BenjaminIzarMD

PubMed

• Pseudoprogression in a patient with metastatic melanoma treated with PD-1 and LAG-3 inhibition.
  Lawrence W Wu, Jacqueline J Tao, Diana McDonnell, Benjamin Izar> ;Melanoma Research. 2024 Apr 18
• Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
  Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, ...> ;Nature Cancer. 2024 Mar 1
• 1 citations
  SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.
  Giuseppe Leuzzi, Alessandro Vasciaveo, Angelo Taglialatela, Xiao Chen, Tessa M Firestone, Allison R Hickman, Wendy Mao, Tanay Thakar, Alina Vaitsiankova, Jen-Wei Huang...> ;Cell. 2024 Feb 15
• 1 citations
  LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells.
  Kumar, D., Gurrapu, S., Wang, Y., Bae, S., Pandey, P., Chen, H., Mondal, J., Han, H., Wu, C., Karaiskos, S., Yang, F., Sahin, A., Wistuba, I., Gao, J., Tripathy, D., G...> ;Nature Cancer. 2024 Feb 1
• Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates...
  Altorki, N., Walsh, Z., Melms, J., Port, J., Lee, B., Nasar, A., Spinelli, C., Caprio, L., Rogava, M., Ho, P., Christos, P., Saxena, A., Elemento, O., Bhinder, B., Age...> ;Nature Communications. 2024 Jan 3
• 1 citations
  Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized ph...
  Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee, Abu Nasar, Cathy Spinelli, Lindsay Caprio, Meri Rogava, Patricia Ho, Paul J Christ...> ;Nature Communications. 2023 Dec 19
• 1 citations
  Smoother: a unified and modular framework for incorporating structural dependency in spatial omics data.
  Su, J., Reynier, J., Fu, X., Zhong, G., Jiang, J., Escalante, R., Wang, Y., Aparicio, L., Knowles, D., Rabadan, R., Izar, B.> ;Genome Biology. 2023 Dec 18
• From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6.
  Melms, J., Ho, P., Rogava, M., Izar, B.> ;Genes and Immunity. 2024 Feb 1
• 1 citations
  Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases.
  Gino K In, Jennifer R Ribeiro, Jun Yin, Joanne Xiu, Matias A Bustos, Fumito Ito, Frances Chow, Gabriel Zada, Lindsay Hwang, April K S Salama, Soo J Park, Justin C Mose...> ;NPJ Precision Oncology. 2023 Nov 14
• 3 citations
  Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0.
  Anna C Pavlick, Charlotte E Ariyan, Elizabeth I Buchbinder, Diwakar Davar, Geoffrey T Gibney, Omid Hamid, Tina J Hieken, Benjamin Izar, Douglas B Johnson, Rajan P Kulk...> ;Journal for Immunotherapy of Cancer. 2023 Oct 1
• Filippo Giancotti (1958-2023).
  Ronald DePinho, Joan Massagué, Gulam Manji, Anil K Rustgi, Benjamin Izar> ;Nature Cancer. 2023 Oct 1
• 2 citations
  Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy.
  Everardo Hegewisch-Solloa, Janine E Melsen, Hiranmayi Ravichandran, André F Rendeiro, Aharon G Freud, Bethany Mundy-Bosse, Johannes C Melms, Shira E Eisman, Benjamin I...> ;Biorxiv. 2023 Sep 6
• KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.
  Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Ca...> ;Journal for Immunotherapy of Cancer. 2023 Sep 1
• 30 citations
  Non-cell-autonomous cancer progression from chromosomal instability.
  Jun Li, Melissa J Hubisz, Ethan M Earlie, Mercedes A Duran, Christy Hong, Austin A Varela, Emanuele Lettera, Matthew Deyell, Bernardo Tavora, Jonathan J Havel, Su M Ph...> ;Nature. 2023 Aug 1
• 12 citations
  The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.
  Patricia Ho, Johannes C Melms, Meri Rogava, Chris J Frangieh, Joanna Poźniak, Shivem B Shah, Zachary Walsh, Oleksandr Kyrysyuk, Amit Dipak Amin, Lindsay Caprio, Benjam...> ;Cancer Cell. 2023 Jul 10
• 5 citations
  Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury.
  Philip Z Mannes, Clayton E Barnes, Jana Biermann, Joseph D Latoche, Kathryn E Day, Qin Zhu, Mohammadreza Tabary, Zeyu Xiong, Jessie R Nedrow, Benjamin Izar, Carolyn J ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 17
• 1 citations
  B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression.
  David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Víctor Arrieta, Jana Biermann, Johannes Melms, Jan Kueckelhaus, Jasim Benotmane, Mark Youngblood, Aid...> ;Research Square. 2023 Jan 9
• 9 citations
  Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.
  Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis, Irving Barrera, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Siyu He, Yinuo J...> ;Nature Genetics. 2023 Jan 1
• 16 citations
  Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
  Yinglu Li, Elizabeth M Goldberg, Xiao Chen, Xinjing Xu, John T McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esthe...> ;Molecular Cell. 2022 Oct 20
• 87 citations
  Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.
  Aveline Filliol, Yoshinobu Saito, Ajay Nair, Dianne H Dapito, Le-Xing Yu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Silvia Affo, Naoto Fujiwara, Hua Su, Qiuyan Sun...> ;Nature. 2022 Oct 1
• 6 citations
  Contribution of-labeled cells to alveolar regeneration is independent of tuft cells.
  Huachao Huang, Yinshan Fang, Ming Jiang, Yihan Zhang, Jana Biermann, Johannes C Melms, Jennifer A Danielsson, Ying Yang, Li Qiang, Jia Liu, Yiwu Zhou, Manli Wang, Zhih...> ;Elife. 2022 Sep 21
• 47 citations
  Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
  Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A Ibarra-Arellano, Massimo Andreat...> ;Cell. 2022 Jul 7
• 14 citations
  Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition.
  Christopher Alvarez-Breckenridge, Samuel C Markson, Jackson H Stocking, Naema Nayyar, Matt Lastrapes, Matthew R Strickland, Albert E Kim, Magali de Sauvage, Ashish Dah...> ;Cancer Immunology Research. 2022 Aug 3
• 18 citations
  An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes.
  Abhinav Jaiswal, Akanksha Verma, Ruth Dannenfelser, Marit Melssen, Itay Tirosh, Benjamin Izar, Tae-Gyun Kim, Christopher J Nirschl, K Sanjana P Devi, Walter C Olson Jr...> ;Cancer Cell. 2022 May 9
• 16 citations
  Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
  Amanda Garrido, Eunjeong Kim, Ana Teijeiro, Paula Sánchez Sánchez, Rosa Gallo, María Matamala Montoya, Cristian Perna, Guillermo P Vicent, Javier Muñoz, Ramón Campos-O...> ;Journal of Hepatology. 2022 Apr 1
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Lectures

• Single-cell RNA-sequencing and -imaging of melanoma ecosystems reveals sources of resistance to immune checkpoint blockade. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018