BrianThomasLaydenMDPhD

PubMed

• β cell acetate production and release are negligible.
  Kai Xu, Chioma Nnyamah, Nupur Pandya, Irene Corona-Avila, Medha Priyadarshini, Barton Wicksteed, Nadia Sweis, Brian T Layden> ;Islets. 2024 Dec 31
• The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice.
  Zuoxiao Shi, Shaolei Xiong, Ruoci Hu, Zilai Wang, Jooman Park, Yanyu Qian, Jaden Wang, Pratibha Bhalla, Nipun Velupally, Qing Song, Zhenyuan Song, Minsun Stacey Jeon, ...> ;Developmental Cell. 2024 Mar 26
• Silhouette showcards confirm altered obesity-associated body image perception in international cohort study of African-origin populations.
  Candice Choo-Kang, Tyler O Reese, Lisa K Micklesfield, Pascal Bovet, Kweku Bedu-Addo, Terrence Forrester, Jack A Gilbert, Julia H Goedecke, Jacob Plange-Rhule, Estelle...> ;BMJ Open. 2024 Mar 8
• Associations between fears related to safety during sleep and self-reported sleep in men and women living in a low-socioeconomic status setting.
  Correia, A., Forshaw, P., Roden, L., Lipinska, G., Rauch, H., Lambert, E., Crowley, S., Luke, A., Dugas, L., Rae, D., Layden, B., Reutrakul, S.> ;Scientific Reports. 2024 Feb 13
• 1 citations
  Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.
  Sidharth P Mishra, Shalini Jain, Bo Wang, Shaohua Wang, Brandi C Miller, Jea Y Lee, Cesar V Borlongan, Lin Jiang, Julie Pollak, Subhash Taraphder, Brian T Layden, Sush...> ;JCI Insight. 2024 Feb 8
• Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice.
  Kristen R Lednovich, Sophie Gough, Medha Priyadarshini, Nupur Pandya, Chioma Nnyamah, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L Zapater, Jose C...> ;The Journal of Endocrinology. 2024 Feb 1
• 1 citations
  HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
  Cui, M., Yamano, K., Yamamoto, K., Yamamoto-Imoto, H., Minami, S., Yamamoto, T., Matsui, S., Kaminishi, T., Shima, T., Ogura, M., Tsuchiya, M., Nishino, K., Layden, B....> ;Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan 9
• 1 citations
  miR-10b-5p rescues leaky gut linked with gastrointestinal dysmotility and diabetes.
  Hannah Zogg, Rajan Singh, Se Eun Ha, Zhuqing Wang, Byungchang Jin, Mariah Ha, Mirabel Dafinone, Tylar Batalon, Nicholas Hoberg, Sandra Poudrier, Linda Nguyen, Wei Yan,...> ;United European Gastroenterology Journal. 2023 Oct 1
• 2 citations
  Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA.
  Dhavamani Sugasini, Jason C Park, J Jason McAnany, Tae-Hoon Kim, Guangying Ma, Xincheng Yao, Babu Antharavally, Anil Oroskar, Asha A Oroskar, Brian T Layden, Papasani ...> ;Scientific Reports. 2023 Jun 6
• Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
  Vladimir Ilievski, Adam De Jesus, Zeenat Farooq, Joseph L Zapater, Hagar Ismail, Md Wasim Khan, Hossein Ardehali, Jose Cordoba-Chacon, Brian T Layden, Carolina M Pusec...> ;Scientific Reports. 2023 May 17
• 1 citations
  Diet, Gut Microbiome, and Their End Metabolites Associate With Acute Pancreatitis Risk.
  Cemal Yazici, Sarang Thaker, Karla K Castellanos, Haya Al Rashdan, Yongchao Huang, Paya Sarraf, Brian Boulay, Paul Grippo, H Rex Gaskins, Kirstie K Danielson, Georgios...> ;Clinical and Translational Gastroenterology. 2023 Jul 1
• 4 citations
  Aiding Cancer's "Sweet Tooth": Role of Hexokinases in Metabolic Reprogramming.
  Zeenat Farooq, Hagar Ismail, Sheraz Ahmad Bhat, Brian T Layden, Md Wasim Khan> ;Life. 2023 Apr 4
• 2 citations
  Prevalence of Undiagnosed Diabetes Identified by a Novel Electronic Medical Record Diabetes Screening Program in an Urban Emergency Department in the US.
  Kirstie K Danielson, Brett Rydzon, Milena Nicosia, Anjana Maheswaren, Yuval Eisenberg, Janet Lin, Brian T Layden> ;JAMA Network Open. 2023 Jan 3
• Stress and human health in diabetes: A report from the 19Chicago Biomedical Consortium symposium.
  Raghavendra G Mirmira, Rohit N Kulkarni, Pingwen Xu, Tina Drossos, Krista Varady, Kristen L Knutson, Sirimon Reutrakul, Pamela Martyn-Nemeth, Robert M Sargis, Amisha W...> ;Journal of Clinical and Translational Science. 2023 Jan 1
• 11 citations
  Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis.
  Jody A Rusch, Brian T Layden, Lara R Dugas> ;Frontiers in Endocrinology. 2023 Jan 1
• 24 citations
  Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection.
  Julia A Brown, Katherine Z Sanidad, Serena Lucotti, Carolin M Lieber, Robert M Cox, Aparna Ananthanarayanan, Srijani Basu, Justin Chen, Mengrou Shan, Mohammed Amir, Fa...> ;Gut Microbes. 2022 Aug 2
• 14 citations
  The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression.
  Md Wasim Khan, Alexander R Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed, Brian T ...> ;Cell Death & Disease. 2022 Jul 28
• 1 citations
  Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.
  Kristen R Lednovich, Chioma Nnyamah, Sophie Gough, Medha Priyadarshini, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L Zapater, Hariom Yadav, Brian ...> ;American Journal of Physiology. Endocrinology and Metabolism. 2022 Sep 1
• 19 citations
  Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis.
  Pei Luo, Kristen Lednovich, Kai Xu, Chioma Nnyamah, Brian T Layden, Pingwen Xu> ;Translational Research. 2022 Oct 1
• 1 citations
  Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet.
  Joseph L Zapater, Barton Wicksteed, Brian T Layden> ;Endocrinology. 2022 Jun 1
• 13 citations
  Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
  Medha Priyadarshini, Guadalupe Navarro, Derek J Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah ...> ;Gastroenterology. 2022 May 1
• 5 citations
  The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells?
  Raza Ali Naqvi, Afsar Raza Naqvi, Amar Singh, Medha Priyadarshini, Appakalai N Balamurugan, Brian T Layden> ;Frontiers in Endocrinology. 2022 Jan 1
• 1 citations
  Utility of silhouette showcards to assess adiposity in three countries across the epidemiological transition.
  Tyler O Reese, Pascal Bovet, Candice Choo-Kang, Kweku Bedu-Addo, Terrence Forrester, Jack A Gilbert, Julia H Goedecke, Estelle V Lambert, Brian T Layden, Lisa K Mickle...> ;PLOS Global Public Health. 2022 Jan 1
• 11 citations
  Hexokinase domain-containing protein-1 in metabolic diseases and beyond.
  Joseph L. Zapater, Kristen Lednovich, Md. Wasim Khan, Brian T. Layden> ;Trends in Endocrinology and Metabolism. 2021 Nov 12
• 24 citations
  Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior
  Tyler Cook, Chaitanya K. Gavini, Jason Jesse, Gregory Aubert, Emily Gornick, Raiza Bonomo, Laurent Gautron, Brian T. Layden, Virginie Mansuy-Aubert> ;Molecular Metabolism. 2021 Oct 6
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Journal Articles

• Risk of Amputations Associated with SGLT2 Inhibitors Compared to DPP‐4 Inhibitors: A Propensity‐Matched Cohort Study  
  Gregory S Calip, Brian T Layden, Diabetes, Obesity and Metabolism
• Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology  
  Brian T. Layden, Brian T. Layden, Wiley
• Gut Microbiota: FFAR Reaching Effects on Islets  
  Brian Layden, MD, Endocrinology