BarbaraJeanHaleyMDFACP

Oncology • Dallas, TX

Breast Cancer, Hematologic Oncology

Professor Internal Medicine Hematology Oncology

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Office
5323 Harry Hines Boulevard
Dallas, TX 75390
Phone+1 214-645-4673
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Education & Training

University of Texas Southwestern Medical CenterFellowship, Hematology and Medical Oncology, 1979 - 1981
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 1976 - 1979
University of Texas Southwestern Medical SchoolClass of 1976

Certifications & Licensure

TX State Medical License 1976 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
Top MD Consumers Checkbook
Super Doctor SuperDoctors.com

Clinical Trials

Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Start of enrollment: 2008 Apr 23
Terminated
Phase 2
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer Start of enrollment: 2010 Mar 01
Recruiting
Phase 2
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence Start of enrollment: 2011 Nov 01
Completed
Phase 3
A Study of the Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation Start of enrollment: 2012 Aug 01
Completed
Phase 2, Phase 3
A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi Start of enrollment: 2012 Oct 03
Terminated
Phase 3
Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI Start of enrollment: 2013 May 31
Completed
Phase 2
Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer Start of enrollment: 2013 Sep 06
Completed
Phase 1
Study of Efficacy and Safety of LEE011 in Postmenopausal Women With Advanced Breast Cancer.(MONALEESA-2) Start of enrollment: 2013 Dec 17
Completed
Phase 3
Phase 1b Study of PD-0332991 in Combination With T-DM1(Trastuzumab-DM1) Start of enrollment: 2014 Jan 24
Completed
Phase 1
Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast Cancer Start of enrollment: 2014 May 01
Completed
Phase 2
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Publications & Presentations

PubMed

Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer.
Beverly Kyalwazi, Christina Yau, Michael J Campbell, Toshio F Yoshimatsu, A Jo Chien, Anne M Wallace, Andres Forero-Torres, Lajos Pusztai, Erin D Ellis, Kathy S Albain...> ;JAMA Network Open. 2023 Dec 1
6 citations
Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer.
Julie E Lang, Andres Forero-Torres, Douglas Yee, Christina Yau, Denise Wolf, John Park, Barbara A Parker, A Jo Chien, Anne M Wallace, Rashmi Murthy, Kathy S Albain, Er...> ;NPJ Breast Cancer. 2022 Dec 1
In Reply to Hannoun-Levi et al.
Asal Rahimi, Ambrosia Simmons, D Nathan Kim, Marilyn Leitch, Jonathan Haas, Xuejun Gu, Chul Ahn, Ang Gao, Ann Spangler, Howard E Morgan, Sally Goudreau, Stephen Seiler...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Jun 1
4 citations
Cardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivors.
Rhys I Beaudry, Mark J Haykowsky, James P MacNamara, Wesley J Tucker, Roshni Rao, Barbara Haley, Satyam Sarma> ;Cardio-Oncology. 2022 Apr 11
34 citations
Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial.
Elias, A., Amy S. Clark, Christina Yau, Denise M. Wolf, Emanuel F. Petricoin, Laura J. van't Veer, Douglas Yee, Stacy L. Moulder, Anne M. Wallace, A. Jo Chien, Claudin...> ;Nature Communications. 2021 Nov 5
Early Follow-Up of Multi-Institutional Trial of Phase I Dose Escalation Using Single Fraction Stereotactic Partial Breast Irradiation (S-PBI) for Early-Stage Breast Ca...
A.S. Rahimi, D.N. Kim, Marilyn Leitch, Xuejun Gu, Jonathan A. Haas, Chul Ahn, Ann Spangler, Sarah Neufeld, S. Bahrami, Sally Goudreau, Stephen J. Seiler, Deborah Farr,...> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
31 citations
A Multicenter Phase II Trial of Ipilimumab and Nivolumab in Unresectable or Metastatic Metaplastic Breast Cancer: Cohort 36 of Dual Anti-CTLA-4 and Anti-PD-1 Blockade ...
Sylvia Adams, Megan Othus, Sandip Pravin Patel, Kathy D. Miller, Rashmi Chugh, Scott M. Schuetze, Mary D. Chamberlin, Barbara J Haley, Anna Maria Storniolo, Mridula P ...> ;Clinical Cancer Research. 2021 Oct 29
10 citations
Preliminary Results of Multi-Institutional Phase I Dose Escalation Trial Using Single Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer: D...
Asal Rahimi, Ambrosia Simmons, D. W Nathan Kim, Marilyn Leitch, Jonathan A. Haas, Xuejun Gu, Chul Ahn, Ang Gao, Ann Spangler, Howard E. Morgan, Sally Goudreau, Stephen...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Oct 25
12 citations
Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer
Douglas Yee, Claudine Isaacs, Denise M. Wolf, Christina Yau, Paul Haluska, Karthik V. Giridhar, Andres Forero-Torres, A. Jo Chien, Anne M. Wallace, Lajos Pusztai, Kath...> ;NPJ Breast Cancer. 2021 Oct 5
37 citations
Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clini...
W. Fraser Symmans, Christina Yau, Yunn Yi Chen, Ronald Balassanian, Molly Klein, Lajos Pusztai, Rita Nanda, Barbara A. Parker, Brian Datnow, Gregor Krings, Shi Wei, Mi...> ;JAMA Oncology. 2021 Sep 16
29 citations
Efficacy of Neratinib Plus Capecitabine in the Subgroup of Patients with Central Nervous System Involvement from the NALA Trial
Sara A. Hurvitz, Cristina Saura, Mafalda Oliveira, Maureen E. Trudeau, Beverly Moy, Suzette Delaloge, William J. Gradishar, Sung Bae Kim, Barbara Haley, Larisa Ryvo, M...> ;The Oncologist. 2021 Aug 1
9 citations
A Phase I/Ib Trial of PD 0332991 (Palbociclib) and T-DM1 in HER2-Positive Advanced Breast Cancer After Trastuzumab and Taxane Therapy.
Barbara Haley, Kiran Batra, Sunati Sahoo, Thomas W. Froehlich, Dawn Klemow, Nisha Unni, Chul Ahn, Melissa Rodriguez, Melanie Hullings, Arthur E. Frankel> ;Clinical Breast Cancer. 2021 Mar 11
9 citations
Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer.
Asal Rahimi, Howard E. Morgan, Dong W. Kim, Yuanyuan Zhang, Marilyn Leitch, Rachel Wooldridge, Sally Goudreau, Barbara Haley, Roshni Rao, Aeisha Rivers, Ann Spangler, ...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jul 1
18 citations
Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer
Jae Mo Park, Galen D. Reed, Jeff Liticker, William C. Putnam, Alvin Chandra, Katarina Yaros, Aneela Afzal, James P Macnamara, Jaffar Raza, Ronald G. Hall, Jeannie Baxt...> ;Circulation Research. 2020 Dec 4
296 citations
Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With >= 2 HER2-Directed Regimens: Phase III...
Cristina Saura, Mafalda Oliveira, Yin-Hsun Feng, Ming-Shen Dai, Shang Wen Chen, Sara A. Hurvitz, Sung Bae Kim, Beverly Moy, Suzette Delaloge, William J. Gradishar, Nor...> ;Journal of Clinical Oncology. 2020 Jul 17
1 citations
Electronic Health Records-Based Cardio-Oncology Registry for Care Gap Identification and Pragmatic Research: Procedure and Observational Study.
Alvin Chandra, Steven Philips, Ambarish Pandey, Mujeeb A. Basit, Vaishnavi Kannan, Evan J. Sara, Sandeep R Das, Simon J. Craddock Lee, Barbara Haley, Duwayne L Willett...> ;JMIR Cardio. 2021 May 12
58 citations
MK-2206 and standard neoadjuvant chemotherapy improves response in patients with human epidermal growth factor receptor 2–positive and/or hormone receptor–negative bre...
A. Jo Chien, Debasish Tripathy, Kathy S. Albain, W. Fraser Symmans, Hope S. Rugo, Michelle E. Melisko, Anne M. Wallace, Richard Schwab, Teresa Helsten, Andres Forero-T...> ;Journal of Clinical Oncology. 2020 Apr 1
4 citations
Novel hyaluronan formulation for preventing acute skin reactions in breast during radiotherapy: a randomized clinical trial
Asal Rahimi, Osama Mohamad, Kevin Albuquerque, D. W Nathan Kim, Diana Chen, Kimberly Thomas, Rachel Wooldridge, Aeisha Rivers, Marilyn Leitch, Roshni Rao, Barbara Hale...> ;Supportive Care in Cancer. 2020 Mar 1
7 citations
Cytogenomic characterization of double minute heterogeneity in therapy related acute myeloid leukemia.
Prasad Koduru, Weina Chen, Barbara Haley, Kevin Ho, Dwight H Oliver, Kathleen S. Wilson> ;Cancer Genetics. 2019 Oct 1
9 citations
Risk Factors for Fat Necrosis After Stereotactic Partial Breast Irradiation for Early-Stage Breast Cancer in a Phase 1 Clinical Trial.
Asal Rahimi, Yuanyuan Zhang, Dong W. Kim, Howard Morgan, Ferzana A. Hossain, Marilyn Leitch, Rachel Wooldridge, Stephen J. Seiler, Sally Goudreau, Barbara Haley, Roshn...> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Sep 1
15 citations
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.
Eylem Kulkoyluoglu-Cotul, Brandi Patrice Smith, Kinga Wrobel, Yiru Chen Zhao, Karen L. Chen, Kadriye Hieronymi, Ozan Berk Imir, Kevin Duong, Caitlin O'Callaghan, Aditi...> ;Cancers. 2019 Apr 4
5 citations
The Promoting Activity in Cancer Survivors (PACES) trial: A multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors
Chad D. Rethorst, Heidi A. Hamann, Thomas J. Carmody, Kendall J. Sharp, Keith E. Argenbright, Barbara Haley, Celette Sugg Skinner, Madhukar H. Trivedi> ;BMC Cancer. 2018 Jul 18
34 citations
Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the In Vitro Integrity of T Cells from Cancer Patients.
Masato Kobayashi, Jin Sung Chung, Muhammad Shaalan Beg, Yull Edwin Arriaga, Udit Verma, Kevin D. Courtney, John C. Mansour, Barbara Haley, Saad A. Khan, Yutaka Horiuch...> ;Clinical Cancer Research. 2019 Jan 15
102 citations
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Ne...
Noah Kornblum, Fengmin Zhao, Judith Manola, Paula Klein, Bhuvaneswari Ramaswamy, Adam Brufsky, P. J. Stella, Brian L. Burnette, Melinda L. Telli, Della F. Makower, Pun...> ;Journal of Clinical Oncology. 2018 Apr 17
66 citations
Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer
Ryan J. Hartmaier, Sally E. Trabucco, Nolan Priedigkeit, Jon Chung, Christine A. Parachoniak, P. Vanden Borre, Samantha Morley, Margaret Rosenzweig, Michael E. Goldber...> ;Annals of Oncology. 2018 Apr 1
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Journal Articles

Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the in Vitro Integrity of T-cells from Cancer Patients
Kevin Courtney, Yull Arriaga, Barbara Haley, John C Mansour, Ponciano D Cruz, David Harker, Farshid Araghizadeh, Clinical Cancer Research

Press Mentions

Drugs Reprogram Genes in Breast Tumors to Prevent Endocrine ResistanceMay 14th, 2019
Researchers Uncover Mutated Genes Involved in Lung Cancer; One Affects NonsmokersOctober 24th, 2017