BabetteBWekslerMD

Hematology • New York, NY

Physician

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Office
520 E 70th St # Starr-341
New York, NY 10021
Phone+1 212-746-2927

Fax+1 212-746-3305
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Education & Training

MedStar Health/Georgetown University HospitalResidency, Internal Medicine, 1965 - 1967
Jacobi Medical Center/Albert Einstein College of MedicineInternship, Internal Medicine, 1963 - 1964
Columbia University Vagelos College of Physicians and SurgeonsClass of 1963

Certifications & Licensure

NY State Medical License 1968 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
Elected Member The American Society for Clinical Investigation, 1979

Publications & Presentations

PubMed

5 citations
A human-derived neurovascular unitmodel to study the effects of cellular cross-talk and soluble factors on barrier integrity.
Chiara Barberio, Aimee Withers, Yash Mishra, Pierre-Olivier Couraud, Ignacio A Romero, Babette Weksler, Róisín M Owens> ;Frontiers in Cellular Neuroscience. 2022 Jan 1
1 citations
High Levels of Receptor Tyrosine Kinases in CCM3-Deficient Cells Increase Their Susceptibility to Tyrosine Kinase Inhibition
Miriam Sartages, Ebel Floridia, Mar García-Colomer, Cristina Iglesias, Manuel Macía, Patricia Peñas, Pierre-Olivier Couraud, Ignacio A. Romero, Babette B. Weksler, Cel...> ;Biomedicines. 2020 Dec 17
37 citations
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis
Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland E. Kontermann, Andreas Herrmann, Babette B...> ;Scientific Reports. 2018 Sep 11
1 citations
Author Correction: Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.
Sara Brilha, Catherine W.M. Ong, Babette B. Weksler, Nacho Romero, Pierre-Olivier Couraud, Jon S. Friedland> ;Scientific Reports. 2018 Sep 12
21 citations
Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro.
Sulay H. Patel, Crystal R. Leibrand, Preetha Palasuberniam, Pierre-Olivier Couraud, Babette B. Weksler, Fay M. Jahr, Joseph L. McClay, Kurt F. Hauser, MaryPeace McRae> ;Antimicrobial Agents and Chemotherapy. 2017 Nov 22
38 citations
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.
Sara Brilha, Catherine W.M. Ong, Babette B. Weksler, Nacho Romero, Pierre-Olivier Couraud, Jon S. Friedland> ;Scientific Reports. 2017 Nov 22
14 citations
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier fol...
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A. Romero, Babette B. Weksler, Luis Villanueva, Michel Pohl, Yves Boucher> ;Molecular Pain. 2017 Jan 1
13 citations
New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Carmen Roncal, Sara Martinez de Lizarrondo, Agustina Salicio, Arnaud Chevilley, Jose A. Rodriguez, Anna Rosell, Pierre-Olivier Couraud, Babette B. Weksler, Joan Montan...> ;Cardiovascular Research. 2017 Aug 1
16 citations
Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels.
Almke Bader, Willem Bintig, Daniela Begandt, Anne Klett, Ina G. Siller, Carola Gregor, Frank Schaarschmidt, Babette B. Weksler, Ignacio A. Romero, Pierre-Olivier Coura...> ;The Journal of Physiology. 2017 Apr 15
18 citations
Effect of cigarette smoke on monocyte procoagulant activity: Focus on platelet-derived brain-derived neurotrophic factor (BDNF).
Patrizia Amadio, Damiano Baldassarre, Leonardo Sandrini, Babette B. Weksler, Elena Tremoli, Silvia S. Barbieri> ;Platelets. 2017 Jan 1
26 citations
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endot...
Vanessa Coelho-Santos, Renato Socodato, Camila C. Portugal, Ricardo A. Leitão, Manuel Rito, Marcos Barbosa, Pierre Olivier Couraud, Ignacio A. Romero, Babette B. Weksl...> ;Cellular and Molecular Life Sciences. 2016 Jul 4
14 citations
Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier.
Marianne Strazza, Vanessa Pirrone, Brian Wigdahl, Will Dampier, Wei Lin, Rui Feng, Monique E. Maubert, Babette B. Weksler, Ignacio A. Romero, Pierre-Olivier Couraud, M...> ;International Journal of Molecular Sciences. 2016 Jun 9
46 citations
Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, ...
Nathan Moreau, Annie Mauborgne, Sylvie Bourgoin, Pierre-Olivier Couraud, Ignacio A. Romero, Babette B. Weksler, Luis Villanueva, Michel Pohl, Yves Boucher> ;Pain. 2016 Apr 1
68 citations
Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System.
Anne Waschbisch, Sina D Schröder, Dana Schraudner, Laura Sammet, Babette B. Weksler, Arthur Melms, Sabine Pfeifenbring, Christine Stadelmann, Stefan Schwab, Ralf A. Li...> ;Journal of Immunology. 2016 Feb 15
453 citations
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
Hans Christian Cederberg Helms, N. Joan Abbott, Malgorzata Burek, Roméo Cecchelli, Pierre Olivier Couraud, Mária A. Deli, Carola Förster, H.-J. Galla, Ignacio A. Romer...> ;Journal of Cerebral Blood Flow and Metabolism. 2016 Feb 11
63 citations
Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?
Mobina Alemi, Cristiana Gaiteiro, Carlos Ribeiro, Luis Miguel Santos, João R. Gomes, Sandra Oliveira, Pierre-Olivier Couraud, Babette B. Weksler, Ignacio A. Romero, Ma...> ;Scientific Reports. 2016 Feb 3
15 citations
Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal.
Christoph Nusshold, Andreas Üllen, Nora Kogelnik, Eva Bernhart, Helga Reicher, Ioanna Plastira, Toma N. Glasnov, Klaus Zangger, Gerald N. Rechberger, Manfred Kollroser...> ;Free Radical Biology & Medicine. 2016 Jan 1
13 citations
Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice
Silvia S. Barbieri, Giovanna Petrucci, Eva Tarantino, Patrizia Amadio, Bianca Rocca, Maurizio Pesce, Kellie R. Machlus, Franco O. Ranelletti, Sara Gianellini, Babette ...> ;Thrombosis and Haemostasis. 2015 Nov 25
67 citations
Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E.
Ana Rute Neves, Joana Fontes Queiroz, Babette B. Weksler, Ignacio A. Romero, Pierre-Olivier Couraud, Salette Reis> ;Nanotechnology. 2015 Nov 17
46 citations
Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC)
Dona Saumya S. Wijetunge, Sudharsan Gongati, Chitrita DebRoy, Kwang Sik Kim, Pierre Olivier Couraud, Ignacio-Andres Romero, Babette B. Weksler, Subhashinie Kariyawasam> ;BMC Microbiology. 2015 Oct 14
19 citations
Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis.
Subramanian Krishnan, Alexander C. Chang, Jacqueline Hodges, Pierre-Olivier Couraud, Ignacio A. Romero, Babette B. Weksler, Bryon A. Nicholson, Lisa K. Nolan, Nemani V...> ;Virulence. 2015 Sep 25
12 citations
Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen–glucose deprivation conditions: an in vitro experimental...
Ping Sun, Gerard Ferrer Esteban, Tsutomu Inokuchi, José Marco-Contelles, Babette B. Weksler, Ignacio-Andres Romero, Pierre-Olivier Couraud, Mercedes Unzeta, Montserrat...> ;British Journal of Pharmacology. 2015 Oct 27
14 citations
Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells
Patrizia Amadio, Damiano Baldassarre, Eva Tarantino, Elena Zacchi, Sara Gianellini, Isabella Squellerio, Mauro Amato, Babette B. Weksler, Elena Tremoli, Silvia S. Barb...> ;FASEB Journal. 2015 Jun 11
12 citations
Prostanoids and NSAIDs in cardiovascular biology and disease.
Babettte B. Weksler> ;Current Atherosclerosis Reports. 2015 May 29
67 citations
Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4
Alain Duperray, Delphin Barbe, Gilda Raguenez, Babette B. Weksler, Ignacio A. Romero, Pierre-Olivier Couraud, Hervé Perron, Patrice N. Marche> ;International Immunology. 2015 Nov 1
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Press Mentions

Statement from ASH President Charles S. Abrams, MD, on the American Board of Internal Medicine’s Announced Plan to Offer Alternatives to the 10-Year Maintenance of Certification Examination (ASH - American Society of Hematology)May 6th, 2016

Grant Support

Cyclooxygenase-2 And Xenobiotics In Vascular InjuryNational Heart, Lung, And Blood Institute2002–2005
Cyclooxygenase 2 And Xenobiotics In Vascular InjuryNational Heart, Lung, And Blood Institute1997–2000
Age Effects On Arterial Cell Function In AtherosclerosisNational Heart, Lung, And Blood Institute1985–1992