmetric homodimer.
  Bradley T. Falk, Paul J. Sapienza, Andrew L. Lee> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Aug 23
• 12 citations
  An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement without Ordered Ground-State Tertiary Structures
  Paul J. Sapienza, Li Li, Tishan Williams, Andrew L. Lee, Charles W. Carter> ;ACS Chemical Biology. 2016 Apr 7
• 19 citations
  The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase
  Kevin Francis, Paul J. Sapienza, Andrew L. Lee, Amnon Kohen> ;Biochemistry. 2016 Feb 9
• 16 citations
  Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.
  Paul J. Sapienza, Bradley T. Falk, Andrew L. Lee> ;Journal of the American Chemical Society. 2015 Nov 9
• 17 citations
  Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95
  Andrew L. Lee> ;Biophysical Reviews. 2015 Apr 22
• 8 citations
  Backbone and ILV methyl resonance assignments of E. coli thymidylate synthase bound to cofactor and a nucleotide analogue.
  Paul J. Sapienza, Andrew L. Lee> ;Biomolecular NMR Assignments. 2014 Apr 1
• 1 citations
  Monitoring Side-Chain Dynamics of Proteins Using 2 H Relaxation
  Chad M. Petit, Andrew L. Lee> ;Methods in Molecular Biology. 2014 Jan 1
• 27 citations
  Colocalization of fast and slow timescale dynamics in the allosteric signaling protein CheY.
  Leanna R. McDonald, Matthew J. Whitley, Joshua A. Boyer, Andrew L. Lee> ;Journal of Molecular Biology. 2013 Jul 10
• 20 citations
  Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
  Zhen Wang, Paul J. Sapienza, Thelma Abeysinghe, Calvin Luzum, Andrew L. Lee, Janet Finer-Moore, Robert M. Stroud, Amnon Kohen> ;Journal of the American Chemical Society. 2013 May 10
• 50 citations
  Supertertiary Structure of the MAGUK Core from PSD-95
  Jun Zhang, Steven M. Lewis, Brian Kuhlman, Andrew L. Lee> ;Structure. 2013 Mar 5
• 35 citations
  Segmental Motions, Not a Two-State Concerted Switch, Underlie Allostery in CheY
  Leanna R. McDonald, Joshua A. Boyer, Andrew L. Lee> ;Structure. 2012 Aug 8
• 22 citations
  Structure and dynamics of the G121V dihydrofolate reductase mutant: lessons from a transition-state inhibitor complex.
  Randall V. Mauldin, Paul J. Sapienza, Chad M. Petit, Andrew L. Lee> ;Plos One. 2012 Mar 13
• 64 citations
  Evidence for dynamics in proteins as a mechanism for ligand dissociation
  Mary J. Carroll, Randall V. Mauldin, Anna V. Gromova, Scott F. Singleton, Edward J. Collins, Andrew L. Lee> ;Nature Chemical Biology. 2012 Mar 1
• 54 citations
  Phosphorylation of a PDZ Domain Extension Modulates Binding Affinity and Interdomain Interactions in Postsynaptic Density-95 (PSD-95) Protein, a Membrane-associated Gu...
  Jun Zhang, Chad M. Petit, David S. King, Andrew L. Lee> ;The Journal of Biological Chemistry. 2011 Dec 2
• 14 citations
  Direct Detection of Structurally Resolved Dynamics in a Multiconformation Receptor—Ligand Complex
  Mary J. Carroll, Anna V. Gromova, Keith R. Miller, Hao Tang, Xiang Simon Wang, Ashutosh Tripathy, Scott F. Singleton, Edward J. Collins, Andrew L. Lee> ;Journal of the American Chemical Society. 2011 Apr 27
• 5 citations
  Exploring the role of structure and dynamics in the function of chymotrypsin inhibitor 2.
  Matthew J. Whitley, Andrew L. Lee> ;Proteins. 2011 Mar 1
• 28 citations
  Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate.
  Paul J. Sapienza, Randall V. Mauldin, Andrew L. Lee> ;Journal of Molecular Biology. 2011 Jan 14
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