ArunP.WiitaMDPhD

PubMed

• Variants of uncertain significance in prenatal microarrays: a retrospective cohort study.
  Anne H. Mardy, Arun P. Wiita, Brette V. Wayman, Kathryn Drexler, Teresa N. Sparks, Mary E. Norton> ;British Journal of Obstetrics and Gynaecology. 2021 Jan 1
• A Guide to Using ClinTAD for Interpretation of DNA Copy Number Variants in the Context of Topologically Associated Domains.
  Jacob D. Spector, Arun P. Wiita> ;Current protocols in human genetics. 2020 Dec 1
• IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
  Jae-Woong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai...> ;Nature. 2020 Nov 4
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Anum A. Glasgow, Jeff E. Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shoshana Zha, Rachel Yamin, Kevin Kao, Oren...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Oct 22
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Anum A. Glasgow, Jeff E. Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shion A. Lim, Shoshana Zha, Rachel Yamin, K...> ;bioRxiv. 2020 Aug 1
• Signalling input from divergent pathways subverts B cell transformation.
  Chan, L. N., Murakami, M. A., Robinson, M. E., Caeser, R., Sadras, T., Lee, J., Cosgun, K. N., Kume, K., Khairnar, V., Xiao, G., Ahmed, M. A., Aghania, E., Deb, G., Hu...> ;Nature. 2020 Jul 24
• CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
  Ramkumar, P., Abarientos, A. B., Tian, R., Seyler, M., Leong, J. T., Chen, M., Choudhry, P., Hechler, T., Shah, N., Wong, S. W., Martin, T. G., Wolf, J. L., Roybal, K....> ;Blood advances. 2020 Jun 27
• Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.
  Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu T. Lin, Priya Choudhry, Margarette C. Mariano, Makeba Marcoulis, Chin F...> ;Nature Communications. 2020 Apr 22
• Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Ap...
  Han, L. M., Grenert, J. P., Wiita, A. P., Quinn, M., Fujimoto, V. Y., Rabban, J. T.> ;The American journal of surgical pathology. 2020 Mar 25
• Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
  Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B. A., Lin, Y. T., Wiita, A. P., Xu, K., Correia, M. A., Kampmann, M.> ;Nature. 2020 Mar 7
• Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
  Sarin, V., Yu, K., Ferguson, I. D., Gugliemini, O., Nix, M. A., Hann, B., Sirota, M., Wiita, A. P.> ;Leukemia. 2020 Mar 4
• The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
  Andrew M. Leidal, Hector H. Huang, Timothy Marsh, Tina Solvik, Dachuan Zhang, Jordan Ye, FuiBoon Kai, Juliet Goldsmith, Jennifer Y. Liu, Yu-Hsin Huang, Teresa Monkkone...> ;Nature Cell Biology. 2020 Jan 13
• Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer.
  Swetha Kambhampati, Arun P. Wiita> ;Advances in Experimental Medicine and Biology. 2020 Jan 1
• X-linked duplication copy number variation in a familial overgrowth condition.
  Thoa K. Ha, Anne H. Mardy, Daniah Beleford, Andrew Spanier, Brette V. Wayman, Monica Penon-Portmann, Arun P. Wiita, Joseph T.C. Shieh> ;American Journal of Medical Genetics Part C-seminars in Medical Genetics. 2019 Nov 25
• Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma.
  Lin, Y. T., Way, G. P., Barwick, B. G., Mariano, M. C., Marcoulis, M., Ferguson, I. D., Driessen, C., Boise, L. H., Greene, C. S., Wiita, A. P.> ;Blood advances. 2019 Nov 8
• DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma.
  Choudhry, P., Mariano, M. C., Geng, H., Martin, T. G., Wolf, J. L., Wong, S. W., Shah, N., Wiita, A. P.> ;Leukemia. 2019 Oct 9
• TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
  Crottès, D., Lin, Y. T., Peters, C. J., Gilchrist, J. M., Wiita, A. P., Jan, Y. N., Jan, L. Y.> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Jun 12
• ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains.
  Jacob D. Spector, Arun P. Wiita> ;Journal of Human Genetics. 2019 Feb 14
• Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies.
  Trinklein, N. D., Pham, D., Schellenberger, U., Buelow, B., Boudreau, A., Choudhry, P., Clarke, S. C., Dang, K., Harris, K. E., Iyer, S., Jorgensen, B., Pratap, P. P.,...> ;mAbs. 2019 Jan 31
• Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001.
  Cristina Abrahams, Xiaofan Li, Millicent Embry, Abigail Yu, Stellanie Krimm, Sarah Krueger, Nancy Y. Greenland, Kwun Wah Wen, Christopher Jones, Venita DeAlmeida, Will...> ;Oncotarget. 2018 Dec 28
• Seeking Convergence and Cure with New Myeloma Therapies
  Priya Choudhry, Derek Galligan, Arun P. Wiita> ;Trends in cancer. 2018 Aug 1
• Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
  Christine Lam, Ian D. Ferguson, Margarette C. Mariano, Yu-Hsiu T. Lin, Megan Murnane, Hui Liu, Geoffrey A. Smith, Sandy W. Wong, Jack Taunton, Jun O. Liu, Constantine ...> ;Haematologica. 2018 Jul 1
• 3 citations
  A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
  Benjamin Goode, Gourish Mondal, Michael Hyun, Diego Garrido Ruiz, Yu Hsiu Lin, Jessica Van Ziffle, Nancy M. Joseph, Courtney Onodera, Eric Talevich, James P. Grenert, ...> ;Nature Communications. 2018 Feb 23
• Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
  Aditi Deshpande, Smita Yadav, Dang Q. Dao, Zhi-Yong Wu, Kenton C. Hokanson, Michelle K. Cahill, Arun P. Wiita, Yuh Nung Jan, Erik M. Ullian, Lauren A. Weiss> ;Cell Reports. 2017 Dec 5
• The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.
  Ronan Le Moigne, Blake T. Aftab, Stevan Djakovic, Eugen Dhimolea, Eduardo Valle, Megan Murnane, Emily M. King, Ferdie Soriano, Mary Kamala Menon, Zhi Yong Wu, Stephen ...> ;Molecular Cancer Therapeutics. 2017 Nov 1
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Abstracts/Posters

• Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis
  Arun P. Wiita, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and _Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology
  Arun P. Wiita, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation
  Arun P. Wiita, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies
  Arun P. Wiita, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

• Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018