BirgitKnoechelMD

PubMed

• Dual role of signaling pathways in myeloma requires cell-type specific targeting of ligand-receptor interactions.
  Pablo Hernandez-Lopez, Tushara Vijaykumar, Praveen Anand, Daniel Auclair, Julia Frede, Birgit Knoechel, Jens G Lohr> ;Blood Advances. 2024 Apr 11
• 13 citations
  Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering.
  Li Li, Vakul Mohanty, Jinzhuang Dou, Yuefan Huang, Pinaki P Banerjee, Qi Miao, Jens G Lohr, Tushara Vijaykumar, Julia Frede, Birgit Knoechel, Luis Muniz-Feliciano, Tam...> ;Science Advances. 2023 Jul 28
• 3 citations
  Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy.
  Nam Gyu Im, Amy Guillaumet-Adkins, Megha Wal, Anna J Rogers, Julia Frede, Claire C Havig, Jing Yang, Praveen Anand, Sarah K Stegmann, Johannes M Waldschmidt, Noori Sot...> ;Cancer Immunology Research. 2022 Sep 1
• 6 citations
  Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia.
  Anna Montanaro, Samuel Kitara, Elisa Cerretani, Matteo Marchesini, Chiara Rompietti, Luca Pagliaro, Andrea Gherli, Angela Su, Maria Laura Minchillo, Mariafrancesca Cap...> ;Cell Death & Disease. 2022 Jun 17
• 13 citations
  Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma.
  Johannes M Waldschmidt, Andrew J Yee, Tushara Vijaykumar, Ricardo A Pinto, Julia Frede, Praveen Anand, Giada Bianchi, Guangwu Guo, Sayalee Potdar, Charles Seifer, Moni...> ;Leukemia. 2022 Apr 1
• 18 citations
  Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma
  Julia Frede, Praveen Anand, Noori Sotudeh, Ricardo A. Pinto, Monica S. Nair, Hannah T. Stuart, Andrew Yee, Tushara Vijaykumar, Johannes M. Waldschmidt, Sayalee Potdar,...> ;Nature Cell Biology. 2021 Oct 21
• 5 citations
  ETV6-NCOA2 fusion induces T/Myeloid mixed-phenotype leukemia by transformation of non-thymic hematopoietic progenitors.
  Hila Fishman, Shreyas Madiwale, Ifat Geron, Vase Bari, Wouter Van Loocke, Yael Kirschenbaum, Itamar Ganmore, Eitan Kugler, Avigail Rein-Gil, Gilgi Friedlander, Ginette...> ;Blood. 2021 Oct 8
• 13 citations
  Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.
  Johannes M. Waldschmidt, Jake A. Kloeber, Praveen Anand, Julia Frede, Antonis Kokkalis, Valeriya Dimitrova, Sayalee Potdar, Monica S. Nair, Tushara Vijaykumar, Nam Gyu...> ;Clinical Cancer Research. 2021 Sep 10
• 28 citations
  Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL
  Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Jollyette Rogers, Madhu M. Ouseph, Monica S. Nair, Sayalee Pot...> ;Blood. 2021 May 6
• 7 citations
  Tracking myeloma tumor DNA in peripheral blood
  Johannes M. Waldschmidt, Tushara Vijaykumar, Birgit Knoechel, Jens G. Lohr> ;Best Practice & Research. Clinical Haematology. 2020 Mar 1
• 30 citations
  PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
  Ingrid M. Ariës, Kimberly Bodaar, Salmaan Karim, Triona Ni Chonghaile, Laura Hinze, Melissa A. Burns, Maren Pfirrmann, James Degar, Jack T Landrigan, Sebastian T. Balb...> ;The Journal of Experimental Medicine. 2018 Dec 3
• 44 citations
  Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.
  Joseph Mandelbaum, Ilya Shestopalov, Rachel E. Henderson, Nicole G. Chau, Birgit Knoechel, Michael J. Wick, Leonard I. Zon> ;The Journal of Experimental Medicine. 2018 Sep 12
• 39 citations
  Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing.
  Guangwu Guo, Noopur Raje, Charles Seifer, Jake A. Kloeber, Randi Isenhart, Gavin Ha, Andrew Yee, Elizabeth O'Donnell, Yu-Tzu Tai, Paul G. Richardson, Giada Bianchi, Ja...> ;Leukemia. 2018 Mar 27
• 58 citations
  Peptidomimetic blockade of MYB in acute myeloid leukemia.
  Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona C. Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanc...> ;Nature Communications. 2018 Jan 9
• 18 citations
  Comprehensive characterization of circulating and bone marrow-derived multiple myeloma cells at minimal residual disease.
  Johannes M. Waldschmidt, Praveen Anand, Birgit Knoechel, Jens G. Lohr> ;Seminars in Hematology. 2018 Jan 1
• 101 citations
  Genetic interrogation of circulating multiple myeloma cells at single-cell resolution.
  Jens G. Lohr, Sora Kim, Joshua Gould, Birgit Knoechel, Yotam Drier, Matthew J. Cotton, Daniel Gray, Nicole Birrer, Bang Wong, Gavin Ha, Cheng-Zhong Zhang, Guangwu Guo,...> ;Science Translational Medicine. 2016 Nov 2
• 197 citations
  An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
  Yotam Drier, Matthew J. Cotton, Kaylyn E. Williamson, Shawn M. Gillespie, Russell J.H. Ryan, Michael J. Kluk, Christopher D. Carey, Scott J. Rodig, Lynette M. Sholl, A...> ;Nature Genetics. 2016 Mar 1
• 13 citations
  Metabolic Mechanisms of Drug Resistance in Leukemia.
  Birgit Knoechel, Jon C. Aster> ;Cell Metabolism. 2015 Nov 3
• 45 citations
  Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an ou...
  Birgit Knoechel, Ami S. Bhatt, Li Pan, Chandra Sekhar Pedamallu, Eric Allan Severson, Alejandro Gutierrez, David M. Dorfman, Frank C. Kuo, Michael J. Kluk, Andrew L. K...> ;Cold Spring Harbor Molecular Case Studies. 2015 Oct 1
• 270 citations
  EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma
  Nicolo Riggi, Birgit Knoechel, Shawn M. Gillespie, Esther Rheinbay, Gaylor Boulay, Mario L. Suvà, Nikki E. Rossetti, Wannaporn E. Boonseng, Ozgur Oksuz, Edward B. Cook...> ;Cancer Cell. 2014 Nov 10
• 132 citations
  Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
  Yumi Yashiro-Ohtani, Hongfang Wang, Chongzhi Zang, Kelly L. Arnett, Will Bailis, Yugong Ho, Birgit Knoechel, Claudia Lanauze, Lumena Louis, Katherine S. Forsyth, Sujun...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Nov 18
• 102 citations
  Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma
  Alexander Stoeck, Serguei Lejnine, Andrew S. Truong, Li Pan, Hongfang Wang, Chongzhi Zang, Jing Yuan, Christopher Ware, John Maclean, Philip W. Garrett-engele, Michael...> ;Cancer Discovery. 2014 Aug 7
• 268 citations
  An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
  Birgit Knoechel, Justine E. Roderick, Kaylyn E. Williamson, Jiang Zhu, Jens G. Lohr, Matthew J. Cotton, Shawn M. Gillespie, Daniel Fernandez, Manching Ku, Hongfang Wan...> ;Nature Genetics. 2014 Apr 1
• 734 citations
  Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy
  Jens G. Lohr, Petar Stojanov, Scott L. Carter, Peter Cruz-Gordillo, Michael S. Lawrence, Daniel Auclair, Carrie Sougnez, Birgit Knoechel, Joshua Gould, Gordon Saksena,...> ;Cancer Cell. 2014 Jan 13
• 3 citations
  Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes
  Birgit Knoechel, Jens G. Lohr> ;Journal of Autoimmunity. 2013 Sep 1
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Abstracts/Posters

• Chromatin Structure Dynamics Preserve Genome Stability in Multiple Myeloma
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Defining the Differentiation States of Multiple Myeloma at Single Cell Resolution Reveals Opportunities for Immunotherapy
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Circulating Tumor DNA in the Peripheral Blood As Early Predictor of Clinical Outcome in Relapsed/ Refractory Multiple Myeloma
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Determining Resistance Mechanisms in BRAF-mutated Multiple Myeloma
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALL
  Birgit Knoechel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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