HolcombeEGrierMD

Pediatric Hematology & Oncology • Boston, MA

Professor of Pediatrics, Dana-Farber Cancer Institute

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Office
44 Binney St
Room G350
Boston, MA 02115
Phone+1 617-632-3971

Fax+1 617-632-5710
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Education & Training

University of North Carolina HospitalsFellowship, Infectious Disease, 1980 - 1981
University of North Carolina HospitalsResidency, Pediatrics, 1979 - 1980
University of North Carolina HospitalsInternship, Transitional Year, 1976 - 1977
Perelman School of Medicine at the University of PennsylvaniaClass of 1976

Certifications & Licensure

MA State Medical License 1981 - 2019
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Doxorubicin Pharmacokinetic (PK) Study Start of enrollment: 2003 Jun 01
Withdrawn
Phase 1, Phase 2
Cytarabine in Treating Young Patients With Recurrent or Refractory Ewing's Sarcoma Start of enrollment: 2007 May 01
Completed
Phase 2

Publications & Presentations

PubMed

In Memoriam: Sharon B. Murphy, MD (1943-2023).
Susan L Cohn, Vita Land, Michael P Link, Holcombe E Grier> ;Pediatric Blood & Cancer. 2024 Feb 1
Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Thomas Cash, Mark D Krailo, Allen B Buxton, Bruce R Pawel, John H Healey, Odion Binitie, Karen J Marcus, Holcombe E Grier, Patrick J Grohar, Damon R Reed, Aaron R Weis...> ;Journal of Clinical Oncology. 2023 Oct 20
5 citations
Analysis of Local Control Outcomes and Clinical Prognostic Factors in Localized Pelvic Ewing Sarcoma Patients Treated With Radiation Therapy: A Report From the Childre...
Safia K Ahmed, Brent G Witten, William S Harmsen, Peter S Rose, Mark Krailo, Karen J Marcus, R Lor Randall, Steven G DuBois, Katherine A Janeway, Richard B Womer, Holc...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Feb 1
32 citations
Phase III Trial Adding Vincristine-Topotecan-Cyclophosphamide to the Initial Treatment of Patients With Nonmetastatic Ewing Sarcoma: A Children's Oncology Group Report
Patrick J. Leavey, Nadia N. Laack, Mark Krailo, Allen Buxton, R. Lor Randall, Steven G. DuBois, Damon R. Reed, Holcombe E. Grier, Douglas S. Hawkins, Bruce R. Pawel, H...> ;Journal of Clinical Oncology. 2021 Oct 15
12 citations
Role of bone marrow biopsy for staging new patients with Ewing sarcoma: A systematic review.
Kevin Campbell, David S. Shulman, Holcombe E. Grier, Steven G. DuBois> ;Pediatric Blood & Cancer. 2021 Feb 1
16 citations
Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group
Lisa M. Kopp, Richard B. Womer, Cindy L. Schwartz, David H. Ebb, Vivian I. Franco, David Hall, Donald A. Barkauskas, Mark Krailo, Holcombe E. Grier, Paul A. Meyers, Le...> ;Cardio-Oncology. 2019 Oct 28
60 citations
High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working ...
Uta Dirksen, Bernadette Brennan, Marie-Cécile Le Deley, Nathalie Cozic, Henk van den Berg, Vivek A Bhadri, Bénédicte Brichard, Line Claude, Alan W. Craft, Susanne Amle...> ;Journal of Clinical Oncology. 2019 Sep 25
11 citations
Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology...
Lisa A. Teot, Michaela Schneider, Aaron R. Thorner, Jing Tian, Yueh-Yun Chi, Matthew D. Ducar, Ling Lin, Marcin W. Wlodarski, Holcombe E. Grier, Christopher D.M. Fletc...> ;Cancer. 2018 May 1
310 citations
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort
Sigbjørn Smeland, Stefan S. Bielack, Jeremy Whelan, Mark L. Bernstein, Pancras C.W. Hogendoorn, Mark Krailo, Richard Gorlick, Katherine A. Janeway, Fiona C. Ingleby, J...> ;European Journal of Cancer. 2019 Mar 1
37 citations
Response Evaluation Criteria in Solid Tumors (RECIST) following neoadjuvant chemotherapy in osteosarcoma
Lillian M. Guenther, R. Grant Rowe, Patricia T. Acharya, David W. Swenson, Stephanie C. Meyer, Catherine Clinton, Dongjing Guo, Madhumitha Sridharan, Wendy B. London, ...> ;Pediatric Blood & Cancer. 2018 Apr 1
27 citations
Identification of Patients With Localized Ewing Sarcoma at Higher Risk for Local Failure: A Report From the Children's Oncology Group.
Safia K. Ahmed, R. Lor Randall, Steven G. DuBois, William S. Harmsen, Mark Krailo, Karen J. Marcus, Katherine A. Janeway, David S. Geller, Joel I. Sorger, Richard B. W...> ;International Journal of Radiation Oncology, Biology, Physics. 2017 Dec 1
6 citations
Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report fr...
Jason Glover, Tsz-Kwong Man, Donald A. Barkauskas, David Hall, Tanya Tello, Mary Beth Sullivan, Richard Gorlick, Katherine A. Janeway, Holcombe E. Grier, Ching C. Lau,...> ;Plos One. 2017 Jul 21
1 citations
Completion of Therapy Talk.
Marta Wilejto, Holcombe E. Grier, Furqan Shaikh> ;Journal of Oncology Practice. 2016 Oct 23
61 citations
Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group.
Thomas Cash, Elizabeth McIlvaine, Mark Krailo, Stephen L. Lessnick, Elizabeth R. Lawlor, Nadia N. Laack, Joel I. Sorger, Neyssa Marina, Holcombe E. Grier, Linda Granow...> ;Pediatric Blood & Cancer. 2016 Oct 1
115 citations
Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Gr...
Joanne Lagmay, Mark Krailo, Ha Dang, Ae Rang Kim, Douglas S. Hawkins, Orren Beaty, Brigitte C. Widemann, Theodore Zwerdling, Lisa Bomgaars, Anne-Marie R Langevin, Holc...> ;Journal of Clinical Oncology. 2016 Sep 27
276 citations
Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, in...
Neyssa Marina, Sigbjørn Smeland, Stefan S. Bielack, Mark L. Bernstein, Gordana Jovic, Mark Krailo, Jane Hook, Carola A.S. Arndt, Henk van den Berg, Bernadette Brennan,...> ;The Lancet. Oncology. 2016 Oct 1
6 citations
Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group.
Najat C. Daw, Nadia N. Laack, Elizabeth McIlvaine, Mark Krailo, Richard B. Womer, Linda Granowetter, Holcombe E. Grier, Neyssa Marina, Mark L. Bernstein, Mark C. Gebha...> ;Annals of Surgical Oncology. 2016 May 23
19 citations
Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group
Kieuhoa T. Vo, Jeremy V. Edwards, C. Lorrie Epling, Elizabeth Sinclair, Douglas S. Hawkins, Holcombe E. Grier, Katherine A. Janeway, Phillip Barnette, Elizabeth McIlva...> ;Clinical Cancer Research. 2016 Jul 15
56 citations
Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group.
Cindy L. Schwartz, Leonard H. Wexler, Mark Krailo, Lisa A. Teot, Meenakshi Devidas, Laurel J. Steinherz, Allen M. Goorin, Mark C. Gebhardt, John H. Healey, Judith K. S...> ;Pediatric Blood & Cancer. 2016 Jan 1
21 citations
Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report
Neyssa Marina, Linda Granowetter, Holcombe E. Grier, Richard B. Womer, R. Lor Randall, Karen J. Marcus, Elizabeth McIlvaine, Mark Krailo> ;Sarcoma. 2015 Oct 5
34 citations
Identification of Discrete Prognostic Groups in Ewing Sarcoma
Erin E. Karski, Elizabeth McIlvaine, Mark R. Segal, Mark Krailo, Holcombe E. Grier, Linda Granowetter, Richard B. Womer, Paul A. Meyers, Judy Felgenhauer, Neyssa Marin...> ;Pediatric Blood & Cancer. 2016 Jan 1
15 citations
Myogenic tumors in nevoid Basal cell carcinoma syndrome.
Simone Hettmer, Lisa A. Teot, Harry P.W. Kozakewich, Annette M. Werger, Kimberly J. Davies, Christopher D.M. Fletcher, Holcombe E. Grier, Carlos Rodriguez-Galindo, Amy...> ;Journal of Pediatric Hematology/oncology. 2015 Mar 1
100 citations
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group.
Steven G. DuBois, Mark Krailo, Mark C. Gebhardt, Sarah S. Donaldson, Karen J. Marcus, John P. Dormans, Robert C. Shamberger, Scott L. Sailer, Richard W. Nicholas, John...> ;Cancer. 2015 Feb 1
19 citations
HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study
Sarah Gorlick, Donald A. Barkauskas, Mark Krailo, Sajida Piperdi, Rebecca Sowers, Jonathan Gill, David S. Geller, R. Lor Randall, Katherine A. Janeway, Cindy L. Schwar...> ;Pediatric Blood & Cancer. 2014 Sep 1
Comparing Oxazaphosphorines for Treating Ewing Sarcoma: Is the Answer Important Two Decades Later?
William H. Meyer, Holcombe E. Grier> ;Journal of Clinical Oncology. 2014 Aug 10
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Grant Support

A Phase I Trial Of G3139 Combined W/ Cytotoxic Chemotherapy In RelapsedNational Center For Research Resources2005
Pediatric Oncology GroupNational Cancer Institute1992–2002