BenjaminLevineEbertMD

PubMed

• 1 citations
  Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
  Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela V Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly Klega, Radosław P Nowak, Katherine A Dono...> ;Blood. 2024 Apr 11
• Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells.
  Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, La...> ;EMBO Molecular Medicine. 2024 Mar 1
• Clonal Hematopoiesis of Indeterminate Potential With Loss ofEnhances Risk for Atrial Fibrillation ThroughInflammasome Activation.
  Lin, A., Bapat, A., Xiao, L., Niroula, A., Ye, J., Wong, W., Agrawal, M., Farady, C., Boettcher, A., Hergott, C., McConkey, M., Flores-Bringas, P., Shkolnik, V., Bick,...> ;Circulation. 2024 Feb 15
• Induced protein degradation for therapeutics: past, present, and future.
  Yoon, H., Rutter, J., Li, Y., Ebert, B.> ;The Journal of Clinical Investigation. 2024 Jan 2
• Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
  Patel, A. A., Caner Saygin, Pu Zhang, Jacob Stauber, Ibrahim Aldoss, Adam S Sperling, Lachelle D Weeks, Marlise R Luskin, Todd C Knepper, Pankhuri Wanjari, Peng Wang, ...> ;Blood Cancer Discovery. 2023 Dec 27
• Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7.
  Kann, M., Schneider, E., Almazan, A., Lane, I., Bouffard, A., Supper, V., Takei, H., Tepper, A., Larson, R., Jan, M., Leick, M., Ebert, B., Maus, M.> ;Leukemia. 2024 Mar 1
• 10 citations
  Proteolysis-targeting chimeras with reduced off-targets.
  Nguyen, T., Sreekanth, V., Deb, A., Kokkonda, P., Tiwari, P., Donovan, K., Shoba, V., Chaudhary, S., Mercer, J., Lai, S., Sadagopan, A., Jan, M., Fischer, E., Liu, D.,...> ;Nature Chemistry. 2024 Feb 1
• Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma.
  Tarek H Mouhieddine, Chidimma Nzerem, Robert Redd, Andrew Dunford, Matthew Leventhal, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Habib El-Khoury, David P Steensma, ...> ;Cancer Research Communications. 2023 Dec 18
• 1 citations
  Enhancedreactivation disruptstranscriptional program and overcomes venetoclax resistance in acute myeloid leukemias.
  Yuki Nishida, Jo Ishizawa, Edward Ayoub, Rafael Heinz Montoya, Lauren B Ostermann, Muharrem Muftuoglu, Vivian R Ruvolo, Tallie Patsilevas, Darah A Scruggs, Shayaun Kha...> ;Science Advances. 2023 Dec 1
• 1 citations
  Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
  Paolino, J., Dimitrov, B., Apsel Winger, B., Sandoval-Perez, A., Rangarajan, A., Ocasio-Martinez, N., Tsai, H., Li, Y., Robichaud, A., Khalid, D., Hatton, C., Gillani,...> ;Clinical Cancer Research. 2023 Nov 14
• 4 citations
  Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias.
  Art Schuermans, Caitlyn Vlasschaert, Victor Nauffal, So Mi Jemma Cho, Md Mesbah Uddin, Tetsushi Nakao, Abhishek Niroula, Marcus D R Klarqvist, Lachelle D Weeks, Amy E ...> ;European Heart Journal. 2024 Mar 7
• 2 citations
  Causes and consequences of clonal hematopoiesis.
  Lachelle D Weeks, Benjamin L Ebert> ;Blood. 2023 Dec 28
• 1 citations
  Association of Somatic TET2 Mutations With Giant Cell Arteritis.
  Michelle L Robinette, Lachelle D Weeks, Ryan J Kramer, Mridul Agrawal, Christopher J Gibson, Zhi Yu, Aswin Sekar, Arnav Mehta, Abhishek Niroula, Jared T Brown, Gregory...> ;Arthritis & Rheumatology. 2024 Mar 1
• Exploration of the Tunability of BRD4 Degradation by DCAF16-labelling Covalent Glues.
  Muhammad Murtaza Hassan, Yen-Der Li, Michelle W Ma, Mingxing Teng, Woong Sub Byun, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Justine C Rutter, Cyrus Y Jin, Michell...> ;Biorxiv. 2023 Oct 10
• 1 citations
  Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.
  Roman C Sarott, Inchul You, Yen-Der Li, Sean T Toenjes, Katherine A Donovan, Pooreum Seo, Martha Ordonez, Woong Sub Byun, Muhammad Murtaza Hassan, Franziska Wachter, E...> ;Journal of the American Chemical Society. 2023 Oct 11
• 1 citations
  Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice.
  Mohd Hafiz Ahmad, Mahesh Hegde, Waihay J Wong, Mona Mohammadhosseini, Lisa Garrett, Anneliese Carrascoso, Neethu Issac, Benjamin Ebert, Jeffrey C Silva, German Pihan, ...> ;Blood Advances. 2023 Dec 12
• 3 citations
  Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.
  Zhi Yu, Trevor P Fidler, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin, Taralynn Mack, Abhishek Niroula, J Brett Heimlich, Seyedeh M Zekavat, Chri...> ;The Journal of Clinical Investigation. 2023 Sep 15
• 10 citations
  UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
  Jonathan M Tsai, Jacob D Aguirre, Yen-Der Li, Jared Brown, Vivian Focht, Lukas Kater, Georg Kempf, Brittany Sandoval, Stefan Schmitt, Justine C Rutter, Pius Galli, Col...> ;Molecular Cell. 2023 Aug 3
• Author Correction: Clonal haematopoiesis and risk of chronic liver disease.
  Waihay J Wong, Connor Emdin, Alexander G Bick, Seyedeh M Zekavat, Abhishek Niroula, James P Pirruccello, Laura Dichtel, Gabriel Griffin, Md Mesbah Uddin, Christopher J...> ;Nature. 2023 Jul 1
• 1 citations
  RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia.
  William Marion, Tiago Koppe, Chun-Chin Chen, Dahai Wang, Katie Frenis, Sara Fierstein, Prerana Sensharma, Olivia Aumais, Michael Peters, Sonya Ruiz-Torres, Tafadzwa Ch...> ;Leukemia. 2023 Aug 1
• 1 citations
  Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.
  Art Schuermans, Tetsushi Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Md Mesbah Uddin, Sara Haidermota, Whitney Hornsby, Adam J Lewandowski, Alexander G Bick, Abhishek...> ;Journal of the American Heart Association. 2023 Jul 4
• 4 citations
  Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.
  Bing Z Carter, Po Yee Mak, Muharrem Muftuoglu, Wenjing Tao, Baozhen Ke, Jingqi Pei, Andrea D Bedoy, Lauren B Ostermann, Yuki Nishida, Sevinj Isgandarova, Mary Sobieski...> ;Blood. 2023 Sep 21
• 18 citations
  Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease.
  Esra D Gumuser, Art Schuermans, So Mi Jemma Cho, Zachary A Sporn, Md Mesbah Uddin, Kaavya Paruchuri, Tetsushi Nakao, Zhi Yu, Sara Haidermota, Whitney Hornsby, Lachelle...> ;Journal of the American College of Cardiology. 2023 May 23
• 1 citations
  The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein.
  Charles Zou, Hojong Yoon, Paul M C Park, J J Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M Tsai, Yen-Der Li, Shourya S Roy Burman, Katherine A Donovan, Jessica G...> ;Iscience. 2023 May 19
• 4 citations
  Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
  Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L Downey-Kopyscinski, Geoffrey M Matthews, Benjamin G Barwick, Vikas A Gupta, Daphné Dupéré-Richer, Shizuka Yamano, ...> ;Nature Cancer. 2023 May 1
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Journal Articles

• The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor  
  Robert Sidlow, Amy E Lin, David P Steensma, Benjamin L Ebert, JAMA Cardiology
• Defining the Human C2H2 Zinc Finger Degrome Targeted by Thalidomide Analogs Through CRBN  
  Benjamin Ebert, MD, Science Magazine
• CrbnI391V Is Sufficient to Confer in Vivo Sensitivity to Thalidomide and Its Derivatives in Mice  
  Benjamin L Ebert, Emma C Fink, Blood
• PPM1D Truncating Mutations Confer Resistance to Chemotherapy and Sensitivity to PPM1D Inhibition in Hematopoietic Cells  
  Peter G Miller, Brenton Mar, Benjamin L Ebert, Shaunt Fereshetian, Anthony Letai, Siddhartha Jaiswal, Blood
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Abstracts/Posters

• High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo Models of Cohesin-Mutant Myeloid Diseases
  Benjamin Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Oncogenic Mechanisms of CBL E3 Ubiquitin Ligase Mutations in Myeloid Malignancies
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Clonal Cytopenias of Undetermined Significance Are Common in Cytopenic Adults Evaluated for MDS in the National MDS Study
  Benjamin Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level
  Benjamin L. Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias _ Implications for the Biology ...
  Benjamin Ebert, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

• When You Least Expect It: Clonal Hematopoiesis as an Incidental Finding 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/1/2019
• Friday Scientific Workshop on Myeloid Development 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Optimizing Clinical Outcomes in Blood Cancers Through Groundbreaking Translational Research 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Friday Scientific Workshop on Myeloid Development: Myeloid Malignancies 
  60th American Society of Hematology Annual Meeting - 11/30/2018
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