BrianCzernieckiMD

General Surgery • Tampa, FL

Surgical Oncology (Other than Breast)

Professor, Surgery, Perelman School of Medicine

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Overview of Dr. Czerniecki

I am Chair if Breast Oncology with strong laboratory research and leadership skills.

Office
10920 N McKinley Drive
Moffitt Cancer Center
Tampa, FL 33612
Book by Phone+1(813) 548-6582
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Education & Training

Ohio State University HospitalResidency, Surgery, 1988 - 1993
Rutgers Robert Wood Johnson Medical SchoolClass of 1988

Certifications & Licensure

FL State Medical License 2016 - 2025
PA State Medical License 1995 - 2016
OH State Medical License 1989 - 1996
American Board of Surgery Surgery

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2013-2014
Philadelphia Magazine Castle Connolly, 2012-2014
America's Top Doctors for Cancer Castle Connolly, 2012-2013
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Fellow (FACS) American College of Surgeons
Super Doctor SuperDoctors.com
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Clinical Trials

Vaccine Therapy in Treating Patients With Stage IV Melanoma Start of enrollment: 1999 Apr 01
Completed
Phase 1
Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Ductal Carcinoma In Situ of the Breast Start of enrollment: 2005 Jan 01
Completed
Phase 1
DC Vaccine for Patients With Ductal Carcinoma In Situ Start of enrollment: 2009 Jul 01
Completed
Phase 1, Phase 2
HER-2 Pulsed DC Vaccine to Prevent Recurrence of Invasive Breast Cancer Post Neoadjuvant Chemotherapy Start of enrollment: 2014 Apr 08
Active, not recruiting
Phase 1
HER-2 Pulsed DC Vaccine to Prevent Recurrence of Invasive Breast Cancer Start of enrollment: 2014 Oct 01
Completed
Phase 1
Evaluation of EnVisio SmartClip for Intraoperative Localization of Breast Masses Start of enrollment: 2020 Oct 27
Completed
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Publications & Presentations

PubMed

Reviewing the significance of dendritic cell vaccines in interrupting breast cancer development.
Gautam, N., Ramamoorthi, G., Champion, N., Han, H., Czerniecki, B.> ;Molecular Aspects of Medicine. 2024 Feb 1
16 citations
Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial.
Hatem Soliman, Deanna Hogue, Hyo Han, Blaise Mooney, Ricardo Costa, Marie C Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Aixa Soyano, Avan Armaghani...> ;Nature Medicine. 2023 Feb 1
26 citations
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses.
Jessica K Mandula, Shiun Chang, Eslam Mohamed, Rachel Jimenez, Rosa A Sierra-Mondragon, Darwin C Chang, Alyssa N Obermayer, Carlos M Moran-Segura, Satyajit Das, Julio ...> ;Cancer Cell. 2022 Oct 10
6 citations
Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma.
Ganesan Ramamoorthi, Krithika Kodumudi, Colin Snyder, Payal Grover, Hongtao Zhang, Mark I Greene, Amrita Basu, Corey Gallen, Doris Wiener, Ricardo L B Costa, Hyo S Han...> ;Journal for Immunotherapy of Cancer. 2022 Jun 1
3 citations
Quantitative Changes in Intratumoral Habitats on MRI Correlate With Pathologic Response in Early-stage ER/PR+ HER2- Breast Cancer Treated With Preoperative Stereotacti...
R Jared Weinfurtner, Mahmoud Abdalah, Olya Stringfield, Dana Ataya, Angela Williams, Blaise Mooney, Marilin Rosa, Marie C Lee, Nazanin Khakpour, Christine Laronga, Bri...> ;Journal of Breast Imaging. 2022 Apr 7
5 citations
A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma.
Vincent Law, Zhihua Chen, Francesca Vena, Inna Smalley, Robert Macaulay, Brittany R Evernden, Nam Tran, Yolanda Pina, John Puskas, Gisela Caceres, Simon Bayle, Joseph ...> ;Neuro-Oncology. 2022 Oct 3
7 citations
Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination
Nadia Nocera Zachariah, Amrita Basu, Namrata Gautam, Ganesan Ramamoorthi, Krithika Kodumudi, Nagi B. Kumar, Loretta Loftus, Brian J. Czerniecki> ;Frontiers in Immunology. 2021 Nov 24
7 citations
Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study
Kamran Ahmed, Young-Chul Kim, John A. Arrington, Sungjune Kim, Michelle DeJesus, Aixa E. Soyano, Avan Armaghani, Ricardo Costa, Hung T. Khong, Loretta Loftus, Marilin ...> ;Advances in Radiation Oncology. 2021 Nov 1
5 citations
The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential implications for screening brain MRIs
Matthew N. Mills, Thrisha K Potluri, Yuki Kawahara, Matthew Fahey, Nicholas B Figura, Aixa E. Soyano, Iman R. Washington, Roberto J. Diaz, Daniel E. Oliver, Hsiang-Hsu...> ;Breast Cancer Research and Treatment. 2021 Oct 20
8 citations
Real‐world benefit of combination palbociclib and endocrine therapy for metastatic breast cancer and correlation with neutropenia
James Sun, Xiaojun Zhong, Junjie Ma, Weihong Sun, Hyo S. Han, Hatem Soliman, Loretta Loftus, Ricardo Costa, Avan Armaghani, Aixa E. Soyano‐Muller, Brian J. Czerniecki,...> ;Cancer Medicine. 2021 Sep 30
1 citations
Murine Dendritic Cells Grown in Serum-Free Culture Show Potent Therapeutic Activity when Loaded with Novel Th Epitopes in an Orthotopic Model of HER2pos Breast Cancer.
Loral E Showalter, Brian J. Czerniecki, Krithika Kodumudi, Gary K. Koski> ;Vaccines. 2021 Sep 18
8 citations
MRI Response to Pre-operative Stereotactic Ablative Body Radiotherapy (SABR) in Early Stage ER/PR+ HER2- Breast Cancer correlates with Surgical Pathology Tumor Bed Cel...
R. Jared Weinfurtner, Natarajan Raghunand, Olya Stringfield, Mahmoud A. Abdalah, Bethany L. Niell, Dana Ataya, Angela Williams, Blaise Mooney, Marilin Rosa, Marie C. L...> ;Clinical Breast Cancer. 2021 Jul 20
1 citations
Capecitabine and stereotactic radiation in the management of breast cancer brain metastases.
, , , , , , , , , , , , , , , > ;BMC Cancer. 2021 May 15
4 citations
Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer.
Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E Showalter> ;International Journal of Breast Cancer. 2021 Apr 14
7 citations
Breast cancer subtype predicts clinical outcomes after stereotactic radiation for brain metastases.
Matthew N. Mills, Chetna Thawani, Nicholas B Figura, Daniel E. Oliver, Aixa E. Soyano, Arnold B. Etame, Timothy J. Robinson, James K. Liu, Michael A. Vogelbaum, Peter ...> ;Journal of Neuro-Oncology. 2021 Mar 19
5 citations
Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
Yael Artzy-Randrup, Tamir Epstein, Joel S. Brown, Ricardo Costa, Brian J. Czerniecki, Robert A. Gatenby> ;NPJ Breast Cancer. 2021 Mar 11
19 citations
Trastuzumab Emtansine (T-DM1) and stereotactic radiation in the management of HER2+ breast cancer brain metastases.
Matthew N. Mills, Chelsea Walker, Chetna Thawani, Nicholas B Figura, Sergiy Kushchayev, Arnold B. Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James K. Liu, Mi...> ;BMC Cancer. 2021 Mar 4
11 citations
Targeted Therapy Given after Anti–PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity
Manali Phadke, Zhihua Chen, Jiannong Li, Eslam Mohamed, Michael A. Davies, Inna Smalley, Derek R. Duckett, Vinayak Palve, Brian J. Czerniecki, Peter A. Forsyth, David ...> ;Cancer Immunology Research. 2021 Mar 2
11 citations
Surgical Predictive Model for Breast Cancer Patients Assessing Acute Postoperative Complications: The Breast Cancer Surgery Risk Calculator
Michael M. Jonczyk, Carla S. Fisher, Russell Babbitt, Jessica K. Paulus, Karen M. Freund, Brian J. Czerniecki, Julie A. Margenthaler, Albert Losken, Abhishek Chatterjee> ;Annals of Surgical Oncology. 2021 Feb 22
17 citations
Disseminated cancer cells in breast cancer: Mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities.
Ganesan Ramamoorthi, Krithika Kodumudi, Corey Gallen, Nadia Nocera Zachariah, Amrita Basu, Gabriella Albert, Amber Beyer, Colin Snyder, Doris Wiener, Ricardo Costa, Br...> ;Seminars in Cancer Biology. 2021 Feb 21
3 citations
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease.
Vincent Law, Margi Baldwin, Ganesan Ramamoorthi, Krithika Kodumudi, Nam D. Tran, Inna Smalley, Derek R. Duckett, Pawel Kalinski, Brian J. Czerniecki, Keiran S.M. Small...> ;Journal of Visualized Experiments. 2021 Jan 29
19 citations
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway
Yongsheng Jia, Krithika Kodumudi, Ganesan Ramamoorthi, Amrita Basu, Colin Snyder, Doris Wiener, Shari Pilon-Thomas, Payal Grover, Hongtao Zhang, Mark I. Greene, Qianxi...> ;Molecular Therapy. 2021 Jan 5
26 citations
A Phase I Trial of Talimogene Laherparepvec in Combination with Neoadjuvant Chemotherapy for the Treatment of Nonmetastatic Triple-Negative Breast Cancer
Hatem Soliman, Deanna Hogue, Hyo S. Han, Blaise Mooney, Ricardo Costa, Marie C. Lee, Bethany L. Niell, Angela Williams, Alec Chau, Shannon Falcon, Nazanin Khakpour, Ro...> ;Clinical Cancer Research. 2021 Feb 15
22 citations
Feasibility of Axillary Lymph Node Localization and Excision Using Radar Reflector Localization.
James Sun, Danielle A. Henry, Michael J Carr, Adel Yazdankhahkenary, Christine Laronga, M. Catherine Lee, Susan J. Hoover, Weihong Sun, Brian J. Czerniecki, Nazanin Kh...> ;Clinical Breast Cancer. 2021 Jun 1
10 citations
Th1 cytokines in conjunction with pharmacological Akt inhibition potentiate apoptosis of breast cancer cells in vitro and suppress tumor growth in vivo.
Loral E Showalter, Brian J. Czerniecki, Gary K. Koski> ;Oncotarget. 2020 Jul 28
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Journal Articles

Feasibility of Radar Reflector Localization of Biopsy Proven Axillary Metastasis After Neoadjuvant Chemotherapy
Marie C Lee, John V Kiluk, Susan J Hoover, Brian J Czerniecki, Nazanin Khakpour, Journal of The American College of Surgeons
Immune Interconnectivity of Anatomically Distant Tumors as a Potential Mediator of Systemic Responses to Local Therapy
Sungjune Kim, Eduardo G. Moros, Brian J. Czerniecki, Nature

Authored Content

Feasibility of Radar Reflector Localization of Biopsy Proven Axillary Metastasis After Neoadjuvant ChemotherapyOctober 2018

Press Mentions

Vaccinex and Its Collaborators Present Two Abstracts Related to Pepinemab Combination Immunotherapy Trials at 37th Annual Meeting of Society for Immunotherapy of CancerNovember 10th, 2022
A No B.S Guide to What to Look for When Giving Yourself a Breast ExamSeptember 28th, 2022
Moffitt Researchers Develop HER3-Specific Dendritic Cell Cancer VaccineDecember 1st, 2021
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Grant Support

A Her-2/Neu Pulsed DC1 Vaccine For Patients With DCISNational Cancer Institute2003–2012
Upcc 08102: A Her-2/Neu Pulsed DC1 Vaccine For Patients With DCISNational Center For Research Resources2005

Research History

Mason ChairResearch Chair in Breast Oncology2016 - Present

Professional Memberships

American College of Surgeons - ACS
Member

Hospital Affiliations

H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida

Insurance Accepted

Aetna Choice POS II
Aetna HMO
AmeriHealth Direct POS
Amerihealth HMO
AmeriHealth PPO
BCBS Blue Card PPO
CIGNA HMO
CIGNA Open Access
CIGNA PPO
Coventry Carelink Health Plans PPO
First Choice
First Health PPO
GHI PPO
Great West PPO
HealthAmerica HealthAssurance PPO
Horizon BCBS Direct Access
Horizon BCBS HMO
Horizon BCBS POS
Horizon BCBS PPO
Humana ChoiceCare Network PPO
IBC Keystone HMO / POS
IBC Personal Choice PPO
Multiplan PPO
ODS Network
Oxford Health Freedom
Oxford Health Liberty
Premera BCBS Heritage & Heritage Plus 1
Providence Health System Personal Option
QualCare HMO
QualCare PPO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO
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