AnneKlibanskiMD

Endocrinology • Boston, MA

Pituitary Disorders & Neuroendocrinology

Laurie Carrol Guthart Professor of Medicine, Massachusetts General Hospital

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Office
Zero Emerson Suite 112 Eo 112
Massachusetts General Hospital
Boston, MA 02114
Phone+1 617-726-7948

Fax+1 617-726-5072
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Education & Training

Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 1981 - 1981
Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 1978 - 1980
NYU Grossman School of MedicineResidency, Internal Medicine, 1975 - 1978
New York University School of MedicineClass of 1975

Certifications & Licensure

MA State Medical License 1978 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1991

Clinical Trials

Androgen Replacement Therapy in Women With Hypopituitarism Start of enrollment: 2001 Sep 01
Completed
Not Applicable
Effects of Anorexia Nervosa on Bone Mass in Adolescents Start of enrollment: 2003 Jul 01
Completed
Phase 2, Phase 3
Bone Loss in Women With Anorexia Nervosa Start of enrollment: 2003 Jun 01
Completed
Phase 2, Phase 3
Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women Start of enrollment: 2002 Jan 01
Completed
Not Applicable
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents Start of enrollment: 2005 May 01
Completed
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency Start of enrollment: 2004 Aug 01
Completed
Not Applicable
Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa Start of enrollment: 2006 Jan 01
Completed
Phase 2
Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea Start of enrollment: 2006 Mar 01
Completed
The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa Start of enrollment: 2008 Sep 01
Completed
Phase 2
The Effect of Testosterone Replacement on Bone Mineral Density in Boys and Men With Anorexia Nervosa Start of enrollment: 2008 Dec 01
Withdrawn
Phase 2
Long-term Cardiovascular Risk in Cured Cushing's Patients Start of enrollment: 2008 Sep 08
Terminated
Hormonal Factors in the Treatment of Anorexia Nervosa Start of enrollment: 2010 Apr 01
Completed
Phase 2
Effects of Anorexia Nervosa on Peak Bone Mass Start of enrollment: 2011 Feb 01
Completed
Phase 3
IGF-1 and Bone Loss in Women With Anorexia Nervosa Start of enrollment: 2011 Oct 01
Completed
Not Applicable
Phase 2 Pilot Study to Evaluate the Safety and Efficacy of RM-131 Administered to Females With Anorexia Nervosa Start of enrollment: 2012 Nov 01
Completed
Phase 2
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Publications & Presentations

PubMed

7 citations
Bone marrow adipose tissue is associated with fracture history in anorexia nervosa.
T Dang, A T Faje, E Meenaghan, M A Bredella, M L Bouxsein, A Klibanski, P K Fazeli> ;Osteoporosis International. 2022 Dec 1
1 citations
Physiologic Transdermal Estradiol Replacement Mimics Effects of Endogenous Estrogen on Bone Outcomes in Hypoestrogenic Women with Anorexia Nervosa.
Vibha Singhal, Supritha Nimmala, Meghan Slattery, Kamryn T Eddy, Karen K Miller, Anne Klibanski, Madhusmita Misra> ;Nutrients. 2022 Jun 21
3 citations
High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M Botticelli, Yunli Zhou, E Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J Soberman, Anne Kliban...> ;Frontiers in Oncology. 2022 Jan 1
3 citations
Sprouting Angiogenesis in Human Pituitary Adenomas.
Jie Zhou, Yaomin Hu, Wende Zhu, Chuansheng Nie, Wenxiu Zhao, Alexander T Faje, Kay E Labelle, Brooke Swearingen, Hang Lee, E Tessa Hedley-Whyte, Xun Zhang, Pamela S Jo...> ;Frontiers in Oncology. 2022 Jan 1
1 citations
Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior.
Franziska Plessow, Francesca Galbiati, Kamryn T Eddy, Madhusmita Misra, Karen K Miller, Anne Klibanski, Anna Aulinas, Elizabeth A Lawson> ;Frontiers in Endocrinology. 2022 Jan 1
2 citations
The effect of short-term high-caloric feeding and fasting on bone microarchitecture.
Miriam A. Bredella, Pouneh K. Fazeli, Jenna Bourassa, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski, Karen K. Miller> ;Bone. 2022 Jan 1
Proton Stereotactic Radiotherapy for Treatment of Nelson's Syndrome.
Daniel Kim, Grace M. Lee, E Cai, Brooke Swearingen, Paul H. Chapman, M.R. Bussiere, Anne Klibanski, Jay S. Loeffler, Helen A. Shih> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
6 citations
Sequential therapy with recombinant human IGF-1 followed by risedronate increases spine bone mineral density in women with anorexia nervosa: A randomized, placebo-cont...
Melanie S Haines, Allison Kimball, Erinne Meenaghan, Katherine N. Bachmann, Kate Santoso, Kamryn T. Eddy, Vibha Singhal, Seda Ebrahimi, Esther Dechant, Thomas Weigel, ...> ;Journal of Bone and Mineral Research. 2021 Sep 2
11 citations
Bone marrow adipose tissue composition following high-caloric feeding and fasting.
Miriam A. Bredella, Colleen Buckless, Pouneh K. Fazeli, Clifford J. Rosen, Martin Torriani, Anne Klibanski, Karen K. Miller> ;Bone. 2021 Jun 27
25 citations
The dynamics of human bone marrow adipose tissue in response to feeding and fasting
Pouneh K. Fazeli, Miriam A. Bredella, Olga Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth O'Donnel...> ;JCI Insight. 2021 Jun 22
2 citations
A cross-nearest neighbor/Monte Carlo algorithm for single-molecule localization microscopy defines interactions between p53, Mdm2, and MEG3.
Nicholas C. Bauer, Anli Yang, Xin Wang, Yunli Zhou, Anne Klibanski, Roy J. Soberman> ;The Journal of Biological Chemistry. 2021 Jan 1
8 citations
Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa
Vibha Singhal, Amita Bose, Meghan Slattery, Melanie S Haines, Mark A. Goldstein, Nupur Gupta, Kathryn S. Brigham, Seda Ebrahimi, Kristin N. Javaras, Mary L. Bouxsein, ...> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Jun 16
5 citations
Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypoth...
Vibha Singhal, Amita Bose, Colleen Buckless, Kathryn E. Ackerman, Miriam A. Bredella, Anne Klibanski, Madhusmita Misra, Nazanin Hazhir Karzar> ;Bone. 2021 Apr 1
7 citations
Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study.
Liya Kerem, Laura M. Holsen, Pouneh K. Fazeli, Miriam A. Bredella, Christopher P. Mancuso, Tara M. Holmes, Anne Klibanski, Elizabeth A. Lawson, Megi Resulaj> ;Physiological Reports. 2021 Jan 1
32 citations
Accuracy of Laboratory Tests for the Diagnosis of Cushing Syndrome
Brandon P Galm, Nidan Qiao, Anne Klibanski, Beverly M. K. Biller, Nicholas A. Tritos> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1
17 citations
Red and White Blood Cell Counts Are Associated With Bone Marrow Adipose Tissue, Bone Mineral Density, and Bone Microarchitecture in Premenopausal Women.
Sai P. Polineni, Alexander T. Faje, Erinne Meenaghan, Miriam A. Bredella, Mary L. Bouxsein, Hang Lee, Ormond A. MacDougald, Anne Klibanski, Pouneh K. Fazeli> ;Journal of Bone and Mineral Research. 2020 Jun 1
8 citations
Impact of BDNF and sex on maintaining intact memory function in early midlife.
Kyoko Konishi, Sara Cherkerzian, Sarah A. Aroner, Emily G. Jacobs, Dorene M. Rentz, Anne Remington, Harlyn G. Aizley, Mady Hornig, Anne Klibanski, Jill M. Goldstein> ;Neurobiology of Aging. 2020 Apr 1
7 citations
All-cause mortality in patients with acromegaly treated with pegvisomant: an ACROSTUDY analysis.
Nicholas A. Tritos, Anders F Mattsson, Greisa Vila, Beverly M. K. Biller, Anne Klibanski, Srinivas Rao Valluri, Judith Hey-Hadavi, Nicky Kelepouris, Camilo Jimenez> ;European Journal of Endocrinology. 2020 Mar 1
22 citations
The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause.
Allison Kimball, Laura E. Dichtel, Maren Nyer, David Mischoulon, Lauren B. Fisher, Cristina Cusin, Christina Dording, Nhi-Ha Trinh, Albert Yeung, Melanie S Haines, Jos...> ;Psychoneuroendocrinology. 2020 Feb 1
5 citations
IGF-1 is associated with estimated bone strength in anorexia nervosa.
Pouneh K. Fazeli, Alexander T. Faje, Erinne Meenaghan, Stephen T. Russell, Megi Resulaj, Hang Lee, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski> ;Osteoporosis International. 2020 Feb 1
18 citations
Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial.
Kathryn E. Ackerman, Vibha Singhal, Meghan Slattery, Kamryn T. Eddy, Mary L. Bouxsein, Hang Lee, Anne Klibanski, Madhusmita Misra> ;Journal of Bone and Mineral Research. 2020 Feb 1
10 citations
MRI texture analysis in acromegaly and its role in predicting response to somatostatin receptor ligands
Brandon P Galm, Colleen Buckless, Brooke Swearingen, Martin Torriani, Anne Klibanski, Miriam A. Bredella, Nicholas A. Tritos> ;Pituitary. 2020 Jan 2
7 citations
Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus
Wende Zhu, Erin M. Botticelli, Rachel Kery, Yanfei Mao, Xin Wang, Anli Yang, Xianling Wang, Jie Zhou, Xun Zhang, Roy J. Soberman, Anne Klibanski, Yunli Zhou> ;Developmental Biology. 2019 Nov 1
1 citations
Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature.
Youn Hee Jee, Kun Song Lee, Shanna Yue, Ellen W. Leschek, Matthew G. Boden, Aysha Jadra, Anne Klibanski, Priya Vaidyanathan, Madhusmita Misra, Young Pyo Chang, Jack A....> ;Plos One. 2019 Oct 24
9 citations
A Randomized Placebo-Controlled Trial of Low-Dose Testosterone Therapy in Women With Anorexia Nervosa.
Allison Kimball, Melanie Schorr, Erinne Meenaghan, Katherine N. Bachmann, Kamryn T. Eddy, Madhusmita Misra, Elizabeth A. Lawson, Elana Kreiger-Benson, David B. Herzog,...> ;The Journal of Clinical Endocrinology and Metabolism. 2019 Oct 1
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Journal Articles

Effects of Anorexia Nervosa on Bone Metabolism
Anne Klibanski, Pouneh K Fazeli, Endocrine Reviews
A Consensus Statement on Acromegaly Therapeutic Outcomes
David R Clemmons, Shlomo Melmed, Anne Klibanski, Nature
Effects of Growth Hormone Therapy on Bone Density and Fracture Risk in Age-Related Osteoporosis in the Absence of Growth Hormone Deficiency: A Systematic Review and Me...
Anne Klibanski, Nicholas A Tritos, Endocrine

Press Mentions

Mass General Brigham Reports Financial Improvement in Second Quarter 2023 Financial ResultsMay 12th, 2023
Mass General Brigham Reports First Quarter 2023 Financial ResultsFebruary 11th, 2023
Mass General Brigham Taps Inaugural Director of New Gene and Cell Therapy InstituteDecember 14th, 2022
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