BrianMWolpinMD

PubMed

• RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.
  Harshabad Singh, Pranshu Sahgal, Kevin Kapner, Steven M Corsello, Hersh Gupta, Rahul Gujrathi, Yvonne Y Li, Andrew D Cherniack, Raquelle El Alam, Joseph Kerfoot, Eliza...> ;Clinical Cancer Research. 2024 Apr 15
• Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer.
  Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Alvaro Curiel-Garcia, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina D...> ;Nature. 2024 Apr 8
• A multicenter phase Ia study of AbGn-107, a novel antibody-drug conjugate, in patients with advanced gastrointestinal cancer.
  Andrew H Ko, Andrew L Coveler, Benjamin L Schlechter, Tanios Bekaii-Saab, Brian M Wolpin, Jeffrey W Clark, Bruno Bockorny, Li-Yuan Bai, Yu-Chin Lin, Evelyn Chiang, Pet...> ;Investigational New Drugs. 2024 Apr 1
• Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system.
  Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamali De Silva, Marios Giannakis, Bri...> ;Nature Communications. 2024 Mar 12
• Machine learning links T-cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer.
  Katie E Blise, Shamilene Sivagnanam, Courtney B Betts, Konjit Betre, Nell Kirchberger, Benjamin J Tate, Emma E Furth, Andressa Dias Costa, Jonathan A Nowak, Brian M Wo...> ;Cancer Immunology Research. 2024 Feb 21
• PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer.
  Ali, L., Lenehan, P., Cardot-Ruffino, V., Dias Costa, A., Katz, M., Bauer, T., Nowak, J., Wolpin, B., Abrams, T., Patel, A., Clancy, T., Wang, J., Mancias, J., Reilley...> ;Clinical Cancer Research. 2024 Feb 1
• Cancer Diagnoses After Recent Weight Loss.
  Wang, Q., Babic, A., Rosenthal, M., Lee, A., Zhang, Y., Zhang, X., Song, M., Rezende, L., Lee, D., Biller, L., Ng, K., Giannakis, M., Chan, A., Meyerhardt, J., Fuchs, ...> ;JAMA. 2024 Jan 23
• Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer.
  Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamail De Silva, Marios Giannakis, Bri...> ;Biorxiv. 2024 Jan 17
• 1 citations
  A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Ad...
  Huffman, B., Feng, H., Parmar, K., Wang, J., Kapner, K., Kochupurakkal, B., Martignetti, D., Sadatrezaei, G., Abrams, T., Biller, L., Giannakis, M., Ng, K., Patel, A.,...> ;Clinical Cancer Research. 2023 Dec 15
• 1 citations
  Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.
  Roni Ben-Ami, Qiao-Li Wang, Jinming Zhang, Julianna G Supplee, Johannes F Fahrmann, Roni Lehmann-Werman, Lauren K Brais, Jonathan Nowak, Chen Yuan, Maureen Loftus, Ana...> ;Gut. 2024 Mar 7
• Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
  Jadhav, H., Pantelidou, C., Phan, T., Grochala, C., Mehta, A., Guerriero, J., D'Andrea, A., Patterson-Fortin, J., Wulf, G., Wolpin, B., Stanger, B., Aguirre, A., Clear...> ;Nature Communications. 2023 Dec 11
• 2 citations
  Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectabl...
  Matthew H G Katz, Gina R Petroni, Todd Bauer, Matthew J Reilley, Brian M Wolpin, Chee-Chee Stucky, Tanios S Bekaii-Saab, Rawad Elias, Nipun Merchant, Andressa Dias Cos...> ;Journal for Immunotherapy of Cancer. 2023 Dec 1
• Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer.
  Katie E Blise, Shamilene Sivagnanam, Courtney B Betts, Konjit Betre, Nell Kirchberger, Benjamin Tate, Emma E Furth, Andressa Dias Costa, Jonathan A Nowak, Brian M Wolp...> ;Biorxiv. 2023 Oct 23
• 5 citations
  A blood-based metabolomic signature predictive of risk for pancreatic cancer.
  Ehsan Irajizad, Ana Kenney, Tiffany Tang, Jody Vykoukal, Ranran Wu, Eunice Murage, Jennifer B Dennison, Marta Sans, James P Long, Maureen Loftus, John A Chabot, Michae...> ;Cell Reports. Medicine. 2023 Sep 19
• Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions.
  Chen Yuan, Qiao-Li Wang, Hanseul Kim, Ana Babic, Jinming Zhang, Brian M Wolpin, Kana Wu, Mingyang Song, Shuji Ogino, Jeffrey A Meyerhardt, Andrew T Chan, Yin Cao, Edwa...> ;Clinical Gastroenterology and Hepatology. 2023 Sep 6
• Sex-Specific Associations between Adiponectin and Leptin Signaling and Pancreatic Cancer Survival.
  Ana Babic, Qiao-Li Wang, Alice A Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K Tabung, Aladdin H Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft,...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Oct 2
• 6 citations
  Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer.
  Ana Babic, Michael H Rosenthal, Tilak K Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K Brais, Maureen Loftus, Leah Caplan, Sarah Denning, Anamol Gurung, Joanna Harr...> ;Nature Communications. 2023 Jul 18
• 3 citations
  Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer.
  Harshabad Singh, Rachel B Keller, Kevin S Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K Brai...> ;Clinical Cancer Research. 2023 Nov 14
• Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.
  Sontoria D King, Swathi Veliginti, Martijn C G J Brouwers, Zhewen Ren, Wei Zheng, Veronica W Setiawan, Lynne R Wilkens, Xiao-Ou Shu, Alan A Arslan, Laura E Beane Freem...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Sep 1
• Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
  Jihye Kim, Chen Yuan, Laufey T Amundadottir, Brian M Wolpin, , Alison P Klein, , Harvey A Risch, Peter Kraft> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Sep 1
• Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance).
  Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M Wolpin, Yin Zhang, Charles S Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A Guthrie, Fel...> ;Clinical Cancer Research. 2023 Jul 14
• G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans.
  Victoire Cardot-Ruffino, Naima Bollenrucher, Luisa Delius, S Jennifer Wang, Lauren K Brais, Joshua Remland, C Elizabeth Keheler, Keri M Sullivan, Thomas A Abrams, Leah...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
• Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer.
  Harshabad Singh, Samuel J Klempner, Nelya Melnitchouk, Deepak P Chander, Ovidiu George Negrea, Anuj K Patel, Benjamin L Schlechter, Douglas A Rubinson, Brandon M Huffm...> ;JCO Precision Oncology. 2023 Jun 1
• Plasma 25-hydroxyvitamin D levels and survival in stage III colon cancer: Findings from CALGB/SWOG 80702 (Alliance).
  Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M Wolpin, Yin Zhang, Charles S Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A Guthrie, Fel...> ;Clinical Cancer Research. 2023 May 11
• Pancreatic cancer is associated with medication changes prior to clinical diagnosis.
  Yin Zhang, Qiao-Li Wang, Chen Yuan, Alice A Lee, Ana Babic, Kimmie Ng, Kimberly Perez, Jonathan A Nowak, Jesper Lagergren, Meir J Stampfer, Edward L Giovannucci, Chris...> ;Nature Communications. 2023 Apr 28
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Journal Articles

• Diabetes, Weight Change, and Pancreatic Cancer Risk  
  Douglas A Rubinson, Kimmie Ng, Meir J Stampfer, Brian M Wolpin, JAMA Oncology
• Germline Cancer Susceptibility Gene Variants, Somatic Second Hits, and Survival Outcomes in Patients with Resected Pancreatic Cancer  
  Richard F Dunne, Leona A Doyle, William C Hahn, Jason L Hornick, Andrea J Bullock, Sapna Syngal, Albert C Koong, Natalia Khalaf, Brian M Wolpin, Douglas A Rubinson, Da..., Nature
• Altered Exocrine Function Can Drive Adipose Wasting in Early Pancreatic Cancer  
  Jared R Mayers, Naoki Takahashi, Nicole Lopez, Brian M Wolpin, Nature

Lectures

• Performance of a blood-based test for the detection of multiple cancer types. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020